G:18747

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Official Symbol Prkaca
Aliases Cs, PKA, PKCD, Pkaca
EntrezGene 18747
UniProt Coming Soon
Unique Molecular Interactions 130
Total Molecular Interactions 152
Total Single Events 753
Unique Interaction Partners 84

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Prkaca. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Prkaca. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Prkaca. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
2 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
3 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
4 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
5 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
6 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
7 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
8 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
9 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
10 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
11 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
12 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
13 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
14 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
15 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
16 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92
17 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
18 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
19 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
20 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8
21 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76
22 INT69692 Helt Regulation of Prkaca 1 0.00 0.33 0.76
23 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75
24 INT196799 Prkaca Positive_regulation of Phosphorylation of Trh 1 0.02 0 0.74
25 INT244025 Prkaca Regulation of Phosphorylation of Gabrg1 1 0.08 0.18 0.72
26 INT148449 Gene_expression of Inhbe Positive_regulation of Prkaca 1 0.05 0.68 0.71
27 INT150754 GTS Negative_regulation of Gene_expression of Prkaca 1 0.32 0.08 0.65
28 INT235881 Prkaca Positive_regulation of Creb1 2 0.10 0.16 0.64
29 INT104858 Prkaca Negative_regulation of Negative_regulation of TRPV1 2 0.10 0.41 0.64
30 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
31 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 0.12 0 0.63
32 INT324065 Ptger2 Positive_regulation of Prkaca 2 0.24 0.63 0.61
33 INT281086 Prkaca Positive_regulation of Mdk 1 0.08 0 0.61
34 INT244055 Prkaca Regulation of Gabrg1 1 0.08 0 0.58
35 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
36 INT356320 ORF61 Positive_regulation of Positive_regulation of Prkaca 1 0.01 0.05 0.57
37 INT296472 Camk2a Positive_regulation of Prkaca 1 0.09 0.32 0.57
38 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55
39 INT296291 Prkaca Regulation of Localization of Calm3 1 0.09 0.62 0.55
40 INT296273 Prkaca Regulation of Localization of Camk4 1 0.16 0.62 0.55
41 INT196830 Arpp21 Regulation of Prkaca 1 0.01 0 0.52
42 INT303720 Prkaca Regulation of Bdkrb1 1 0.02 0.33 0.52
43 INT196824 Ppp1r1b Regulation of Prkaca 1 0.10 0 0.51
44 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51
45 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5
46 INT243998 Binding of Prkaca and Dnm1 1 0.11 0.24 0.49
47 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
48 INT244021 Positive_regulation of Binding of Cacnb3 and Prkaca 1 0.02 0.24 0.49
49 INT243999 Positive_regulation of Binding of Prkaca and Dnm1 1 0.14 0.24 0.49
50 INT244036 Binding of Cacnb3 and Prkaca 1 0.01 0.24 0.49
51 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
52 INT342693 Binding of Prkaca and Gopc 1 0.01 0.23 0.48
53 INT296451 Prkaca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
54 INT235404 Positive_regulation of RTCA Positive_regulation of Positive_regulation of Prkaca 1 0.00 0.22 0.45
55 INT153994 Regulation of Prkaca Regulation of TRPV1 1 0.02 0.46 0.44
56 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
57 INT196821 Phosphorylation of Ppp1r1b Positive_regulation of Prkaca 1 0.09 0 0.41
58 INT196797 Trh Negative_regulation of Prkaca 1 0.01 0 0.41
59 INT196828 Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.4
60 INT235880 Binding of Mtap2 and Prkaca 1 0.07 0.41 0.38
61 INT113289 TRPV1 Regulation of Phosphorylation of Prkaca 1 0.02 0.1 0.37
62 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
63 INT306692 Prkaca Regulation of Positive_regulation of Nav1 1 0.13 0.06 0.35
64 INT112917 Nts Negative_regulation of Negative_regulation of Prkaca 1 0.20 0 0.33
65 INT104856 Prkaca Positive_regulation of Phosphorylation of TRPV1 1 0.11 0.23 0.33
66 INT112918 Phospho1 Negative_regulation of Prkaca 1 0.01 0 0.33
67 INT104857 Prkaca Negative_regulation of Localization of TRPV1 1 0.10 0.23 0.33
68 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31
69 INT196825 Prkaca Positive_regulation of Phosphorylation of Ppp2ca 1 0.20 0 0.29
70 INT196831 Positive_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.29
71 INT196814 Negative_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.17 0 0.29
72 INT283732 Prkaca Positive_regulation of Creb1 1 0.03 0 0.28
73 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27
74 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
75 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
76 INT356098 Prkca Regulation of Prkaca 1 0.01 0.11 0.24
77 INT291448 Prkaca Regulation of Gene_expression of Kcnn2 1 0.04 0 0.23
78 INT291447 Bdnf Positive_regulation of Prkaca 1 0.04 0 0.23
79 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
80 INT276046 Negative_regulation of Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 1 0.15 0.11 0.23
81 INT196823 Adcy5 Positive_regulation of Prkaca 1 0.13 0 0.22
82 INT112920 Nts Positive_regulation of Phosphorylation of Prkaca 1 0.24 0 0.21
83 INT244054 Prkaca Regulation of Neurod1 1 0.02 0.06 0.19
84 INT250052 Prkaca Regulation of Gria2 1 0.05 0 0.17
85 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
86 INT329985 Positive_regulation of Prkaca Positive_regulation of Positive_regulation of Mapk14 1 0.15 0.87 0.15
87 INT182303 Positive_regulation of Prkaca Positive_regulation of EDN1 Positive_regulation of NOS2 1 0.01 0.27 0.15
88 INT350069 Prkaca Positive_regulation of Hmox1 1 0.05 0.2 0.15
89 INT244051 Ppp1ca Regulation of Prkaca 1 0.00 0.18 0.14
90 INT190747 Adcyap1 Regulation of Positive_regulation of Prkaca 1 0.05 0 0.14
91 INT244017 Prkaca Positive_regulation of Phosphorylation of Gabrg1 1 0.09 0.17 0.13
92 INT326247 Prkcg Positive_regulation of Prkaca 1 0.00 0.62 0.13
93 INT326248 Prkaca Positive_regulation of ras 1 0.00 0.62 0.13
94 INT276037 Binding of Prkaca and Ppp1cc 1 0.08 0 0.12
95 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
96 INT276057 Binding of Prkaca and Ppp1r1b 1 0.10 0 0.12
97 INT196827 Phosphorylation of Prkaca Positive_regulation of Ppp2ca 1 0.18 0 0.11
98 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
99 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
100 INT276061 Gabbr2 Negative_regulation of Prkaca 1 0.09 0 0.11
101 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
102 INT196819 Prkaca Positive_regulation of Binding of Ppp2ca 1 0.20 0 0.11
103 INT15902 PKIA Negative_regulation of Positive_regulation of Prkaca 1 0.10 0 0.1
104 INT269415 Prkaca Regulation of Localization of TMPO 1 0.00 0 0.1
105 INT263173 Binding of PDE7A and Prkaca 1 0.01 0.27 0.09
106 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
107 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
108 INT249411 Binding of Prkaca and Napa 1 0.12 0.1 0.09
109 INT324731 Binding of Prkaca and HR 1 0.00 1.11 0.08
110 INT324732 Positive_regulation of Binding of Prkaca and HR 1 0.00 1.12 0.08
111 INT196810 Binding of Prkaca and Ppp2ca 1 0.14 0 0.07
112 INT272734 Prkaca Positive_regulation of Gene_expression of Prkca 1 0.00 0 0.06
113 INT326253 Prkaca Negative_regulation of ARAF 1 0.00 0 0.05
114 INT326251 Prkaca Positive_regulation of ARAF 1 0.00 0 0.05
115 INT258006 PTGER2 Positive_regulation of Phosphorylation of Prkaca 1 0.03 0.13 0.04
116 INT258005 Binding of PTGER3 and Prkaca 1 0.03 0.52 0.04
117 INT231848 Pcdh8 Positive_regulation of Prkaca 1 0.00 0 0.04
118 INT185938 Phosphorylation of Prkaca Positive_regulation of CREB1 1 0.04 0.07 0.04
119 INT276036 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Prkaca 1 0.27 0 0.03
120 INT276055 Negative_regulation of Pde1b Positive_regulation of Prkaca 1 0.27 0 0.03
121 INT253477 Binding of Prkaca and Ptger2 1 0.09 0.05 0
122 INT280823 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Crh 1 0.08 0.11 0
123 INT253474 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Bcl2 1 0.04 1.27 0
124 INT276062 Negative_regulation of Rtcd1 Negative_regulation of Prkaca 1 0.01 0 0
125 INT258007 PTGER2 Negative_regulation of Phosphorylation of Prkaca 1 0.02 0 0
126 INT276080 Gabbr2 Negative_regulation of Prkaca Negative_regulation of Positive_regulation of Rpa1 1 0.01 0 0
127 INT326085 Prkaca Regulation of Phosphorylation of ABCA1 1 0.02 0.44 0
128 INT280831 Prkaca Positive_regulation of Gene_expression of Crh 1 0.08 0 0
129 INT326084 Prkaca Positive_regulation of Phosphorylation of ABCA1 1 0.06 0.44 0
130 INT315133 Binding of Prkaca and PAR4 1 0.03 0.19 0
131 INT258008 PTGER2 Negative_regulation of Prkaca 1 0.02 0 0
132 INT108360 Prkaca Regulation of Phosphorylation of FOS 1 0.66 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 18747. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 18747. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
2 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
3 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
4 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
5 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
6 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
7 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
8 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
9 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57
10 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37
11 INT116623 Localization of Prkaca 15 0.73 2.89 3.59
12 INT169874 Positive_regulation of Gene_expression of Prkaca 11 0.38 1.64 2.01
13 INT108352 Regulation of Phosphorylation of Prkaca 8 0.59 0.68 1.53
14 INT155346 Negative_regulation of Negative_regulation of Prkaca 4 0.21 1.34 1.23
15 INT135102 Positive_regulation of Localization of Prkaca 3 0.17 1.21 0.75
16 INT150753 Negative_regulation of Gene_expression of Prkaca 1 0.41 0.08 0.65
17 INT164148 Negative_regulation of Localization of Prkaca 4 0.28 0.28 0.41
18 INT66380 Regulation of Negative_regulation of Prkaca 2 0.41 0 0.28
19 INT185926 Regulation of Positive_regulation of Prkaca 5 0.26 0.27 0.25
20 INT272697 Transcription of Prkaca 2 0.06 0.32 0.22
21 INT275321 Negative_regulation of Transcription of Prkaca 1 0.02 0.32 0.15
22 INT114739 Positive_regulation of Negative_regulation of Prkaca 2 0.41 2.03 0
23 INT108353 Positive_regulation of Regulation of Prkaca 1 0.45 0.08 0
24 INT276018 Regulation of Gene_expression of Prkaca 1 0.25 0 0
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