G:18750

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Official Symbol Prkca
Aliases Pkca, AI875142
EntrezGene 18750
UniProt Coming Soon
Unique Molecular Interactions 108
Total Molecular Interactions 123
Total Single Events 809
Unique Interaction Partners 74

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Prkca. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Prkca. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Prkca. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
3 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
4 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
5 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
6 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
7 INT118157 Binding of Prkca and Prkcz Positive_regulation of Binding of Prkca Prkcz 1 0.02 0.58 1.55
8 INT118159 Binding of Prkca and Prkcz Positive_regulation of Prkcz 1 0.02 0.58 1.54
9 INT118160 Binding of Prkca and Prkcz Positive_regulation of Prkca 1 0.11 0.58 1.54
10 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
11 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
12 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
13 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
14 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
15 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
16 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
17 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
18 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
19 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
20 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
21 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
22 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
23 INT126384 Binding of Bdnf and Ntrk2 Positive_regulation of Prkca 1 0.49 0.63 0.85
24 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
25 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
26 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
27 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
28 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
29 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
30 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
31 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
32 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
33 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
34 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
35 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
36 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
37 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
38 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
39 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
40 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
41 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
42 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
43 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
44 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
45 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
46 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
47 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
48 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
49 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
50 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
51 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
52 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
53 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
54 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
55 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
56 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
57 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 0.10 0.06 0.39
58 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
59 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
60 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
61 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
62 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36
63 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
64 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
65 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
66 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
67 INT307215 Negative_regulation of Prkca Negative_regulation of Ppara 1 0.09 0.21 0.3
68 INT296473 Prkca Regulation of Serac1 1 0.00 0.14 0.3
69 INT185144 Prkca Positive_regulation of Snrpd1 1 0.00 0.16 0.29
70 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29
71 INT137684 Binding of Cyp27b1 and Prkca 1 0.02 0 0.29
72 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
73 INT221236 Ros1 Positive_regulation of Localization of Prkca 1 0.01 0.15 0.27
74 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
75 INT356114 Prkca Positive_regulation of Binding of App and Tg 1 0.02 0.12 0.26
76 INT196886 Ly6 Positive_regulation of Binding of Ly6 and Prkca 1 0.00 0.18 0.25
77 INT196880 Binding of Ly6 and Prkca 1 0.01 0.18 0.25
78 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
79 INT207641 Positive_regulation of Prkca Positive_regulation of Mapk1 1 0.08 0.09 0.24
80 INT356098 Prkca Regulation of Prkaca 1 0.01 0.11 0.24
81 INT207632 Prkca Positive_regulation of Phosphorylation of Mapk1 1 0.08 0 0.23
82 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2
83 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
84 INT226720 Binding of Prkca and Il27ra 1 0.00 0.52 0.2
85 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
86 INT239235 Prkca Positive_regulation of Prkca Regulation of Nos3 1 0.01 0.97 0.2
87 INT226756 Positive_regulation of Binding of Prkca and Il27ra 1 0.00 0.52 0.2
88 INT226738 Binding of Cd4 and Prkca 1 0.02 0.52 0.2
89 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
90 INT338043 F2 Positive_regulation of Localization of Prkca 1 0.04 0.1 0.2
91 INT226727 Positive_regulation of Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.46 0.19
92 INT226761 Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.45 0.19
93 INT191890 Pbsn Negative_regulation of Binding of Prkca 1 0.03 0.29 0.18
94 INT191881 Pbsn Negative_regulation of Prkca 1 0.03 0.29 0.18
95 INT328923 Car2 Positive_regulation of Prkca 1 0.00 0 0.18
96 INT266899 Binding of Prkca and Plat 1 0.02 0.57 0.17
97 INT112133 Gast Positive_regulation of Prkca 1 0.18 0.13 0.16
98 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
99 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12
100 INT338054 Par2 Positive_regulation of Localization of Prkca 1 0.06 0 0.11
101 INT272734 Prkaca Positive_regulation of Gene_expression of Prkca 1 0.00 0 0.06
102 INT191893 Pbsn Regulation of Gene_expression of Prkca 1 0.03 0.13 0.05
103 INT245369 Gpm6a Negative_regulation of Phosphorylation of Prkca 1 0.20 0.08 0.05
104 INT191891 Prkca Regulation of Gene_expression of Mapk3 1 0.03 0.13 0.05
105 INT172912 CYP4A11 Regulation of Prkca 1 0.00 0.05 0.04
106 INT231845 Pcdh8 Positive_regulation of Prkca 1 0.00 0 0.04
107 INT350347 Negative_regulation of Prkca Negative_regulation of Chrm1 1 0.08 0 0.03
108 INT350346 Negative_regulation of Prkca Negative_regulation of Negative_regulation of Chrm1 1 0.08 0 0.03
109 INT350341 Negative_regulation of Prkca Negative_regulation of Localization of Chrm1 1 0.08 0 0.03
110 INT213039 Hdl1 Positive_regulation of Prkca 1 0.10 0.98 0.03
111 INT295858 Prkca Positive_regulation of Gtf3a 1 0.00 0 0
112 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0
113 INT311375 Phosphorylation of Prkca Positive_regulation of Celf1 1 0.04 0.1 0
114 INT295855 Prkca Positive_regulation of Akt1 1 0.02 0 0
115 INT169485 Dbi Regulation of Prkca 1 0.02 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 18750. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 18750. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
4 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
5 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
6 INT117527 Binding of Prkca 25 0.48 6.43 21.05
7 INT79458 Localization of Prkca 30 0.81 11.13 15.78
8 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
9 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
10 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
11 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
12 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
13 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
14 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
15 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
16 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
17 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
18 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
19 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
20 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
21 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
22 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
23 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
24 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
25 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
26 INT94211 Positive_regulation of Negative_regulation of Prkca 1 0.43 0 0.67
27 INT79459 Protein_catabolism of Prkca 2 1.00 0.09 0.6
28 INT227120 Transcription of Prkca 2 0.59 0.51 0.1
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