G:18976

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Official Symbol Pomc
Aliases BE, ACTH, Pomc1, Pomc-1, alphaMSH, beta-MSH, alpha-MSH, gamma-MSH
EntrezGene 18976
UniProt Coming Soon
Unique Molecular Interactions 137
Total Molecular Interactions 220
Total Single Events 1879
Unique Interaction Partners 84

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Pomc. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Pomc. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Pomc. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
2 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
3 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
4 INT91539 Pomc Positive_regulation of Pomc Positive_regulation of P9Ehs1 1 0.03 0.84 3.13
5 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
6 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
7 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
8 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
9 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
10 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
11 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
12 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
13 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
14 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
15 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
16 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
17 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36
18 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
19 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
20 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
21 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
22 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06
23 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
24 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
25 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
26 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
27 INT26991 Pomc Negative_regulation of Localization of Ins1 1 0.38 0 0.89
28 INT26987 Pomc Regulation of Ins1 1 0.40 0 0.87
29 INT120149 Positive_regulation of Pomc Positive_regulation of Localization of Ins1 1 0.03 0.09 0.82
30 INT150681 Pomc Positive_regulation of Camk2a 1 0.47 0.07 0.8
31 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
32 INT150679 Pomc Regulation of Gene_expression of Camk2a 1 0.30 0.07 0.79
33 INT42929 Pomc Negative_regulation of Localization of Oxt 1 0.11 0 0.76
34 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
35 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
36 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
37 INT138428 Binding of Oprm1 and Pomc Positive_regulation of Gene_expression of Pomc 1 0.30 0.38 0.7
38 INT40134 Binding of Pomc and Noc2l 1 0.01 0.08 0.7
39 INT75405 Pdyn Positive_regulation of Localization of Pomc 1 0.06 0 0.7
40 INT99172 Pomc Positive_regulation of Tyr 1 0.35 0.17 0.69
41 INT54502 Pomc Positive_regulation of Gene_expression of Il2 1 0.16 0 0.68
42 INT32396 Oxt Negative_regulation of Pomc 1 0.45 0 0.67
43 INT5614 Cck Regulation of Localization of Pomc 1 0.12 0.08 0.62
44 INT32747 Avp Positive_regulation of Localization of Pomc 4 0.16 1.92 0.61
45 INT128606 Pomc Positive_regulation of Gene_expression of Fos 1 0.02 0.55 0.59
46 INT149473 Avp Positive_regulation of Localization of Pomc 4 0.48 2.64 0.56
47 INT114009 Pomc Regulation of Binding of Crygs and Oprm1 1 0.03 0 0.56
48 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
49 INT141020 Crh Positive_regulation of Gene_expression of Pomc 1 0.05 0.17 0.55
50 INT114008 Pomc Positive_regulation of Binding of Crygs and Oprm1 1 0.03 0 0.54
51 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
52 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
53 INT72525 Positive_regulation of TCEA1 Positive_regulation of Pomc 1 0.08 0 0.5
54 INT54503 Pomc Positive_regulation of Gene_expression of Pbk 1 0.00 0 0.48
55 INT72524 Positive_regulation of TCEA1 Positive_regulation of Localization of Pomc 1 0.08 0 0.48
56 INT43646 Negative_regulation of Binding of Pomc and Lct 1 0.38 0 0.47
57 INT81035 Binding of Oprl1 and Pomc 1 0.03 0.13 0.47
58 INT214162 Gabrg1 Negative_regulation of Pomc 1 0.05 0.65 0.46
59 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
60 INT57356 Sct Positive_regulation of Pomc 1 0.41 0.2 0.45
61 INT25618 Pomc Regulation of Gene_expression of Il1f5 1 0.17 0 0.42
62 INT25616 Pomc Regulation of Gene_expression of Il1 1 0.60 0 0.42
63 INT33348 Binding of IFNA1 and Pomc 1 0.27 0.09 0.41
64 INT99171 Negative_regulation of Pomc Positive_regulation of Tyr 1 0.22 0.08 0.35
65 INT99173 Pomc Positive_regulation of Pomc Positive_regulation of Tyr 1 0.25 0.08 0.35
66 INT54504 Pomc Positive_regulation of Gene_expression of Il4 1 0.13 0 0.34
67 INT32445 Pomc Positive_regulation of Il1f5 1 0.21 0 0.34
68 INT29618 Cga Positive_regulation of Gene_expression of Pomc 1 0.06 0 0.34
69 INT5613 Cck Positive_regulation of Localization of Pomc 1 0.09 0.1 0.32
70 INT60628 Crh Positive_regulation of Pomc 1 0.52 0.17 0.32
71 INT42422 Pomc Positive_regulation of Rtcd1 1 0.07 0.35 0.32
72 INT25614 Pomc Regulation of Localization of Il1f5 1 0.07 0 0.31
73 INT97546 Pomc Negative_regulation of Mc1r 1 0.40 0.15 0.3
74 INT108019 Clec4d Negative_regulation of Binding of Pomc 1 0.00 0.44 0.28
75 INT222440 Tlr4 Positive_regulation of Localization of Pomc 1 0.01 0.35 0.27
76 INT222427 Il6 Positive_regulation of Localization of Pomc 1 0.02 0.27 0.26
77 INT65507 Oprl1 Positive_regulation of Gene_expression of Pomc 1 0.28 0 0.26
78 INT88777 Positive_regulation of Binding of Oprm1 and Pomc 1 0.16 0.09 0.24
79 INT68491 Positive_regulation of Binding of Pomc and Spdya 1 0.00 0 0.24
80 INT98379 Regulation of Binding of Pomc and Oprd1 1 0.01 0.35 0.23
81 INT98380 Binding of Pomc and Oprd1 1 0.02 0.35 0.23
82 INT121050 Crh Regulation of Localization of Pomc 4 0.43 0.6 0.22
83 INT25617 Pomc Positive_regulation of Gene_expression of Il1 1 0.45 0 0.2
84 INT25615 Pomc Positive_regulation of Binding of Il1 1 0.49 0 0.2
85 INT150366 Nfkb1 Regulation of Gene_expression of Pomc 1 0.03 0.17 0.17
86 INT222443 INCENP Positive_regulation of Localization of Pomc 1 0.00 0.75 0.17
87 INT150365 Camk2a Regulation of Gene_expression of Pomc 1 0.08 0.17 0.17
88 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17
89 INT49198 Binding of Pomc and Il1 1 0.30 0.2 0.16
90 INT49200 Binding of Il6 and Pomc 1 0.19 0.2 0.16
91 INT222430 Il11 Positive_regulation of Localization of Pomc 1 0.01 0.69 0.16
92 INT49199 Binding of Pomc and Gtf3a 1 0.05 0.2 0.16
93 INT43492 Pomc Regulation of Gene_expression of Ifng 1 0.34 0 0.16
94 INT49201 Binding of Pomc and Il1f5 1 0.08 0.2 0.16
95 INT56596 Pomc Positive_regulation of Localization of Il4 1 0.20 0 0.15
96 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
97 INT121047 Crh Regulation of Gene_expression of Pomc 1 0.58 0.29 0.15
98 INT97544 Pomc Negative_regulation of a 1 0.19 0.07 0.15
99 INT325449 Pomc Negative_regulation of Mif-ps1 1 0.08 0.5 0.13
100 INT354065 Pomc Regulation of Cort 1 0.07 1.69 0.12
101 INT68493 Pomc Positive_regulation of NR3C1 1 0.02 0 0.12
102 INT68492 Binding of Pomc and Spdya 1 0.00 0 0.12
103 INT337897 Ins1 Positive_regulation of Gene_expression of Pomc 1 0.11 0.27 0.11
104 INT66109 SIGMAR1 Regulation of Localization of Pomc 1 0.00 0 0.1
105 INT214138 Son Regulation of Gene_expression of Pomc 1 0.05 0.1 0.09
106 INT214161 Pomc Regulation of Mc4r 1 0.21 0.1 0.09
107 INT214156 Pomc Negative_regulation of Gene_expression of Npy 1 0.39 0.07 0.09
108 INT214169 Localization of PYY3 Positive_regulation of Localization of Pomc 1 0.13 0.29 0.08
109 INT354078 Avpr1b Positive_regulation of Localization of Pomc 1 0.28 2.71 0.08
110 INT354072 Cort Regulation of Pomc 1 0.07 1.22 0.08
111 INT32745 Crh Positive_regulation of Localization of Pomc 2 0.16 0.49 0.07
112 INT51719 Nppa Regulation of Regulation of Pomc 1 0.14 0.1 0.07
113 INT280810 Avp Negative_regulation of Gene_expression of Pomc 1 0.02 0.22 0.06
114 INT280816 Crh Positive_regulation of Gene_expression of Pomc 1 0.15 0.28 0.06
115 INT29385 Positive_regulation of Crh Regulation of Pomc 1 0.00 0.21 0.06
116 INT32746 Oxt Positive_regulation of Localization of Pomc 1 0.03 0.14 0.04
117 INT32744 Agt Positive_regulation of Localization of Pomc 1 0.06 0.14 0.04
118 INT222417 Ucn Positive_regulation of Localization of Pomc 1 0.01 0 0.04
119 INT214149 Binding of Lepr and Pomc 1 0.33 0.21 0.03
120 INT354071 Pomc Positive_regulation of Localization of Cort 1 0.12 0.86 0.03
121 INT354069 Oxt Positive_regulation of Localization of Pomc 1 0.11 0.88 0.03
122 INT214167 Binding of DST and Pomc 1 0.03 0.22 0.03
123 INT354059 Negative_regulation of Pomc Regulation of Cort 1 0.12 0.74 0.03
124 INT174290 Lep Positive_regulation of Pomc 2 0.50 0.47 0
125 INT213868 ERF Regulation of Gene_expression of Pomc 1 0.01 0.08 0
126 INT174292 Ins1 Positive_regulation of Pomc 1 0.02 0.47 0
127 INT214139 Lep Regulation of Localization of Pomc 1 0.20 0.4 0
128 INT13225 Pomc Positive_regulation of TNF 1 0.09 0.28 0
129 INT214155 Lep Regulation of Gene_expression of Pomc 1 0.20 0.4 0
130 INT280840 Avp Regulation of Localization of Pomc 1 0.02 0.16 0
131 INT222423 Binding of Pomc and Fshb 1 0.01 0 0
132 INT280806 Avpr1b Positive_regulation of Localization of Pomc 1 0.19 0.17 0
133 INT289601 Acsm3 Negative_regulation of Pomc 1 0.00 0.27 0
134 INT297854 Agrp Regulation of Pomc 1 0.24 0 0
135 INT222438 Nps Positive_regulation of Localization of Pomc 1 0.01 0.66 0
136 INT222424 Binding of Pomc and Gnrh1 1 0.03 0 0
137 INT354074 Avpr1b Regulation of Localization of Pomc 1 0.16 1.44 0
138 INT69256 Drd2 Regulation of Regulation of Pomc 1 0.29 0 0
139 INT19495 Pomc Negative_regulation of Ins1 1 0.25 0.27 0
140 INT222415 Binding of Pomc and LH 1 0.01 0 0
141 INT69255 Drd2 Regulation of Transcription of Pomc 1 0.29 0 0
142 INT222419 Nmu Positive_regulation of Localization of Pomc 1 0.03 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 18976. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 18976. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
2 INT1438 Localization of Pomc 360 0.81 101.26 116.47
3 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
4 INT462 Regulation of Pomc 157 0.62 41.67 67.27
5 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
6 INT1295 Binding of Pomc 85 0.48 12.92 42.8
7 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
8 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
9 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
10 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8
11 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59
12 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26
13 INT6276 Negative_regulation of Positive_regulation of Pomc 12 0.57 3.65 5.49
14 INT24420 Transcription of Pomc 13 0.69 3.32 4.54
15 INT20408 Regulation of Negative_regulation of Pomc 3 0.45 0.38 3.51
16 INT25611 Negative_regulation of Binding of Pomc 6 0.56 1.05 2.74
17 INT33697 Regulation of Positive_regulation of Pomc 5 0.45 0.83 2.5
18 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37
19 INT13294 Negative_regulation of Regulation of Pomc 5 0.38 2.83 2.01
20 INT6246 Negative_regulation of Negative_regulation of Pomc 3 0.43 1.34 1.78
21 INT32805 Regulation of Regulation of Pomc 2 0.42 0.1 1.35
22 INT131007 Positive_regulation of Transcription of Pomc 2 0.49 1.68 0.86
23 INT18229 Positive_regulation of Regulation of Pomc 2 0.44 0.15 0.76
24 INT3690 Protein_catabolism of Pomc 6 0.96 0.6 0.6
25 INT23561 Positive_regulation of Negative_regulation of Pomc 1 0.47 0.25 0.57
26 INT21405 Regulation of Binding of Pomc 1 0.10 0 0.34
27 INT39579 Regulation of Transcription of Pomc 1 0.26 0 0.33
28 INT294483 Negative_regulation of Transcription of Pomc 1 0.42 0.9 0.1
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