G:2064

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Official Symbol ERBB2
Aliases NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu
EntrezGene 2064
UniProt Coming Soon
Unique Molecular Interactions 54
Total Molecular Interactions 91
Total Single Events 1153
Unique Interaction Partners 41

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to ERBB2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to ERBB2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to ERBB2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
2 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
3 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
4 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
5 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
6 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
7 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
8 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
9 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
10 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
11 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
12 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
13 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
14 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
15 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
16 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
17 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
18 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
19 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
20 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
21 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
22 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
23 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
24 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03
25 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0
26 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
27 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0
28 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0
29 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
30 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
31 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0
32 INT186603 Binding of ERBB2 and Ednra 1 0.02 0.53 0
33 INT339113 Binding of ASIP and ERBB2 1 0.00 0.64 0
34 INT339104 Binding of ERBB2 and GRB7 1 0.30 1.29 0
35 INT186589 Binding of ERBB2 and SCFV 1 0.13 0.65 0
36 INT293807 Positive_regulation of Binding of ERBB2 and RORC 1 0.02 0.12 0
37 INT250667 KLF1 Regulation of ERBB2 1 0.00 1.16 0
38 INT293803 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of AR 1 0.10 0 0
39 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
40 INT250666 ERBB2 Positive_regulation of PIK3CB 1 0.15 0.69 0
41 INT293814 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of GOPC 1 0.02 0 0
42 INT277860 MUC4 Negative_regulation of ERBB2 1 0.19 0.29 0
43 INT223583 TXK Negative_regulation of ERBB2 1 0.07 0.18 0
44 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0
45 INT293718 Binding of ERBB2 and RORC Positive_regulation of RORC 1 0.00 0.12 0
46 INT339115 Binding of ERBB2 and PVT1 1 0.43 1.11 0
47 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0
48 INT293799 Binding of ERBB2 and RORC 1 0.02 0.12 0
49 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0
50 INT294087 Negative_regulation of Binding of ERBB2 and ERBB3 1 0.08 0.6 0
51 INT339103 Binding of ERBB2 and TRPS1 1 0.39 0.3 0
52 INT339106 Binding of BCS1L and ERBB2 1 0.04 0.17 0
53 INT339114 Binding of ERBB2 and MYC 1 0.22 0.81 0
54 INT277863 Binding of ERBB2 and Abcc3 1 0.01 0.28 0
55 INT293717 Binding of ERBB2 and RORC Positive_regulation of PIK3CG 1 0.00 0.13 0
56 INT339120 Binding of ERBB2 and MIEN1 1 0.31 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 2064. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 2064. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
2 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
3 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
4 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
5 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
6 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
7 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
8 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
9 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
10 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
11 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
12 INT339167 Positive_regulation of Localization of ERBB2 2 0.49 1.49 0.17
13 INT181787 Transcription of ERBB2 13 0.71 10.03 0.16
14 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11
15 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06
16 INT213915 Negative_regulation of Positive_regulation of ERBB2 2 0.41 1.09 0.05
17 INT212270 Regulation of Localization of ERBB2 1 0.42 0.45 0.05
18 INT266927 Positive_regulation of Transcription of ERBB2 2 0.46 2.5 0.03
19 INT234210 Regulation of Negative_regulation of ERBB2 1 0.25 0.5 0.03
20 INT265512 Negative_regulation of Binding of ERBB2 4 0.40 1.43 0
21 INT234204 Protein_catabolism of ERBB2 3 0.82 1.6 0
22 INT286987 Positive_regulation of Phosphorylation of ERBB2 2 0.23 0.91 0
23 INT279213 Positive_regulation of Binding of ERBB2 2 0.46 2.29 0
24 INT277861 Positive_regulation of Positive_regulation of ERBB2 1 0.64 0.32 0
25 INT223291 Regulation of Transcription of ERBB2 1 0.25 0.21 0
26 INT341850 Positive_regulation of Protein_catabolism of ERBB2 1 0.42 0.97 0
27 INT293781 Regulation of Phosphorylation of ERBB2 1 0.24 0.13 0
28 INT213924 Regulation of Binding of ERBB2 1 0.43 0.46 0
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