G:207

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Official Symbol AKT1
Aliases AKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA
EntrezGene 207
UniProt Coming Soon
Unique Molecular Interactions 146
Total Molecular Interactions 173
Total Single Events 1263
Unique Interaction Partners 99

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to AKT1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to AKT1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to AKT1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
2 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
3 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
4 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
5 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
6 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
7 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
8 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
9 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
10 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
11 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
12 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
13 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
14 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
15 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
16 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
17 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
18 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
19 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
20 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
21 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
22 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
23 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
24 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
25 INT291249 Map3k8 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
26 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
27 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
28 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
29 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
30 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
31 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
32 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
33 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
34 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
35 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
36 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
37 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14
38 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
39 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
40 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
41 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
42 INT176130 AKT1 Regulation of Gene_expression of COX18 1 0.13 0.82 0.11
43 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
44 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
45 INT249193 Negative_regulation of CA2 Negative_regulation of Binding of AKT1 1 0.03 0.08 0.05
46 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
47 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
48 INT328429 PRB4 Negative_regulation of Gene_expression of AKT1 1 0.03 0.52 0.05
49 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05
50 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05
51 INT328434 PRB4 Negative_regulation of AKT1 1 0.02 0.29 0.05
52 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 0.36 1.37 0.04
53 INT249170 Binding of AKT1 and ARHGDIA 1 0.00 0.15 0.04
54 INT200645 Binding of AKT1 and TBK1 1 0.02 0.43 0.04
55 INT347291 Binding of AKT1 and CCL16 1 0.06 0.99 0.04
56 INT347299 Binding of AKT1 and ITK 1 0.04 0.99 0.04
57 INT266661 AKT1 Regulation of BAD 2 0.10 1.86 0.03
58 INT315066 AKT1 Negative_regulation of PAR4 1 0.39 1.8 0.03
59 INT265891 IGF1 Regulation of AKT1 1 0.05 1.24 0.03
60 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03
61 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
62 INT347295 CCL16 Positive_regulation of Gene_expression of AKT1 1 0.12 0.29 0.03
63 INT328428 PRB4 Regulation of Positive_regulation of AKT1 1 0.04 0.4 0.03
64 INT234195 HSP90AA1 Regulation of AKT1 1 0.14 0.65 0.03
65 INT133490 AKT1 Positive_regulation of Csnk2b 1 0.02 0.42 0.03
66 INT133483 AKT1 Positive_regulation of KCNMA1 1 0.00 0.43 0.03
67 INT328440 PRB4 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.24 0.03
68 INT291357 CXCR4 Positive_regulation of AKT1 1 0.08 1.27 0.03
69 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0
70 INT351155 AKT1 Positive_regulation of Positive_regulation of FGF2 1 0.03 0.81 0
71 INT200642 GOPC Regulation of AKT1 1 0.14 0.2 0
72 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0
73 INT198022 AKT1 Regulation of Gene_expression of MCL1 1 0.15 2.25 0
74 INT347304 PDGFA Positive_regulation of Gene_expression of AKT1 1 0.19 0.6 0
75 INT315053 Negative_regulation of AKT1 Positive_regulation of Binding of RELA 1 0.10 0.12 0
76 INT292511 Mlph Regulation of AKT1 1 0.01 0.21 0
77 INT336033 PIK3CG Regulation of AKT1 1 0.03 0.43 0
78 INT292512 AKT1 Regulation of Birc5 1 0.08 0.76 0
79 INT285909 AKT1 Regulation of Phosphorylation of Bad 1 0.01 0.4 0
80 INT340927 Negative_regulation of PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
81 INT176137 Negative_regulation of Binding of AKT1 and PIK3CG 1 0.17 0.25 0
82 INT302145 Positive_regulation of AKT1 Positive_regulation of Phosphorylation of BAD 1 0.07 0.9 0
83 INT223575 AKT1 Regulation of MTOR 1 0.12 0.37 0
84 INT298193 AKT1 Regulation of IST1 1 0.00 0.3 0
85 INT293818 AKT1 Positive_regulation of Gene_expression of AR 1 0.05 0.31 0
86 INT250668 AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
87 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
88 INT337492 AKT1 Positive_regulation of Akt1 1 0.26 0.17 0
89 INT246147 AKT1 Positive_regulation of Phosphorylation of RNF123 1 0.01 0.09 0
90 INT292514 Mlph Regulation of Positive_regulation of AKT1 1 0.01 0.42 0
91 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0
92 INT250663 Phosphorylation of AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
93 INT206060 FDPS Positive_regulation of AKT1 1 0.00 0.4 0
94 INT292452 Gene_expression of PTK2 Negative_regulation of Positive_regulation of AKT1 1 0.14 0.6 0
95 INT320713 NRAS Positive_regulation of AKT1 1 0.37 0.84 0
96 INT225873 Ilk Positive_regulation of AKT1 1 0.00 0.07 0
97 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
98 INT300877 Negative_regulation of AKT1 Negative_regulation of Il6 1 0.04 0.16 0
99 INT246149 AKT1 Regulation of Gene_expression of RNF123 1 0.02 0.09 0
100 INT299295 OR3A4P Negative_regulation of Phosphorylation of AKT1 1 0.00 0.22 0
101 INT229884 Gart Regulation of AKT1 1 0.02 0.4 0
102 INT292456 AKT1 Regulation of BAX 1 0.00 0.76 0
103 INT318787 Binding of AKT1 and VEGFA 1 0.37 0.34 0
104 INT200651 AKT2 Regulation of AKT1 1 0.31 0.21 0
105 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
106 INT299279 AKT1 Negative_regulation of PI3 1 0.08 0 0
107 INT177915 EGF Positive_regulation of Phosphorylation of AKT1 1 0.03 0.51 0
108 INT340924 PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
109 INT315050 AKT1 Regulation of Localization of PAR4 1 0.41 0.07 0
110 INT182257 EDN1 Positive_regulation of Phosphorylation of AKT1 1 0.21 0.05 0
111 INT328427 PIK3CD Negative_regulation of Phosphorylation of AKT1 1 0.09 0.29 0
112 INT292494 Mlph Positive_regulation of Phosphorylation of AKT1 1 0.01 0.84 0
113 INT329745 AKT1 Negative_regulation of BAD 1 0.03 1.43 0
114 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0
115 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
116 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
117 INT225897 PDPK1 Positive_regulation of AKT1 1 0.01 0.07 0
118 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
119 INT293805 AKT1 Regulation of PDZD2 1 0.02 0.45 0
120 INT200650 HDAC4 Regulation of Gene_expression of AKT1 1 0.16 0.66 0
121 INT236012 HIST2H2AA3 Positive_regulation of AKT1 1 0.00 0.17 0
122 INT347303 Positive_regulation of CCL16 Positive_regulation of AKT1 1 0.08 0.57 0
123 INT236010 GOPC Positive_regulation of AKT1 1 0.03 0.17 0
124 INT315074 Negative_regulation of AKT1 Positive_regulation of Binding of PAR4 1 0.46 0.12 0
125 INT315068 Binding of AKT1 and PAR4 1 0.34 4.41 0
126 INT292499 Mlph Positive_regulation of AKT1 1 0.01 0.87 0
127 INT292448 Positive_regulation of PTK2 Positive_regulation of Phosphorylation of AKT1 1 0.15 0.28 0
128 INT250664 PIK3CB Positive_regulation of AKT1 1 0.09 0.62 0
129 INT249174 Binding of AKT1 and S100B 1 0.02 0 0
130 INT250660 PIK3CB Negative_regulation of AKT1 1 0.09 0.83 0
131 INT164070 AKT1 Positive_regulation of NFKB1 1 0.32 0.09 0
132 INT164071 AKT1 Regulation of Positive_regulation of NFKB1 1 0.17 0.09 0
133 INT298190 AKT1 Regulation of MPHOSPH6 1 0.00 0.3 0
134 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0
135 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0
136 INT315072 Binding of AKT1 and YWHAQ 1 0.34 0.78 0
137 INT315051 AKT1 Regulation of Localization of RELA 1 0.09 0.07 0
138 INT292513 Mlph Regulation of Gene_expression of AKT1 1 0.01 0.21 0
139 INT266658 SH3BP5 Negative_regulation of AKT1 1 0.05 0.21 0
140 INT350428 Binding of AKT1 and ATF3 1 0.10 1.7 0
141 INT351159 CAV1 Positive_regulation of AKT1 1 0.11 0.87 0
142 INT225888 AKT1 Positive_regulation of PAK1 1 0.01 0.08 0
143 INT200646 AKT1 Regulation of CASP9 1 0.10 1.09 0
144 INT293804 PTEN Regulation of AKT1 1 0.04 0.07 0
145 INT329747 AKT1 Negative_regulation of GSK 1 0.09 1.55 0
146 INT347297 ILK Regulation of Gene_expression of AKT1 1 0.21 0.62 0
147 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 207. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 207. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
2 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
3 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
4 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
5 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
6 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
7 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
8 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
9 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
10 INT118791 Binding of AKT1 32 0.48 15.51 2.25
11 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
12 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
13 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
14 INT135556 Localization of AKT1 38 0.69 12.78 1.17
15 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
16 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
17 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
18 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
19 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
20 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
21 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
22 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
23 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
24 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
25 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
26 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
27 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
28 INT198028 Regulation of Regulation of AKT1 1 0.22 1.08 0
29 INT223603 Regulation of Localization of AKT1 1 0.23 0.65 0
30 INT200688 Negative_regulation of Transcription of AKT1 1 0.54 1.53 0
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