G:20848

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Official Symbol Stat3
Aliases Aprf, AW109958, 1110034C02Rik
EntrezGene 20848
UniProt Coming Soon
Unique Molecular Interactions 64
Total Molecular Interactions 81
Total Single Events 422
Unique Interaction Partners 38

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Stat3. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Stat3. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Stat3. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
2 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
3 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
4 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
5 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
6 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
7 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49
8 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49
9 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45
10 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43
11 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4
12 INT254217 Tyk2 Positive_regulation of Stat3 1 0.23 0.83 0.33
13 INT254209 Jak1 Positive_regulation of Stat3 1 0.18 0.84 0.33
14 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
15 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
16 INT315200 Negative_regulation of Binding of Socs3 and Stat3 1 0.26 1.18 0.27
17 INT240539 Il12a Positive_regulation of Stat3 1 0.11 0.75 0.22
18 INT276968 Il6 Positive_regulation of Gene_expression of Stat3 2 0.20 1.54 0.21
19 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18
20 INT316477 Stat3 Positive_regulation of Il10 1 0.39 0.35 0.18
21 INT295268 S100a8 Positive_regulation of Stat3 1 0.00 0.5 0.18
22 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
23 INT129592 St13 Positive_regulation of Protein_catabolism of Stat3 1 0.26 0.84 0.16
24 INT129593 St13 Positive_regulation of Positive_regulation of Stat3 1 0.28 0.84 0.16
25 INT316490 Il6 Positive_regulation of Positive_regulation of Stat3 1 0.50 0.33 0.15
26 INT332254 Pdgfa Positive_regulation of Stat3 1 0.02 0.52 0.14
27 INT320770 Dsg2 Positive_regulation of Stat3 1 0.28 0.74 0.13
28 INT289253 Il23a Positive_regulation of Stat3 1 0.04 0.37 0.12
29 INT321826 Stat3 Positive_regulation of Localization of CSF2 1 0.02 0 0.12
30 INT348021 Stat3 Regulation of Vps54 1 0.02 1.32 0.07
31 INT316492 Stat3 Positive_regulation of Socs3 1 0.46 0.19 0.06
32 INT354822 Negative_regulation of Stat3 Negative_regulation of Positive_regulation of IFNA1 1 0.02 0.85 0.06
33 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
34 INT316489 Stat3 Positive_regulation of Transcription of Ccnb1 1 0.02 1.27 0.04
35 INT316486 Stat3 Positive_regulation of Transcription of Cdc2b 1 0.28 1.27 0.04
36 INT276965 Gbp6 Positive_regulation of Localization of Stat3 1 0.01 0.69 0.04
37 INT276947 Gbp6 Positive_regulation of Phosphorylation of Stat3 1 0.01 0.7 0.04
38 INT316499 Stat3 Positive_regulation of Transcription of MYC 1 0.55 1.27 0.04
39 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
40 INT276986 Gbp6 Positive_regulation of Stat3 1 0.01 0.69 0.04
41 INT205480 Egfr Positive_regulation of Stat3 5 0.58 4.11 0.03
42 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
43 INT316478 Binding of Stat3 and Hist1h3f 1 0.05 1.08 0.03
44 INT227700 MET Positive_regulation of Stat3 1 0.04 0.8 0.03
45 INT316481 Positive_regulation of Stat3 Positive_regulation of Localization of Hand1 1 0.19 1.48 0.03
46 INT205481 Regulation of Egfr Positive_regulation of Stat3 1 0.38 3.37 0
47 INT316497 Negative_regulation of Stat3 Negative_regulation of Gene_expression of VEGFA 1 0.13 0.93 0
48 INT276959 Gopc Positive_regulation of Phosphorylation of Stat3 1 0.16 0.16 0
49 INT205479 Egfr Positive_regulation of Transcription of Stat3 1 0.42 1.66 0
50 INT276971 Il6 Positive_regulation of Phosphorylation of Stat3 1 0.08 0.16 0
51 INT321825 IL6 Positive_regulation of Stat3 1 0.04 0.58 0
52 INT276982 Il6 Positive_regulation of Localization of Stat3 1 0.08 0.16 0
53 INT321824 IL6 Positive_regulation of Positive_regulation of Stat3 1 0.06 0.6 0
54 INT276960 Gopc Positive_regulation of Localization of Stat3 1 0.16 0.16 0
55 INT276957 Il10 Positive_regulation of Localization of Stat3 1 0.14 0.16 0
56 INT305272 Gene_expression of Lep Positive_regulation of Positive_regulation of Stat3 1 0.40 0.46 0
57 INT305258 Lep Regulation of Gene_expression of Stat3 1 0.24 0.92 0
58 INT276961 Gopc Positive_regulation of Gene_expression of Stat3 1 0.16 0.16 0
59 INT227697 Stat3 Regulation of Bcl2l1 1 0.05 1.29 0
60 INT319661 Binding of Stat3 and Gadd45gip1 1 0.20 0.17 0
61 INT305261 Gene_expression of Lep Positive_regulation of Gene_expression of Stat3 1 0.40 0.46 0
62 INT276985 Il10 Positive_regulation of Phosphorylation of Stat3 1 0.14 0.16 0
63 INT305269 Lep Positive_regulation of Phosphorylation of Stat3 1 0.40 1.03 0
64 INT276975 Il10 Positive_regulation of Gene_expression of Stat3 1 0.14 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 20848. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 20848. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
2 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
3 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
4 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
5 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
6 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
7 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27
8 INT140268 Negative_regulation of Positive_regulation of Stat3 9 0.47 7.59 2.05
9 INT192965 Localization of Stat3 15 0.74 7.05 1.68
10 INT121207 Negative_regulation of Phosphorylation of Stat3 16 0.45 9.35 1.4
11 INT178186 Regulation of Stat3 7 0.44 6.23 0.74
12 INT205476 Binding of Stat3 12 0.47 4.73 0.72
13 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64
14 INT205477 Transcription of Stat3 4 0.68 3.15 0.5
15 INT276919 Regulation of Phosphorylation of Stat3 3 0.35 1.32 0.27
16 INT289227 Regulation of Gene_expression of Stat3 4 0.47 3.66 0.21
17 INT335080 Negative_regulation of Negative_regulation of Stat3 1 0.16 0.46 0.18
18 INT129583 Protein_catabolism of Stat3 1 0.41 0.83 0.16
19 INT276934 Negative_regulation of Localization of Stat3 4 0.45 1.99 0.15
20 INT290661 Regulation of Regulation of Stat3 1 0.29 0.36 0.14
21 INT290655 Positive_regulation of Transcription of Stat3 1 0.33 0.41 0.13
22 INT276922 Positive_regulation of Localization of Stat3 1 0.39 1.34 0.12
23 INT316449 Negative_regulation of Binding of Stat3 2 0.42 0.4 0.05
24 INT276940 Regulation of Localization of Stat3 1 0.35 0.74 0.04
25 INT305250 Regulation of Positive_regulation of Stat3 1 0.21 0.44 0
26 INT316433 Regulation of Transcription of Stat3 1 0.44 0.67 0
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