G:2099

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Official Symbol ESR1
Aliases ER, ESR, Era, ESRA, NR3A1, DKFZp686N23123
EntrezGene 2099
UniProt Coming Soon
Unique Molecular Interactions 122
Total Molecular Interactions 155
Total Single Events 1680
Unique Interaction Partners 93

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to ESR1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to ESR1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to ESR1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
2 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
3 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
4 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
5 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
6 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
7 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
8 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
9 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
10 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
11 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
12 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
13 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
14 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
15 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
16 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
17 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
18 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
19 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
20 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
21 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
22 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
23 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
24 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
25 INT19045 ESR1 Positive_regulation of Salpa1 1 0.02 0.6 0.17
26 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
27 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
28 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13
29 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
30 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11
31 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
32 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1
33 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
34 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
35 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08
36 INT38188 PGR Positive_regulation of Gene_expression of ESR1 1 0.42 0.22 0.07
37 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
38 INT224293 AR Positive_regulation of Protein_catabolism of ESR1 1 0.24 0.4 0.07
39 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07
40 INT187845 Binding of ESR1 and Esr2 1 0.01 0.17 0.06
41 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05
42 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05
43 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
44 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
45 INT206853 ESR1 Positive_regulation of Gene_expression of PCP4 1 0.08 1.39 0.04
46 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
47 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04
48 INT206851 NR4A1 Regulation of Gene_expression of ESR1 1 0.08 0.9 0.04
49 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04
50 INT206847 ESR1 Negative_regulation of Gene_expression of PTGER3 1 0.08 1.52 0.04
51 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
52 INT206849 ESR1 Regulation of Gene_expression of ALDH1A1 1 0.11 2.26 0.04
53 INT206852 ESR1 Regulation of Gene_expression of CRABP2 1 0.08 1.52 0.04
54 INT183614 Binding of ESR1 and TMED4 2 0.02 0.13 0.03
55 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03
56 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
57 INT245075 Binding of ESR1 and NR4A1 1 0.01 1.08 0.03
58 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03
59 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
60 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0
61 INT335214 Binding of ESR1 and RARS 1 0.08 0.92 0
62 INT178638 Gh1 Regulation of Gene_expression of ESR1 1 0.01 0.47 0
63 INT206895 Binding of ESR1 and Aldh1a1 1 0.03 0 0
64 INT264663 Binding of ESR1 and PRL 1 0.22 0.18 0
65 INT98354 TXNRD1 Positive_regulation of Positive_regulation of ESR1 1 0.00 0.05 0
66 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0
67 INT120549 Binding of ESR1 and Mpo 1 0.26 0.05 0
68 INT199975 ESR1 Positive_regulation of PGR 1 0.05 0.11 0
69 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
70 INT264662 ESR1 Regulation of Gene_expression of PRL 1 0.43 0.21 0
71 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
72 INT206850 Binding of CRABP2 and ESR1 1 0.06 0 0
73 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0
74 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0
75 INT219421 Binding of ESR1 and MALAT1 1 0.34 0.63 0
76 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
77 INT98353 THRB Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
78 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
79 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0
80 INT192913 Binding of ESR1 and HAMP 1 0.02 0.72 0
81 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0
82 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
83 INT333929 Binding of ESR1 and ERLEC1 1 0.01 0.09 0
84 INT223582 Negative_regulation of MTOR Positive_regulation of Phosphorylation of ESR1 1 0.31 0.67 0
85 INT178639 Binding of ESR1 and Igf1 1 0.02 0.39 0
86 INT244450 TMBIM6 Negative_regulation of Gene_expression of ESR1 1 0.04 0.68 0
87 INT260601 Binding of ESR1 and Ppargc1a 1 0.01 0.48 0
88 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0
89 INT264661 ESR1 Positive_regulation of PRL 1 0.43 0.68 0
90 INT339102 Binding of ESR1 and PVT1 1 0.34 0.3 0
91 INT98356 ADRA1D Positive_regulation of Positive_regulation of ESR1 1 0.02 0.05 0
92 INT192915 Binding of ESR1 and MIER3 1 0.00 0.72 0
93 INT219404 Binding of ESR1 and VEGFA 1 0.33 0.63 0
94 INT252805 ENOPH1 Positive_regulation of Gene_expression of ESR1 1 0.00 2.46 0
95 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
96 INT197676 ESR1 Regulation of Gene_expression of Pgr 1 0.06 0.1 0
97 INT191168 DBT Negative_regulation of ESR1 1 0.02 0 0
98 INT335216 RARS Negative_regulation of Binding of ESR1 1 0.10 0.92 0
99 INT234179 Binding of DDR1 and ESR1 1 0.05 0.86 0
100 INT199988 ESR1 Positive_regulation of Fos 1 0.40 0.18 0
101 INT197675 Regulation of Binding of ESR1 and Arg1 1 0.05 0 0
102 INT244471 TMBIM6 Negative_regulation of ESR1 1 0.04 0.68 0
103 INT289426 Binding of ESR1 and RXFP1 1 0.01 0.18 0
104 INT230148 Binding of ESR1 and Positive_regulation of MAPK1 1 0.07 0 0
105 INT223318 Binding of ESR1 and ESR2 1 0.40 1.22 0
106 INT218012 EE Positive_regulation of ESR1 1 0.03 0 0
107 INT230135 Binding of ESR1 and OSBP 1 0.11 0.08 0
108 INT98355 TXNRD1 Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
109 INT339098 Binding of ESR1 and TRPS1 1 0.30 0.3 0
110 INT218961 Binding of ESR1 and Esyt1 1 0.00 0 0
111 INT178637 Igf1 Positive_regulation of ESR1 1 0.03 0.17 0
112 INT191172 DBT Positive_regulation of Regulation of ESR1 1 0.02 0 0
113 INT199977 ESR1 Positive_regulation of JUN 1 0.03 0.18 0
114 INT191167 DBT Positive_regulation of Localization of ESR1 1 0.03 0 0
115 INT206899 ESR1 Negative_regulation of Gene_expression of Calcrl 1 0.07 0.15 0
116 INT206843 Binding of ALDH1A1 and ESR1 1 0.07 0 0
117 INT350980 ESR1 Regulation of VEGFA 1 0.01 0.62 0
118 INT197916 Binding of ESR1 and Eutr1 1 0.00 0 0
119 INT191173 Regulation of DBT Negative_regulation of ESR1 1 0.01 0 0
120 INT264664 Binding of AES and ESR1 1 0.15 0.18 0
121 INT224290 ESR1 Positive_regulation of CCND1 1 0.17 0.07 0
122 INT335218 RARS Negative_regulation of Binding of ESR1 and RARS 1 0.04 0.92 0
123 INT89474 TGFB1 Positive_regulation of ESR1 Positive_regulation of ESR1 1 0.18 0.11 0
124 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 2099. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 2099. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
2 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
3 INT20462 Binding of ESR1 210 0.44 102.7 26.34
4 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
5 INT92354 Localization of ESR1 77 0.75 33.04 15.51
6 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
7 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
8 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
9 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
10 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
11 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
12 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
13 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
14 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
15 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
16 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
17 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
18 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
19 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
20 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
21 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
22 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
23 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
24 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
25 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
26 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17
27 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07
28 INT178868 Regulation of Positive_regulation of ESR1 1 0.42 0.52 0.07
29 INT174726 Regulation of Regulation of ESR1 1 0.41 0.73 0.03
30 INT174724 Regulation of Transcription of ESR1 2 0.18 0.49 0
31 INT178629 Positive_regulation of Phosphorylation of ESR1 2 0.36 0.93 0
32 INT223607 Regulation of Phosphorylation of ESR1 1 0.35 0.65 0
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