G:21926

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Official Symbol Tnf
Aliases DIF, Tnfa, TNFSF2, Tnfsf1a, TNFalpha, MGC151434, TNF-alpha
EntrezGene 21926
UniProt Coming Soon
Unique Molecular Interactions 95
Total Molecular Interactions 121
Total Single Events 1371
Unique Interaction Partners 61

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Tnf. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Tnf. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Tnf. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
2 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
3 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
4 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
5 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
6 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
7 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
8 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
9 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
10 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
11 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
12 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
13 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
14 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
15 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
16 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
17 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
18 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
19 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
20 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
21 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
22 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
23 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
24 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
25 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 0.40 0.86 0.66
26 INT120145 seb Positive_regulation of Tnf 1 0.40 0.85 0.65
27 INT132689 Tnf Regulation of Dnajc13 1 0.01 1.27 0.65
28 INT158362 Tnf Positive_regulation of Steap4 1 0.55 1.6 0.61
29 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
30 INT131316 Tnf Positive_regulation of Mpo 1 0.29 0.65 0.55
31 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
32 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48
33 INT67440 Pdyn Regulation of Gene_expression of Tnf 1 0.23 0.19 0.48
34 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48
35 INT137416 Binding of SDC1 and Tnf 1 0.00 1.19 0.47
36 INT161652 Gsr Regulation of Gene_expression of Tnf 1 0.17 0.98 0.46
37 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
38 INT126019 Binding of Ltbr and Tnf 1 0.18 1.61 0.43
39 INT126020 Binding of fc and Tnf 1 0.22 1.61 0.43
40 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
41 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
42 INT165568 Tnf Regulation of Gene_expression of Il1b 1 0.41 1.26 0.41
43 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
44 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4
45 INT154756 Tnf Positive_regulation of Nfkb1 1 0.31 0.78 0.4
46 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
47 INT165565 Tnf Regulation of Gene_expression of Sdf2l1 1 0.26 1.15 0.39
48 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
49 INT228761 Tnf Positive_regulation of Gene_expression of Ccl17 1 0.20 0.66 0.39
50 INT165566 Tnf Regulation of Gene_expression of Il6 1 0.32 1.15 0.39
51 INT189493 Tnf Positive_regulation of Localization of Darc 1 0.00 0.53 0.37
52 INT109091 Tnf Positive_regulation of Localization of Il1b 1 0.56 1.08 0.36
53 INT110994 Tnf Regulation of Il6 1 0.17 0.67 0.36
54 INT163974 Trpv1 Negative_regulation of Gene_expression of Tnf 1 0.34 0.24 0.35
55 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
56 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
57 INT168781 Tnf Positive_regulation of Binding of Pik3r1 and Tnf 1 0.00 0.73 0.33
58 INT223962 Tnf Negative_regulation of Gene_expression of Bglap 1 0.21 1.21 0.32
59 INT223964 Tnf Negative_regulation of Bglap 1 0.21 1.2 0.32
60 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
61 INT168616 Tlr4 Negative_regulation of Localization of Tnf 1 0.33 0.44 0.3
62 INT164434 Il12a Positive_regulation of Tnf 1 0.00 1.7 0.29
63 INT164432 Ifng Positive_regulation of Tnf 1 0.01 1.71 0.29
64 INT154755 Tnf Positive_regulation of Gene_expression of Ccl2 2 0.23 1.7 0.27
65 INT103156 Tnf Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.94 0.27
66 INT233515 Pklr Positive_regulation of Gene_expression of Tnf 1 0.05 1.12 0.27
67 INT154757 Negative_regulation of Tnf Positive_regulation of Nfkb1 1 0.19 0.45 0.22
68 INT152748 Negative_regulation of Cpox Negative_regulation of Localization of Tnf 1 0.17 0.98 0.21
69 INT129594 St13 Positive_regulation of Positive_regulation of Tnf 1 0.26 0.85 0.21
70 INT152747 Negative_regulation of Abmm Positive_regulation of Tnf 1 0.01 0.64 0.2
71 INT152746 Abmm Positive_regulation of Tnf 1 0.01 0.64 0.2
72 INT159794 Tnf Positive_regulation of Mapk9 1 0.01 0.42 0.19
73 INT159795 Tnf Positive_regulation of TLR4 1 0.01 0.42 0.19
74 INT159796 Tnf Positive_regulation of Gene_expression of TLR4 1 0.02 0.42 0.19
75 INT159793 Tnf Positive_regulation of Gene_expression of Mapk9 1 0.01 0.42 0.19
76 INT159788 Tnf Positive_regulation of Phosphorylation of Nfkbia 1 0.01 0.39 0.19
77 INT139502 Binding of Crp and Tnf 1 0.03 0.48 0.19
78 INT337762 Tnf Regulation of Gene_expression of Tlr4 1 0.49 1.16 0.18
79 INT154754 Positive_regulation of Tnf Positive_regulation of Nfkb1 1 0.21 0.34 0.18
80 INT66033 FOLR2 Negative_regulation of Tnf 1 0.00 0.56 0.18
81 INT129943 Tnf Positive_regulation of Nfkb1 1 0.03 0.17 0.17
82 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16
83 INT75738 Ltf Negative_regulation of Tnf 1 0.31 0.39 0.13
84 INT152907 Pag1 Regulation of Gene_expression of Tnf 1 0.19 0.51 0.12
85 INT302380 Tnf Positive_regulation of Nfib 1 0.00 1.41 0.09
86 INT306505 Binding of Clu and Tnf 1 0.24 0.4 0.04
87 INT338769 Tlr4 Positive_regulation of Localization of Tnf 1 0.08 0.76 0.04
88 INT306501 Negative_regulation of Binding of Clu and Tnf 1 0.29 0.4 0.04
89 INT153730 Tnf Positive_regulation of Positive_regulation of Calca 1 0.36 0 0
90 INT306508 Tnf Regulation of Mmv7 1 0.17 0.17 0
91 INT129944 Negative_regulation of Tnf Positive_regulation of Nfkb1 1 0.03 0 0
92 INT306502 Tnf Positive_regulation of Gene_expression of Tpt1 1 0.17 0.4 0
93 INT129942 Regulation of Tnf Positive_regulation of Nfkb1 1 0.02 0 0
94 INT306507 Regulation of Tnf Regulation of Mmv7 1 0.17 0.17 0
95 INT306503 Tnf Negative_regulation of Gene_expression of Esr1 1 0.22 0.36 0
96 INT306499 Tnf Positive_regulation of Gene_expression of Esr1 1 0.24 0.36 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 21926. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 21926. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
2 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
3 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
4 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
5 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
6 INT35406 Localization of Tnf 94 0.81 64.63 31.65
7 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
8 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
9 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
10 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
11 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
12 INT68299 Binding of Tnf 17 0.39 12.55 7.49
13 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
14 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
15 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
16 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
17 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
18 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
19 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
20 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
21 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
22 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
23 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
24 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47
25 INT138003 Positive_regulation of Negative_regulation of Tnf 2 0.49 2.07 0.43
26 INT159782 Phosphorylation of Tnf 2 0.79 1.51 0.36
27 INT116034 Negative_regulation of Transcription of Tnf 2 0.41 0.17 0.29
28 INT159783 Positive_regulation of Phosphorylation of Tnf 1 0.12 0.39 0.19
29 INT159591 Positive_regulation of Binding of Tnf 1 0.43 0.06 0
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