G:24088

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Official Symbol Tlr2
Aliases Ly105
EntrezGene 24088
UniProt Coming Soon
Unique Molecular Interactions 64
Total Molecular Interactions 119
Total Single Events 469
Unique Interaction Partners 40

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Tlr2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Tlr2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Tlr2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
2 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
3 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
4 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
5 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
6 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
7 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
8 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
9 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
10 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
11 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
12 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
13 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
14 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
15 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
16 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
17 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
18 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
19 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
20 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
21 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
22 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
23 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
24 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
25 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
26 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
27 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
28 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
29 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
30 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
31 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
32 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
33 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
34 INT324876 Tlr4 Positive_regulation of Tlr4 Positive_regulation of Tlr2 1 0.09 0.92 0.1
35 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
36 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
37 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
38 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
39 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
40 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
41 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
42 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
43 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
44 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
45 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
46 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
47 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
48 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
49 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
50 INT276991 Tlr2 Positive_regulation of Hspd1 Positive_regulation of Il13 1 0.07 0.76 0.04
51 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
52 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
53 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
54 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
55 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
56 INT350483 Binding of Myd88 and Tlr2 Positive_regulation of Binding of Tirap 1 0.18 0.05 0.03
57 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
58 INT313077 Cd180 Regulation of Tlr2 1 0.01 0.09 0
59 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0
60 INT344224 Tlr2 Regulation of Gene_expression of Tlr4 1 0.03 0 0
61 INT313076 Tlr2 Positive_regulation of Gene_expression of Il10 1 0.02 0.14 0
62 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0
63 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
64 INT313080 ST2 Regulation of Tlr2 1 0.02 0.09 0
65 INT313079 SIGIRR Regulation of Tlr2 1 0.18 0.09 0
66 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0
67 INT316536 Binding of Tlr2 and Il23a 1 0.11 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 24088. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 24088. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
2 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
3 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
4 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
5 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
6 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
7 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
8 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
9 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
10 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
11 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
12 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
13 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
14 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
15 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
16 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
17 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
18 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
19 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
20 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
21 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
22 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
23 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
24 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
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