G:24241

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Official Symbol Calca
Aliases CAL6, CGRP, Cal1, Calc, RATCAL6, calcitonin
EntrezGene 24241
UniProt Coming Soon
Unique Molecular Interactions 217
Total Molecular Interactions 353
Total Single Events 7189
Unique Interaction Partners 135

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Calca. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Calca. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Calca. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
3 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
4 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
5 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
6 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
7 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
8 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
9 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
10 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
11 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
12 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
13 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
14 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
15 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
16 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
17 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
18 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
19 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
20 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
21 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
22 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
23 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
24 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
25 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
26 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
27 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
28 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
29 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
30 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
31 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
32 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
33 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
34 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
35 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
36 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
37 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
38 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
39 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
40 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
41 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
42 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
43 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
44 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
45 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
46 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
47 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
48 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
49 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
50 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
51 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
52 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
53 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
54 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
55 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
56 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
57 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
58 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
59 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
60 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
61 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
62 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
63 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
64 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
65 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
66 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
67 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
68 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
69 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
70 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
71 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
72 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
73 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
74 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
75 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
76 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
77 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
78 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
79 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
80 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
81 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
82 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
83 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
84 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
85 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
86 INT28657 Calca Regulation of Ghrh Positive_regulation of Gh1 1 0.19 0 1.05
87 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
88 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
89 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
90 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
91 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
92 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
93 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
94 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
95 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
96 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
97 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
98 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
99 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
100 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
101 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
102 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
103 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
104 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
105 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
106 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88
107 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
108 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
109 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
110 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 0.11 0 0.83
111 INT86150 Inhba Positive_regulation of Gene_expression of Calca 1 0.09 0.61 0.81
112 INT109142 Calca Positive_regulation of Transcription of Creb1 1 0.47 0.13 0.8
113 INT180782 Bdnf Positive_regulation of Calca 1 0.16 0.77 0.8
114 INT86151 Olr1745 Positive_regulation of Gene_expression of Calca 1 0.51 0.6 0.8
115 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
116 INT111361 Cnr1 Negative_regulation of Localization of Calca 1 0.01 0 0.78
117 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
118 INT96783 Positive_regulation of Binding of CALCA and Calca 1 0.29 0.17 0.77
119 INT224283 Bdnf Regulation of Gene_expression of Calca 1 0.19 0.35 0.76
120 INT109141 Calca Positive_regulation of Creb1 1 0.47 0.13 0.76
121 INT109143 Calca Positive_regulation of Phosphorylation of Creb1 1 0.47 0.13 0.76
122 INT125626 Binding of Calca and Atp8a2 1 0.00 0.4 0.76
123 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
124 INT147620 Gpi Positive_regulation of Localization of Calca 1 0.10 0 0.75
125 INT63874 Calca Positive_regulation of SRPX 1 0.01 0.17 0.74
126 INT145592 Vamp1 Positive_regulation of Calca 1 0.01 0.28 0.73
127 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
128 INT180769 Calca Regulation of Binding of Ngf 1 0.40 0.15 0.72
129 INT180765 Calca Regulation of Binding of Bdnf 1 0.15 0.15 0.72
130 INT68211 Binding of Calca and Chat 1 0.37 0 0.71
131 INT159386 Positive_regulation of TRPV1 Positive_regulation of Localization of Calca 1 0.05 0.44 0.69
132 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
133 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68
134 INT12759 Npy Regulation of Localization of Calca 1 0.26 0.08 0.68
135 INT7418 Calca Positive_regulation of Localization of SST 1 0.04 0.19 0.67
136 INT48800 Ptgir Positive_regulation of Localization of Calca 1 0.28 0.1 0.66
137 INT48799 Ptgir Positive_regulation of Calca 1 0.30 0.1 0.66
138 INT134281 Calca Positive_regulation of Nfat5 1 0.36 0.14 0.65
139 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
140 INT313703 Binding of Calca and Fig4 1 0.11 0 0.65
141 INT259088 Trpv1 Positive_regulation of Calca 1 0.32 1.02 0.65
142 INT148773 Binding of Calca and Usf2 1 0.46 0.42 0.64
143 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
144 INT8695 Binding of Calca and Lgals3 1 0.02 0.09 0.62
145 INT136162 Binding of TRPV1 and Calca 1 0.04 0 0.61
146 INT281650 Trpv1 Positive_regulation of Localization of Calca 1 0.12 0.71 0.61
147 INT148779 Usf1 Negative_regulation of Calca 1 0.44 0.4 0.59
148 INT133500 Calca Negative_regulation of Adarb1 1 0.02 0.26 0.59
149 INT148771 Usf2 Negative_regulation of Calca 1 0.42 0.4 0.59
150 INT151766 Calca Regulation of P2rx6 1 0.00 0.56 0.58
151 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
152 INT169877 Negative_regulation of Ngf Negative_regulation of Gene_expression of Calca 1 0.40 0.09 0.55
153 INT17707 Binding of Calca and Iapp 1 0.42 0 0.54
154 INT281649 Negative_regulation of Binding of Calca and Trpv1 1 0.13 0.67 0.54
155 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
156 INT298462 Calca Regulation of PPR 1 0.03 0 0.54
157 INT14410 Tac1 Negative_regulation of Calca 1 0.26 0.33 0.52
158 INT87558 Calca Positive_regulation of Prkaca 1 0.35 0 0.51
159 INT15273 Calca Regulation of Tacr1 1 0.22 0 0.5
160 INT63459 Binding of Calca and Phax 1 0.00 0.12 0.49
161 INT89225 Calca Regulation of Localization of Cck 1 0.44 0 0.48
162 INT89224 Calca Regulation of Cck 1 0.44 0 0.48
163 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
164 INT34988 Ghrh Positive_regulation of Calca 1 0.06 0 0.48
165 INT34990 Calca Positive_regulation of Ghrh 1 0.06 0 0.47
166 INT138424 Binding of RAMP1 and Calca 1 0.01 0.08 0.47
167 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
168 INT103032 Calca Positive_regulation of Calca Positive_regulation of Nos3 1 0.24 0.41 0.46
169 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
170 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46
171 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
172 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 0.17 0.58 0.44
173 INT53649 Acot1 Positive_regulation of Calca 1 0.25 0 0.44
174 INT70227 Binding of Calca and B3GAT1 1 0.36 0.35 0.42
175 INT48038 Adm Regulation of Calca 1 0.31 0.14 0.42
176 INT118889 Phax Regulation of Localization of Calca 1 0.05 0.18 0.42
177 INT118890 Phax Positive_regulation of Localization of Calca 1 0.05 0.18 0.42
178 INT127563 Calca Negative_regulation of am 1 0.01 0 0.41
179 INT55428 Grpr Positive_regulation of Localization of Calca 1 0.02 0 0.39
180 INT24755 GAL Regulation of Regulation of Calca 1 0.16 0 0.38
181 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
182 INT54361 Penk Regulation of Localization of Calca 1 0.65 0 0.37
183 INT94875 Binding of Calca and Egf 1 0.25 0 0.35
184 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
185 INT7415 Calca Positive_regulation of Positive_regulation of SST 1 0.05 0.1 0.34
186 INT59428 NA Regulation of Localization of Calca 1 0.01 0 0.34
187 INT138423 Binding of RAMP3 and Calca 1 0.01 0 0.32
188 INT7417 Calca Positive_regulation of Localization of FGFR3 1 0.03 0.09 0.3
189 INT7407 Calca Positive_regulation of Localization of Gast 1 0.12 0.09 0.3
190 INT7406 Calca Regulation of Localization of Gast 1 0.07 0.09 0.3
191 INT7419 Calca Regulation of Localization of FGFR3 1 0.02 0.09 0.3
192 INT352452 Calca Regulation of Gene_expression of Tnc 1 0.04 0 0.28
193 INT148774 Usf2 Regulation of Calca 1 0.11 0.24 0.27
194 INT352461 Calca Regulation of Gene_expression of Slc1a3 1 0.03 0 0.27
195 INT352457 Gse1 Regulation of Calca 1 0.02 0 0.27
196 INT352466 Calca Regulation of Gene_expression of Dusp1 1 0.04 0 0.27
197 INT14412 Positive_regulation of Tac1 Negative_regulation of Calca 1 0.28 0.16 0.26
198 INT135965 Calca Negative_regulation of Gene_expression of Tnf 1 0.33 0.72 0.26
199 INT78780 Binding of Calca and Adm 1 0.32 0.07 0.26
200 INT78781 Binding of Adm and Calca 1 0.01 0.07 0.26

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 24241. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 24241. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
9 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
10 INT2541 Binding of Calca 200 0.48 67.14 134.62
11 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
12 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
13 INT4891 Transcription of Calca 81 0.72 35.27 53.75
14 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
15 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
16 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
17 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
18 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
19 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
20 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
21 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
22 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
23 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
24 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
25 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
26 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
27 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
28 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
29 INT48300 Regulation of Binding of Calca 2 0.39 0.73 1.49
30 INT36588 Protein_catabolism of Calca 7 0.87 1.98 1.31
31 INT95719 Negative_regulation of Phosphorylation of Calca 1 0.41 0.09 1.02
32 INT95718 Positive_regulation of Phosphorylation of Calca 1 0.49 0.09 1.01
33 INT329791 Negative_regulation of Protein_catabolism of Calca 1 0.21 1.17 0.1
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