G:24493

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Official Symbol Il1a
Aliases IL-1 alpha
EntrezGene 24493
UniProt Coming Soon
Unique Molecular Interactions 71
Total Molecular Interactions 96
Total Single Events 572
Unique Interaction Partners 42

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Il1a. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Il1a. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Il1a. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
2 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
3 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
4 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
5 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
6 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
7 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
8 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
9 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
10 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
11 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
12 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
13 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
14 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
15 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
16 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
17 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
18 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
19 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
20 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
21 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
22 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
23 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
24 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
25 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
26 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
27 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
28 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
29 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
30 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
31 INT159438 seb Positive_regulation of Gene_expression of Il1a 1 0.02 0 0.41
32 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 0.07 0 0.41
33 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
34 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
35 INT250878 Il1a Positive_regulation of Fgf8 Positive_regulation of Ecm1 1 0.01 0.85 0.38
36 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
37 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
38 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
39 INT21945 Negative_regulation of Il1a Negative_regulation of LH 1 0.18 0 0.36
40 INT21946 Il1a Negative_regulation of LH 1 0.18 0 0.35
41 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
42 INT78063 Il1a Positive_regulation of Il1b 1 0.02 0.07 0.32
43 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
44 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
45 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
46 INT21947 Il1a Positive_regulation of Localization of Pomc 1 0.48 0 0.32
47 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
48 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
49 INT50310 Binding of Il1a and Ptger2 1 0.20 0.06 0.28
50 INT188518 Il1a Negative_regulation of Gene_expression of Ptger2 1 0.00 0.17 0.28
51 INT188517 Il1a Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.28
52 INT188524 Il1a Positive_regulation of Ptges 1 0.00 0.31 0.28
53 INT220381 Il1a Positive_regulation of Gene_expression of Igfbp1 1 0.01 0.28 0.27
54 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
55 INT264503 Mapk1 Positive_regulation of Il1a Positive_regulation of Il6 1 0.01 0.18 0.2
56 INT264477 Il1a Positive_regulation of Jun 1 0.02 0.17 0.2
57 INT264470 Il1a Positive_regulation of Il6 1 0.06 0.18 0.2
58 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
59 INT222525 Il1a Regulation of Localization of Gh1 1 0.00 0.64 0.19
60 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19
61 INT203088 Il1a Positive_regulation of Gene_expression of Mmp3 1 0.03 0.26 0.18
62 INT66035 FOLR2 Negative_regulation of Il1a 1 0.00 0.56 0.18
63 INT221352 Tnf Negative_regulation of Il1a 1 0.05 0.3 0.15
64 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12
65 INT71310 Il1a Positive_regulation of NOS1 1 0.07 0.09 0.11
66 INT71311 Il1a Positive_regulation of Positive_regulation of NOS1 1 0.07 0.09 0.11
67 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
68 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
69 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08
70 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08
71 INT188525 Il1a Regulation of Ptges 1 0.00 0.07 0.04
72 INT203094 Il1a Positive_regulation of Gene_expression of B4GALNT1 1 0.00 0.05 0.03
73 INT66034 FOLR2 Negative_regulation of Gene_expression of Il1a 1 0.00 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 24493. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 24493. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
2 INT5966 Localization of Il1a 50 0.78 22.91 26.54
3 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
4 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
5 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
6 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
7 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
8 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
9 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
10 INT50309 Binding of Il1a 22 0.40 5.4 4.49
11 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
12 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
13 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
14 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
15 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
16 INT190077 Regulation of Transcription of Il1a 2 0.02 0.87 0.99
17 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92
18 INT292526 Negative_regulation of Negative_regulation of Il1a 1 0.05 0.87 0.66
19 INT250838 Protein_catabolism of Il1a 1 0.13 1.16 0.49
20 INT250843 Negative_regulation of Protein_catabolism of Il1a 1 0.06 0.9 0.43
21 INT292528 Regulation of Positive_regulation of Il1a 1 0.06 0.52 0.39
22 INT60460 Positive_regulation of Negative_regulation of Il1a 1 0.36 0 0.18
23 INT250827 Positive_regulation of Protein_catabolism of Il1a 1 0.07 0.21 0.09
24 INT188502 Positive_regulation of Binding of Il1a 2 0.07 0 0.04
25 INT203070 Regulation of Negative_regulation of Il1a 1 0.14 0 0
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