G:24498

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Official Symbol Il6
Aliases ILg6, Ifnb2
EntrezGene 24498
UniProt Coming Soon
Unique Molecular Interactions 150
Total Molecular Interactions 223
Total Single Events 2526
Unique Interaction Partners 93

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Il6. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Il6. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Il6. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
2 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
3 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
4 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
5 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
6 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
7 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
8 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
9 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
10 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
11 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
12 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
13 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
14 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
15 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
16 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
17 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
18 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
19 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
20 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
21 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
22 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
23 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
24 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
25 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
26 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
27 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
28 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
29 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
30 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
31 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
32 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
33 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
34 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
35 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
36 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
37 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
38 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
39 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
40 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
41 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
42 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
43 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
44 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
45 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
46 INT155462 Tnfrsf1a Positive_regulation of Nfkb1 Regulation of Gene_expression of Il6 1 0.20 1.17 0.67
47 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
48 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
49 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
50 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
51 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
52 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
53 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
54 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57
55 INT142312 Lalba Negative_regulation of Localization of Il6 1 0.23 0.73 0.57
56 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
57 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54
58 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
59 INT348322 Il6 Positive_regulation of Localization of Crp 1 0.06 3.51 0.51
60 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
61 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47
62 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
63 INT224282 Binding of Bdnf and Il6 1 0.08 0.26 0.45
64 INT51475 Binding of Il6 and Tnf 1 0.15 0.61 0.43
65 INT264326 IL-17 Positive_regulation of Gene_expression of Il6 1 0.13 0.83 0.43
66 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4
67 INT140574 Ifnb1 Positive_regulation of Il6 1 0.05 0.9 0.39
68 INT328819 Binding of Il6 and Jak1 1 0.08 0 0.38
69 INT328826 Binding of Il6 and TYK2 1 0.04 0 0.38
70 INT328818 Regulation of Il6 Positive_regulation of Stat3 1 0.04 0 0.38
71 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
72 INT328825 Il6 Positive_regulation of Stat3 1 0.07 0 0.37
73 INT140569 Ifng Positive_regulation of Gene_expression of Il6 1 0.00 0.82 0.36
74 INT140575 Il6 Positive_regulation of Ifnb1 1 0.02 0.82 0.36
75 INT19476 Binding of IL1A and Il6 1 0.00 2.19 0.36
76 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
77 INT114755 Il6 Positive_regulation of Crp 1 0.08 0.41 0.35
78 INT126385 Ptger2 Positive_regulation of Positive_regulation of Il6 1 0.01 0.07 0.35
79 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
80 INT137020 Il6 Positive_regulation of Pscs 1 0.07 0.43 0.34
81 INT137015 Il6 Positive_regulation of Gene_expression of Pscs 1 0.07 0.43 0.34
82 INT240130 Il6 Positive_regulation of Crp 1 0.01 1.57 0.34
83 INT207408 Il6 Positive_regulation of Gene_expression of Tacr1 1 0.08 0.56 0.33
84 INT274531 Il6 Regulation of Localization of Lpl 1 0.04 1.49 0.33
85 INT274530 Il6 Regulation of Lpl 1 0.07 1.48 0.32
86 INT78064 Cyp3a23/3a1 Regulation of Localization of Il6 1 0.08 0.07 0.32
87 INT130946 IL8 Positive_regulation of Il6 1 0.00 0.29 0.3
88 INT142311 Lalba Negative_regulation of Positive_regulation of Il6 1 0.32 0.35 0.29
89 INT280612 Binding of Il6 and Ins1 1 0.05 0.55 0.29
90 INT215683 P2ry2 Positive_regulation of Gene_expression of Il6 1 0.02 0.76 0.29
91 INT264474 Il6 Regulation of Positive_regulation of Jun 1 0.15 0 0.28
92 INT78065 Cyp3a23/3a1 Negative_regulation of Gene_expression of Il6 1 0.12 0.07 0.27
93 INT214658 Fabp1 Regulation of Gene_expression of Il6 1 0.02 0.59 0.27
94 INT220380 Il6 Positive_regulation of Gene_expression of Igfbp1 1 0.09 0.29 0.27
95 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
96 INT222428 Negative_regulation of Tlr4 Positive_regulation of Il6 1 0.01 0.26 0.27
97 INT78061 Cyp3a23/3a1 Negative_regulation of Localization of Il6 1 0.12 0.07 0.27
98 INT137019 Il6 Positive_regulation of Localization of Pscs 1 0.10 0.51 0.27
99 INT222427 Il6 Positive_regulation of Localization of Pomc 1 0.02 0.27 0.26
100 INT120896 Binding of CCL2 and Il6 1 0.08 1.2 0.26
101 INT222422 Tlr4 Positive_regulation of Il6 1 0.01 0.25 0.26
102 INT222563 Vip Positive_regulation of Gene_expression of Il6 1 0.05 0.38 0.25
103 INT222560 Calca Positive_regulation of Gene_expression of Il6 1 0.06 0.39 0.25
104 INT222540 Mzb1 Positive_regulation of Gene_expression of Il6 1 0.03 0.38 0.25
105 INT137011 Il6 Positive_regulation of Acta2 1 0.00 0.34 0.22
106 INT20034 Il6 Negative_regulation of Gene_expression of LH 1 0.12 0.2 0.22
107 INT285343 Mtx1 Regulation of Il6 1 0.04 0.78 0.22
108 INT264503 Mapk1 Positive_regulation of Il1a Positive_regulation of Il6 1 0.01 0.18 0.2
109 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
110 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2
111 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
112 INT264470 Il1a Positive_regulation of Il6 1 0.06 0.18 0.2
113 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
114 INT82554 Sele Regulation of Il6 1 0.25 0.83 0.19
115 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19
116 INT222531 Il6 Positive_regulation of Hpse 1 0.00 0.61 0.18
117 INT292519 Ptger2 Regulation of Gene_expression of Il6 1 0.14 0.29 0.18
118 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
119 INT153469 Ctgf Positive_regulation of Binding of Il6 and Nfkb1 1 0.38 0.93 0.16
120 INT153456 Regulation of Binding of Il6 and Nfkb1 1 0.22 1 0.16
121 INT159961 Gtf3a Positive_regulation of Localization of Il6 1 0.02 0.85 0.16
122 INT153459 Binding of Il6 and Nfkb1 1 0.23 0.92 0.16
123 INT153458 Ctgf Positive_regulation of Gene_expression of Il6 1 0.34 1.03 0.15
124 INT243671 Mp Negative_regulation of Gene_expression of Il6 1 0.00 0.05 0.14
125 INT222551 Il6 Positive_regulation of Positive_regulation of Hpse 1 0.01 0.5 0.13
126 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13
127 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08
128 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
129 INT244289 Il6 Positive_regulation of Gene_expression of Jak1 1 0.38 0.09 0.07
130 INT114321 TNF Regulation of Il6 1 0.07 0.45 0.07
131 INT244290 Il6 Positive_regulation of Hmox1 1 0.38 0.09 0.07
132 INT253362 Il6 Positive_regulation of Akt1 1 0.21 0.07 0.05
133 INT222664 Il6 Positive_regulation of Localization of VEGFA 1 0.01 0 0.05
134 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04
135 INT253365 Il6 Negative_regulation of Prkaa2 1 0.23 0 0.04
136 INT128214 Binding of Il6 and Stap1 1 0.00 0 0.04
137 INT348323 Binding of Crp and Il6 1 0.05 0.06 0.03
138 INT76972 Prl Regulation of Il6 1 0.01 0.06 0
139 INT151147 Crp Regulation of Gene_expression of Il6 1 0.03 0.07 0
140 INT130688 Binding of Il6 and Sele 1 0.00 0 0
141 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
142 INT186685 Edn1 Regulation of Gene_expression of Il6 1 0.11 1.1 0
143 INT76971 Prl Regulation of Gene_expression of Il6 1 0.01 0.06 0
144 INT151142 Il6 Regulation of Gene_expression of Cp 1 0.02 0.07 0
145 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0
146 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0
147 INT253380 Il6 Positive_regulation of Phosphorylation of Rps6kb1 1 0.29 0.07 0
148 INT151144 Il6 Regulation of Gene_expression of Fga 1 0.01 0.07 0
149 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
150 INT253381 Il6 Regulation of Prkaa2 1 0.16 0 0
151 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
152 INT253367 Il6 Regulation of Gene_expression of Lep 1 0.31 1.66 0
153 INT151145 Il6 Regulation of Gene_expression of Crp 1 0.03 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 24498. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 24498. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
2 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
3 INT19511 Localization of Il6 212 0.81 118.17 67.67
4 INT10706 Regulation of Il6 150 0.62 93.23 62.34
5 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
6 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
7 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
8 INT51474 Binding of Il6 55 0.48 44.99 20.52
9 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
10 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
11 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
12 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
13 INT50933 Transcription of Il6 38 0.72 24.31 11.58
14 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
15 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
16 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
17 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
18 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
19 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
20 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
21 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
22 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
23 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
24 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
25 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
26 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
27 INT158354 Negative_regulation of Binding of Il6 2 0.20 2.21 0.71
28 INT264490 Regulation of Negative_regulation of Il6 2 0.23 1.18 0.6
29 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56
30 INT98447 Positive_regulation of Negative_regulation of Il6 1 0.44 0.75 0.45
31 INT82552 Negative_regulation of Regulation of Il6 2 0.38 1.43 0.36
32 INT143536 Protein_catabolism of Il6 2 0.69 1.89 0.31
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