G:24835

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Official Symbol Tnf
Aliases Tnfa, RATTNF, MGC124630, TNF-alpha
EntrezGene 24835
UniProt Coming Soon
Unique Molecular Interactions 139
Total Molecular Interactions 180
Total Single Events 2424
Unique Interaction Partners 95

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Tnf. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Tnf. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Tnf. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
3 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
4 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
5 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
6 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
7 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
8 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
9 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
10 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
11 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
12 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
13 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
14 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
15 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
16 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
17 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
18 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
19 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
20 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
21 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
22 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
23 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
24 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
25 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
26 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
27 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
28 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
29 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
30 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
31 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
32 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
33 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
34 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
35 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
36 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
37 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
38 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
39 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
40 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
41 INT9163 Tnf Regulation of Gene_expression of Glul 1 0.12 1.99 0.62
42 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
43 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
44 INT96241 Il13 Negative_regulation of Tnf 1 0.08 0.6 0.59
45 INT56451 Ifng Positive_regulation of Tnf 1 0.00 1.92 0.59
46 INT61827 Tnf Regulation of Lta 1 0.40 1.5 0.58
47 INT94506 Tnf Positive_regulation of Gene_expression of Avp 1 0.31 0.98 0.57
48 INT94507 Tnf Positive_regulation of Gene_expression of AVP 1 0.39 0.98 0.57
49 INT8402 Tnf Regulation of Gene_expression of Vip 1 0.02 0.38 0.56
50 INT8400 Tnf Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
51 INT148922 Pdia4 Negative_regulation of Tnf 1 0.09 1.01 0.56
52 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
53 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55
54 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54
55 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54
56 INT8397 Tnf Regulation of Nts 1 0.00 0.38 0.53
57 INT8398 Tnf Regulation of Vip 1 0.01 0.38 0.53
58 INT206960 Lipg Regulation of Tnf 1 0.02 0.85 0.51
59 INT23090 Tnf Positive_regulation of Localization of Prl 1 0.18 0.15 0.5
60 INT23091 Tnf Positive_regulation of Localization of Ggh 1 0.05 0.15 0.5
61 INT23092 Tnf Positive_regulation of Prl 1 0.08 0.15 0.5
62 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
63 INT23089 Tnf Positive_regulation of Ggh 1 0.04 0.15 0.5
64 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49
65 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
66 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49
67 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
68 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
69 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
70 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
71 INT96245 Negative_regulation of Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
72 INT96246 Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
73 INT148635 Abat Negative_regulation of Gene_expression of Tnf 1 0.10 0.53 0.44
74 INT107694 Tnf Positive_regulation of Gene_expression of Cxcl1 1 0.60 0.63 0.43
75 INT142273 KITLG Positive_regulation of Gene_expression of Tnf 1 0.07 0.9 0.43
76 INT51475 Binding of Il6 and Tnf 1 0.15 0.61 0.43
77 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
78 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
79 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
80 INT112618 Pdpk1 Regulation of Tnf 1 0.03 1.11 0.36
81 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
82 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35
83 INT9162 Tnf Negative_regulation of Localization of Penk 1 0.34 0.85 0.3
84 INT9161 Tnf Negative_regulation of Localization of Ifng 1 0.20 0.85 0.3
85 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
86 INT114389 Csf3 Negative_regulation of Localization of Tnf 1 0.02 0.46 0.26
87 INT135965 Calca Negative_regulation of Gene_expression of Tnf 1 0.33 0.72 0.26
88 INT114388 Csf3 Negative_regulation of Tnf 1 0.02 0.46 0.25
89 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 0.03 0.44 0.25
90 INT136364 Cpz Positive_regulation of Localization of Tnf 1 0.29 0.36 0.25
91 INT114390 Regulation of Csf3 Negative_regulation of Tnf 1 0.02 0.46 0.25
92 INT308817 Ldha Positive_regulation of Tnf 1 0.06 0.71 0.24
93 INT308818 Got1 Positive_regulation of Tnf 1 0.08 0.71 0.24
94 INT308816 Gpt Positive_regulation of Tnf 1 0.08 0.72 0.24
95 INT285341 Mtx1 Regulation of Gene_expression of Tnf 1 0.03 0.78 0.22
96 INT133163 Nos2 Regulation of Tnf 1 0.36 0.97 0.22
97 INT285340 Mtx1 Regulation of Tnf 1 0.03 0.78 0.22
98 INT133166 ELANE Regulation of Tnf 1 0.01 0.98 0.22
99 INT133164 Ptgs2 Regulation of Tnf 1 0.14 0.98 0.22
100 INT88023 Tnf Negative_regulation of Gene_expression of Fas 1 0.29 0.74 0.22
101 INT136366 MCPH1 Regulation of Localization of Tnf 1 0.01 0.26 0.22
102 INT88022 Tnf Positive_regulation of Gene_expression of Faslg 1 0.26 0.76 0.2
103 INT123922 asa Positive_regulation of Tnf 1 0.04 1.96 0.19
104 INT153461 Tnf Positive_regulation of Gene_expression of Ctgf 1 0.48 1.13 0.19
105 INT66036 FOLR2 Negative_regulation of Tnf 1 0.00 0.56 0.18
106 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
107 INT61976 TBP Negative_regulation of Tnf 1 0.24 1.17 0.17
108 INT229245 Positive_regulation of Binding of FAS and Tnf 1 0.25 0.92 0.17
109 INT229246 Binding of FAS and Tnf 1 0.19 0.91 0.17
110 INT146841 Tnf Positive_regulation of Trib3 1 0.03 0.77 0.16
111 INT221353 Tnf Positive_regulation of Gene_expression of RT1-CE1 1 0.05 0.39 0.16
112 INT350020 ARID1B Regulation of Positive_regulation of Tnf 1 0.04 1.78 0.16
113 INT146845 Tnf Positive_regulation of Positive_regulation of Trib3 1 0.03 0.77 0.16
114 INT310263 Rb1 Negative_regulation of Gene_expression of Tnf 1 0.07 0.97 0.15
115 INT221352 Tnf Negative_regulation of Il1a 1 0.05 0.3 0.15
116 INT139340 Il1b Positive_regulation of Positive_regulation of Tnf 1 0.09 1.26 0.14
117 INT146846 Tnf Negative_regulation of Plin1 1 0.59 0.66 0.13
118 INT139342 Cts8 Regulation of Gene_expression of Tnf 1 0.06 0.96 0.13
119 INT114836 Tnf Negative_regulation of Vegfa 1 0.10 1.56 0.11
120 INT350019 Regulation of Binding of Tnf and ARID1B 1 0.04 1.34 0.1
121 INT146840 Tnf Regulation of Pnpla2 1 0.25 0.4 0.08
122 INT112660 TNF Regulation of Tnf 1 0.02 0.94 0.08
123 INT146842 Tnf Regulation of Lipe 1 0.19 0.4 0.08
124 INT80930 Tnf Positive_regulation of Negative_regulation of Cyp2b1 1 0.10 0.21 0.08
125 INT168143 Tnf Positive_regulation of PLF 1 0.02 0.63 0.06
126 INT351979 Mtpn Positive_regulation of Gene_expression of Tnf 1 0.02 0.41 0.05
127 INT10178 Binding of Tnf and Ns5atp9 1 0.25 0.71 0.04
128 INT159960 Rock2 Regulation of Phosphorylation of Tnf 1 0.04 0.55 0.03
129 INT100089 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.01 0 0
130 INT81588 Positive_regulation of Tnf Positive_regulation of RFFL 1 0.00 0 0
131 INT100087 Negative_regulation of Prl Positive_regulation of Localization of Tnf 1 0.17 0 0
132 INT81587 Tnf Positive_regulation of RFFL 1 0.00 0 0
133 INT166850 Tnf Positive_regulation of NOS1 1 0.01 0 0
134 INT100088 Tlr4 Positive_regulation of Tnf 1 0.01 0 0
135 INT107438 Tgfb1i1 Positive_regulation of Tnf 1 0.00 0 0
136 INT107435 Tgfb1i1 Positive_regulation of Gene_expression of Tnf 1 0.00 0 0
137 INT166848 Tnf Positive_regulation of Nos2 1 0.23 0 0
138 INT100090 Tlr4 Positive_regulation of Localization of Tnf 1 0.01 0 0
139 INT141576 Slc6a14 Positive_regulation of Gene_expression of Tnf 1 0.05 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 24835. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 24835. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
2 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
3 INT10166 Localization of Tnf 237 0.81 153.95 88.64
4 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
5 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
6 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
7 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
8 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
9 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
10 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
11 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
12 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
13 INT10173 Binding of Tnf 45 0.48 35.6 14.32
14 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
15 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
16 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
17 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
18 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
19 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
20 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
21 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
22 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
23 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
24 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
25 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
26 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
27 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
28 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
29 INT72086 Regulation of Regulation of Tnf 1 0.45 0.3 0.4
30 INT143535 Protein_catabolism of Tnf 2 0.86 3.43 0.33
31 INT170142 Regulation of Protein_catabolism of Tnf 1 0.44 1.53 0.13
32 INT295324 Regulation of Binding of Tnf 2 0.44 1.11 0.09
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