G:26413

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Official Symbol Mapk1
Aliases ERK, Erk2, MAPK2, PRKM2, Prkm1, C78273, p41mapk, p42mapk, AA407128, AU018647, 9030612K14Rik
EntrezGene 26413
UniProt Coming Soon
Unique Molecular Interactions 171
Total Molecular Interactions 203
Total Single Events 1672
Unique Interaction Partners 114

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Mapk1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Mapk1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Mapk1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
2 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
3 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
4 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
5 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
6 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
7 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
8 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
9 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
10 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
11 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
12 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
13 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
14 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
15 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
16 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
17 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
18 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
19 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
20 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
21 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
22 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
23 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
24 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
25 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
26 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
27 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
28 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
29 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
30 INT190870 BDNF Positive_regulation of Phosphorylation of Mapk1 1 0.12 0.54 0.44
31 INT223863 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Ltp 1 0.31 0 0.43
32 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
33 INT161521 Negative_regulation of H2-M3 Positive_regulation of Mapk1 1 0.14 0.41 0.42
34 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41
35 INT161522 H2-M3 Positive_regulation of Mapk1 1 0.15 0.41 0.41
36 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41
37 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
38 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
39 INT152239 Mapk1 Positive_regulation of Localization of Nfkb1 1 0.29 0.13 0.39
40 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
41 INT274941 Ephb2 Regulation of Phosphorylation of Mapk1 1 0.19 0 0.36
42 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35
43 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33
44 INT274866 Mapk1 Positive_regulation of Gene_expression of TNF 1 0.06 0.35 0.33
45 INT337112 Negative_regulation of Nr1d2-rs2 Positive_regulation of Mapk1 1 0.00 0.14 0.33
46 INT280814 Positive_regulation of Mapk1 Positive_regulation of Transcription of Fos 1 0.02 0.06 0.33
47 INT291240 Map3k8 Positive_regulation of Positive_regulation of Mapk1 1 0.16 0.72 0.32
48 INT291241 Map3k8 Positive_regulation of Gene_expression of Mapk1 1 0.17 0.72 0.32
49 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
50 INT337111 Positive_regulation of Nr1d2-rs2 Negative_regulation of Positive_regulation of Mapk1 1 0.00 0.15 0.31
51 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29
52 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
53 INT291254 MAP3K3 Regulation of Mapk1 1 0.00 1.25 0.29
54 INT291242 Positive_regulation of Mdk Regulation of Mapk1 1 0.03 1.28 0.29
55 INT286703 Mapk1 Positive_regulation of Phosphorylation of Hist1h3f 1 0.22 0.18 0.29
56 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
57 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28
58 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28
59 INT280825 Mapk1 Positive_regulation of Avp 1 0.01 0.08 0.28
60 INT280807 Mapk1 Positive_regulation of Positive_regulation of Prkcg 1 0.01 0.08 0.28
61 INT286709 Mapk1 Positive_regulation of Rps6ka5 Positive_regulation of Rps6ka5 1 0.36 0.18 0.28
62 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28
63 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
64 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
65 INT314040 THL Regulation of Mapk1 1 0.28 0.67 0.26
66 INT207646 Binding of Calm3 and Nrgn Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.14 0.25
67 INT132839 TPT1 Regulation of Mapk1 1 0.01 0.07 0.25
68 INT207641 Positive_regulation of Prkca Positive_regulation of Mapk1 1 0.08 0.09 0.24
69 INT207632 Prkca Positive_regulation of Phosphorylation of Mapk1 1 0.08 0 0.23
70 INT161175 Binding of Trpc6 and Mapk1 1 0.32 1.49 0.23
71 INT103356 Positive_regulation of Binding of Mapk1 and Mapk3 1 0.41 0.17 0.22
72 INT103358 Binding of Mapk1 and Mink1 1 0.07 0.17 0.22
73 INT103357 Binding of Mapk1 and Mapk3 1 0.32 0.17 0.22
74 INT266038 Atp6v1e1 Positive_regulation of Positive_regulation of Mapk1 1 0.07 0.64 0.22
75 INT124262 Negative_regulation of Plat Positive_regulation of Mapk1 1 0.13 0.41 0.21
76 INT127322 Gpx3 Regulation of Mapk1 1 0.00 0.27 0.21
77 INT291259 MAP3K3 Positive_regulation of Mapk1 1 0.00 0.62 0.21
78 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
79 INT206539 Trem2 Positive_regulation of Phosphorylation of Mapk1 1 0.22 0.62 0.2
80 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
81 INT190651 Mdk Negative_regulation of Positive_regulation of Mapk1 1 0.40 0.23 0.19
82 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
83 INT171391 Lpar1 Positive_regulation of Mapk1 1 0.04 0.13 0.18
84 INT191329 Mir327 Negative_regulation of Mapk1 1 0.01 0 0.18
85 INT235875 Bdnf Positive_regulation of Phosphorylation of Mapk1 1 0.09 0.38 0.17
86 INT274169 Mapk1 Regulation of Pde4a 1 0.05 0.62 0.17
87 INT340562 Mstn Positive_regulation of Mapk1 1 0.16 1.16 0.17
88 INT282859 Bpifa2 Negative_regulation of Mapk1 1 0.01 0.91 0.17
89 INT112137 Gast Positive_regulation of Positive_regulation of Mapk1 1 0.17 0.13 0.16
90 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15
91 INT266036 Gpr30 Positive_regulation of Positive_regulation of Mapk1 1 0.19 0.24 0.15
92 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
93 INT171383 Ppp1cc Positive_regulation of Positive_regulation of Mapk1 1 0.18 0 0.11
94 INT171389 Src Positive_regulation of Positive_regulation of Mapk1 1 0.16 0 0.11
95 INT272735 Ptger2 Positive_regulation of Phosphorylation of Mapk1 1 0.02 0 0.1
96 INT314599 Binding of Ifnar1 and Positive_regulation of Mapk1 1 0.14 0 0.1
97 INT304881 Ros1 Positive_regulation of Mapk1 1 0.25 0.36 0.1
98 INT207638 Nrgn Regulation of Regulation of Mapk1 1 0.14 0.18 0.1
99 INT207633 Gene_expression of Nrgn Positive_regulation of Phosphorylation of Mapk1 1 0.20 0.07 0.09
100 INT304887 Agtr2 Positive_regulation of Positive_regulation of Mapk1 1 0.10 0.45 0.09
101 INT213482 Lep Positive_regulation of Mapk1 1 0.06 0.08 0.09
102 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
103 INT305257 Obsty1 Regulation of Gene_expression of Mapk1 1 0.03 2.05 0.08
104 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08
105 INT221471 Gadd45b Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.27 0.08
106 INT184108 Csf3 Positive_regulation of Mapk1 1 0.09 0.64 0.08
107 INT300867 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of Il6 1 0.02 0.42 0.08
108 INT325264 Il1rap Positive_regulation of Mapk1 1 0.08 0 0.07
109 INT236936 Ppara Positive_regulation of Mapk1 1 0.09 0.64 0.07
110 INT325273 IL1RAP Positive_regulation of Mapk1 1 0.13 0 0.07
111 INT207637 Calm3 Regulation of Positive_regulation of Mapk1 1 0.03 0 0.06
112 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
113 INT304885 Gene_expression of Ros1 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.52 0.06
114 INT327338 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of VEGFA 1 0.05 0.93 0.05
115 INT282860 Bpifa2 Regulation of Mapk1 1 0.01 0.65 0.05
116 INT274863 Mapk1 Positive_regulation of Tlr4 1 0.01 0.1 0.05
117 INT327314 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Ttpa 1 0.02 0.91 0.05
118 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
119 INT196435 Lhb Positive_regulation of Mapk1 1 0.12 0.77 0.04
120 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04
121 INT178435 Mapk1 Regulation of Phosphorylation of Src 1 0.03 0.49 0.04
122 INT207645 Binding of Calm3 and Nrgn Regulation of Positive_regulation of Mapk1 1 0.03 0.13 0.04
123 INT340568 Fgf1 Positive_regulation of Mapk1 1 0.06 1.02 0.04
124 INT332410 Mapk1 Positive_regulation of Phosphorylation of Met 1 0.32 0.05 0.04
125 INT229498 Binding of Vim and Mapk1 1 0.03 0.21 0.04
126 INT340552 Binding of Mapk1 and Mapk14 1 0.07 0.27 0.03
127 INT263783 Grin1 Positive_regulation of Mapk1 1 0.14 0 0.03
128 INT313464 Negative_regulation of Ppp2ca Positive_regulation of Phosphorylation of Mapk1 1 0.09 0 0.03
129 INT271527 Binding of ESB3 and Mapk1 1 0.01 0.98 0.03
130 INT178442 Mapk1 Regulation of Gene_expression of Il6 1 0.03 0.59 0.03
131 INT313451 Gene_expression of Syp Negative_regulation of Mapk1 1 0.09 0 0.03
132 INT306646 Mapk1 Regulation of Pik3r1 1 0.03 0.39 0
133 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
134 INT241030 Agtr2 Positive_regulation of Phosphorylation of Mapk1 1 0.06 0.19 0
135 INT176538 Mapk1 Positive_regulation of Gene_expression of Spp1 1 0.12 0.43 0
136 INT340560 Myog Positive_regulation of Mapk1 1 0.07 0.25 0
137 INT306630 Mapk1 Regulation of Gene_expression of Mstn 1 0.09 1.21 0
138 INT306650 Mapk1 Regulation of Ahsa1 1 0.02 0.39 0
139 INT241019 Positive_regulation of Mapk1 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
140 INT178448 Mapk1 Regulation of Localization of VEGFA 1 0.01 0.51 0
141 INT306641 Mapk1 Regulation of Mstn 1 0.21 3.2 0
142 INT305276 Obsty1 Regulation of Phosphorylation of Mapk1 1 0.02 1.11 0
143 INT306629 Mapk1 Positive_regulation of Positive_regulation of Mstn 1 0.16 0.26 0
144 INT241024 Mapk1 Positive_regulation of Gene_expression of Gopc 1 0.21 0.85 0
145 INT306639 Mapk1 Regulation of Positive_regulation of Myef2 1 0.08 1.33 0
146 INT300863 Bdnf Positive_regulation of Mapk1 1 0.02 0.11 0
147 INT241023 Mapk1 Positive_regulation of Gene_expression of Agtrap 1 0.40 0.85 0
148 INT240898 Mapk1 Regulation of Phosphorylation of Creb1 1 0.11 0.17 0
149 INT304185 Mapk1 Positive_regulation of Positive_regulation of Egf 1 0.09 0.71 0
150 INT300866 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of Ngf 1 0.03 0 0
151 INT176542 Pik3r1 Positive_regulation of Positive_regulation of Mapk1 1 0.01 0.41 0
152 INT340557 Myog Positive_regulation of Negative_regulation of Mapk1 1 0.16 0.25 0
153 INT340554 Myod1 Positive_regulation of Negative_regulation of Mapk1 1 0.28 0.25 0
154 INT292721 Mapk1 Negative_regulation of Phosphorylation of Hsf1 1 0.02 0.06 0
155 INT340551 Myod1 Positive_regulation of Mapk1 1 0.19 0.25 0
156 INT306622 Mapk1 Positive_regulation of Positive_regulation of Myef2 1 0.06 1.3 0
157 INT332405 Met Regulation of Positive_regulation of Mapk1 1 0.17 0.18 0
158 INT325953 Ezr Positive_regulation of Mapk1 1 0.02 0.4 0
159 INT182887 Jun Regulation of Mapk1 1 0.04 0.18 0
160 INT342854 Binding of Casp8 and Mapk1 1 0.05 2.18 0
161 INT340561 Mapk1 Negative_regulation of Gene_expression of Pax7 1 0.23 0.25 0
162 INT241026 Agtrap Positive_regulation of Mapk1 1 0.37 0.19 0
163 INT325946 Gene_expression of Ezr Positive_regulation of Positive_regulation of Mapk1 1 0.02 0.28 0
164 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0
165 INT332406 Negative_regulation of Irgm1 Positive_regulation of Mapk1 1 0.02 0.29 0
166 INT306628 Mapk1 Positive_regulation of Gene_expression of Mstn 1 0.17 1.3 0
167 INT335019 Fgf23 Positive_regulation of Phosphorylation of Mapk1 1 0.08 0.45 0
168 INT178429 Negative_regulation of Mapk1 Negative_regulation of Positive_regulation of Eno2 1 0.02 0.73 0
169 INT340566 Binding of Mstn and Mapk1 1 0.12 0.5 0
170 INT313438 Mapk1 Regulation of Th 1 0.06 0 0
171 INT325448 Mif-ps1 Positive_regulation of Phosphorylation of Mapk1 1 0.06 0 0
172 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0
173 INT176541 Mapk1 Positive_regulation of Spp1 1 0.13 0.42 0
174 INT176547 Mapk1 Positive_regulation of Transcription of Spp1 1 0.18 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 26413. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 26413. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
3 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
4 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
5 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
6 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
7 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
8 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
9 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
10 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
11 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
12 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
13 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
14 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
15 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
16 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
17 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
18 INT190645 Positive_regulation of Negative_regulation of Mapk1 1 0.44 0.39 0.54
19 INT274923 Protein_catabolism of Mapk1 1 0.47 0 0.39
20 INT274911 Positive_regulation of Protein_catabolism of Mapk1 1 0.27 0 0.39
21 INT121782 Transcription of Mapk1 3 0.50 1.58 0.35
22 INT164149 Negative_regulation of Localization of Mapk1 3 0.33 1.32 0.22
23 INT178411 Regulation of Negative_regulation of Mapk1 1 0.44 0.94 0.19
24 INT167723 Positive_regulation of Localization of Mapk1 2 0.10 0.76 0.13
25 INT236920 Positive_regulation of Binding of Mapk1 2 0.39 0.71 0.12
26 INT274825 Negative_regulation of Negative_regulation of Mapk1 1 0.08 0.06 0.08
27 INT182882 Regulation of Binding of Mapk1 1 0.11 0.11 0
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