G:29237

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Official Symbol Penk
Aliases Enk, Penk1, Penk2, Penk-rs, MGC93514
EntrezGene 29237
UniProt Coming Soon
Unique Molecular Interactions 362
Total Molecular Interactions 595
Total Single Events 8188
Unique Interaction Partners 195

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Penk. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Penk. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Penk. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
2 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
3 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
4 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
5 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
6 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
7 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
8 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
9 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
10 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
11 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
12 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
13 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
14 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
15 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
16 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
17 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
18 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
19 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
20 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1
21 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
22 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
23 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
24 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
25 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
26 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
27 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
28 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
29 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
30 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
31 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
32 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
33 INT18355 Penk Positive_regulation of Localization of Sst 1 0.31 0 2.04
34 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
35 INT58678 Binding of Penk and Abat 2 0.40 1.39 1.97
36 INT2653 Slc3a1 Regulation of Penk 3 0.04 0.37 1.96
37 INT37882 Penk Positive_regulation of LOC100366054 1 0.08 0.35 1.93
38 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
39 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
40 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
41 INT40238 Penk Regulation of Oxt 1 0.04 0 1.83
42 INT14576 Tac4 Regulation of Penk 1 0.07 0 1.77
43 INT140892 Penk Negative_regulation of Mnp 1 0.13 0.55 1.75
44 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74
45 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
46 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
47 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
48 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
49 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
50 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
51 INT42928 Penk Negative_regulation of Localization of Oxt 2 0.03 0 1.57
52 INT54844 Negative_regulation of Penk Positive_regulation of Vip 1 0.26 0 1.54
53 INT33815 Vta1 Negative_regulation of Penk 1 0.25 0 1.54
54 INT40887 Penk Regulation of Th 1 0.04 0 1.53
55 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53
56 INT62481 Penk Negative_regulation of Slc6a7 2 0.60 0 1.5
57 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5
58 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
59 INT48101 RT1-DMb Positive_regulation of Penk 1 0.10 0 1.5
60 INT158282 Binding of Penk and Csf2 1 0.33 0.87 1.44
61 INT158283 Binding of Penk and Accn4 1 0.07 0.87 1.43
62 INT2170 Penk Regulation of Localization of LH 2 0.44 0 1.38
63 INT75807 Gpm6a Positive_regulation of Localization of Penk 1 0.04 0 1.35
64 INT87812 Penk Regulation of Prl 1 0.16 0 1.34
65 INT143999 IK Regulation of Gene_expression of Penk 1 0.04 0 1.33
66 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
67 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
68 INT24378 Penk Regulation of Oprl1 1 0.10 0 1.29
69 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
70 INT136200 Binding of Penk and NUP37 1 0.04 0 1.28
71 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27
72 INT88449 Uncx Positive_regulation of Penk 1 0.12 0 1.27
73 INT52205 Prl Positive_regulation of Gene_expression of Penk 1 0.52 0.15 1.25
74 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
75 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
76 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
77 INT21424 Binding of Penk and Gtpbp4 1 0.02 0.16 1.2
78 INT3302 Penk Positive_regulation of Slc43a3 1 0.01 0.09 1.19
79 INT25660 Binding of Penk and Pag1 1 0.01 0.67 1.19
80 INT140010 Avp Regulation of Gene_expression of Penk 1 0.25 0.58 1.19
81 INT102570 Abat Regulation of Gene_expression of Penk 3 0.13 0 1.12
82 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
83 INT70603 Penk Positive_regulation of Pdyn 1 0.13 0 1.11
84 INT7927 Penk Regulation of Trh 2 0.26 0.66 1.09
85 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
86 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
87 INT79322 Penk Regulation of Vmn2r1 1 0.00 0 1.08
88 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08
89 INT83936 Binding of Mtap2 and Penk 1 0.22 0.19 1.07
90 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
91 INT90050 Binding of GRP and Penk 1 0.06 0 1.06
92 INT107566 Penk Regulation of Hps4 1 0.00 0.1 1.04
93 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
94 INT101443 Penk Positive_regulation of Localization of Gcg 1 0.50 1.21 1.04
95 INT10552 Penk Positive_regulation of Regulation of Cebpz 1 0.44 0.25 1.03
96 INT40715 Binding of SST and Penk 1 0.10 0 1.02
97 INT34535 Regulation of Binding of Penk and Oprl1 1 0.05 0 1.02
98 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
99 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
100 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
101 INT30378 Binding of Sst and Penk 1 0.28 0.52 1.01
102 INT53843 Penk Regulation of Pag1 1 0.07 0.9 1.01
103 INT53846 Positive_regulation of Penk Regulation of Pag1 1 0.07 0.9 1.01
104 INT47163 Penk Regulation of Rtcd1 1 0.00 0 1.01
105 INT53844 Penk Regulation of Kitl 1 0.00 0.9 1
106 INT40950 Binding of Penk and Srms 1 0.05 0 1
107 INT63803 RGD1560349 Positive_regulation of Penk 1 0.04 0 1
108 INT53845 Positive_regulation of Penk Regulation of Kitl 1 0.00 0.9 1
109 INT71319 Binding of Penk and Fos 3 0.40 0.15 0.99
110 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
111 INT18139 Binding of Penk and Stmn1 1 0.08 0 0.99
112 INT6077 Cck Negative_regulation of Localization of Penk 1 0.06 0 0.99
113 INT45664 Fpr1 Negative_regulation of Penk 1 0.13 0 0.99
114 INT22109 Positive_regulation of Pomc Positive_regulation of Penk 1 0.35 0 0.99
115 INT97721 Akr1d1 Regulation of Gene_expression of Penk 1 0.00 0 0.98
116 INT18890 Penk Regulation of Oprd1 1 0.25 0.45 0.97
117 INT78171 Pigm Regulation of Penk 1 0.02 1.04 0.97
118 INT29366 Mnt Positive_regulation of Localization of Penk 1 0.01 0 0.96
119 INT70947 Penk Regulation of Hpse 1 0.20 0 0.96
120 INT47342 Penk Regulation of Fabp6 1 0.01 0.39 0.95
121 INT51543 Positive_regulation of Binding of Oxt and Penk 1 0.56 0.05 0.94
122 INT51542 Negative_regulation of Binding of Avp and Penk 1 0.46 0.05 0.94
123 INT51544 Binding of Oxt and Penk 1 0.54 0.05 0.94
124 INT51541 Positive_regulation of Binding of Avp and Penk 1 0.74 0.05 0.94
125 INT51545 Binding of Avp and Penk 1 0.51 0.05 0.94
126 INT42861 Negative_regulation of Binding of Penk and Oprl1 1 0.45 0 0.94
127 INT65024 Binding of Oprm1 and Penk 1 0.03 0 0.93
128 INT9014 Binding of Npy and Penk 1 0.37 0 0.93
129 INT75823 Penk Positive_regulation of Gene_expression of Ddx5 1 0.03 0 0.92
130 INT75825 Ddx5 Positive_regulation of Gene_expression of Penk 1 0.03 0 0.92
131 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91
132 INT32840 Regulation of Binding of Trh and Penk 1 0.26 0 0.91
133 INT42798 Gtf3a Positive_regulation of Penk 1 0.11 0.1 0.91
134 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
135 INT2168 Penk Regulation of LH 2 0.32 0.42 0.88
136 INT48455 Scd1 Regulation of Penk 1 0.06 0 0.88
137 INT62478 Binding of Penk and Flvcr2 1 0.09 0 0.87
138 INT62480 Binding of Penk and Slc6a7 1 0.32 0 0.87
139 INT62482 Binding of Penk and Slc6a7 Negative_regulation of Slc6a7 1 0.41 0 0.87
140 INT63858 Oprm1 Negative_regulation of Penk 1 0.05 0.08 0.86
141 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
142 INT62477 Penk Negative_regulation of Binding of Slc6a7 1 0.44 0 0.86
143 INT70670 Scd1 Positive_regulation of Gene_expression of Penk 1 0.11 0.1 0.86
144 INT30422 Penk Regulation of Ins1 1 0.06 0 0.85
145 INT128740 Penk Regulation of Mors1 1 0.02 0 0.84
146 INT30425 Penk Regulation of Sst 1 0.20 0 0.84
147 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
148 INT46085 Binding of MET and Penk 1 0.02 0.06 0.83
149 INT46084 Binding of SELL and Penk 1 0.02 0.06 0.83
150 INT20817 Binding of Penk and Apbb3 1 0.02 0 0.83
151 INT122728 Pes1 Positive_regulation of Transcription of Penk 1 0.07 0 0.81
152 INT122727 Pes1 Positive_regulation of Penk 1 0.07 0 0.81
153 INT33464 Binding of DMRT1 and Penk 1 0.28 0.16 0.81
154 INT98863 Penk Positive_regulation of Mpv17l 1 0.01 0 0.8
155 INT7926 Regulation of Penk Regulation of Trh 1 0.26 0.66 0.8
156 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
157 INT42796 Ngf Positive_regulation of Binding of Penk 1 0.56 0.08 0.79
158 INT55923 Penk Regulation of Transcription of Oprm1 1 0.26 0 0.78
159 INT55922 Penk Regulation of Oprm1 1 0.26 0 0.78
160 INT128739 Penk Negative_regulation of Acot1 1 0.19 0 0.77
161 INT46243 Binding of Ptger1 and Penk 1 0.01 0 0.77
162 INT16933 Tsc22d3 Positive_regulation of Localization of Penk 2 0.24 0 0.76
163 INT52206 Prl Regulation of Gene_expression of Penk 2 0.46 0.66 0.75
164 INT28620 Penk Regulation of Crh 2 0.40 0.25 0.75
165 INT74252 Binding of Penk and Set 1 0.03 0 0.75
166 INT15420 Binding of Penk and SFTPA1 1 0.11 0.16 0.75
167 INT2171 Penk Positive_regulation of Positive_regulation of Gnrh1 1 0.43 0 0.74
168 INT46916 Binding of Thop1 and Positive_regulation of Penk 1 0.14 0 0.74
169 INT19818 Penk Positive_regulation of Gene_expression of Ins1 1 0.32 0 0.74
170 INT136199 Hnrpd Regulation of Gene_expression of Penk 1 0.46 0 0.74
171 INT2167 Penk Positive_regulation of Positive_regulation of LH 1 0.36 0 0.74
172 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
173 INT46917 Binding of Tyr and Positive_regulation of Penk 1 0.02 0 0.73
174 INT101442 Penk Positive_regulation of Localization of Ins1 1 0.29 0.9 0.73
175 INT44519 Penk Regulation of PRL 1 0.01 0 0.73
176 INT43717 Positive_regulation of Binding of Trh and Penk 1 0.56 0 0.72
177 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
178 INT101444 Penk Regulation of Localization of Gcg 1 0.45 0.77 0.71
179 INT92721 Positive_regulation of Penk Regulation of OTSC1 1 0.02 0.14 0.71
180 INT92720 Penk Regulation of OTSC1 1 0.01 0.14 0.7
181 INT51705 Binding of Penk and Naga 1 0.19 0.08 0.69
182 INT22922 Penk Negative_regulation of Negative_regulation of Cck 1 0.48 0 0.68
183 INT35920 Penk Positive_regulation of Gnrhr 1 0.29 0 0.67
184 INT13595 Penk Positive_regulation of Localization of Prss12 1 0.12 0 0.67
185 INT147257 Tac1 Regulation of Penk 1 0.19 0 0.67
186 INT144000 Binding of IK and Regulation of Gene_expression of Penk 1 0.04 0 0.67
187 INT48999 Penk Regulation of Nts 1 0.28 0 0.66
188 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
189 INT69206 Ntf3 Negative_regulation of Ntf3 Positive_regulation of Penk 1 0.05 0.06 0.66
190 INT69205 Ntf3 Positive_regulation of Penk 1 0.06 0.06 0.66
191 INT41225 Pdyn Positive_regulation of Penk 1 0.20 0 0.66
192 INT40763 Trh Negative_regulation of Penk 1 0.19 0 0.65
193 INT30730 Penk Positive_regulation of Binding of Ptger2 1 0.02 0 0.65
194 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
195 INT40311 Regulation of Binding of Pomc and Penk 1 0.23 0 0.64
196 INT23555 POMC Positive_regulation of Penk 1 0.56 0 0.63
197 INT23108 Gm12597 Regulation of Penk 1 0.01 0 0.63
198 INT90925 Penk Regulation of Binding of Fgfr1op2 1 0.02 0 0.63
199 INT32241 Pomc Negative_regulation of Pomc Positive_regulation of Penk 1 0.23 0 0.63
200 INT45663 Fpr1 Positive_regulation of Penk 1 0.15 0 0.63

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 29237. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 29237. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 812 0.62 111.13 542.24
5 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81
6 INT1396 Binding of Penk 355 0.48 22.79 269.65
7 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07
8 INT4803 Transcription of Penk 435 0.72 59.09 182.4
9 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88
10 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73
11 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45
12 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66
13 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68
14 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32
15 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95
16 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37
17 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24
18 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45
19 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42
20 INT10684 Negative_regulation of Protein_catabolism of Penk 41 0.59 2.33 28.63
21 INT5592 Regulation of Regulation of Penk 36 0.62 4.37 24.02
22 INT8056 Regulation of Positive_regulation of Penk 34 0.59 4.71 17.66
23 INT7290 Negative_regulation of Transcription of Penk 33 0.59 7.28 16.5
24 INT20495 Regulation of Protein_catabolism of Penk 17 0.62 0.96 13.3
25 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92
26 INT1459 Positive_regulation of Binding of Penk 15 0.67 0.08 10.45
27 INT2777 Positive_regulation of Regulation of Penk 21 0.67 0.63 9.96
28 INT9157 Negative_regulation of Negative_regulation of Penk 13 0.43 2.3 9.54
29 INT1712 Positive_regulation of Negative_regulation of Penk 10 0.67 1.48 7.06
30 INT20496 Positive_regulation of Protein_catabolism of Penk 7 0.50 0.86 4.42
31 INT9159 Negative_regulation of Regulation of Penk 7 0.43 3.05 2.41
32 INT72373 Phosphorylation of Penk 4 0.62 0.18 1.56
33 INT109589 Regulation of Negative_regulation of Penk 1 0.16 0.25 0
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