G:309757

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Official Symbol Sirt1
Aliases Sir2
EntrezGene 309757
UniProt Coming Soon
Unique Molecular Interactions 25
Total Molecular Interactions 30
Total Single Events 164
Unique Interaction Partners 16

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Sirt1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Sirt1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Sirt1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
2 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
3 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
4 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
5 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
6 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
7 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
8 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
9 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
10 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
11 INT289606 Sirt1 Negative_regulation of Stat3 Positive_regulation of Stat3 1 0.28 0.31 0.03
12 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
13 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
14 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
15 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
16 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
17 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
18 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
19 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
20 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
21 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
22 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
23 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
24 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
25 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
26 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 309757. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 309757. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
2 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
3 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
4 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
5 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
6 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
7 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
8 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
9 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
10 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
11 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
12 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
13 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
14 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
15 INT289569 Transcription of Sirt1 1 0.71 0.25 0
16 INT300287 Localization of Sirt1 1 0.66 1.46 0
17 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
18 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
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