G:3553

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Official Symbol IL1B
Aliases IL-1, IL1F2, IL1-BETA
EntrezGene 3553
UniProt Coming Soon
Unique Molecular Interactions 279
Total Molecular Interactions 442
Total Single Events 2695
Unique Interaction Partners 156

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to IL1B. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to IL1B. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to IL1B. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
6 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
7 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
8 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
9 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
10 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
11 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
12 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
13 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
14 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
15 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
16 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
17 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
18 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
19 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
20 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
21 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
22 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
23 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
24 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
25 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
26 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
27 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
28 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
29 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
30 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
31 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
32 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
33 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
34 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
35 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
36 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
37 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
38 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
39 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
40 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
41 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
42 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
43 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
44 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
45 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
46 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
47 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
48 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
49 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
50 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
51 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
52 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
53 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
54 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
55 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
56 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
57 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
58 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
59 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
60 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
61 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
62 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
63 INT270762 IL1B Positive_regulation of IL1B Negative_regulation of IKBKB 1 0.02 1.13 0.66
64 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
65 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
66 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
67 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
68 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
69 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
70 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
71 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
72 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
73 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
74 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
75 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
76 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
77 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
78 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51
79 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51
80 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51
81 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
82 INT250933 IL1B Positive_regulation of Gene_expression of BDNF 1 0.10 0.27 0.5
83 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5
84 INT20546 IL1B Regulation of Gene_expression of SGCG 1 0.65 0.14 0.5
85 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
86 INT225025 IL1B Positive_regulation of Positive_regulation of Cxcl1 1 0.04 0.32 0.49
87 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
88 INT94262 IL1B Positive_regulation of Localization of PTGER2 1 0.22 0.8 0.49
89 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
90 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48
91 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
92 INT130726 Negative_regulation of Binding of IL1B and Il1rn 1 0.01 0.6 0.48
93 INT148818 IL1B Regulation of Gene_expression of TNC 1 0.29 0.57 0.47
94 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
95 INT138154 IL1B Positive_regulation of Transcription of Mmp2 1 0.04 0.23 0.46
96 INT138160 IL1B Positive_regulation of Gene_expression of Mmp3 1 0.03 0.23 0.46
97 INT197113 RETNLB Regulation of IL1B 1 0.00 1.27 0.44
98 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
99 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43
100 INT60063 IL1B Regulation of NPEPPS 1 0.00 0.29 0.42
101 INT107704 IL1B Positive_regulation of Localization of RELA 1 0.02 0.13 0.41
102 INT346238 PREP Negative_regulation of IL1B 1 0.04 0.99 0.41
103 INT107699 IL1B Positive_regulation of Localization of NFKB1 1 0.03 0.13 0.41
104 INT146476 IL1B Regulation of Gene_expression of HAS1 1 0.30 0.35 0.4
105 INT298584 IL1B Regulation of Gene_expression of TNFRSF11B 1 0.22 0.7 0.4
106 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
107 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39
108 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39
109 INT227906 IL10 Regulation of Gene_expression of IL1B 1 0.07 0.57 0.38
110 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38
111 INT182497 IL1B Regulation of Localization of GH1 1 0.00 0.84 0.38
112 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
113 INT224582 Binding of IL1B and Positive_regulation of Gene_expression of TNF 1 0.05 1.33 0.37
114 INT322015 Binding of IL1B and P2RX7 1 0.07 1 0.37
115 INT74938 Negative_regulation of IL1B Positive_regulation of PTGER2 1 0.07 0.23 0.36
116 INT298588 IL1B Regulation of Gene_expression of CSF1 1 0.35 0.59 0.36
117 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35
118 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35
119 INT173111 IL1B Positive_regulation of VCAM1 1 0.31 1.32 0.35
120 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
121 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33
122 INT107616 IL1B Positive_regulation of PTGER3 1 0.37 0 0.33
123 INT15141 MME Negative_regulation of IL1B 1 0.39 0.19 0.32
124 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
125 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32
126 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
127 INT197112 Binding of IL1B and TP53TG3 1 0.03 1.17 0.31
128 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
129 INT209931 IL1B Positive_regulation of PPARA 1 0.32 0.62 0.31
130 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31
131 INT197114 IL1B Regulation of Binding of MCF2 1 0.03 0.48 0.31
132 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3
133 INT209933 PPARA Regulation of Positive_regulation of IL1B 1 0.21 0.58 0.29
134 INT55682 IL1B Positive_regulation of TIMP1 2 0.46 0.17 0.28
135 INT55679 IL1B Positive_regulation of MMP11 1 0.02 0.17 0.28
136 INT230337 IL1B Regulation of IL5 1 0.04 0.57 0.28
137 INT55684 IL1B Positive_regulation of Gene_expression of MMP11 1 0.04 0.17 0.28
138 INT55683 IL1B Positive_regulation of Gene_expression of TIMP1 1 0.64 0.17 0.28
139 INT207435 IL1B Negative_regulation of Gene_expression of PLA2G7 1 0.07 0.9 0.28
140 INT230334 IL1B Regulation of IL9 1 0.02 0.57 0.28
141 INT230343 IL1B Regulation of IL13 1 0.02 0.57 0.28
142 INT55681 IL1B Regulation of Gene_expression of TIMP1 1 0.56 0.18 0.28
143 INT15142 MME Regulation of IL1B 1 0.40 0.16 0.28
144 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28
145 INT230338 IL1B Regulation of IL4 1 0.02 0.57 0.28
146 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27
147 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27
148 INT56071 NFKB1 Positive_regulation of Gene_expression of IL1B 1 0.36 0.4 0.27
149 INT121265 Mod2 Negative_regulation of Gene_expression of IL1B 1 0.29 0.6 0.27
150 INT107615 IL1B Positive_regulation of PTGES 2 0.55 0.05 0.26
151 INT219194 Nlrp3 Positive_regulation of IL1B 1 0.04 1.03 0.26
152 INT20547 IL1B Positive_regulation of Gene_expression of FN1 1 0.29 0.06 0.26
153 INT20553 IL1B Positive_regulation of Vwa2 1 0.00 0.06 0.26
154 INT322021 Negative_regulation of CASP1 Positive_regulation of IL1B 1 0.04 0.13 0.26
155 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26
156 INT20549 IL1B Positive_regulation of FN1 1 0.19 0.06 0.26
157 INT20545 IL1B Regulation of SGCG 1 0.48 0.07 0.25
158 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25
159 INT322018 CR1 Negative_regulation of IL1B 1 0.00 0.17 0.25
160 INT20548 IL1B Regulation of Gene_expression of FN1 1 0.19 0.07 0.25
161 INT144240 TNF Positive_regulation of Transcription of IL1B 1 0.44 0.45 0.24
162 INT146478 IL1B Positive_regulation of Gene_expression of HAS1 1 0.48 0.24 0.24
163 INT184192 IL1B Positive_regulation of SPAM1 1 0.04 0.49 0.24
164 INT221416 Binding of IL1B and Positive_regulation of NFKB2 1 0.02 0.88 0.23
165 INT65012 IL1B Regulation of Gene_expression of IL6 1 0.25 0.16 0.23
166 INT133246 IL1B Regulation of Localization of IL8 1 0.56 0.16 0.23
167 INT184191 IL1B Positive_regulation of Gene_expression of SPAM1 1 0.03 0.59 0.23
168 INT346232 PREP Negative_regulation of Binding of IL1B 1 0.04 0.47 0.23
169 INT107749 IL1B Positive_regulation of HSD17B1 1 0.20 0.21 0.22
170 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
171 INT342994 IL1B Positive_regulation of Gene_expression of PTAFR 1 0.09 0.39 0.22
172 INT69042 Negative_regulation of Casp1 Negative_regulation of Positive_regulation of IL1B 1 0.21 0.17 0.22
173 INT69041 Casp1 Negative_regulation of Gene_expression of IL1B 1 0.21 0.17 0.22
174 INT189157 MTNR1B Positive_regulation of Gene_expression of IL1B 1 0.00 0.06 0.22
175 INT58306 C4A Regulation of Gene_expression of IL1B 1 0.00 0.15 0.21
176 INT60523 Binding of IL1B and TNFRSF1A 1 0.25 1.73 0.21
177 INT322017 RPA1 Positive_regulation of IL1B 1 0.00 0 0.21
178 INT125153 IL1B Regulation of ITGB2 1 0.22 0.1 0.2
179 INT91654 Negative_regulation of CASP1 Negative_regulation of IL1B 1 0.46 0.15 0.2
180 INT125154 IL1B Regulation of Gene_expression of ITGB2 1 0.50 0.1 0.2
181 INT125155 IL1B Regulation of ITGAM 1 0.49 0.1 0.2
182 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2
183 INT125156 IL1B Regulation of Gene_expression of ITGAM 1 0.49 0.1 0.2
184 INT125152 IL1B Regulation of Gene_expression of ICAM1 1 0.50 0.1 0.2
185 INT175727 IL1B Regulation of VEGFA 2 0.04 0.7 0.19
186 INT197095 IL1B Regulation of Positive_regulation of TNF 1 0.01 0.64 0.19
187 INT197093 TNF Regulation of Positive_regulation of IL1B 1 0.01 0.64 0.19
188 INT346230 IL1B Positive_regulation of Binding of RUNX2 1 0.17 0.38 0.19
189 INT20554 IL1B Negative_regulation of Gene_expression of Vwa2 1 0.00 0 0.19
190 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19
191 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
192 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
193 INT66030 FOLR2 Negative_regulation of IL1B 1 0.00 0.56 0.18
194 INT209930 IL1B Positive_regulation of MAPK1 1 0.13 0.37 0.18
195 INT132809 TNF Positive_regulation of IL1B 2 0.33 1.26 0.16
196 INT353041 IL4 Positive_regulation of Localization of IL1B 1 0.02 0.99 0.16
197 INT209196 IL1B Positive_regulation of Gene_expression of TRPC3 1 0.68 0.23 0.15
198 INT99241 IFNG Regulation of IL1B 2 0.21 1.26 0.14
199 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14
200 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3553. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3553. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
3 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
4 INT6849 Localization of IL1B 229 0.81 112.56 69.63
5 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
6 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
7 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
8 INT6484 Binding of IL1B 122 0.47 75.84 35.07
9 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
10 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
11 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
12 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
13 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
14 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
15 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
16 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
17 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
18 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
19 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
20 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
21 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
22 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
23 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
24 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
25 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
26 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
27 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
28 INT81352 Negative_regulation of Regulation of IL1B 2 0.41 0.51 0.58
29 INT91975 Regulation of Binding of IL1B 2 0.14 0.66 0.38
30 INT209937 Negative_regulation of Protein_catabolism of IL1B 2 0.24 1.15 0.32
31 INT155532 Regulation of Regulation of IL1B 2 0.26 0.32 0.22
32 INT134981 Positive_regulation of Regulation of IL1B 2 0.49 0.69 0.1
33 INT192301 Positive_regulation of Protein_catabolism of IL1B 1 0.18 0.15 0.03
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