G:3565

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Official Symbol IL4
Aliases BSF1, IL-4, BCGF1, BSF-1, BCGF-1, MGC79402
EntrezGene 3565
UniProt Coming Soon
Unique Molecular Interactions 165
Total Molecular Interactions 212
Total Single Events 688
Unique Interaction Partners 88

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to IL4. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to IL4. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to IL4. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
2 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2
3 INT142075 IL4 Negative_regulation of Binding of IDO1 1 0.02 2.07 1.19
4 INT100678 IL4 Positive_regulation of STAT6 1 0.49 2.63 1.08
5 INT174468 IL7 Positive_regulation of Gene_expression of IL4 1 0.40 1.88 1.02
6 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
7 INT133073 IL4 Positive_regulation of Phosphorylation of STAT6 1 0.39 0 0.9
8 INT73492 PTGER2 Positive_regulation of Gene_expression of IL4 1 0.08 1.11 0.87
9 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79
10 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
11 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72
12 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
13 INT209859 IL4 Positive_regulation of PPARA 1 0.22 1.66 0.69
14 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
15 INT190177 Gene_expression of IL13 Regulation of Gene_expression of IL4 1 0.04 0.05 0.68
16 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68
17 INT190171 Gene_expression of IL4 Regulation of Gene_expression of IL13 1 0.04 0.05 0.68
18 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68
19 INT230336 IL4 Regulation of IL5 2 0.04 0.82 0.67
20 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
21 INT209854 IL4 Positive_regulation of Gene_expression of CD36 1 0.51 1.2 0.65
22 INT142076 IL4 Negative_regulation of Gene_expression of IFNG 1 0.01 1.58 0.64
23 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
24 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 0.28 0.26 0.62
25 INT190170 IL4 Regulation of Gene_expression of IL13 1 0.04 0 0.62
26 INT190175 IL13 Regulation of Gene_expression of IL4 1 0.04 0 0.62
27 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6
28 INT62034 POMC Regulation of Positive_regulation of IL4 1 0.44 0 0.58
29 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
30 INT172133 IL4 Negative_regulation of Gene_expression of HMOX2 1 0.00 0.81 0.58
31 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54
32 INT328058 IL4 Positive_regulation of FAAH 1 0.29 4.29 0.53
33 INT349636 IL17A Positive_regulation of Gene_expression of IL4 1 0.06 1.28 0.5
34 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47
35 INT323905 Positive_regulation of CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
36 INT323904 CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
37 INT72087 IL4 Positive_regulation of POMC 1 0.16 0 0.46
38 INT323907 ACCS Positive_regulation of IL4 1 0.04 0.9 0.45
39 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43
40 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43
41 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
42 INT292627 IL21 Positive_regulation of IL4 1 0.10 0.41 0.42
43 INT299789 IL4 Negative_regulation of Gene_expression of RAE1 1 0.00 0.84 0.41
44 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4
45 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4
46 INT292887 IL4 Regulation of IL12A 1 0.01 0.25 0.39
47 INT292892 IL4 Regulation of IL8 1 0.01 0.25 0.39
48 INT144047 IL4 Positive_regulation of PTGES 1 0.29 0.43 0.37
49 INT299790 IL4 Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37
50 INT292622 IL6 Positive_regulation of IL4 1 0.02 0.36 0.36
51 INT144050 IL4 Negative_regulation of Gene_expression of PTGES 1 0.27 0.48 0.35
52 INT209847 IL4 Positive_regulation of PPARA Positive_regulation of Gene_expression of CD36 1 0.22 0.83 0.34
53 INT98292 IL4 Regulation of Transcription of OPRM1 1 0.05 0 0.33
54 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33
55 INT98291 FAIM3 Regulation of IL4 1 0.02 0 0.32
56 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
57 INT94073 ARSA Negative_regulation of Transcription of IL4 1 0.20 0.16 0.31
58 INT174464 IL7 Positive_regulation of IL4 1 0.40 0.61 0.31
59 INT100684 IL13 Positive_regulation of Positive_regulation of IL4 1 0.18 0.74 0.3
60 INT100675 IL13 Positive_regulation of IL4 1 0.18 0.73 0.3
61 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29
62 INT98293 IL4 Positive_regulation of Transcription of FAIM3 1 0.02 0 0.29
63 INT171723 IL4 Positive_regulation of Positive_regulation of TNF 1 0.01 0.67 0.28
64 INT171719 IL4 Positive_regulation of TNF Positive_regulation of CXCL10 1 0.01 0.67 0.28
65 INT230342 IL6 Regulation of IL4 1 0.02 0.57 0.28
66 INT171720 IL4 Positive_regulation of Positive_regulation of IFNG 1 0.01 0.67 0.28
67 INT230338 IL1B Regulation of IL4 1 0.02 0.57 0.28
68 INT171722 IL4 Positive_regulation of Positive_regulation of CXCL10 1 0.04 0.67 0.28
69 INT171721 IL4 Positive_regulation of Positive_regulation of CXCL9 1 0.04 0.67 0.28
70 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27
71 INT100674 IL4 Positive_regulation of IL4 Positive_regulation of STAT6 1 0.24 0.68 0.27
72 INT100683 Negative_regulation of IL4 Positive_regulation of STAT6 1 0.30 0.65 0.27
73 INT100676 IL4 Positive_regulation of Positive_regulation of STAT6 1 0.35 0.68 0.27
74 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27
75 INT132801 IL4 Positive_regulation of Localization of IL6 2 0.26 1.47 0.26
76 INT100679 IL4 Positive_regulation of Gene_expression of FCER2 1 0.34 0.61 0.26
77 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
78 INT209884 Binding of IL4 and TNF 1 0.04 0.73 0.26
79 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
80 INT225652 Gene_expression of IL4 Positive_regulation of Positive_regulation of IL12A 1 0.06 1.2 0.25
81 INT80282 IL4 Positive_regulation of Gene_expression of CCL13 1 0.35 0.39 0.24
82 INT80290 IL4 Positive_regulation of CCL7 1 0.11 0.39 0.24
83 INT80291 IL4 Positive_regulation of CCL13 1 0.10 0.39 0.24
84 INT189150 IL4 Positive_regulation of CSF2 1 0.02 0.09 0.23
85 INT80292 IL4 Positive_regulation of Gene_expression of CCL11 1 0.05 0.37 0.23
86 INT189149 Positive_regulation of IL4 Positive_regulation of IL6 1 0.02 0.09 0.23
87 INT189155 Positive_regulation of IL4 Positive_regulation of CSF2 1 0.02 0.09 0.23
88 INT209880 IL4 Regulation of Gene_expression of TNFRSF11B 1 0.09 0.74 0.23
89 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
90 INT189153 Positive_regulation of IL4 Positive_regulation of IL3 1 0.01 0.09 0.22
91 INT174469 Binding of IL4 and Positive_regulation of Gene_expression of TH1L 1 0.27 0.55 0.22
92 INT189158 IL4 Positive_regulation of IL3 1 0.01 0.09 0.22
93 INT243683 IL4 Regulation of Localization of TNF 1 0.20 0.1 0.22
94 INT328059 IL4 Regulation of FAAH 1 0.25 4.57 0.21
95 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2
96 INT226369 IL19 Positive_regulation of IL4 1 0.03 0.55 0.2
97 INT226353 IL19 Positive_regulation of Gene_expression of IL4 1 0.03 0.56 0.2
98 INT209850 IL4 Positive_regulation of Gene_expression of PPARA 1 0.18 0.23 0.19
99 INT221017 IL4 Positive_regulation of Gene_expression of CCL18 1 0.05 0.13 0.19
100 INT221021 IL4 Positive_regulation of Gene_expression of IL10 1 0.01 0.13 0.19
101 INT174472 IL4 Regulation of IL7 1 0.16 0.38 0.19
102 INT225649 IL4 Positive_regulation of Localization of DCPS 1 0.02 1.03 0.19
103 INT284677 IFNG Negative_regulation of IL4 1 0.01 0.98 0.18
104 INT353041 IL4 Positive_regulation of Localization of IL1B 1 0.02 0.99 0.16
105 INT226526 BTPs Negative_regulation of IL4 1 0.03 0.27 0.16
106 INT353036 IL4 Positive_regulation of Localization of IL10 1 0.03 0.99 0.16
107 INT119557 CD1D Positive_regulation of IL4 1 0.00 0.67 0.16
108 INT353040 IL4 Positive_regulation of IL8 1 0.02 0.99 0.16
109 INT353037 IL4 Positive_regulation of IL2 1 0.02 0.99 0.16
110 INT226334 TH1L Negative_regulation of Localization of IL4 1 0.07 0.18 0.16
111 INT353038 IL4 Positive_regulation of Localization of IL2 1 0.02 0.99 0.16
112 INT226382 Negative_regulation of PDE4A Negative_regulation of Localization of IL4 1 0.12 0.18 0.16
113 INT353039 IL4 Positive_regulation of Localization of IL8 1 0.02 0.99 0.16
114 INT119559 TLE4 Negative_regulation of Positive_regulation of IL4 1 0.01 0.67 0.15
115 INT174470 IL4 Negative_regulation of IFNA1 1 0.09 0.27 0.14
116 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
117 INT226347 ST2 Positive_regulation of Gene_expression of IL4 1 0.08 0.15 0.12
118 INT222777 IL4 Positive_regulation of Positive_regulation of MR1 1 0.03 0.45 0.12
119 INT222774 IL4 Positive_regulation of MRC1 1 0.01 0.45 0.12
120 INT222786 IL4 Positive_regulation of Positive_regulation of MRC1 1 0.01 0.45 0.12
121 INT222748 IL4 Positive_regulation of IL4 Positive_regulation of MR1 1 0.01 0.45 0.12
122 INT171547 IL4 Regulation of GSTK1 1 0.03 0.6 0.12
123 INT298474 IL4 Positive_regulation of HLA-DRB1 1 0.02 0.33 0.12
124 INT222780 IL4 Positive_regulation of MR1 1 0.02 0.45 0.12
125 INT298478 IL4 Positive_regulation of CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12
126 INT298473 IL4 Positive_regulation of CD80 1 0.06 0.33 0.12
127 INT328063 IL4 Positive_regulation of Gene_expression of CNR1 1 0.14 0.93 0.11
128 INT307012 MT1JP Regulation of IL4 1 0.01 0 0.11
129 INT202544 Binding of IFNA1 and IL4 1 0.00 0.49 0.11
130 INT174471 IL4 Regulation of Gene_expression of IFNA1 1 0.06 0.21 0.11
131 INT328067 IL4 Positive_regulation of BTG2 1 0.03 0.8 0.11
132 INT79444 IL4 Negative_regulation of Positive_regulation of IRF6 2 0.09 0.09 0.1
133 INT149177 IL4 Negative_regulation of Positive_regulation of TNF 1 0.16 0.28 0.1
134 INT328062 IL4 Regulation of CNR1 1 0.18 2.53 0.1
135 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1
136 INT132804 Positive_regulation of IL4 Positive_regulation of CCL2 1 0.22 0.6 0.09
137 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09
138 INT270566 IGHE Regulation of IL4 1 0.21 0.99 0.09
139 INT304581 IL4 Positive_regulation of Gene_expression of IGHE 1 0.17 0.35 0.09
140 INT132812 Positive_regulation of IL4 Positive_regulation of IL1B 1 0.34 0.6 0.09
141 INT132818 IL4 Positive_regulation of Gene_expression of IL6 1 0.28 0.48 0.09
142 INT132802 IL4 Positive_regulation of IL1B 1 0.34 0.6 0.08
143 INT222788 IL4 Positive_regulation of Gene_expression of MR1 1 0.02 0.96 0.08
144 INT202541 IL4 Regulation of IGHE 1 0.02 0.49 0.08
145 INT132793 IL4 Positive_regulation of CCL2 1 0.22 0.73 0.08
146 INT132795 IL4 Positive_regulation of KITLG 1 0.12 0.73 0.08
147 INT171546 IL4 Positive_regulation of IFI27 1 0.14 0.06 0.08
148 INT202545 Binding of IGHE and IL4 1 0.03 0.49 0.08
149 INT171545 IL4 Positive_regulation of PPBP 1 0.01 0 0.05
150 INT202542 IGHE Positive_regulation of Localization of IL4 1 0.06 0.44 0.05
151 INT171543 IL4 Positive_regulation of Transcription of C3 1 0.28 0 0.05
152 INT171542 IL4 Positive_regulation of Gene_expression of C3 1 0.19 0 0.05
153 INT202566 Re Positive_regulation of Localization of IL4 1 0.00 0.44 0.05
154 INT226534 Binding of IL4 and Maf 1 0.02 0.21 0.04
155 INT226499 Binding of IL4 and Maf Positive_regulation of Positive_regulation of Il2ra 1 0.01 0.22 0.04
156 INT195195 IL4 Regulation of Gene_expression of IGHE 1 0.10 0.68 0.04
157 INT328057 IL4 Regulation of Binding of FAAH 1 0.19 1.1 0.04
158 INT328065 IL4 Regulation of Gene_expression of FAAH 1 0.19 0.82 0.03
159 INT225648 IL4 Positive_regulation of Gene_expression of IL12A 1 0.06 0.89 0.03
160 INT328066 FAAH Regulation of IL4 1 0.16 0.97 0.03
161 INT195199 Gene_expression of IL4 Positive_regulation of Gene_expression of IGHE 1 0.08 1.76 0
162 INT132799 IL4 Positive_regulation of Localization of CCL2 1 0.22 0.13 0
163 INT222773 IL4 Positive_regulation of SLURP1 1 0.14 0.43 0
164 INT226531 Gtf3a Positive_regulation of Gene_expression of IL4 1 0.00 0.51 0
165 INT312220 IL4 Positive_regulation of Regulation of INPP5K 1 0.05 0.24 0
166 INT163078 IL4 Positive_regulation of Gene_expression of STAT6 1 0.26 0 0
167 INT328061 IL4 Regulation of Gene_expression of CNR1 1 0.18 0.81 0
168 INT164906 IL33 Positive_regulation of Gene_expression of IL4 1 0.43 0.05 0
169 INT164897 IL4 Positive_regulation of Gene_expression of IL1RL1 1 0.54 0.06 0
170 INT132807 IL4 Positive_regulation of Localization of KITLG 1 0.28 0.13 0
171 INT346971 Binding of IL4 and IL10 1 0.12 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3565. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3565. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92
2 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39
3 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65
4 INT69158 Localization of IL4 48 0.71 31.3 11.98
5 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18
6 INT56299 Transcription of IL4 15 0.64 10.2 5.44
7 INT77146 Binding of IL4 23 0.36 13.69 5.39
8 INT171562 Regulation of IL4 19 0.36 12.12 5.33
9 INT64473 Regulation of Gene_expression of IL4 17 0.58 6.61 3.96
10 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56
11 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49
12 INT174478 Negative_regulation of Localization of IL4 6 0.34 3.56 1.65
13 INT100694 Negative_regulation of Positive_regulation of IL4 5 0.34 3.27 1.58
14 INT72099 Positive_regulation of Positive_regulation of IL4 4 0.43 0.71 1.24
15 INT177965 Negative_regulation of Transcription of IL4 3 0.25 2.11 0.78
16 INT72096 Regulation of Positive_regulation of IL4 2 0.20 0.51 0.72
17 INT174487 Protein_catabolism of IL4 3 0.71 1.64 0.55
18 INT94081 Negative_regulation of Binding of IL4 2 0.38 0.43 0.43
19 INT226493 Regulation of Transcription of IL4 1 0.19 0.8 0.41
20 INT106185 Phosphorylation of IL4 3 0.79 1.17 0.36
21 INT226430 Regulation of Localization of IL4 1 0.19 1.22 0.31
22 INT106186 Positive_regulation of Phosphorylation of IL4 1 0.16 0.77 0.13
23 INT295609 Negative_regulation of Phosphorylation of IL4 1 0.41 0.33 0.08
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