G:3569

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Official Symbol IL6
Aliases HGF, HSF, BSF2, IL-6, IFNB2
EntrezGene 3569
UniProt Coming Soon
Unique Molecular Interactions 338
Total Molecular Interactions 538
Total Single Events 4397
Unique Interaction Partners 173

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to IL6. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to IL6. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to IL6. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
2 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
3 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
4 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
5 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
6 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
7 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
8 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
9 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
10 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
11 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
12 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
13 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
14 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
15 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
16 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
17 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
18 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
19 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
20 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
21 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
22 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
23 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
24 INT124119 IL6 Regulation of IL6 Positive_regulation of CCL2 1 0.12 0.92 1.13
25 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
26 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
27 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
28 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
29 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
30 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
31 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
32 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
33 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
34 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
35 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
36 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
37 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
38 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
39 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
40 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
41 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
42 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
43 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
44 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
45 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
46 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
47 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
48 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
49 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
50 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
51 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
52 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
53 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
54 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
55 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
56 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
57 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
58 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
59 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
60 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
61 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
62 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
63 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
64 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
65 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
66 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
67 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57
68 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
69 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56
70 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
71 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54
72 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53
73 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
74 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52
75 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
76 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51
77 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
78 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5
79 INT97801 Gm5564 Regulation of Gene_expression of IL6 1 0.00 0.07 0.5
80 INT195220 Binding of CPB2 and IL6 1 0.04 0.5 0.49
81 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
82 INT100595 RPL21P132 Positive_regulation of IL6 1 0.01 0.43 0.49
83 INT61616 TNF Negative_regulation of Gene_expression of IL6 1 0.37 0.33 0.49
84 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48
85 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48
86 INT286352 IL6 Positive_regulation of Gene_expression of IL8 2 0.24 1.32 0.48
87 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
88 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
89 INT150536 OPRM1 Positive_regulation of Positive_regulation of IL6 1 0.04 0.38 0.48
90 INT150537 OPRM1 Positive_regulation of Negative_regulation of IL6 1 0.04 0.38 0.48
91 INT132448 MIR3607 Negative_regulation of IL6 1 0.01 2.45 0.48
92 INT150539 OPRM1 Positive_regulation of IL6 1 0.04 0.38 0.48
93 INT135589 CSF2 Regulation of IL6 1 0.08 1.27 0.48
94 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47
95 INT189151 MTNR1B Positive_regulation of Gene_expression of IL6 1 0.01 0.35 0.47
96 INT231340 INCENP Regulation of Gene_expression of IL6 1 0.01 1.09 0.47
97 INT138152 IL6 Positive_regulation of Transcription of Mmp2 1 0.00 0.23 0.46
98 INT138159 IL6 Positive_regulation of Gene_expression of Mmp3 1 0.00 0.23 0.46
99 INT67528 PTGER2 Positive_regulation of Gene_expression of IL6 2 0.10 1.38 0.45
100 INT67527 MRXS5 Positive_regulation of Gene_expression of IL6 1 0.21 1.5 0.45
101 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
102 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
103 INT188194 OSM Regulation of IL6 1 0.16 1.12 0.43
104 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
105 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
106 INT169288 TRPV1 Positive_regulation of Localization of IL6 1 0.24 0 0.42
107 INT83913 Il1b Positive_regulation of Gene_expression of IL6 1 0.01 0.5 0.41
108 INT83916 Il1b Positive_regulation of IL6 1 0.02 0.5 0.41
109 INT100594 DCSTAMP Positive_regulation of Gene_expression of IL6 1 0.03 0.24 0.41
110 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41
111 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
112 INT343919 Hspa1a Positive_regulation of Gene_expression of IL6 1 0.02 1.17 0.4
113 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4
114 INT294780 IL6 Positive_regulation of IL10 2 0.10 1.26 0.39
115 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39
116 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39
117 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
118 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38
119 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37
120 INT172135 Binding of IL2 and IL6 1 0.01 0.57 0.37
121 INT285935 IL6 Positive_regulation of Gene_expression of POU5F1 1 0.14 2.68 0.37
122 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
123 INT292622 IL6 Positive_regulation of IL4 1 0.02 0.36 0.36
124 INT311264 IL6 Positive_regulation of Gene_expression of PPIAP10 1 0.30 0.98 0.36
125 INT286347 IL8 Positive_regulation of Gene_expression of IL6 1 0.11 0.7 0.36
126 INT179202 NLRP1 Regulation of Gene_expression of IL6 1 0.07 0.77 0.36
127 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
128 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35
129 INT334948 IL6 Positive_regulation of IL6 Regulation of IL1RN 1 0.17 1.11 0.35
130 INT334951 IL6 Positive_regulation of Regulation of IL1RN 1 0.23 1.11 0.35
131 INT334947 IL6 Regulation of IL6 Positive_regulation of IL1RN 1 0.10 1.11 0.35
132 INT334949 IL6 Regulation of Regulation of IL1RN 1 0.13 1.11 0.35
133 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
134 INT343912 Fgg Positive_regulation of Gene_expression of IL6 1 0.00 0.83 0.35
135 INT334950 IL6 Regulation of IL1RN 1 0.13 1.11 0.35
136 INT172004 IL17A Positive_regulation of Gene_expression of IL6 2 0.14 1.35 0.34
137 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 0.28 0.54 0.34
138 INT222973 NFKBIB Negative_regulation of NFKB2 Negative_regulation of IL6 1 0.00 1.6 0.33
139 INT231715 GAGE2C Regulation of Localization of IL6 1 0.01 0.58 0.33
140 INT231714 GPR174 Regulation of Localization of IL6 1 0.01 0.58 0.33
141 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32
142 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
143 INT312573 AMBP Negative_regulation of IL6 1 0.11 1.41 0.32
144 INT307014 LBR Positive_regulation of Gene_expression of IL6 1 0.01 0.58 0.32
145 INT312571 AMBP Negative_regulation of Positive_regulation of IL6 1 0.11 1.41 0.32
146 INT307008 MT1JP Positive_regulation of Gene_expression of IL6 1 0.02 0.27 0.32
147 INT102874 TNF Negative_regulation of Transcription of IL6 1 0.53 0.42 0.31
148 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
149 INT102869 PTGER2 Negative_regulation of Transcription of IL6 1 0.17 0.42 0.31
150 INT304280 CCNE1 Positive_regulation of IL6 1 0.00 1.93 0.31
151 INT102872 IL1A Negative_regulation of Transcription of IL6 1 0.43 0.42 0.31
152 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
153 INT177901 Binding of IL6 and Wbc1 1 0.00 1.05 0.31
154 INT323855 IL6 Positive_regulation of Positive_regulation of TNF 1 0.04 1.03 0.31
155 INT315369 Binding of IL6 and Crp 1 0.10 2.09 0.3
156 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
157 INT67529 PTGDS Positive_regulation of Positive_regulation of IL6 1 0.30 0.69 0.29
158 INT230342 IL6 Regulation of IL4 1 0.02 0.57 0.28
159 INT230333 IL6 Regulation of IL13 1 0.03 0.57 0.28
160 INT230339 IL6 Regulation of IL5 1 0.03 0.57 0.28
161 INT116595 CASP1 Positive_regulation of IL6 1 0.07 0.46 0.28
162 INT230335 IL6 Regulation of IL9 1 0.03 0.57 0.28
163 INT116593 CPOX Regulation of IL6 1 0.10 0.45 0.28
164 INT101510 PPARA Regulation of IL6 1 0.31 0.53 0.27
165 INT282647 IL6 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
166 INT101511 PPARA Regulation of Gene_expression of IL6 1 0.31 0.53 0.27
167 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
168 INT163301 Binding of IFNA1 and IL6 2 0.04 2.95 0.26
169 INT132801 IL4 Positive_regulation of Localization of IL6 2 0.26 1.47 0.26
170 INT249831 Binding of CHI3L1 and IL6 1 0.30 2.81 0.26
171 INT299494 Binding of IL6 and IGKV2D-38 1 0.25 0.59 0.26
172 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26
173 INT76081 Plg Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.26
174 INT123468 IL6 Regulation of CSF2 1 0.25 1.22 0.26
175 INT76082 Plg Regulation of Gene_expression of IL6 1 0.01 0.19 0.26
176 INT102621 IL6 Regulation of Gene_expression of CPOX 1 0.13 0.78 0.25
177 INT175321 IL6 Positive_regulation of Localization of Oxt 1 0.01 0.7 0.25
178 INT278963 IL6 Regulation of Gene_expression of NOS2 1 0.12 0.41 0.25
179 INT179166 TFPI Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.25
180 INT312569 IL6 Positive_regulation of Localization of ELANE 1 0.11 1.05 0.24
181 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
182 INT292621 Binding of IL6 and Gpt 1 0.01 3.88 0.24
183 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
184 INT65015 IL6 Negative_regulation of Gene_expression of PTGER2 1 0.09 0.17 0.24
185 INT180982 SERPINC1 Negative_regulation of IRF6 Positive_regulation of IL6 1 0.00 0.54 0.24
186 INT102620 PTAFR Regulation of Gene_expression of IL6 1 0.24 0.29 0.24
187 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24
188 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24
189 INT102622 PTAFR Regulation of IL6 1 0.24 0.29 0.24
190 INT292635 IL6 Regulation of Localization of IL9 1 0.04 0.18 0.24
191 INT132447 TF Positive_regulation of IL6 1 0.09 1.1 0.23
192 INT354926 IL6 Regulation of Gene_expression of ALB 1 0.14 1.3 0.23
193 INT189149 Positive_regulation of IL4 Positive_regulation of IL6 1 0.02 0.09 0.23
194 INT65012 IL1B Regulation of Gene_expression of IL6 1 0.25 0.16 0.23
195 INT183945 INCENP Positive_regulation of Localization of IL6 1 0.00 0.2 0.23
196 INT354924 IL6 Positive_regulation of Gene_expression of ALB 1 0.26 1.3 0.23
197 INT189143 IL6 Positive_regulation of CSF2 1 0.02 0.09 0.23
198 INT194046 Binding of IL6 and PM20D2 1 0.01 1.71 0.22
199 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
200 INT87061 Binding of AVP and IL6 1 0.26 1.04 0.22

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3569. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3569. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
3 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
4 INT12082 Localization of IL6 365 0.81 241.78 105.78
5 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
6 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
7 INT9210 Regulation of IL6 166 0.62 125.61 49.95
8 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
9 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
10 INT86437 Binding of IL6 154 0.48 121.22 29.3
11 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
12 INT61626 Transcription of IL6 73 0.72 42.04 17.86
13 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
14 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
15 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
16 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
17 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
18 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
19 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
20 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
21 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
22 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
23 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
24 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98
25 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92
26 INT115192 Phosphorylation of IL6 7 0.70 1.55 0.84
27 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56
28 INT115189 Regulation of Phosphorylation of IL6 1 0.04 0 0.48
29 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46
30 INT298665 Positive_regulation of Protein_catabolism of IL6 1 0.09 2.03 0.25
31 INT188222 Positive_regulation of Regulation of IL6 2 0.29 0.51 0.13
32 INT298669 Negative_regulation of Protein_catabolism of IL6 1 0.08 1.02 0.13
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