G:3664

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Official Symbol IRF6
Aliases LPS, PIT, PPS, VWS, OFC6, VWS1
EntrezGene 3664
UniProt Coming Soon
Unique Molecular Interactions 185
Total Molecular Interactions 307
Total Single Events 679
Unique Interaction Partners 98

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to IRF6. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to IRF6. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to IRF6. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
3 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
4 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
5 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
6 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44
7 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
8 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
9 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
10 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
11 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
12 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
13 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
14 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
15 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
16 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
17 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
18 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
19 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
20 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
21 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
22 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
23 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87
24 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
25 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
26 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
27 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
28 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
29 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
30 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
31 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
32 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65
33 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
34 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
35 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
36 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
37 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
38 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59
39 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59
40 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
41 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
42 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
43 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
44 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51
45 INT97800 Gm5564 Regulation of IRF6 1 0.00 0.07 0.5
46 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5
47 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
48 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
49 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
50 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
51 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
52 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
53 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
54 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
55 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
56 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
57 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
58 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
59 INT188564 IRF6 Positive_regulation of Gene_expression of PRF1 1 0.01 0.44 0.44
60 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
61 INT243682 IRF6 Positive_regulation of NEU2 1 0.01 0.18 0.43
62 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43
63 INT188562 IRF6 Regulation of Gene_expression of PRF1 1 0.01 0.7 0.43
64 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
65 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
66 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
67 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
68 INT188544 ETV5 Negative_regulation of Binding of IRF6 and TLR4 1 0.00 0.59 0.38
69 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
70 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
71 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
72 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
73 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
74 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
75 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
76 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35
77 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
78 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
79 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35
80 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34
81 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
82 INT76088 IFNA1 Positive_regulation of IRF6 1 0.19 0.18 0.31
83 INT76086 IRF6 Positive_regulation of ISYNA1 1 0.07 0.18 0.31
84 INT105437 IRF6 Positive_regulation of Localization of PTGER1 1 0.01 0.61 0.31
85 INT105433 CPOX Negative_regulation of IRF6 Positive_regulation of PTGER1 1 0.01 0.62 0.31
86 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31
87 INT105438 IRF6 Positive_regulation of PTGER1 1 0.01 0.61 0.3
88 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29
89 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
90 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
91 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
92 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27
93 INT318477 Regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1 0.27
94 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26
95 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26
96 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25
97 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25
98 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
99 INT188561 IRF6 Positive_regulation of Transcription of CD14 1 0.03 0.25 0.25
100 INT14065 IRF6 Positive_regulation of PCA 1 0.24 0.51 0.24
101 INT180982 SERPINC1 Negative_regulation of IRF6 Positive_regulation of IL6 1 0.00 0.54 0.24
102 INT14064 Negative_regulation of IRF6 Positive_regulation of PCA 1 0.22 0.52 0.24
103 INT318485 Positive_regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1.03 0.23
104 INT250779 PROC Regulation of IRF6 Positive_regulation of AMIGO2 1 0.00 0.74 0.22
105 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
106 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
107 INT103861 SFTPA1 Positive_regulation of IRF6 Positive_regulation of Hmox1 1 0.00 0.23 0.2
108 INT103860 IRF6 Positive_regulation of IRF6 Positive_regulation of Hmox1 1 0.10 0.22 0.2
109 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
110 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19
111 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
112 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19
113 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19
114 INT323593 IRF6 Positive_regulation of PROCR 1 0.00 0.46 0.19
115 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
116 INT323592 IRF6 Positive_regulation of Positive_regulation of PROCR 1 0.00 0.46 0.19
117 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
118 INT335306 IRF6 Positive_regulation of MMP3 1 0.03 0.21 0.18
119 INT340447 Negative_regulation of IRF6 Positive_regulation of RELA 1 0.00 0.87 0.18
120 INT335304 IRF6 Positive_regulation of Gene_expression of MMP1 1 0.01 0.21 0.18
121 INT335302 IRF6 Positive_regulation of MMP1 1 0.01 0.21 0.18
122 INT355569 IRF6 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17
123 INT73506 Binding of IFNG and IRF6 1 0.02 0.42 0.17
124 INT340448 IRF6 Positive_regulation of RELA 1 0.00 0.86 0.17
125 INT104827 IRF6 Positive_regulation of IL12A 2 0.07 0.13 0.16
126 INT208217 IRF6 Positive_regulation of Gene_expression of ISYNA1 1 0.00 0.54 0.16
127 INT104829 Negative_regulation of IRF6 Positive_regulation of IL10 1 0.30 0 0.16
128 INT334590 IRF6 Positive_regulation of Localization of Ptger2 1 0.00 0 0.15
129 INT343836 Binding of IRF6 and LBP 1 0.02 0.8 0.14
130 INT316130 IRF6 Positive_regulation of Gene_expression of HLA-DRA 1 0.02 0.27 0.13
131 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
132 INT322014 Binding of IRF6 and Positive_regulation of Localization of IL1B 1 0.01 0 0.13
133 INT105436 IRF6 Positive_regulation of CPOX 1 0.08 0.74 0.11
134 INT231767 Positive_regulation of CD14 Positive_regulation of Binding of IRF6 1 0.04 1.6 0.11
135 INT231770 CD14 Positive_regulation of Binding of IRF6 1 0.04 1.59 0.11
136 INT231755 CD14 Positive_regulation of Binding of IRF6 and TLR4 1 0.03 1.6 0.11
137 INT79444 IL4 Negative_regulation of Positive_regulation of IRF6 2 0.09 0.09 0.1
138 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
139 INT343843 Binding of FN1 and IRF6 1 0.01 0.9 0.1
140 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
141 INT294779 IRF6 Positive_regulation of TLR2 1 0.06 0.17 0.1
142 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
143 INT285423 LBP Positive_regulation of Gene_expression of IRF6 1 0.07 0.19 0.09
144 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
145 INT180983 IRF6 Regulation of Localization of IL8 1 0.06 0.38 0.08
146 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
147 INT208218 NFKB1 Regulation of IRF6 1 0.01 0.07 0.07
148 INT306255 IRF6 Positive_regulation of TFAM 1 0.01 0 0.07
149 INT208219 RELA Regulation of IRF6 1 0.00 0.07 0.07
150 INT318028 Binding of IRF6 and Tlr4 1 0.00 0.61 0.06
151 INT322002 CR1 Negative_regulation of IRF6 Positive_regulation of IL1B 1 0.00 0 0.06
152 INT82578 IRF6 Positive_regulation of Gene_expression of PDE4B 1 0.21 0.09 0.05
153 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
154 INT250780 IRF6 Positive_regulation of ASAP1 1 0.06 0.34 0.04
155 INT295475 IRF6 Positive_regulation of Gene_expression of FBRS 1 0.12 0.17 0.04
156 INT335289 IRF6 Positive_regulation of Gene_expression of TIMP1 1 0.03 0.16 0.04
157 INT206071 IRF6 Positive_regulation of Positive_regulation of IL1B 1 0.00 0.58 0.03
158 INT133631 IRF6 Negative_regulation of Transcription of PDYN 1 0.17 0 0.03
159 INT283252 IRF6 Regulation of MIR155 1 0.01 1.04 0.03
160 INT318479 Positive_regulation of IRF6 Positive_regulation of FPR2 1 0.10 0.94 0.03
161 INT283255 IRF6 Regulation of MIR15B 1 0.00 1.04 0.03
162 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
163 INT103286 Negative_regulation of IRF6 Positive_regulation of NFKB1 1 0.18 0 0
164 INT103287 IRF6 Positive_regulation of NFKB1 1 0.19 0 0
165 INT27743 IRF6 Positive_regulation of TBXA2R 1 0.01 1.03 0
166 INT329477 Binding of IRF6 and Gpr55 1 0.01 0.53 0
167 INT335303 Binding of IRF6 and MMP2 1 0.01 0 0
168 INT329472 Binding of IRF6 and Ca2 1 0.00 0.26 0
169 INT337291 TLR4 Regulation of Localization of IRF6 1 0.05 0.47 0
170 INT185384 IRF6 Regulation of Gene_expression of CD14 1 0.04 0.99 0
171 INT95364 IFNG Positive_regulation of IRF6 1 0.24 0 0
172 INT79447 IRF6 Positive_regulation of Transcription of PDE4B 1 0.19 0 0
173 INT235181 IRF6 Positive_regulation of RASGRP1 1 0.00 0.2 0
174 INT335309 IRF6 Positive_regulation of Gene_expression of MMP3 1 0.03 0.07 0
175 INT337309 PTAFR Regulation of Localization of IRF6 1 0.06 0.89 0
176 INT235182 IRF6 Positive_regulation of VIM 1 0.05 0.08 0
177 INT156472 IRF6 Positive_regulation of Binding of IRF6 and IgG 1 0.13 0.15 0
178 INT335292 IRF6 Positive_regulation of Localization of MMP1 1 0.01 0.06 0
179 INT335288 SLC15A4 Negative_regulation of IRF6 Positive_regulation of MMP9 1 0.00 0.07 0
180 INT333561 CD14 Positive_regulation of IRF6 1 0.01 0.08 0
181 INT333566 IRF6 Positive_regulation of JUN 1 0.01 0.09 0
182 INT285420 IRF6 Regulation of Localization of IL6 1 0.03 0.14 0
183 INT331685 IRF6 Positive_regulation of IL23A 1 0.03 0.14 0
184 INT95365 Positive_regulation of IFNG Positive_regulation of IRF6 1 0.24 0 0
185 INT283259 MIR146B Positive_regulation of Gene_expression of IRF6 1 0.01 0.95 0
186 INT337294 IRF6 Positive_regulation of Gene_expression of TLR4 1 0.06 0.16 0
187 INT283254 MIR150 Positive_regulation of Gene_expression of IRF6 1 0.04 0.95 0
188 INT335297 IRF6 Positive_regulation of Gene_expression of MMP2 1 0.01 0.07 0
189 INT333562 IRF6 Positive_regulation of FOS 1 0.01 0.09 0
190 INT335296 IRF6 Positive_regulation of Localization of SLC15A4 1 0.00 0.06 0
191 INT285429 Binding of IRF6 and TLR6 1 0.08 0.1 0
192 INT283258 MIR342 Positive_regulation of Gene_expression of IRF6 1 0.02 0.96 0
193 INT335294 IRF6 Positive_regulation of Gene_expression of MMP9 1 0.01 0.07 0
194 INT274437 Binding of IRF6 and LIPA 1 0.00 0.09 0
195 INT156474 Binding of IRF6 and IgG 1 0.09 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3664. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3664. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81
2 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51
3 INT97798 Localization of IRF6 86 0.73 33.27 20.94
4 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13
5 INT99586 Binding of IRF6 60 0.36 27.87 13.2
6 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39
7 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28
8 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51
9 INT97799 Regulation of IRF6 23 0.26 6.54 3.75
10 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35
11 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96
12 INT237700 Regulation of Negative_regulation of IRF6 2 0.11 1.08 2.58
13 INT188397 Regulation of Positive_regulation of IRF6 4 0.12 1.34 1.47
14 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34
15 INT185929 Regulation of Gene_expression of IRF6 9 0.20 1.66 0.99
16 INT185397 Positive_regulation of Binding of IRF6 3 0.12 0.56 0.57
17 INT97796 Regulation of Localization of IRF6 2 0.20 0.32 0.5
18 INT216998 Regulation of Binding of IRF6 2 0.05 0.06 0.48
19 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47
20 INT188395 Regulation of Regulation of IRF6 1 0.06 0.89 0.46
21 INT289471 Negative_regulation of Negative_regulation of IRF6 1 0.10 0.31 0.45
22 INT181007 Protein_catabolism of IRF6 3 0.61 1.17 0.39
23 INT185399 Negative_regulation of Binding of IRF6 1 0.07 1.12 0.25
24 INT263475 Negative_regulation of Protein_catabolism of IRF6 1 0.36 0.48 0.21
25 INT318506 Positive_regulation of Negative_regulation of IRF6 1 0.11 0.75 0.19
26 INT237708 Negative_regulation of Regulation of IRF6 1 0.03 0 0
27 INT333599 Positive_regulation of Phosphorylation of IRF6 1 0.03 0 0
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