G:3952

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Official Symbol LEP
Aliases OB, OBS, FLJ94114
EntrezGene 3952
UniProt Coming Soon
Unique Molecular Interactions 71
Total Molecular Interactions 109
Total Single Events 860
Unique Interaction Partners 44

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to LEP. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to LEP. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to LEP. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
2 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
3 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
4 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
5 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
6 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
7 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
8 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
9 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
10 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
11 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
12 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
13 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
14 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
15 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
16 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
17 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
18 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
19 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
20 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
21 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
22 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
23 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
24 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
25 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
26 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
27 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
28 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
29 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
30 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
31 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
32 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
33 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
34 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
35 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
36 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
37 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
38 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
39 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
40 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
41 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
42 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
43 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
44 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
45 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
46 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
47 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
48 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09
49 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
50 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
51 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
52 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
53 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
54 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
55 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
56 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
57 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
58 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
59 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03
60 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
61 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
62 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03
63 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0
64 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0
65 INT225085 Binding of ADM and Negative_regulation of LEP 1 0.16 1.04 0
66 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0
67 INT204085 Binding of LEP and TNF 1 0.37 0.39 0
68 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
69 INT249047 CENPJ Negative_regulation of LEP 1 0.22 0.8 0
70 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0
71 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3952. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3952. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
3 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
4 INT75908 Regulation of LEP 77 0.60 60.16 15.19
5 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
6 INT75907 Binding of LEP 53 0.46 46.65 8.44
7 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
8 INT65356 Localization of LEP 46 0.79 41.17 5.43
9 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
10 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
11 INT156533 Transcription of LEP 9 0.69 4.35 0.74
12 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
13 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
14 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
15 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
16 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
17 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
18 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
19 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
20 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
21 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
22 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
23 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
24 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
25 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
26 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
27 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
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