G:4157

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Official Symbol MC1R
Aliases CMM5, MSH-R, SHEP2, MGC14337
EntrezGene 4157
UniProt Coming Soon
Unique Molecular Interactions 55
Total Molecular Interactions 152
Total Single Events 653
Unique Interaction Partners 35

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to MC1R. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to MC1R. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to MC1R. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
4 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
5 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
6 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
7 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
8 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
9 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
10 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
11 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
12 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 1 0.37 0 0.9
13 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
14 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
15 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
16 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
17 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
18 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
19 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
20 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
21 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
22 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
23 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
24 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
25 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
26 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
27 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
28 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
29 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
30 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
31 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
32 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
33 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
34 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
35 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
36 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
37 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
38 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
39 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
40 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
41 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
42 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
43 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
44 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
45 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2
46 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19
47 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19
48 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15
49 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
50 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
51 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12
52 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12
53 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12
54 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12
55 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12
56 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 4157. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 4157. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54
3 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
4 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
5 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
6 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
7 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
8 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
9 INT61136 Localization of MC1R 8 0.75 2.8 2.85
10 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
11 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
12 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
13 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
14 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
15 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
16 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
17 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
18 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
19 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
20 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
21 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
22 INT335614 Positive_regulation of Regulation of MC1R 1 0.23 0 0
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