G:5054

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Official Symbol SERPINE1
Aliases PAI, PAI1, PAI-1, PLANH1
EntrezGene 5054
UniProt Coming Soon
Unique Molecular Interactions 42
Total Molecular Interactions 69
Total Single Events 533
Unique Interaction Partners 30

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to SERPINE1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to SERPINE1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to SERPINE1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
2 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
3 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
4 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
5 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
6 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
7 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
8 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
9 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
10 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
11 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
12 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
13 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
14 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
15 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
16 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22
17 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
18 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 0.02 0.28 0.22
19 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
20 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
21 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
22 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
23 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
24 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
25 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
26 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
27 INT99737 Serpinf2 Negative_regulation of Localization of SERPINE1 1 0.00 0.24 0.12
28 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
29 INT22670 PLAT Positive_regulation of SERPINE1 1 0.03 0.1 0.1
30 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1
31 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1
32 INT22672 Positive_regulation of Binding of SERPINE1 and PLAT 1 0.03 0.1 0.1
33 INT22666 PLAT Positive_regulation of Binding of SERPINE1 and PLAT 1 0.00 0.1 0.1
34 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07
35 INT57268 SERPINE1 Positive_regulation of SERPINC1 1 0.07 0.94 0.07
36 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06
37 INT319120 CRP Positive_regulation of Gene_expression of SERPINE1 1 0.70 0.54 0.04
38 INT355637 OLR1 Positive_regulation of Gene_expression of SERPINE1 1 0.03 1.15 0
39 INT337616 SERPINE1 Positive_regulation of Binding of PLAU and PLAUR 1 0.03 0.51 0
40 INT337624 SERPINE1 Positive_regulation of Binding of F13A1 and PLAU 1 0.01 0.51 0
41 INT337620 SERPINB2 Positive_regulation of Binding of SERPINE1 and PLAU 1 0.02 0.51 0
42 INT22668 PNMA1 Regulation of SERPINE1 1 0.03 0 0
43 INT337623 SERPINE1 Positive_regulation of Binding of SERPINE1 and PLAU 1 0.02 0.51 0
44 INT337619 F13A1 Positive_regulation of Binding of SERPINE1 and PLAU 1 0.01 0.51 0
45 INT130414 TNFSF14 Positive_regulation of SERPINE1 1 0.29 0 0
46 INT337618 SERPINE1 Positive_regulation of Binding of SERPINB2 and PLAU 1 0.02 0.51 0
47 INT197040 SERPINE1 Regulation of PLAU 1 0.31 0.68 0
48 INT265934 SREBF1 Positive_regulation of Transcription of SERPINE1 1 0.01 0.62 0
49 INT22677 Binding of SERPINE1 and SGCG 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5054. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5054. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
2 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
3 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
4 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
5 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
6 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
7 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
8 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
9 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
10 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
11 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83
12 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69
13 INT70971 Negative_regulation of Positive_regulation of SERPINE1 3 0.40 2.65 0.58
14 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47
15 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38
16 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33
17 INT48719 Negative_regulation of Transcription of SERPINE1 1 0.42 0.17 0.26
18 INT180280 Positive_regulation of Phosphorylation of SERPINE1 2 0.48 0 0.24
19 INT180281 Phosphorylation of SERPINE1 2 0.78 0 0.24
20 INT202186 Negative_regulation of Phosphorylation of SERPINE1 1 0.41 0 0.24
21 INT100870 Positive_regulation of Binding of SERPINE1 2 0.49 1.24 0.21
22 INT48723 Regulation of Transcription of SERPINE1 1 0.27 0.26 0.2
23 INT270426 Regulation of Binding of SERPINE1 1 0.06 0.42 0.17
24 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14
25 INT305016 Positive_regulation of Negative_regulation of SERPINE1 1 0.10 1.13 0.11
26 INT277070 Negative_regulation of Negative_regulation of SERPINE1 1 0.12 0.55 0.1
27 INT81879 Regulation of Regulation of SERPINE1 1 0.27 0.73 0.06
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