G:5179

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Official Symbol PENK
Aliases none
EntrezGene 5179
UniProt Coming Soon
Unique Molecular Interactions 51
Total Molecular Interactions 63
Total Single Events 666
Unique Interaction Partners 34

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to PENK. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to PENK. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to PENK. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
2 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
3 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
4 INT154114 PENK Positive_regulation of YY1 1 0.50 0.06 1.41
5 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
6 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
7 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
8 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
9 INT42806 Binding of CCT6A and PENK 1 0.02 0 1.23
10 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
11 INT1583 PENK Negative_regulation of Binding of PENK and POMC 1 0.08 0 0.83
12 INT1582 Binding of PENK and POMC 1 0.16 0 0.83
13 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
14 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
15 INT81011 CNR1 Positive_regulation of Gene_expression of PENK 1 0.54 0 0.75
16 INT33989 PENK Negative_regulation of Localization of IGKV1D-39 1 0.01 0.27 0.68
17 INT54542 Binding of PENK and SLBP 1 0.07 0 0.59
18 INT69389 CNTN2 Positive_regulation of PENK 1 0.20 0.53 0.54
19 INT113752 Binding of PENK and Oprm1 1 0.01 0 0.47
20 INT113750 Negative_regulation of Binding of PENK and Oprm1 1 0.01 0 0.47
21 INT66890 Binding of PENK and Oprd1 1 0.05 0 0.45
22 INT189309 Binding of MME and PENK 1 0.15 1.16 0.42
23 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
24 INT109454 Binding of PENK and OGFR 1 0.22 0.07 0.37
25 INT101968 TAC1 Regulation of PENK 1 0.00 0 0.33
26 INT101978 Regulation of Tac1 Regulation of PENK 1 0.01 0 0.33
27 INT51631 Binding of DRD3 and PENK 1 0.08 0 0.33
28 INT101980 Tac1 Regulation of PENK 1 0.01 0 0.33
29 INT69376 CNTN2 Regulation of CNTN2 Positive_regulation of PENK 1 0.08 0.28 0.31
30 INT57221 Binding of ATF3 and PENK 1 0.17 0.26 0.24
31 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
32 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
33 INT69390 Binding of PENK and PROC 1 0.00 0.22 0.21
34 INT69387 Binding of PENK and CNTN2 1 0.14 0.22 0.21
35 INT74431 Negative_regulation of Cpe Positive_regulation of Localization of PENK 1 0.44 0 0.2
36 INT74434 Negative_regulation of Cpe Positive_regulation of PENK 1 0.44 0 0.2
37 INT69379 CNTN2 Positive_regulation of Gene_expression of PENK 1 0.18 0.19 0.18
38 INT25258 Fos Regulation of PENK 1 0.12 0.09 0.18
39 INT57217 ATF3 Positive_regulation of Gene_expression of PENK 1 0.24 0.18 0.16
40 INT57218 Binding of JUND and PENK 1 0.11 0.16 0.15
41 INT54544 CREB1 Regulation of PENK 1 0.59 0 0.12
42 INT12830 Regulation of CRH Regulation of PENK 1 0.10 0.41 0.12
43 INT54545 Binding of CREB1 and PENK 1 0.35 0 0.12
44 INT54543 DBP Regulation of PENK 1 0.28 0 0.12
45 INT12828 CRH Regulation of PENK 1 0.10 0.41 0.12
46 INT138727 Binding of PCa and PENK 1 0.14 0.55 0.09
47 INT57212 ATF3 Positive_regulation of Binding of JUND and PENK 1 0.16 0.08 0.08
48 INT57216 JUND Positive_regulation of Gene_expression of PENK 1 0.10 0.07 0.07
49 INT111933 Cacna1c Positive_regulation of PENK 1 0.01 0 0.07
50 INT175083 TAF6L Regulation of Gene_expression of PENK 1 0.00 0.05 0.04
51 INT77956 Binding of PENK and DEAF1 1 0.21 0.22 0
52 INT57385 Binding of PENK and Creb1 1 0.33 0.59 0
53 INT74435 Binding of PENK and Cpe 1 0.27 0 0
54 INT6675 Edn1 Positive_regulation of Negative_regulation of PENK 1 0.07 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5179. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5179. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49
2 INT4862 Localization of PENK 62 0.81 11.57 40.28
3 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54
4 INT610 Regulation of PENK 47 0.62 14.17 31.55
5 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21
6 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91
7 INT8223 Transcription of PENK 53 0.69 6.84 14.7
8 INT1590 Binding of PENK 27 0.47 2.99 12.81
9 INT2294 Protein_catabolism of PENK 19 1.00 0.64 10.22
10 INT21214 Negative_regulation of Gene_expression of PENK 21 0.58 9.14 9.53
11 INT154115 Positive_regulation of Localization of PENK 5 0.49 3.15 6.93
12 INT20805 Regulation of Gene_expression of PENK 20 0.62 4.55 6.02
13 INT26539 Positive_regulation of Transcription of PENK 10 0.67 1.28 2.9
14 INT12832 Positive_regulation of Positive_regulation of PENK 6 0.67 1.13 2.13
15 INT78479 Negative_regulation of Localization of PENK 2 0.43 1.9 1.81
16 INT1588 Positive_regulation of Binding of PENK 2 0.26 0.57 1.72
17 INT15461 Phosphorylation of PENK 2 0.72 0.17 1.49
18 INT27956 Negative_regulation of Positive_regulation of PENK 6 0.43 1.37 1.25
19 INT1589 Regulation of Binding of PENK 1 0.23 0 0.84
20 INT32173 Regulation of Localization of PENK 2 0.23 0.1 0.83
21 INT28716 Regulation of Positive_regulation of PENK 2 0.60 0.89 0.81
22 INT20809 Regulation of Transcription of PENK 4 0.60 0.07 0.69
23 INT106771 Negative_regulation of Protein_catabolism of PENK 1 0.48 0 0.47
24 INT12831 Regulation of Regulation of PENK 2 0.44 0.91 0.44
25 INT28718 Negative_regulation of Regulation of PENK 1 0.41 0.42 0.25
26 INT141126 Negative_regulation of Transcription of PENK 1 0.41 0.71 0.18
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