G:5290

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Official Symbol PIK3CA
Aliases PI3K, MGC142161, MGC142163, p110-alpha
EntrezGene 5290
UniProt Coming Soon
Unique Molecular Interactions 18
Total Molecular Interactions 19
Total Single Events 94
Unique Interaction Partners 14

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to PIK3CA. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to PIK3CA. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to PIK3CA. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
2 INT190145 Binding of JUN and MMP12 Positive_regulation of Positive_regulation of PIK3CA 1 0.01 0.57 0.57
3 INT190146 Positive_regulation of PIK3CA Positive_regulation of Binding of JUN and MMP12 1 0.01 0.57 0.57
4 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
5 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
6 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
7 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
8 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
9 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
10 INT246845 Binding of PIK3CA and Ppp1r13b 1 0.13 0.15 0.08
11 INT179951 Binding of PIK3CA and Ins1 1 0.39 0.32 0.03
12 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
13 INT295476 PIK3CA Regulation of Gene_expression of TNF 1 0.00 0.05 0.03
14 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0
15 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
16 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0
17 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
18 INT198001 Negative_regulation of PIK3CA Negative_regulation of Gene_expression of MCL1 1 0.26 0.89 0
19 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0
20 INT225904 Binding of GAB1 and PIK3CA 1 0.07 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5290. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5290. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
2 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
3 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
4 INT89399 Negative_regulation of Positive_regulation of PIK3CA 3 0.57 1 0.22
5 INT147732 Binding of PIK3CA 3 0.36 1.13 0.2
6 INT246833 Positive_regulation of Binding of PIK3CA 1 0.49 0.29 0.16
7 INT147731 Phosphorylation of PIK3CA 3 0.44 1.93 0.14
8 INT147733 Regulation of Binding of PIK3CA 1 0.10 0.23 0.08
9 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03
10 INT176150 Localization of PIK3CA 2 0.73 0.22 0.03
11 INT176160 Positive_regulation of Localization of PIK3CA 1 0.13 0.22 0.03
12 INT198037 Regulation of PIK3CA 2 0.28 2.63 0
13 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0
14 INT315886 Regulation of Positive_regulation of PIK3CA 1 0.10 0.53 0
15 INT198035 Regulation of Negative_regulation of PIK3CA 1 0.15 0.95 0
16 INT198030 Regulation of Regulation of PIK3CA 1 0.24 1.08 0
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