G:5443

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Official Symbol POMC
Aliases LPH, MSH, NPP, POC, ACTH, CLIP
EntrezGene 5443
UniProt Coming Soon
Unique Molecular Interactions 312
Total Molecular Interactions 532
Total Single Events 5148
Unique Interaction Partners 174

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to POMC. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to POMC. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to POMC. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
5 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
6 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
7 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
8 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
9 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
10 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
11 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
12 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
13 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
14 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
15 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
16 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
17 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
18 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
19 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
20 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
21 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
22 INT32442 POMC Positive_regulation of POMC Positive_regulation of ELANE 1 0.15 0.18 1.66
23 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
24 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
25 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
26 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
27 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
28 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
29 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
30 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
31 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
32 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 1 0.04 0 1.52
33 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
34 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
35 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
36 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
37 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
38 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
39 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
40 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
41 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
42 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
43 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
44 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
45 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
46 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
47 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
48 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
49 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
50 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
51 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
52 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
53 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
54 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
55 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
56 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
57 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
58 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
59 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
60 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
61 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
62 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
63 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
64 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
65 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
66 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
67 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
68 INT20888 POMC Positive_regulation of Localization of PDYN 1 0.40 0 0.92
69 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
70 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 1 0.37 0 0.9
71 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
72 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
73 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89
74 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
75 INT59497 Adh1 Regulation of POMC 1 0.03 0 0.86
76 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
77 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
78 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
79 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
80 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
81 INT1583 PENK Negative_regulation of Binding of PENK and POMC 1 0.08 0 0.83
82 INT1582 Binding of PENK and POMC 1 0.16 0 0.83
83 INT79617 Htr1a Positive_regulation of Localization of POMC 1 0.38 0 0.83
84 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
85 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
86 INT18099 POMC Positive_regulation of Binding of Prl 1 0.00 0 0.76
87 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
88 INT32163 Binding of CALM1 and POMC 4 0.46 0 0.75
89 INT164055 POMC Regulation of Agrp 1 0.29 0.3 0.75
90 INT164057 POMC Regulation of Pomc 1 0.09 0.3 0.75
91 INT124404 Binding of POMC and Oprm1 1 0.00 0.25 0.75
92 INT164056 Agrp Regulation of POMC 1 0.29 0.3 0.75
93 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
94 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
95 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
96 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
97 INT26872 ABAT Positive_regulation of Localization of POMC 1 0.03 0 0.71
98 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
99 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
100 INT12711 POMC Regulation of Prl 1 0.04 1.25 0.7
101 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
102 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
103 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
104 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
105 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
106 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
107 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
108 INT61798 Binding of NDP and POMC 2 0.22 0 0.66
109 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
110 INT28080 POMC Negative_regulation of Gene_expression of ITGAM 1 0.00 0.16 0.65
111 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
112 INT72146 POMC Positive_regulation of Phosphorylation of MYOT 1 0.00 0.25 0.65
113 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
114 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
115 INT23555 POMC Positive_regulation of Penk 1 0.56 0 0.63
116 INT23554 POMC Positive_regulation of Localization of Penk 1 0.56 0 0.63
117 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
118 INT42269 POMC Negative_regulation of Localization of AVP 1 0.09 0 0.61
119 INT47461 PDYN Regulation of POMC 1 0.01 0 0.6
120 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
121 INT13238 POMC Regulation of Gene_expression of IL2 1 0.09 0.26 0.59
122 INT130288 POMC Regulation of Gene_expression of VTCN1 1 0.01 0.1 0.59
123 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
124 INT130287 POMC Regulation of Localization of IL10 1 0.12 0.1 0.59
125 INT31640 POMC Regulation of POMC Regulation of GCG 1 0.19 0.38 0.58
126 INT62034 POMC Regulation of Positive_regulation of IL4 1 0.44 0 0.58
127 INT35181 Binding of STT3A and POMC 1 0.29 0.75 0.57
128 INT93541 Ntsr1 Regulation of POMC 1 0.00 0 0.57
129 INT102422 POMC Regulation of Gene_expression of Sst 1 0.14 0.24 0.54
130 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
131 INT56390 CCK Positive_regulation of Localization of POMC 1 0.14 0.06 0.52
132 INT119030 Binding of POMC and Ighg1 1 0.06 0 0.52
133 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
134 INT150244 POMC Positive_regulation of Mc3r Regulation of POMC 1 0.03 0.88 0.52
135 INT55323 GNRH1 Regulation of POMC 1 0.35 0 0.49
136 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
137 INT72088 IL10 Positive_regulation of POMC 1 0.15 0 0.46
138 INT72087 IL4 Positive_regulation of POMC 1 0.16 0 0.46
139 INT28081 POMC Regulation of Gene_expression of VIM 1 0.13 0.09 0.46
140 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
141 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45
142 INT28082 POMC Regulation of PDYN 1 0.04 0.09 0.45
143 INT56132 CALCA Positive_regulation of Localization of POMC 1 0.51 0.16 0.44
144 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43
145 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
146 INT128287 POMC Positive_regulation of RTCA 1 0.04 0.13 0.42
147 INT47595 Binding of POMC and Pomc 1 0.02 0 0.41
148 INT61799 Negative_regulation of Binding of NDP and POMC 1 0.20 0 0.41
149 INT32550 POMC Positive_regulation of Regulation of Nts 1 0.02 0 0.41
150 INT46225 Binding of ALB and POMC 1 0.36 0 0.4
151 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4
152 INT79618 Htr1a Positive_regulation of POMC 1 0.17 0 0.39
153 INT13097 POMC Negative_regulation of Localization of CGA 1 0.46 0 0.39
154 INT81731 POMC Regulation of Gene_expression of TNF 1 0.28 1.07 0.39
155 INT67445 Oprd1 Regulation of Localization of POMC 1 0.00 0 0.39
156 INT6657 Binding of POMC and D15Mit108 1 0.03 0.49 0.37
157 INT21828 Binding of POMC and Serpinb1a 1 0.02 0 0.36
158 INT114903 POMC Regulation of Gene_expression of COL7A1 1 0.06 0.2 0.36
159 INT126123 Cck Positive_regulation of POMC 1 0.08 0.29 0.35
160 INT126122 Cck Regulation of POMC 1 0.04 0.29 0.35
161 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
162 INT12522 Binding of FSHR and POMC 1 0.33 3.89 0.34
163 INT29292 POMC Negative_regulation of HP 1 0.01 0 0.34
164 INT30293 POMC Positive_regulation of Gene_expression of IGKV1D-39 1 0.36 0 0.34
165 INT128076 POMC Positive_regulation of Gene_expression of TNF 1 0.33 0.31 0.33
166 INT14062 Binding of POMC and RNPEP 1 0.01 0 0.33
167 INT107751 POMC Negative_regulation of HSD17B1 1 0.33 0.39 0.33
168 INT12390 AVP Regulation of Localization of POMC 1 0.29 0.27 0.3
169 INT31507 FEM1B Positive_regulation of Localization of POMC 1 0.51 0 0.29
170 INT89909 AVP Positive_regulation of Localization of POMC 1 0.44 0 0.29
171 INT18246 POMC Negative_regulation of Gene_expression of GNRH1 1 0.53 0.49 0.29
172 INT89913 LHB Positive_regulation of Localization of POMC 1 0.10 0 0.29
173 INT41192 Trh Positive_regulation of Localization of POMC 1 0.04 0 0.29
174 INT42899 POMC Negative_regulation of Binding of Gast 1 0.01 0 0.29
175 INT189148 MTNR1B Positive_regulation of POMC 1 0.00 0.34 0.29
176 INT89897 PLOD1 Positive_regulation of Localization of POMC 1 0.13 0 0.29
177 INT26175 POMC Positive_regulation of GCG 2 0.47 0.57 0.28
178 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
179 INT43837 POMC Positive_regulation of GHRH 1 0.16 0 0.28
180 INT43836 Regulation of POMC Positive_regulation of GHRH 1 0.14 0 0.28
181 INT89898 GH1 Positive_regulation of Localization of POMC 1 0.12 0 0.28
182 INT89907 SST Positive_regulation of Localization of POMC 1 0.44 0 0.28
183 INT62753 IL2 Regulation of POMC 1 0.27 0 0.28
184 INT89904 POMC Positive_regulation of Localization of GH1 1 0.12 0 0.28
185 INT89910 GHRH Positive_regulation of Localization of POMC 1 0.33 0 0.28
186 INT89899 PRL Positive_regulation of Localization of POMC 1 0.33 0 0.28
187 INT210828 POMC Positive_regulation of ADCY1 1 0.03 0.34 0.28
188 INT43838 POMC Positive_regulation of PRL 1 0.36 0 0.28
189 INT43839 Regulation of POMC Positive_regulation of PRL 1 0.32 0 0.28
190 INT29140 POMC Regulation of Oprl1 1 0.00 0 0.27
191 INT66813 Umod Negative_regulation of POMC 1 0.03 0.42 0.26
192 INT66812 Foxp4 Negative_regulation of POMC 1 0.00 0.42 0.26
193 INT159991 Ctsk Positive_regulation of POMC 1 0.01 0.35 0.25
194 INT101040 Binding of MC3R and POMC 1 0.30 0.35 0.25
195 INT86634 POMC Positive_regulation of TYR 2 0.42 0 0.24
196 INT32330 POMC Positive_regulation of Localization of GHRH 1 0.12 0 0.24
197 INT42262 Pomc Positive_regulation of POMC 1 0.21 0.35 0.24
198 INT62033 POMC Regulation of Gene_expression of IGHE 1 0.64 0 0.24
199 INT100281 POMC Negative_regulation of Gene_expression of HSP90B2P 1 0.24 0.29 0.23
200 INT49384 POMC Positive_regulation of Positive_regulation of HIVEP1 1 0.09 0.7 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5443. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5443. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT738 Regulation of POMC 459 0.62 111.19 243.74
5 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
6 INT695 Binding of POMC 304 0.48 56.66 126.85
7 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
8 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
9 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
10 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
11 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
12 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
13 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
14 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
15 INT1416 Transcription of POMC 40 0.72 10.71 15.38
16 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
17 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
18 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
19 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
20 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
21 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
22 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
23 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
24 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61
25 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99
26 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96
27 INT41580 Negative_regulation of Negative_regulation of POMC 5 0.50 0.46 1.79
28 INT6130 Positive_regulation of Regulation of POMC 6 0.69 3.57 1.7
29 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3
30 INT33048 Positive_regulation of Protein_catabolism of POMC 1 0.04 0 1.02
31 INT162073 Negative_regulation of Transcription of POMC 1 0.34 0.34 0.88
32 INT46231 Regulation of Protein_catabolism of POMC 1 0.05 0 0.6
33 INT128288 Negative_regulation of Phosphorylation of POMC 1 0.37 0.17 0.33
34 INT54039 Positive_regulation of Transcription of POMC 2 0.67 3.24 0.23
35 INT120321 Regulation of Transcription of POMC 1 0.18 0.95 0.17
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