G:5465

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Official Symbol PPARA
Aliases PPAR, NR1C1, hPPAR, MGC2237, MGC2452, PPARalpha
EntrezGene 5465
UniProt Coming Soon
Unique Molecular Interactions 126
Total Molecular Interactions 169
Total Single Events 2473
Unique Interaction Partners 95

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to PPARA. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to PPARA. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to PPARA. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
2 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
3 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99
4 INT209859 IL4 Positive_regulation of PPARA 1 0.22 1.66 0.69
5 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
6 INT114950 YY1 Positive_regulation of Positive_regulation of PPARA 1 0.52 0.25 0.64
7 INT114948 NCOA1 Positive_regulation of Positive_regulation of PPARA 1 0.20 0.24 0.62
8 INT103092 Binding of PPARA and ISYNA1 1 0.01 0.45 0.54
9 INT285688 Cpox Positive_regulation of PPARA 1 0.02 1 0.5
10 INT240441 Ltb4r1 Positive_regulation of PPARA 1 0.03 1.01 0.47
11 INT240442 Binding of PPARA and Ltb4r1 1 0.02 0.94 0.46
12 INT107706 PPARA Positive_regulation of Gene_expression of CPOX 1 0.18 0.14 0.4
13 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35
14 INT209847 IL4 Positive_regulation of PPARA Positive_regulation of Gene_expression of CD36 1 0.22 0.83 0.34
15 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
16 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33
17 INT240434 PPARA Negative_regulation of Gene_expression of CPOX 1 0.03 0.64 0.33
18 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31
19 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
20 INT209931 IL1B Positive_regulation of PPARA 1 0.32 0.62 0.31
21 INT209933 PPARA Regulation of Positive_regulation of IL1B 1 0.21 0.58 0.29
22 INT299956 Binding of PPARA and EPC1 1 0.09 0.34 0.29
23 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
24 INT101510 PPARA Regulation of IL6 1 0.31 0.53 0.27
25 INT101508 PPARA Regulation of IL8 1 0.31 0.53 0.27
26 INT101509 PPARA Regulation of Gene_expression of IL8 1 0.31 0.53 0.27
27 INT101511 PPARA Regulation of Gene_expression of IL6 1 0.31 0.53 0.27
28 INT335130 PPARA Positive_regulation of Cyp8b1 1 0.37 0 0.27
29 INT335049 PPARA Negative_regulation of Gene_expression of CYP7B1 1 0.27 0 0.26
30 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26
31 INT335126 Ptgs2 Positive_regulation of Gene_expression of PPARA 1 0.24 0.72 0.25
32 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
33 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23
34 INT298785 PPARA Positive_regulation of ACOX1 3 0.29 1.58 0.23
35 INT233929 PPARA Negative_regulation of ras 1 0.02 2.39 0.22
36 INT109409 PPARA Positive_regulation of Gene_expression of SAT1 1 0.54 0.75 0.2
37 INT209850 IL4 Positive_regulation of Gene_expression of PPARA 1 0.18 0.23 0.19
38 INT298787 Binding of PPARA and TUSC5 1 0.32 1.38 0.19
39 INT298784 PPARA Positive_regulation of CPT1B 1 0.28 1.61 0.19
40 INT335053 PPARA Positive_regulation of Gene_expression of LPL 1 0.21 0.34 0.19
41 INT335046 PPARA Positive_regulation of Gene_expression of ABCA1 1 0.33 0.25 0.18
42 INT312519 DAK Positive_regulation of PPARA 1 0.00 1.46 0.18
43 INT302295 PPARA Regulation of OAS2 1 0.01 0.72 0.17
44 INT335131 PPARA Negative_regulation of Gene_expression of Fgg 1 0.01 0.59 0.17
45 INT278609 PPARA Positive_regulation of Gene_expression of SULT2A1 1 0.33 0 0.17
46 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16
47 INT235441 HMBS Regulation of PPARA 1 0.03 0.76 0.16
48 INT298782 PPARA Positive_regulation of Gene_expression of TUSC5 1 0.42 0.62 0.15
49 INT170585 PPARA Negative_regulation of DYM 1 0.03 0.07 0.14
50 INT265956 Clas4 Regulation of PPARA 1 0.01 0.7 0.14
51 INT329847 PPARA Regulation of Gene_expression of CREB3L3 1 0.17 0.84 0.13
52 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12
53 INT278607 SULT2A1 Positive_regulation of Binding of PPARA 1 0.24 0 0.11
54 INT298828 Binding of PPARA and Lpl 1 0.05 0.77 0.11
55 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1
56 INT157265 PPARG Positive_regulation of PPARA 1 0.22 1.15 0.09
57 INT157266 PPARA Positive_regulation of ADIPOR1 1 0.00 1.19 0.09
58 INT298783 PPARA Positive_regulation of TUSC5 1 0.37 0.15 0.09
59 INT298786 PPARA Positive_regulation of Transcription of CPT1B 1 0.17 0.93 0.09
60 INT298781 Positive_regulation of PPARA Positive_regulation of TUSC5 1 0.37 0.15 0.09
61 INT209919 SFTPA2 Negative_regulation of IL1B Negative_regulation of PPARA 1 0.00 0.17 0.09
62 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08
63 INT186729 Csf2 Positive_regulation of PPARA 1 0.06 1.04 0.08
64 INT335051 PPARA Positive_regulation of PCTP 1 0.10 0.38 0.08
65 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08
66 INT157263 PPARA Positive_regulation of APRT 1 0.54 0.92 0.08
67 INT279419 RARB Regulation of PPARA 1 0.01 0.13 0.08
68 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08
69 INT186712 INCENP Positive_regulation of PPARA 1 0.01 1.05 0.08
70 INT157270 PPARA Positive_regulation of Adipor2 1 0.05 0.92 0.08
71 INT278683 PPARA Regulation of Chst10 1 0.22 0.09 0.08
72 INT254495 Binding of PPARA and GOPC 1 0.04 0.34 0.08
73 INT335132 PPARA Positive_regulation of Cyp4x1 1 0.25 0 0.08
74 INT279417 Binding of PPARA and MLXIPL 3 0.00 0.33 0.07
75 INT329897 PPARA Regulation of Cpt2 1 0.09 0.05 0.07
76 INT329552 Binding of PPARA and SNRNP70 1 0.01 1.3 0.07
77 INT335129 PPARA Positive_regulation of Gene_expression of Insig1 1 0.20 0.15 0.07
78 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07
79 INT279652 PPARA Positive_regulation of Gene_expression of Apoa1 1 0.00 0.75 0.07
80 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07
81 INT339711 TRO Regulation of PPARA 1 0.09 0.97 0.06
82 INT223537 Binding of PPARA and Gtf3a 1 0.02 0.6 0.06
83 INT223540 Binding of PPARA and Myb 1 0.13 0.6 0.06
84 INT145059 Binding of PPARA and Nr1i3 1 0.06 0.26 0.05
85 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
86 INT335047 PPARA Positive_regulation of Gene_expression of APOA1 1 0.20 0.42 0.05
87 INT197741 Binding of Rdh5 and Positive_regulation of PPARA 1 0.27 0.95 0.05
88 INT335052 PPARA Positive_regulation of Gene_expression of ACSL1 1 0.51 0.06 0.05
89 INT145060 Binding of PPARA and Ppara 1 0.10 0.26 0.05
90 INT332942 Binding of PPARA and A.seq 1 0.01 0.2 0.05
91 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05
92 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
93 INT338988 SULT2A1 Positive_regulation of PPARA 1 0.00 0.42 0.05
94 INT335133 PPARA Positive_regulation of Slc27a1 1 0.10 0.14 0.04
95 INT329549 PPARA Negative_regulation of Binding of ESRRA 1 0.25 0.23 0.04
96 INT155239 PPARA Regulation of Txn1 1 0.02 0.18 0.04
97 INT155231 Positive_regulation of PPARA Positive_regulation of TXN 1 0.37 0.17 0.04
98 INT329849 PPARA Regulation of AGXT 1 0.03 0.06 0.04
99 INT332906 Binding of PPARA and TF 1 0.03 0.1 0.04
100 INT335127 PPARA Regulation of Slc27a1 1 0.13 0.13 0.04
101 INT329848 PPARA Regulation of Localization of AGXT 1 0.03 0.06 0.04
102 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04
103 INT206898 Binding of PPARA and Rxrg 1 0.00 1.36 0.03
104 INT339703 TRO Positive_regulation of Gene_expression of PPARA 1 0.21 0.33 0.03
105 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03
106 INT279418 Binding of PPARA and RARB 1 0.01 0.14 0.03
107 INT278608 PPARA Positive_regulation of UGT1A9 1 0.25 0.29 0.03
108 INT237920 PPARA Negative_regulation of STAT3 1 0.16 0.91 0.03
109 INT233905 PPARA Positive_regulation of Localization of NCOR2 1 0.01 0.19 0
110 INT233930 Binding of PPARA and Ncoa1 1 0.12 0.19 0
111 INT329548 Binding of ESRRA and PPARA 1 0.22 0 0
112 INT285666 PPARA Positive_regulation of TGFB1I1 1 0.15 0.82 0
113 INT339696 Binding of PPARA and TRO 1 0.10 0.74 0
114 INT238396 ELANE Regulation of PPARA 1 0.04 0.65 0
115 INT233928 PPARA Positive_regulation of Localization of Ncoa1 1 0.18 0.19 0
116 INT238406 Binding of ELANE and PPARA 1 0.07 0.43 0
117 INT335048 PPARA Regulation of PCK1 1 0.16 0.26 0
118 INT347257 Binding of LOX and PPARA 1 0.15 0.6 0
119 INT238388 ELANE Positive_regulation of ELANE Positive_regulation of PPARA 1 0.02 0.46 0
120 INT173123 Binding of HNF4A and PPARA 1 0.10 0.19 0
121 INT233927 PPARA Positive_regulation of Ncoa1 1 0.08 0.19 0
122 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0
123 INT238405 ELANE Positive_regulation of PPARA 1 0.08 0.46 0
124 INT239239 Binding of PPARA and RXRB 1 0.12 0.63 0
125 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
126 INT329551 PPARA Regulation of Negative_regulation of ESRRA 1 0.20 0 0
127 INT347258 PPARA Negative_regulation of Localization of VEGFA 1 0.16 1.36 0
128 INT238403 PPARA Regulation of ELANE 1 0.04 0.65 0
129 INT237979 PPARA Negative_regulation of Birc5 1 0.49 1.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5465. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5465. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
2 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
3 INT103094 Binding of PPARA 308 0.47 177.26 34.75
4 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41
5 INT103096 Regulation of PPARA 113 0.60 62.47 14.57
6 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53
7 INT173159 Localization of PPARA 96 0.74 64.55 10.26
8 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76
9 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96
10 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74
11 INT86023 Transcription of PPARA 60 0.66 25.8 5.7
12 INT114957 Positive_regulation of Transcription of PPARA 18 0.62 10.36 3.65
13 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72
14 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68
15 INT173180 Positive_regulation of Binding of PPARA 14 0.49 3.66 1.88
16 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74
17 INT173198 Regulation of Binding of PPARA 17 0.43 9.58 1.47
18 INT112963 Regulation of Positive_regulation of PPARA 8 0.44 5.29 1.43
19 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38
20 INT190361 Protein_catabolism of PPARA 12 0.97 3.01 0.87
21 INT190363 Positive_regulation of Negative_regulation of PPARA 10 0.44 4.8 0.87
22 INT238442 Regulation of Transcription of PPARA 3 0.37 2.64 0.77
23 INT186727 Negative_regulation of Localization of PPARA 4 0.35 4.56 0.69
24 INT209935 Regulation of Regulation of PPARA 4 0.44 1.56 0.69
25 INT188714 Regulation of Negative_regulation of PPARA 2 0.32 1.44 0.61
26 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42
27 INT188715 Negative_regulation of Negative_regulation of PPARA 3 0.37 1.25 0.37
28 INT234411 Negative_regulation of Phosphorylation of PPARA 2 0.36 0.29 0.16
29 INT332934 Positive_regulation of Protein_catabolism of PPARA 2 0.68 0.26 0.12
30 INT206972 Regulation of Localization of PPARA 4 0.44 2.49 0.04
31 INT173178 Positive_regulation of Regulation of PPARA 3 0.48 0.66 0.04
32 INT234458 Regulation of Protein_catabolism of PPARA 1 0.42 0.43 0
33 INT234415 Positive_regulation of Phosphorylation of PPARA 1 0.37 0.07 0
34 INT332936 Negative_regulation of Regulation of PPARA 1 0.10 0.31 0
35 INT190360 Negative_regulation of Protein_catabolism of PPARA 1 0.11 0.18 0
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