G:5578

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Official Symbol PRKCA
Aliases AAG6, PKCA, PRKACA, MGC129900, MGC129901, PKC-alpha
EntrezGene 5578
UniProt Coming Soon
Unique Molecular Interactions 70
Total Molecular Interactions 75
Total Single Events 450
Unique Interaction Partners 50

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to PRKCA. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to PRKCA. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to PRKCA. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
2 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
3 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
4 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
5 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
6 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
7 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
8 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
9 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
10 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
11 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
12 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
13 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
14 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
15 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
16 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
17 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
18 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
19 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
20 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
21 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
22 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
23 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
24 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
25 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
26 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
27 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
28 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4
29 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
30 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
31 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
32 INT193034 PRKCA Regulation of Positive_regulation of CDK20 1 0.05 0.15 0.37
33 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
34 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
35 INT171679 PPY Regulation of PRKCA 1 0.08 0.33 0.33
36 INT171677 PRKCA Regulation of CISD1 1 0.00 0 0.33
37 INT189692 INSRR Positive_regulation of PRKCA 1 0.00 0 0.24
38 INT189693 CHKB Positive_regulation of PRKCA 1 0.11 0 0.24
39 INT189700 CHKB Negative_regulation of PRKCA 1 0.11 0 0.24
40 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
41 INT189645 CHKB Negative_regulation of ASAP1 Negative_regulation of PRKCA 1 0.04 0 0.24
42 INT335462 IGHE Regulation of Positive_regulation of PRKCA 1 0.07 0 0.23
43 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22
44 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
45 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
46 INT106630 Binding of GRK5 and PRKCA 1 0.16 0.82 0.19
47 INT193081 PRKCA Positive_regulation of Ppp1r14a 1 0.01 0.13 0.18
48 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
49 INT269330 DYNC1I2 Negative_regulation of PRKCA 1 0.03 0 0.15
50 INT189647 INSRR Negative_regulation of CHKB Regulation of Negative_regulation of PRKCA 1 0.00 0.07 0.15
51 INT269326 PRKCA Positive_regulation of Localization of TMPO 1 0.01 0 0.13
52 INT269336 PRKCA Regulation of Localization of TMPO 1 0.01 0.12 0.13
53 INT269335 PRKG1 Positive_regulation of Gene_expression of PRKCA 1 0.14 0 0.12
54 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12
55 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08
56 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
57 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
58 INT261647 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of BDKRB1 1 0.04 0.6 0.04
59 INT261649 Positive_regulation of PRKCA Positive_regulation of BDKRB1 1 0.04 0.59 0.04
60 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
61 INT249184 PRKCA Regulation of CYBB 1 0.09 0 0
62 INT333567 PRKCA Positive_regulation of Phosphorylation of TRAM1 1 0.02 0 0
63 INT97566 CPOX Positive_regulation of Gene_expression of PRKCA 1 0.06 0.07 0
64 INT333563 PRKCA Positive_regulation of Gene_expression of IRF3 1 0.05 0.06 0
65 INT97091 HSPG2 Regulation of PRKCA 1 0.04 0 0
66 INT232574 ROS1 Positive_regulation of PRKCA 1 0.13 0.69 0
67 INT286651 OLR1 Positive_regulation of PRKCA 1 0.14 0.5 0
68 INT326058 Negative_regulation of PRKCA Negative_regulation of APOA1 1 0.15 0.32 0
69 INT249189 CA2 Regulation of PRKCA 1 0.04 0 0
70 INT249196 Positive_regulation of PRKCA Positive_regulation of TRPC3 1 0.08 0 0
71 INT102623 Negative_regulation of PRKCA Negative_regulation of Gene_expression of CPOX 1 0.09 0.12 0
72 INT72214 Positive_regulation of PRKCA Regulation of OPRM1 1 0.17 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5578. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5578. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
2 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
3 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
4 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
5 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
6 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
7 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
8 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
9 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
10 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
11 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
12 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
13 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
14 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
15 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
16 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
17 INT52713 Regulation of Negative_regulation of PRKCA 5 0.36 1.23 1.41
18 INT220763 Regulation of Phosphorylation of PRKCA 3 0.29 0.84 1.22
19 INT79568 Regulation of Protein_catabolism of PRKCA 1 0.45 0.1 0.76
20 INT85349 Negative_regulation of Localization of PRKCA 1 0.09 0 0.74
21 INT82366 Positive_regulation of Protein_catabolism of PRKCA 1 0.49 0 0.73
22 INT76855 Negative_regulation of Gene_expression of PRKCA 4 0.30 1.8 0.36
23 INT341785 Regulation of Localization of PRKCA 1 0.08 0 0.19
24 INT76856 Negative_regulation of Transcription of PRKCA 1 0.30 0.08 0.13
25 INT76859 Transcription of PRKCA 1 0.49 0.08 0.13
26 INT269369 Regulation of Gene_expression of PRKCA 1 0.12 0 0.1
27 INT97092 Positive_regulation of Negative_regulation of PRKCA 2 0.27 0.31 0
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