G:5594

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Official Symbol MAPK1
Aliases ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk
EntrezGene 5594
UniProt Coming Soon
Unique Molecular Interactions 183
Total Molecular Interactions 234
Total Single Events 1518
Unique Interaction Partners 116

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to MAPK1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to MAPK1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to MAPK1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
2 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
3 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
4 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
5 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
6 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
7 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
8 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
9 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
10 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
11 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
12 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
13 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
14 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
15 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
16 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
17 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
18 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
19 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
20 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
21 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
22 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
23 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
24 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
25 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
26 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
27 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
28 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
29 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
30 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
31 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
32 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
33 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
34 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
35 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
36 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
37 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
38 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
39 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
40 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
41 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
42 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
43 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
44 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
45 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
46 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
47 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
48 INT167156 FPR1 Positive_regulation of MAPK1 1 0.18 0.09 0.35
49 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
50 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
51 INT167155 FPR1 Positive_regulation of Phosphorylation of MAPK1 1 0.18 0.17 0.33
52 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
53 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
54 INT194710 MAPK1 Regulation of Gene_expression of IK 1 0.00 0.24 0.31
55 INT112797 Positive_regulation of CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.3
56 INT112805 CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.29
57 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
58 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
59 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
60 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
61 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28
62 INT194682 Negative_regulation of MAPK1 Positive_regulation of Gene_expression of IL10 1 0.05 0.17 0.27
63 INT270256 MAPK1 Positive_regulation of Mknk1 1 0.03 0.52 0.27
64 INT188209 OSM Positive_regulation of MAPK1 1 0.35 0.47 0.27
65 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
66 INT236005 Positive_regulation of MAPK1 Positive_regulation of Binding of Map2 1 0.04 0 0.25
67 INT236004 Positive_regulation of MAPK1 Positive_regulation of Phosphorylation of Map2 1 0.04 0 0.24
68 INT261650 LGR6 Positive_regulation of MAPK1 1 0.04 0.71 0.24
69 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
70 INT194662 MAPK1 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.02 0.17 0.23
71 INT194702 MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.16 0.23
72 INT115143 MAPK1 Positive_regulation of TFAM 2 0.02 0.49 0.22
73 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22
74 INT283857 APOA5 Positive_regulation of Positive_regulation of MAPK1 1 0.00 0.6 0.22
75 INT112804 IL4I1 Positive_regulation of Positive_regulation of MAPK1 1 0.03 0 0.22
76 INT194725 MAPK1 Regulation of Transcription of IK 1 0.00 0.06 0.22
77 INT283860 APOA5 Negative_regulation of MAPK1 1 0.00 0.59 0.21
78 INT291264 Mdk Regulation of Positive_regulation of MAPK1 1 0.02 0.61 0.21
79 INT122871 HTR1A Positive_regulation of MAPK1 1 0.56 0 0.2
80 INT158208 Binding of MAPK1 and TNFSF14 1 0.03 0.3 0.2
81 INT158225 Binding of CCR1 and MAPK1 1 0.18 0.3 0.2
82 INT137228 MAPK1 Positive_regulation of Phosphorylation of Creb1 1 0.46 0 0.2
83 INT158222 Positive_regulation of Binding of MAPK1 and CCR2 1 0.26 0.3 0.2
84 INT158232 Positive_regulation of Binding of MAPK1 and TNFSF14 1 0.04 0.3 0.2
85 INT158204 Negative_regulation of Binding of MAPK1 and CCR2 1 0.22 0.3 0.2
86 INT158227 Negative_regulation of Binding of ICAM1 and MAPK1 1 0.16 0.3 0.2
87 INT158228 Negative_regulation of Binding of MAPK1 and TNFSF14 1 0.04 0.3 0.2
88 INT158236 Positive_regulation of Binding of ICAM1 and MAPK1 1 0.19 0.3 0.2
89 INT158226 Binding of ICAM1 and MAPK1 1 0.14 0.3 0.2
90 INT158234 Binding of MAPK1 and CCR2 1 0.19 0.3 0.2
91 INT158221 Positive_regulation of Binding of CCR1 and MAPK1 1 0.25 0.3 0.2
92 INT158219 Negative_regulation of Binding of CCR1 and MAPK1 1 0.21 0.3 0.2
93 INT158205 TNFSF14 Positive_regulation of MAPK1 1 0.04 0.3 0.2
94 INT257985 PTGER2 Positive_regulation of MAPK1 1 0.04 0.61 0.2
95 INT194809 MAPK1 Positive_regulation of Binding of Crebbp and Nfatc1 1 0.00 0.08 0.19
96 INT194807 MAPK1 Positive_regulation of Binding of CREB1 and Nfatc1 1 0.01 0.08 0.19
97 INT194805 MAPK1 Positive_regulation of Binding of CREB1 and Crebbp 1 0.02 0.08 0.19
98 INT194830 MAPK1 Positive_regulation of Gene_expression of Nfatc1 1 0.02 0.08 0.19
99 INT209930 IL1B Positive_regulation of MAPK1 1 0.13 0.37 0.18
100 INT235984 HTR1A Negative_regulation of MAPK1 1 0.01 0 0.16
101 INT194700 CD28 Positive_regulation of MAPK1 1 0.10 0.55 0.16
102 INT188199 IL6 Positive_regulation of MAPK1 1 0.27 0.25 0.16
103 INT194708 TNFRSF8 Positive_regulation of MAPK1 1 0.06 0.55 0.16
104 INT194667 EPHB6 Positive_regulation of MAPK1 1 0.12 0.54 0.16
105 INT194816 MAPK1 Negative_regulation of Phosphorylation of Nfatc1 1 0.01 0.07 0.15
106 INT194836 MAPK1 Negative_regulation of Nfatc1 1 0.01 0.07 0.15
107 INT194697 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL5 1 0.03 0.1 0.14
108 INT291252 Gene_expression of Map3k8 Positive_regulation of MAPK1 1 0.09 0.64 0.14
109 INT117912 CREB1 Positive_regulation of Positive_regulation of MAPK1 1 0.04 0.89 0.13
110 INT194806 MAPK1 Positive_regulation of CD28 Positive_regulation of Il4 1 0.08 0.42 0.13
111 INT91457 IL1B Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.47 0.12
112 INT117911 MAPK1 Regulation of Positive_regulation of BIRC2 1 0.04 0.9 0.12
113 INT188202 HBE1 Positive_regulation of MAPK1 1 0.01 0.14 0.11
114 INT91454 MAPK1 Positive_regulation of Gene_expression of CPOX 1 0.20 0.6 0.1
115 INT194822 Negative_regulation of MAPK1 Negative_regulation of Binding of Sp1 1 0.04 0.05 0.1
116 INT194721 MAPK1 Positive_regulation of CREB1 1 0.08 0.05 0.1
117 INT194819 Positive_regulation of Trav6-3 Positive_regulation of MAPK1 1 0.02 0.39 0.1
118 INT194730 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL2 1 0.06 0 0.09
119 INT194718 DPP4 Positive_regulation of MAPK1 1 0.02 0.29 0.09
120 INT224020 MAPK1 Negative_regulation of EPHB2 1 0.08 0.56 0.09
121 INT194728 Binding of EPHB6 and Positive_regulation of MAPK1 1 0.12 0.26 0.08
122 INT194739 MAPK1 Negative_regulation of Gene_expression of IL13 1 0.03 0.05 0.08
123 INT306945 NAMPT Positive_regulation of Positive_regulation of MAPK1 1 0.10 0.33 0.08
124 INT194663 MAPK1 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL13 1 0.02 0.05 0.08
125 INT194740 EPHA1 Positive_regulation of MAPK1 1 0.01 0.28 0.08
126 INT297971 Positive_regulation of Binding of CDK8 and MAPK1 1 0.22 0.3 0.07
127 INT194723 GADD45A Regulation of Regulation of MAPK1 1 0.06 0 0.07
128 INT297963 Binding of CDK8 and MAPK1 1 0.16 0.29 0.07
129 INT143117 VEGFB Positive_regulation of Phosphorylation of MAPK1 1 0.50 0.57 0.07
130 INT194824 Il4 Positive_regulation of MAPK1 1 0.26 0 0.07
131 INT194683 Negative_regulation of MAPK1 Negative_regulation of IFNA1 1 0.02 0.07 0.07
132 INT194834 Il4 Positive_regulation of Positive_regulation of MAPK1 1 0.18 0 0.06
133 INT194678 IL2 Positive_regulation of Positive_regulation of MAPK1 1 0.05 0 0.06
134 INT194664 Negative_regulation of MAPK1 Negative_regulation of IL2 1 0.06 0 0.05
135 INT183863 RHOC Positive_regulation of Gene_expression of MAPK1 1 0.25 0.26 0.05
136 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
137 INT194665 IL12A Positive_regulation of MAPK1 1 0.06 0 0.05
138 INT194672 GADD45A Positive_regulation of Positive_regulation of MAPK1 1 0.14 0.06 0.05
139 INT183851 RHOC Positive_regulation of MAPK1 1 0.34 0.26 0.05
140 INT355906 MAPK1 Positive_regulation of Localization of IL8 1 0.02 0.67 0.05
141 INT272417 Binding of PROK1 and Positive_regulation of MAPK1 1 0.01 0.08 0.05
142 INT194735 IL18 Positive_regulation of Positive_regulation of MAPK1 1 0.05 0 0.04
143 INT194694 MAPK1 Negative_regulation of Gene_expression of IL2 1 0.04 0 0.04
144 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
145 INT282555 POU5F1 Positive_regulation of Positive_regulation of MAPK1 1 0.11 0.28 0.04
146 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
147 INT282540 STAT3 Positive_regulation of Positive_regulation of MAPK1 1 0.04 0.27 0.04
148 INT194680 MAP3K4 Positive_regulation of MAPK1 1 0.08 0 0.04
149 INT194729 MAP3K4 Positive_regulation of Gene_expression of MAPK1 1 0.08 0 0.04
150 INT194736 Positive_regulation of MAPK1 Positive_regulation of Gene_expression of GADD45A 1 0.13 0 0.04
151 INT194823 Binding of Trav6-3 and Positive_regulation of Phosphorylation of MAPK1 1 0.02 0.1 0.03
152 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
153 INT183858 Negative_regulation of RHOC Positive_regulation of MAPK1 1 0.26 0.17 0.03
154 INT194690 MAPK1 Regulation of IFNA1 1 0.02 0 0
155 INT293809 MAPK1 Positive_regulation of AR 1 0.03 0.12 0
156 INT303333 MAPK1 Positive_regulation of Mknk2 1 0.04 0.14 0
157 INT290474 MAPK1 Regulation of Mitf 1 0.04 0.15 0
158 INT329568 GOPC Positive_regulation of Phosphorylation of MAPK1 1 0.04 0.79 0
159 INT194743 GADD45A Positive_regulation of Negative_regulation of MAPK1 1 0.13 0.06 0
160 INT193971 TRGC1 Negative_regulation of Phosphorylation of MAPK1 1 0.01 0.14 0
161 INT293815 MAPK1 Positive_regulation of Gene_expression of CCND3 1 0.01 0 0
162 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0
163 INT193973 TRGC1 Negative_regulation of Positive_regulation of MAPK1 1 0.01 0.09 0
164 INT283863 Binding of MAPK1 and PTK2 1 0.12 0.97 0
165 INT339823 MAPK1 Negative_regulation of Gene_expression of SRP72 1 0.29 0.55 0
166 INT283865 Binding of MAPK1 and APOA5 1 0.00 0.22 0
167 INT325771 EPOR Positive_regulation of MAPK1 1 0.16 0.29 0
168 INT342552 Binding of MAPK1 and CCL11 1 0.05 1.07 0
169 INT303257 MAPK1 Positive_regulation of NEK4 1 0.05 0.14 0
170 INT258206 S1PR1 Positive_regulation of Phosphorylation of MAPK1 1 0.12 0 0
171 INT342554 Positive_regulation of Binding of MAPK1 and CCL11 1 0.06 1.07 0
172 INT194003 MAPK1 Regulation of Positive_regulation of Akt1 1 0.01 0 0
173 INT282558 POU5F1 Positive_regulation of MAPK1 1 0.16 0.26 0
174 INT236011 HIST2H2AA3 Positive_regulation of MAPK1 1 0.00 0.17 0
175 INT193972 SPANXB1 Positive_regulation of Positive_regulation of MAPK1 1 0.01 0 0
176 INT342559 FGF2 Positive_regulation of MAPK1 1 0.08 1.22 0
177 INT198018 MAPK1 Positive_regulation of JUN 1 0.05 1.05 0
178 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0
179 INT230148 Binding of ESR1 and Positive_regulation of MAPK1 1 0.07 0 0
180 INT230145 OSBP Regulation of MAPK1 1 0.22 0 0
181 INT342555 FGF9 Positive_regulation of MAPK1 1 0.07 1.22 0
182 INT254708 Map2k2 Positive_regulation of Phosphorylation of MAPK1 1 0.11 0.86 0
183 INT258205 LPA Positive_regulation of Phosphorylation of MAPK1 1 0.10 0 0
184 INT156449 ANGPTL5 Positive_regulation of Gene_expression of MAPK1 1 0.04 0 0
185 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0
186 INT292496 Mlph Regulation of MAPK1 1 0.00 0.21 0
187 INT339821 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of SRP72 1 0.29 0.28 0
188 INT292493 Mlph Regulation of Gene_expression of MAPK1 1 0.00 0.21 0
189 INT334319 IL8 Positive_regulation of MAPK1 1 0.25 1.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5594. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5594. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
3 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
4 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
5 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
6 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
7 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
8 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
9 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
10 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
11 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
12 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
13 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
14 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
15 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
16 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
17 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76
18 INT75524 Positive_regulation of Regulation of MAPK1 1 0.43 1.12 0.59
19 INT109911 Positive_regulation of Localization of MAPK1 4 0.33 0.56 0.48
20 INT109907 Protein_catabolism of MAPK1 2 0.58 1.82 0.34
21 INT130113 Regulation of Regulation of MAPK1 1 0.22 0.16 0.33
22 INT109931 Positive_regulation of Protein_catabolism of MAPK1 1 0.33 0.14 0.24
23 INT194801 Binding of MAPK1 7 0.29 1.9 0.23
24 INT261680 Positive_regulation of Negative_regulation of MAPK1 2 0.33 1.2 0.21
25 INT190389 Transcription of MAPK1 2 0.44 2.58 0.15
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