G:5599

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Official Symbol MAPK8
Aliases JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2
EntrezGene 5599
UniProt Coming Soon
Unique Molecular Interactions 67
Total Molecular Interactions 77
Total Single Events 818
Unique Interaction Partners 51

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to MAPK8. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to MAPK8. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to MAPK8. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
2 INT134681 FSCN1 Positive_regulation of FSCN1 Positive_regulation of MAPK8 1 0.00 0.56 1.39
3 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
4 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
5 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
6 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
7 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
8 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
9 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
10 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
11 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
12 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
13 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
14 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
15 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
16 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
17 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
18 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
19 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
20 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
21 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
22 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
23 INT329168 MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.56 0.15
24 INT329172 Phosphorylation of MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.62 0.15
25 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
26 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
27 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
28 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
29 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
30 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
31 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
32 INT292555 Binding of MAPK8 and GTPBP4 1 0.00 0.36 0.09
33 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
34 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07
35 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07
36 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
37 INT286049 Binding of MAPK8 and Wwox 1 0.31 0.26 0.05
38 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
39 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05
40 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
41 INT194731 MAP3K4 Positive_regulation of MAPK8 1 0.02 0 0.04
42 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04
43 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
44 INT209932 MAPK8 Positive_regulation of IL1B 1 0.14 0.05 0.03
45 INT321405 AGT Positive_regulation of MAPK8 1 0.00 0.94 0.03
46 INT300986 Negative_regulation of MAPK8 Negative_regulation of Localization of TNF 1 0.01 1.25 0.03
47 INT220914 GNS Negative_regulation of Phosphorylation of MAPK8 1 0.00 0.05 0.03
48 INT237680 LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
49 INT236016 ROS1 Positive_regulation of MAPK8 2 0.18 1.81 0
50 INT280162 Twist1 Negative_regulation of Binding of MAPK8 and Twist1 1 0.18 0.78 0
51 INT306257 Binding of MAPK8 and RAC2 1 0.24 0 0
52 INT344315 MAPK8 Positive_regulation of Negative_regulation of PDPN 1 0.35 0.56 0
53 INT352859 IKBKAP Regulation of Regulation of MAPK8 1 0.10 0.28 0
54 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0
55 INT209929 Binding of IL1B and MAPK8 1 0.11 0 0
56 INT344310 MAPK8 Positive_regulation of Negative_regulation of VEGFA 1 0.08 0.57 0
57 INT244459 ERN1 Regulation of Positive_regulation of MAPK8 1 0.03 0.47 0
58 INT236014 HIST2H2AA3 Positive_regulation of MAPK8 1 0.02 0.44 0
59 INT348525 MAPK8 Positive_regulation of Gene_expression of JUND 1 0.01 0.28 0
60 INT236017 GOPC Positive_regulation of MAPK8 1 0.09 0.17 0
61 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
62 INT344319 MAPK8 Positive_regulation of PDPN 1 0.35 0.5 0
63 INT310805 MAPK8 Regulation of Regulation of Ptges2 1 0.01 0 0
64 INT339820 MAPK8 Regulation of Phosphorylation of SRP72 1 0.31 0.08 0
65 INT252783 ROS1 Negative_regulation of MAPK8 1 0.05 0.77 0
66 INT279800 ATP6V0A2 Positive_regulation of Phosphorylation of MAPK8 1 0.01 1.03 0
67 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
68 INT337493 Gene_expression of Mapk8 Negative_regulation of MAPK8 1 0.16 0.53 0
69 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5599. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5599. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
3 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
4 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
5 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
6 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
7 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
8 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
9 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
10 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
11 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
12 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
13 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
14 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
15 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
16 INT158689 Positive_regulation of Regulation of MAPK8 1 0.46 0.41 0.6
17 INT109926 Positive_regulation of Localization of MAPK8 4 0.49 0.87 0.52
18 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52
19 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43
20 INT261685 Regulation of Gene_expression of MAPK8 3 0.26 1.45 0.34
21 INT109915 Protein_catabolism of MAPK8 3 0.86 1.92 0.34
22 INT109905 Positive_regulation of Protein_catabolism of MAPK8 1 0.49 0.14 0.24
23 INT182282 Negative_regulation of Binding of MAPK8 2 0.39 0.29 0.04
24 INT292587 Regulation of Negative_regulation of MAPK8 3 0.23 1.45 0
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