G:5743

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Official Symbol PTGS2
Aliases COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, GRIPGHS
EntrezGene 5743
UniProt Coming Soon
Unique Molecular Interactions 78
Total Molecular Interactions 88
Total Single Events 1989
Unique Interaction Partners 60

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to PTGS2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to PTGS2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to PTGS2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
2 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
3 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
4 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
5 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
6 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
7 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
8 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
9 INT71940 VN1R106P Regulation of ZNF697 Negative_regulation of PTGS2 1 0.00 0.07 0.54
10 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
11 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
12 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
13 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
14 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
15 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
16 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
17 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
18 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
19 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
20 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
21 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
22 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
23 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
24 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
25 INT134302 Cpox Negative_regulation of PTGS2 Negative_regulation of Gene_expression of Ptger2 1 0.00 0.78 0.34
26 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
27 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
28 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
29 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
30 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
31 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
32 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
33 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
34 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
35 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
36 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
37 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
38 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
39 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
40 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
41 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
42 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
43 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
44 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
45 INT145014 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.31 0.51 0.22
46 INT145012 GAST Positive_regulation of PTGS2 1 0.42 0.51 0.22
47 INT145015 CREB5 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.06 0.51 0.22
48 INT69318 ST3GAL4 Positive_regulation of Gene_expression of PTGS2 1 0.35 0.09 0.21
49 INT231639 Binding of PTGER2 and PTGS2 1 0.00 0.44 0.19
50 INT117517 PROC Positive_regulation of PTGS2 1 0.01 0.61 0.19
51 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
52 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19
53 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
54 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
55 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
56 INT69317 PTGS2 Positive_regulation of Gene_expression of PTGS1 1 0.42 0.09 0.16
57 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16
58 INT176621 PTGS2 Regulation of Gene_expression of PTGER2 1 0.00 0.09 0.15
59 INT87710 MYB Regulation of PTGS2 1 0.28 0.64 0.15
60 INT138321 PPA1 Positive_regulation of Gene_expression of PTGS2 1 0.02 0.09 0.14
61 INT328851 Binding of PTGS2 and ZNF434 1 0.00 0.7 0.14
62 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13
63 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12
64 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12
65 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
66 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
67 INT133361 FABP6 Negative_regulation of PTGS2 1 0.01 0.07 0.11
68 INT294454 KLK4 Negative_regulation of PTGS2 1 0.01 0 0.1
69 INT140895 PTGS2 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.07 0.07
70 INT98715 HGF Positive_regulation of Gene_expression of PTGS2 1 0.02 1.03 0.07
71 INT17850 Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04
72 INT17851 Negative_regulation of Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04
73 INT346838 ZNF434 Regulation of PTGS2 1 0.01 0.34 0
74 INT346836 MECP2 Regulation of PTGS2 1 0.00 0.34 0
75 INT352066 Binding of PTGS2 and PTGES2 1 0.04 0 0
76 INT343163 ACSL4 Regulation of Gene_expression of PTGS2 1 0.08 0.5 0
77 INT352064 Binding of PTGS2 and HPGDS 1 0.20 0 0
78 INT165863 Binding of HSPG2 and PTGS2 1 0.01 0.19 0
79 INT352065 Binding of PTGDS and PTGS2 1 0.28 0 0
80 INT143293 Negative_regulation of Nfkb1 Negative_regulation of Gene_expression of PTGS2 1 0.00 0 0
81 INT166070 PTGS2 Regulation of VEGFA 1 0.29 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 5743. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 5743. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
3 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
4 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
5 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
6 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
7 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
8 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
9 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
10 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
11 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
12 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
13 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
14 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
15 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
16 INT86823 Regulation of Transcription of PTGS2 3 0.19 1.48 1.4
17 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21
18 INT59078 Positive_regulation of Transcription of PTGS2 5 0.69 2.36 1.17
19 INT62981 Protein_catabolism of PTGS2 5 0.78 1.09 1.11
20 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09
21 INT64177 Negative_regulation of Transcription of PTGS2 4 0.41 1.99 1.03
22 INT120057 Regulation of Localization of PTGS2 1 0.28 0.14 0.78
23 INT71950 Positive_regulation of Binding of PTGS2 2 0.31 0.31 0.74
24 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71
25 INT82545 Positive_regulation of Regulation of PTGS2 1 0.19 0.15 0.35
26 INT17849 Negative_regulation of Binding of PTGS2 2 0.38 0.16 0.2
27 INT148274 Negative_regulation of Regulation of PTGS2 1 0.01 0.47 0.19
28 INT129433 Regulation of Binding of PTGS2 1 0.25 1.01 0.14
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