G:6098

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Official Symbol ROS1
Aliases ROS, MCF3, c-ros-1
EntrezGene 6098
UniProt Coming Soon
Unique Molecular Interactions 113
Total Molecular Interactions 133
Total Single Events 2013
Unique Interaction Partners 80

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to ROS1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to ROS1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to ROS1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
2 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
3 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
4 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
5 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
6 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
7 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
8 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
9 INT327992 TRPV1 Positive_regulation of Gene_expression of ROS1 1 0.28 0.35 0.6
10 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
11 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53
12 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46
13 INT342998 DUOX1 Positive_regulation of ROS1 1 0.23 0.25 0.43
14 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
15 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
16 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41
17 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
18 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
19 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4
20 INT327991 Positive_regulation of TRPV1 Positive_regulation of ROS1 1 0.26 0.2 0.4
21 INT267123 ROS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.01 1.05 0.31
22 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
23 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28
24 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28
25 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26
26 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26
27 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25
28 INT98671 ROS1 Positive_regulation of Gene_expression of Penk 1 0.00 0.52 0.25
29 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25
30 INT311531 IMMT Negative_regulation of Gene_expression of ROS1 1 0.11 1.09 0.24
31 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
32 INT164635 CSF2 Regulation of Gene_expression of ROS1 1 0.15 0.09 0.24
33 INT307013 MT1JP Negative_regulation of Binding of ROS1 1 0.02 0.64 0.23
34 INT252777 ROS1 Positive_regulation of Gene_expression of CCL2 1 0.31 0.77 0.23
35 INT168172 Binding of TNFRSF9 and Positive_regulation of Gene_expression of ROS1 1 0.05 0 0.23
36 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22
37 INT189156 MTNR1B Positive_regulation of Gene_expression of ROS1 1 0.01 0.06 0.22
38 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
39 INT252787 Binding of FCGR3B and ROS1 1 0.06 0.58 0.2
40 INT285604 ROS1 Positive_regulation of Gene_expression of Tlr4 1 0.01 1.14 0.2
41 INT252782 ROS1 Positive_regulation of Positive_regulation of CCL2 1 0.22 0.8 0.2
42 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19
43 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
44 INT346459 Binding of RNASE1 and ROS1 1 0.06 1.42 0.18
45 INT352896 PTGDS Positive_regulation of Gene_expression of ROS1 1 0.12 0.91 0.18
46 INT117137 Gene_expression of ROS1 Positive_regulation of Protein_catabolism of Egf 1 0.00 0 0.16
47 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16
48 INT285605 Binding of ROS1 and Tlr4 1 0.01 1.25 0.16
49 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16
50 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
51 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
52 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
53 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14
54 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14
55 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
56 INT252778 RAF1 Positive_regulation of Positive_regulation of ROS1 1 0.04 2.05 0.11
57 INT324829 ROS1 Positive_regulation of Gene_expression of Ecm1 1 0.00 0.66 0.09
58 INT303759 IGHG3 Regulation of Localization of ROS1 1 0.07 0 0.09
59 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
60 INT191755 ROS1 Positive_regulation of JUN 1 0.00 0.54 0.08
61 INT191757 ROS1 Positive_regulation of TBK1 1 0.00 0.6 0.08
62 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08
63 INT217651 Binding of ROS1 and fa 1 0.01 1.09 0.07
64 INT355641 Positive_regulation of MPO Positive_regulation of Gene_expression of ROS1 1 0.24 0.84 0.07
65 INT140289 ROS1 Positive_regulation of MAPK14 1 0.44 1.27 0.06
66 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
67 INT285402 HP Positive_regulation of Gene_expression of ROS1 1 0.00 0.51 0.05
68 INT321401 Gene_expression of ROS1 Negative_regulation of Positive_regulation of AKR1B1 1 0.01 0.8 0.05
69 INT265456 CSPG4 Regulation of ROS1 1 0.05 0.24 0.04
70 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04
71 INT252797 ROS1 Positive_regulation of Positive_regulation of FAS 1 0.08 1.03 0.04
72 INT265453 CSPG4 Regulation of Phosphorylation of ROS1 1 0.05 0.24 0.04
73 INT341236 ROS1 Positive_regulation of Phosphorylation of Eif4ebp1 1 0.02 0.25 0.04
74 INT311535 ROS1 Negative_regulation of CA2 1 0.19 0.61 0.04
75 INT341237 ROS1 Negative_regulation of Ppp2r1a 1 0.01 0.31 0.04
76 INT237921 ROS1 Positive_regulation of TNFRSF10B 1 0.08 1.24 0.03
77 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03
78 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03
79 INT324836 Nox4 Regulation of Gene_expression of ROS1 1 0.01 0.13 0.03
80 INT266415 Binding of ROS1 and S100a6 1 0.02 0.82 0.03
81 INT285406 ELF3 Positive_regulation of Binding of ROS1 1 0.08 0.9 0.03
82 INT236016 ROS1 Positive_regulation of MAPK8 2 0.18 1.81 0
83 INT268723 Binding of PRB1 and ROS1 1 0.01 0 0
84 INT351734 SSD Positive_regulation of ROS1 1 0.27 0.3 0
85 INT252774 ROS1 Regulation of FUT1 1 0.04 0.57 0
86 INT252810 ROS1 Regulation of Gene_expression of MMRN1 1 0.04 0.16 0
87 INT265458 RNGTT Positive_regulation of Gene_expression of ROS1 1 0.08 0.88 0
88 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
89 INT262619 Gopc Regulation of Gene_expression of ROS1 1 0.01 0.51 0
90 INT265468 CSPG4 Positive_regulation of Gene_expression of ROS1 1 0.08 0.4 0
91 INT311012 SNRPB Positive_regulation of Gene_expression of ROS1 1 0.00 0.27 0
92 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
93 INT252798 ELANE Regulation of Gene_expression of ROS1 1 0.04 0.16 0
94 INT204320 SOD1 Positive_regulation of Protein_catabolism of ROS1 1 0.06 0.05 0
95 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
96 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
97 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
98 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
99 INT301178 UCP2 Negative_regulation of ROS1 1 0.29 1.41 0
100 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
101 INT323506 ROS1 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.69 0
102 INT275232 DUOX2 Positive_regulation of ROS1 1 0.10 0.33 0
103 INT232574 ROS1 Positive_regulation of PRKCA 1 0.13 0.69 0
104 INT201755 ROS1 Positive_regulation of Casp3 1 0.00 1.4 0
105 INT252802 ROS1 Regulation of Gene_expression of COL1A1 1 0.05 0.58 0
106 INT252783 ROS1 Negative_regulation of MAPK8 1 0.05 0.77 0
107 INT189021 NOX5 Positive_regulation of ROS1 1 0.26 0.2 0
108 INT307422 Binding of MT1JP and ROS1 1 0.06 1.48 0
109 INT252819 ELANE Positive_regulation of Localization of ROS1 1 0.04 0.05 0
110 INT252789 TP53 Regulation of ROS1 1 0.02 0 0
111 INT351731 SSD Positive_regulation of Positive_regulation of ROS1 1 0.18 0.71 0
112 INT252824 ROS1 Regulation of FBN1 1 0.00 0.57 0
113 INT207263 ZNF236 Positive_regulation of Gene_expression of ROS1 1 0.01 0.67 0
114 INT232576 ROS1 Positive_regulation of Localization of OLR1 1 0.04 0.7 0
115 INT301177 Gene_expression of UCP2 Positive_regulation of Gene_expression of ROS1 1 0.32 0.98 0
116 INT106439 Binding of ROS1 and PHB2 1 0.30 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 6098. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 6098. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
2 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
3 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
4 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71
5 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22
6 INT112003 Localization of ROS1 94 0.73 66.32 12.16
7 INT94784 Binding of ROS1 113 0.40 71.57 10.26
8 INT69439 Regulation of ROS1 46 0.45 31.22 6.94
9 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78
10 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33
11 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14
12 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58
13 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27
14 INT127944 Negative_regulation of Localization of ROS1 8 0.36 3.14 2.02
15 INT117330 Negative_regulation of Binding of ROS1 13 0.37 8.33 1.67
16 INT160885 Positive_regulation of Regulation of ROS1 1 0.18 0.06 0.84
17 INT252704 Regulation of Localization of ROS1 5 0.28 3.54 0.7
18 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62
19 INT202140 Protein_catabolism of ROS1 7 0.28 2.58 0.62
20 INT181916 Regulation of Binding of ROS1 4 0.28 2.72 0.61
21 INT193819 Regulation of Positive_regulation of ROS1 6 0.36 3.73 0.45
22 INT186256 Transcription of ROS1 4 0.39 2.37 0.25
23 INT161803 Negative_regulation of Phosphorylation of ROS1 2 0.12 0.91 0.21
24 INT319181 Regulation of Regulation of ROS1 1 0.06 0.6 0.2
25 INT186257 Positive_regulation of Transcription of ROS1 2 0.34 0.1 0.03
26 INT149024 Regulation of Negative_regulation of ROS1 1 0.12 0.66 0
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