G:6696

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Official Symbol SPP1
Aliases OPN, BNSP, BSPI, ETA-1, MGC110940
EntrezGene 6696
UniProt Coming Soon
Unique Molecular Interactions 36
Total Molecular Interactions 55
Total Single Events 283
Unique Interaction Partners 18

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to SPP1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to SPP1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to SPP1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
2 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
3 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
4 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38
5 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38
6 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
7 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37
8 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
9 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36
10 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
11 INT127974 RAX2 Positive_regulation of SPP1 1 0.03 1.49 0.31
12 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
13 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28
14 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28
15 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19
16 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 0.46 0.36 0.18
17 INT185803 Binding of MMP11 and SPP1 1 0.06 0.34 0.17
18 INT185815 Binding of MMP1 and SPP1 1 0.21 0.34 0.17
19 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17
20 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16
21 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16
22 INT88937 Mmv7 Regulation of Gene_expression of SPP1 1 0.00 1.24 0.12
23 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
24 INT133306 Positive_regulation of Binding of CD44 and SPP1 1 0.16 0.83 0.07
25 INT205154 Binding of MMP9 and SPP1 1 0.25 0.45 0.05
26 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
27 INT185796 SPP1 Regulation of Gene_expression of COL7A1 1 0.06 0 0
28 INT185817 SPP1 Positive_regulation of Gene_expression of TIMP1 1 0.64 0 0
29 INT205153 Gene_expression of SPP1 Regulation of Localization of MMP9 1 0.14 0.57 0
30 INT205150 SPP1 Positive_regulation of Positive_regulation of MMP9 1 0.21 0 0
31 INT185801 SPP1 Regulation of Gene_expression of TIMP1 1 0.25 0 0
32 INT185794 SPP1 Regulation of Gene_expression of MMP1 1 0.16 0 0
33 INT290679 Binding of SPP1 and KRTAP19-9P 1 0.05 1.2 0
34 INT185812 SPP1 Negative_regulation of MMP1 1 0.26 0 0
35 INT290675 SPP1 Positive_regulation of Gene_expression of VEGFA 1 0.16 2.37 0
36 INT293410 HRAS Regulation of Localization of SPP1 1 0.00 0.8 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 6696. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 6696. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
2 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
3 INT97128 Localization of SPP1 32 0.80 21.75 4.02
4 INT133311 Binding of SPP1 10 0.37 9.47 1.65
5 INT88934 Regulation of SPP1 9 0.54 6.94 1.47
6 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44
7 INT185838 Protein_catabolism of SPP1 1 0.65 1.68 0.74
8 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59
9 INT127975 Negative_regulation of SPP1 15 0.42 11.25 0.56
10 INT133314 Positive_regulation of Binding of SPP1 2 0.22 2.38 0.52
11 INT127976 Negative_regulation of Regulation of SPP1 1 0.37 1.62 0.41
12 INT185830 Positive_regulation of Localization of SPP1 2 0.50 3.39 0.33
13 INT185828 Phosphorylation of SPP1 1 0.62 1.36 0.26
14 INT97129 Transcription of SPP1 4 0.51 0.67 0.23
15 INT185826 Negative_regulation of Gene_expression of SPP1 1 0.42 0.8 0.23
16 INT88936 Positive_regulation of Regulation of SPP1 1 0.40 1.1 0.11
17 INT155305 Positive_regulation of Transcription of SPP1 2 0.11 0.29 0.04
18 INT293422 Regulation of Localization of SPP1 1 0.07 0.8 0
19 INT155306 Regulation of Positive_regulation of SPP1 1 0.06 0.11 0
20 INT341671 Positive_regulation of Negative_regulation of SPP1 1 0.30 0.7 0
21 INT205163 Regulation of Binding of SPP1 1 0.31 0.31 0
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