G:6774

From wiki-pain
Jump to: navigation, search
Official Symbol STAT3
Aliases APRF, HIES, FLJ20882, MGC16063
EntrezGene 6774
UniProt Coming Soon
Unique Molecular Interactions 97
Total Molecular Interactions 128
Total Single Events 586
Unique Interaction Partners 61

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to STAT3. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to STAT3. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to STAT3. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
2 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
3 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
4 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
5 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
6 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
7 INT121822 Binding of STAT3 and Olr1583 1 0.00 0.21 0.51
8 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
9 INT303982 Il6 Positive_regulation of STAT3 1 0.03 0.41 0.37
10 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 0.28 0.54 0.34
11 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
12 INT118842 Negative_regulation of JAK2 Negative_regulation of GNA14 Positive_regulation of STAT3 1 0.00 0.08 0.28
13 INT118860 MCC Positive_regulation of Phosphorylation of STAT3 1 0.01 0.1 0.27
14 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
15 INT118841 GNA14 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.00 0.14 0.26
16 INT300779 STAT3 Positive_regulation of CRP 1 0.41 0.62 0.26
17 INT300778 STAT3 Positive_regulation of Transcription of CRP 1 0.38 0.62 0.26
18 INT325312 IL20 Positive_regulation of Phosphorylation of STAT3 1 0.13 0.58 0.24
19 INT325316 IL22 Positive_regulation of Phosphorylation of STAT3 1 0.19 0.58 0.24
20 INT325315 Binding of STAT3 and TH1L 1 0.16 0.6 0.23
21 INT118861 OPRD1 Positive_regulation of STAT3 1 0.07 0.07 0.23
22 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
23 INT337295 PTAFR Positive_regulation of Localization of STAT3 1 0.43 0.85 0.22
24 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22
25 INT188201 OSM Positive_regulation of Phosphorylation of STAT3 1 0.40 0.24 0.21
26 INT279964 STAT3 Regulation of Transcription of FGG 1 0.22 1.37 0.2
27 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
28 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19
29 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16
30 INT188197 LIF Positive_regulation of STAT3 1 0.35 0.27 0.12
31 INT188198 OSM Positive_regulation of STAT3 1 0.52 0.24 0.12
32 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12
33 INT286963 EGF Positive_regulation of Gene_expression of STAT3 1 0.03 0.57 0.1
34 INT286964 IL23A Positive_regulation of STAT3 1 0.05 0.57 0.09
35 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09
36 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08
37 INT273373 SOCS3 Regulation of Phosphorylation of STAT3 1 0.42 0.06 0.08
38 INT238215 Binding of STAT3 and Bmx 1 0.12 0.63 0.08
39 INT273374 Binding of JAK2 and STAT3 1 0.24 0 0.07
40 INT337290 PTAFR Positive_regulation of Phosphorylation of STAT3 1 0.43 0.07 0.07
41 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 0.28 0 0.07
42 INT188208 EGF Regulation of STAT3 1 0.46 0 0.07
43 INT286955 IL2 Positive_regulation of Binding of STAT3 and FOXP3 1 0.03 0.63 0.06
44 INT286966 IL2 Positive_regulation of Binding of STAT3 1 0.04 0.5 0.06
45 INT212440 STAT3 Regulation of Phosphorylation of SOAT1 1 0.11 1.42 0.05
46 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 0.11 0 0.05
47 INT238218 STAT3 Positive_regulation of Gene_expression of Socs3 1 0.14 0 0.05
48 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05
49 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 0.16 0 0.05
50 INT206083 LDLR Positive_regulation of Binding of STAT3 1 0.02 0.53 0.04
51 INT238211 Binding of STAT3 and Sik1 1 0.04 0.25 0.04
52 INT286968 Positive_regulation of STAT3 Regulation of Gene_expression of CD4 1 0.16 0.44 0.04
53 INT286967 Positive_regulation of STAT3 Regulation of Gene_expression of FOXP3 1 0.35 0.44 0.04
54 INT282540 STAT3 Positive_regulation of Positive_regulation of MAPK1 1 0.04 0.27 0.04
55 INT206066 LDLR Positive_regulation of Phosphorylation of STAT3 1 0.02 0.52 0.04
56 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
57 INT238212 Binding of STAT3 and Pxn 1 0.02 0 0.03
58 INT206076 IL6 Positive_regulation of Positive_regulation of STAT3 1 0.19 0.3 0.03
59 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03
60 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03
61 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03
62 INT238214 Bmx Positive_regulation of Phosphorylation of STAT3 1 0.13 0 0.03
63 INT238210 Binding of STAT3 and Bcar1 1 0.04 0 0.03
64 INT238217 Positive_regulation of Binding of STAT3 and Bcar1 1 0.04 0 0.03
65 INT237920 PPARA Negative_regulation of STAT3 1 0.16 0.91 0.03
66 INT238213 Positive_regulation of Bmx Positive_regulation of Phosphorylation of STAT3 1 0.12 0.16 0.03
67 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03
68 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
69 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0
70 INT294829 STAT3 Regulation of Gene_expression of REXO1 1 0.10 0.48 0
71 INT337300 STAT3 Regulation of TLR4 1 0.15 0 0
72 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
73 INT338180 Binding of AR and STAT3 1 0.18 0.3 0
74 INT144033 STAT6 Positive_regulation of Positive_regulation of STAT3 1 0.04 0.08 0
75 INT238119 STAT3 Regulation of FANCC 1 0.02 0.17 0
76 INT238209 Matk Positive_regulation of Positive_regulation of STAT3 1 0.06 0 0
77 INT338899 THPO Positive_regulation of STAT3 1 0.16 0 0
78 INT225890 Binding of RAC1 and STAT3 1 0.01 0 0
79 INT294830 Phosphorylation of STAT3 Regulation of Gene_expression of REXO1 1 0.08 0.48 0
80 INT337292 STAT3 Negative_regulation of Gene_expression of PTAFR 1 0.27 0.3 0
81 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
82 INT225896 HGF Positive_regulation of STAT3 1 0.01 0 0
83 INT338192 CDCP1 Positive_regulation of STAT3 1 0.00 0.34 0
84 INT337301 STAT3 Negative_regulation of Gene_expression of TLR4 1 0.33 0 0
85 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
86 INT250657 STAT3 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.74 0
87 INT337299 PTAFR Regulation of STAT3 1 0.28 0 0
88 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0
89 INT144031 STAT3 Regulation of BCL2L1 1 0.11 0.06 0
90 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
91 INT275763 STAT3 Regulation of Phosphorylation of Stat3 1 0.31 0 0
92 INT337307 Positive_regulation of PTAFR Positive_regulation of Localization of STAT3 1 0.25 0 0
93 INT298632 STAT3 Positive_regulation of MIR21 1 0.03 0.84 0
94 INT238115 Binding of CSK and STAT3 1 0.09 0.06 0
95 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0
96 INT238216 Positive_regulation of Binding of STAT3 and Bmx 1 0.18 0 0
97 INT144042 STAT3 Regulation of Birc5 1 0.47 0.06 0
98 INT144029 STAT3 Regulation of FIGF 1 0.12 0.06 0
99 INT275762 STAT3 Regulation of xn 1 0.07 0 0
100 INT144034 STAT6 Positive_regulation of STAT3 1 0.04 0.1 0
101 INT337285 STAT3 Regulation of STAT3 Regulation of TLR4 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 6774. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 6774. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
2 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
3 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
4 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
5 INT121818 Binding of STAT3 25 0.47 11.16 3.67
6 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
7 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
8 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
9 INT165617 Localization of STAT3 28 0.78 9.04 1.72
10 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2
11 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1
12 INT101240 Regulation of Phosphorylation of STAT3 5 0.57 3.04 0.98
13 INT165618 Negative_regulation of Localization of STAT3 2 0.39 0.31 0.59
14 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5
15 INT121816 Positive_regulation of Binding of STAT3 3 0.49 0.8 0.4
16 INT101242 Regulation of Gene_expression of STAT3 4 0.62 2.11 0.39
17 INT119371 Regulation of Positive_regulation of STAT3 2 0.42 0.36 0.35
18 INT101241 Positive_regulation of Negative_regulation of STAT3 1 0.70 1.53 0.32
19 INT144038 Transcription of STAT3 4 0.56 0.99 0.25
20 INT206166 Negative_regulation of Binding of STAT3 4 0.55 1.13 0.2
21 INT158508 Negative_regulation of Gene_expression of STAT3 2 0.43 1.74 0.15
22 INT206163 Positive_regulation of Localization of STAT3 4 0.29 0.43 0.13
23 INT144039 Negative_regulation of Negative_regulation of STAT3 2 0.55 0.85 0.07
24 INT206143 Positive_regulation of Transcription of STAT3 1 0.21 0.34 0.06
25 INT238192 Negative_regulation of Regulation of STAT3 1 0.35 0.38 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox