G:7099

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Official Symbol TLR4
Aliases TOLL, CD284, TLR-4, ARMD10
EntrezGene 7099
UniProt Coming Soon
Unique Molecular Interactions 78
Total Molecular Interactions 135
Total Single Events 804
Unique Interaction Partners 46

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to TLR4. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to TLR4. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to TLR4. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
3 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
4 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
5 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
6 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
7 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
8 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
9 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
10 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
11 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
12 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
13 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
14 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
15 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
16 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
17 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
18 INT188544 ETV5 Negative_regulation of Binding of IRF6 and TLR4 1 0.00 0.59 0.38
19 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
20 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
21 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
22 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
23 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
24 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
25 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27
26 INT343864 EDA Positive_regulation of Gene_expression of TLR4 1 0.11 0.44 0.25
27 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25
28 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
29 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
30 INT343910 TLR4 Regulation of Gene_expression of Icam1 1 0.04 1.3 0.22
31 INT343849 Binding of FAS and TLR4 1 0.04 0.32 0.21
32 INT188566 TLR4 Regulation of Gene_expression of PRF1 1 0.01 0.2 0.2
33 INT343831 TICAM1 Positive_regulation of Gene_expression of TLR4 1 0.11 0.19 0.19
34 INT343827 MIRLET7I Regulation of Gene_expression of TLR4 1 0.00 0.13 0.19
35 INT159795 Tnf Positive_regulation of TLR4 1 0.01 0.42 0.19
36 INT159796 Tnf Positive_regulation of Gene_expression of TLR4 1 0.02 0.42 0.19
37 INT139302 Binding of CRP and TLR4 1 0.38 1.18 0.19
38 INT337310 PTAFR Regulation of Gene_expression of TLR4 1 0.24 0.8 0.18
39 INT153347 Binding of TLR4 and Cd14 1 0.10 0.17 0.17
40 INT246414 TLR4 Regulation of Gene_expression of TLR3 1 0.35 1.16 0.17
41 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
42 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16
43 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
44 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
45 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
46 INT343828 MMRN1 Positive_regulation of TLR4 1 0.02 0.91 0.14
47 INT343833 INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
48 INT343840 Protein_catabolism of INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
49 INT285419 Positive_regulation of Binding of CD14 and TLR4 1 0.32 0.19 0.14
50 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
51 INT285421 Positive_regulation of Binding of TLR4 and LY96 1 0.17 0.18 0.13
52 INT342518 HSP90B1 Positive_regulation of Gene_expression of TLR4 1 0.04 0.4 0.13
53 INT231755 CD14 Positive_regulation of Binding of IRF6 and TLR4 1 0.03 1.6 0.11
54 INT231756 Positive_regulation of TLR4 Positive_regulation of Binding of HMOX1 and TLR4 1 0.25 0.96 0.11
55 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
56 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
57 INT337308 PTAFR Regulation of TLR4 1 0.24 0.1 0.1
58 INT343862 Binding of FN1 and TLR4 1 0.05 0.89 0.1
59 INT306452 Binding of MBL2 and TLR4 1 0.38 0.37 0.1
60 INT294776 PAM Positive_regulation of TLR4 1 0.00 0.17 0.1
61 INT306453 MBL2 Regulation of Binding of TLR4 1 0.48 0.37 0.1
62 INT242880 Binding of SPI1 and TLR4 1 0.03 0.24 0.07
63 INT242867 INS Negative_regulation of Binding of SPI1 and TLR4 1 0.02 0.14 0.07
64 INT306260 TLR4 Positive_regulation of TFAM 1 0.01 0 0.07
65 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
66 INT246413 TLR4 Regulation of TLR3 1 0.28 0.81 0.05
67 INT352087 Binding of ADAM11 and TLR4 1 0.05 1.09 0.04
68 INT295477 Binding of TLR4 and LANCL1 1 0.01 0.16 0.04
69 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
70 INT352076 Binding of TLR4 and Positive_regulation of ADAM11 1 0.06 1.09 0.04
71 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
72 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
73 INT337300 STAT3 Regulation of TLR4 1 0.15 0 0
74 INT242876 Negative_regulation of Binding of SPI1 and TLR4 1 0.04 0.05 0
75 INT337291 TLR4 Regulation of Localization of IRF6 1 0.05 0.47 0
76 INT246412 Binding of TLR3 and TLR4 1 0.38 0 0
77 INT285425 Binding of LTA and TLR4 1 0.09 0.1 0
78 INT337301 STAT3 Negative_regulation of Gene_expression of TLR4 1 0.33 0 0
79 INT337294 IRF6 Positive_regulation of Gene_expression of TLR4 1 0.06 0.16 0
80 INT242879 Positive_regulation of Binding of SPI1 and TLR4 1 0.04 0.05 0
81 INT246411 Positive_regulation of Binding of TLR3 and TLR4 1 0.51 0 0
82 INT337306 TLR4 Regulation of Localization of IL8 1 0.06 0.47 0
83 INT337285 STAT3 Regulation of STAT3 Regulation of TLR4 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 7099. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 7099. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
2 INT134651 Binding of TLR4 89 0.48 66.96 23.19
3 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
4 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
5 INT97797 Localization of TLR4 18 0.77 13.78 6
6 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
7 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
8 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
9 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
10 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
11 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
12 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
13 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
14 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
15 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
16 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
17 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
18 INT157768 Negative_regulation of Binding of TLR4 1 0.43 0.29 0.27
19 INT285435 Protein_catabolism of TLR4 2 0.62 0.9 0.14
20 INT246424 Negative_regulation of Transcription of TLR4 2 0.41 0.52 0.14
21 INT285441 Regulation of Localization of TLR4 2 0.38 0.15 0.12
22 INT242899 Negative_regulation of Negative_regulation of TLR4 1 0.20 0.09 0.05
23 INT231780 Regulation of Transcription of TLR4 1 0.19 0.62 0.04
24 INT337311 Negative_regulation of Positive_regulation of TLR4 1 0.35 0 0
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