G:7124

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Official Symbol TNF
Aliases DIF, TNFA, TNFSF2, TNF-alpha
EntrezGene 7124
UniProt Coming Soon
Unique Molecular Interactions 673
Total Molecular Interactions 944
Total Single Events 9303
Unique Interaction Partners 397

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to TNF. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to TNF. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to TNF. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
2 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
3 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
4 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
5 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
6 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
7 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
8 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
9 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
10 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
11 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
12 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
13 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
14 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
15 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
16 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
17 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
18 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
19 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
20 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
21 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
22 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
23 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
24 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
25 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
26 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
27 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
28 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
29 INT66205 TNF Positive_regulation of TNF Positive_regulation of NFKB1 4 0.41 2.74 1.24
30 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
31 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
32 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
33 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
34 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
35 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
36 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
37 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
38 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
39 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
40 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
41 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
42 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
43 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
44 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
45 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
46 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
47 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
48 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
49 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
50 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
51 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
52 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
53 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
54 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
55 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
56 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
57 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
58 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
59 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
60 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
61 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
62 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
63 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
64 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
65 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
66 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
67 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
68 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
69 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
70 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
71 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
72 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
73 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
74 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
75 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79
76 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
77 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
78 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
79 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
80 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
81 INT130138 TNF Negative_regulation of Gene_expression of S100A10 1 0.06 1.32 0.78
82 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
83 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
84 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77
85 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
86 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
87 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76
88 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
89 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
90 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
91 INT301141 Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
92 INT301142 Negative_regulation of Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
93 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
94 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
95 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
96 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
97 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
98 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
99 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
100 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
101 INT113499 TNF Positive_regulation of Gene_expression of BHLHE23 1 0.25 0.1 0.71
102 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
103 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
104 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
105 INT117533 TNF Positive_regulation of Positive_regulation of SETBP1 1 0.34 0.29 0.7
106 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7
107 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
108 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
109 INT113959 TNF Positive_regulation of Gene_expression of IK 1 0.02 0.66 0.69
110 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68
111 INT119107 Negative_regulation of Binding of LTBR and TNF 1 0.17 1.16 0.68
112 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
113 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67
114 INT119105 Binding of FCGR1A and TNF 1 0.03 1.16 0.67
115 INT119106 Negative_regulation of Binding of FCGR1A and TNF 1 0.03 1.16 0.67
116 INT264338 Binding of IL-17 and Positive_regulation of Localization of TNF 1 0.04 1.71 0.67
117 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
118 INT252293 Binding of TNF and Positive_regulation of Gene_expression of Ccl20 1 0.04 0.54 0.66
119 INT254230 Ik Negative_regulation of Gene_expression of TNF 1 0.00 1.29 0.65
120 INT295705 Binding of IK and TNF 1 0.00 0.27 0.64
121 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63
122 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
123 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
124 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
125 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
126 INT230595 Binding of TNF and Tecr 1 0.03 1 0.62
127 INT172048 Binding of TNF and MICA 1 0.29 1.63 0.62
128 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
129 INT293704 Binding of TNF and DDX41 1 0.00 1.01 0.61
130 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
131 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
132 INT327334 Il10 Negative_regulation of TNF 1 0.02 1.46 0.6
133 INT179203 NLRP1 Regulation of Gene_expression of TNF 1 0.31 1.73 0.6
134 INT327164 RETNLB Regulation of TNF 1 0.00 2.27 0.6
135 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
136 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58
137 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
138 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56
139 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56
140 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 0.01 1.5 0.56
141 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
142 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
143 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
144 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56
145 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
146 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
147 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
148 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55
149 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
150 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54
151 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54
152 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
153 INT137157 TNF Positive_regulation of Gene_expression of CXCL9 1 0.38 0.61 0.54
154 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
155 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53
156 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53
157 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
158 INT221033 TNF Positive_regulation of Gene_expression of CCL18 1 0.29 0.76 0.52
159 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52
160 INT112659 Cpox Positive_regulation of Gene_expression of TNF 1 0.01 0.79 0.52
161 INT112661 Cpox Positive_regulation of Localization of TNF 1 0.01 0.79 0.52
162 INT113243 TNF Positive_regulation of Transcription of OPRM1 1 0.23 0.84 0.51
163 INT100596 RPL21P132 Positive_regulation of TNF 1 0.00 0.43 0.5
164 INT271874 IL10 Negative_regulation of TNF 1 0.07 0.78 0.5
165 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5
166 INT148580 TNF Regulation of Gene_expression of SAMD9 1 0.48 3.01 0.5
167 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5
168 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5
169 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49
170 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49
171 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
172 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49
173 INT252426 Binding of SLURP1 and Negative_regulation of Gene_expression of TNF 1 0.01 1.13 0.49
174 INT120854 IRF1 Positive_regulation of Localization of TNF 1 0.20 0.94 0.49
175 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49
176 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
177 INT61616 TNF Negative_regulation of Gene_expression of IL6 1 0.37 0.33 0.49
178 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48
179 INT150534 OPRM1 Positive_regulation of TNF 1 0.03 0.38 0.48
180 INT327333 Binding of TNF and Fxr1 1 0.06 3.74 0.48
181 INT150535 OPRM1 Positive_regulation of Positive_regulation of TNF 1 0.08 0.38 0.48
182 INT130137 TNF Positive_regulation of Positive_regulation of S100A10 1 0.07 0.62 0.47
183 INT172137 IL11 Negative_regulation of Gene_expression of TNF 1 0.09 0.73 0.47
184 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 0.01 1.21 0.47
185 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46
186 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
187 INT161662 Gsr Regulation of Gene_expression of TNF 1 0.01 0.93 0.46
188 INT171123 TNF Positive_regulation of Localization of Spg7 1 0.01 1.35 0.46
189 INT355672 Il6 Negative_regulation of Transcription of TNF 1 0.05 0.98 0.46
190 INT308171 Binding of TNF and thd 1 0.00 1.84 0.45
191 INT327386 TNF Regulation of Gene_expression of Oxtr 1 0.20 0.98 0.45
192 INT312814 TNF Positive_regulation of Spg21 1 0.00 0.6 0.45
193 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
194 INT221024 TNF Negative_regulation of Gene_expression of CCL18 1 0.18 0.8 0.44
195 INT224434 TNF Positive_regulation of VEGFA 1 0.10 2.04 0.44
196 INT320695 TNF Positive_regulation of Localization of Il1 1 0.05 1.38 0.44
197 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43
198 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42
199 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42
200 INT250328 Binding of TNF and Il17a 1 0.02 0.5 0.42

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 7124. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 7124. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT6852 Localization of TNF 883 0.81 705.95 270.84
5 INT6481 Binding of TNF 624 0.48 510.2 214.82
6 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
7 INT9660 Regulation of TNF 363 0.62 312.94 139.99
8 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
9 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
10 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
11 INT13354 Transcription of TNF 108 0.72 85.81 42.32
12 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
13 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
14 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
15 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
16 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
17 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
18 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
19 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
20 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
21 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
22 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
23 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
24 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
25 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
26 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
27 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
28 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
29 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
30 INT51263 Regulation of Phosphorylation of TNF 2 0.26 1.06 0.63
31 INT235079 Negative_regulation of Phosphorylation of TNF 2 0.41 1.16 0.6
32 INT194643 Positive_regulation of Regulation of TNF 2 0.28 2.4 0.21
33 INT81351 Negative_regulation of Regulation of TNF 1 0.33 0.23 0.21
34 INT251578 Positive_regulation of Protein_catabolism of TNF 1 0.41 0.26 0.16
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