G:7157

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Official Symbol TP53
Aliases P53, LFS1, TRP53, FLJ92943
EntrezGene 7157
UniProt Coming Soon
Unique Molecular Interactions 130
Total Molecular Interactions 154
Total Single Events 1070
Unique Interaction Partners 88

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to TP53. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to TP53. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to TP53. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
3 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
4 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
5 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
6 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
7 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
8 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
9 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
10 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
11 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
12 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
13 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
14 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
15 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
16 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
17 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
18 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
19 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
20 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
21 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
22 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
23 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
24 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
25 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
26 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
27 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
28 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
29 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
30 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
31 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
32 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
33 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
34 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
35 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
36 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
37 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
38 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
39 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
40 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
41 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
42 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
43 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
44 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
45 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
46 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
47 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
48 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
49 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
50 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
51 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
52 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
53 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
54 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
55 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
56 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
57 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
58 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
59 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
60 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
61 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
62 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
63 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
64 INT304020 AR Regulation of TP53 1 0.24 1.11 0
65 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
66 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
67 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0
68 INT334322 Binding of RB1 and TP53 1 0.34 2 0
69 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
70 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
71 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
72 INT241256 TP53 Regulation of OPCML 1 0.12 1.31 0
73 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
74 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
75 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
76 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 0.18 0.44 0
77 INT284232 Binding of TP53 and HNRNPUL1 1 0.26 0.88 0
78 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
79 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
80 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
81 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0
82 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
83 INT268513 MIR34A Regulation of Gene_expression of TP53 1 0.00 0.9 0
84 INT172604 Binding of EP300 and TP53 1 0.00 0 0
85 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
86 INT337639 TP53 Regulation of Gene_expression of MIR34A 1 0.08 1.19 0
87 INT350983 TP53 Regulation of VEGFA 1 0.03 0.61 0
88 INT337680 Binding of TP53 and Scrib 1 0.03 1.6 0
89 INT187575 TP53 Regulation of Gene_expression of Birc5 1 0.05 1.1 0
90 INT217781 Binding of MITF and TP53 1 0.00 1.2 0
91 INT267258 Binding of TP53 and BCL11B 1 0.09 0.42 0
92 INT113343 Phosphorylation of TP53 Positive_regulation of Gene_expression of BAX 1 0.11 0.14 0
93 INT338969 Binding of ING1 and TP53 1 0.13 0.98 0
94 INT235650 TP53 Regulation of EFNA1 1 0.06 0.97 0
95 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
96 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
97 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
98 INT338971 ING1 Regulation of TP53 1 0.09 1.02 0
99 INT175399 Binding of TP53 and SACM1L 1 0.00 2.37 0
100 INT284231 Binding of TP53 and C4orf3 1 0.02 0.88 0
101 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0
102 INT217787 Binding of TP53 and MIR208A 1 0.21 0.5 0
103 INT187574 Binding of TP53 and Birc5 1 0.04 1.27 0
104 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0
105 INT189956 TP53 Positive_regulation of Gene_expression of Pttg1 1 0.06 1.21 0
106 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
107 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0
108 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0
109 INT324908 TP53 Regulation of Gene_expression of BAX 1 0.47 1.33 0
110 INT238390 ELANE Positive_regulation of Gene_expression of TP53 1 0.04 0.42 0
111 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0
112 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
113 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0
114 INT315054 TP53 Positive_regulation of MIR34A 1 0.02 0.47 0
115 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0
116 INT252789 TP53 Regulation of ROS1 1 0.02 0 0
117 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0
118 INT333459 TP53 Positive_regulation of CHEK1 1 0.09 0 0
119 INT217791 TP53 Positive_regulation of TSC1 1 0.04 0.61 0
120 INT259051 Binding of TP53 and UBE3A 1 0.01 3.48 0
121 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
122 INT248387 CHD5 Regulation of Gene_expression of TP53 1 0.20 0.83 0
123 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
124 INT314679 NEU1 Negative_regulation of TP53 1 0.12 1.23 0
125 INT250669 Binding of TP53 and ST8SIA4 1 0.02 0.51 0
126 INT200724 HDAC9 Positive_regulation of TP53 1 0.36 0.27 0
127 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0
128 INT214922 Binding of MDM2 and TP53 1 0.08 1.55 0
129 INT324909 Negative_regulation of TP53 Positive_regulation of Negative_regulation of BAX 1 0.36 1.33 0
130 INT241262 TP53 Positive_regulation of Gene_expression of OPCML 1 0.31 1.22 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 7157. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 7157. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
4 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
5 INT60585 Regulation of TP53 59 0.59 54.55 5.21
6 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
7 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
8 INT8103 Binding of TP53 46 0.44 40.2 2.96
9 INT55952 Transcription of TP53 16 0.61 12.14 2.36
10 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
11 INT65855 Localization of TP53 18 0.76 17.08 1.89
12 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
13 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
14 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
15 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
16 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
17 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
18 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
19 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
20 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
21 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
22 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
23 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
24 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
25 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
26 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
27 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
28 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
29 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
30 INT305295 Regulation of Binding of TP53 1 0.39 1.09 0
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