G:7852

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Official Symbol CXCR4
Aliases FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E
EntrezGene 7852
UniProt Coming Soon
Unique Molecular Interactions 31
Total Molecular Interactions 64
Total Single Events 425
Unique Interaction Partners 24

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to CXCR4. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to CXCR4. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to CXCR4. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
2 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
3 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
4 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94
5 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
6 INT182201 Binding of CXCR5 and CXCR4 1 0.36 1.15 0.72
7 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
8 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
9 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66
10 INT117184 GOLPH3 Regulation of CXCR4 1 0.30 0.29 0.37
11 INT117182 GOLPH3 Regulation of Binding of CXCR4 1 0.50 0.29 0.37
12 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26
13 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23
14 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
15 INT117183 Binding of CXCR4 and GOLPH3 1 0.53 0.27 0.16
16 INT117191 Binding of CXCR4 and Coro1a 1 0.39 0.28 0.16
17 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15
18 INT291347 Positive_regulation of TXK Positive_regulation of CXCR4 Positive_regulation of EPHB2 1 0.02 0.61 0.13
19 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13
20 INT294441 KLK4 Negative_regulation of CXCR4 1 0.01 0 0.1
21 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09
22 INT193776 ITIH4 Positive_regulation of CXCR4 Positive_regulation of Phosphorylation of APAF1 1 0.03 0.42 0.08
23 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04
24 INT245076 CXCR4 Regulation of Gene_expression of VEGFA 1 0.16 1.05 0.03
25 INT183769 Csf2 Negative_regulation of Transcription of CXCR4 1 0.48 0.92 0.03
26 INT183757 INCENP Negative_regulation of Transcription of CXCR4 1 0.01 0.93 0.03
27 INT291357 CXCR4 Positive_regulation of AKT1 1 0.08 1.27 0.03
28 INT121650 Negative_regulation of Binding of CXCL12 and CXCR4 2 0.47 1.61 0
29 INT245078 FGF2 Positive_regulation of CXCR4 1 0.07 1.36 0
30 INT245073 VEGFA Positive_regulation of CXCR4 1 0.27 5.09 0
31 INT245074 Gene_expression of VHL Negative_regulation of Gene_expression of CXCR4 1 0.31 1.84 0
32 INT336169 Binding of HIVEP1 and CXCR4 1 0.01 0.44 0
33 INT353129 Binding of CD4 and CXCR4 1 0.13 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 7852. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 7852. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
2 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84
3 INT117189 Binding of CXCR4 34 0.37 24.27 5.81
4 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36
5 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08
6 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54
7 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39
8 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15
9 INT182211 Transcription of CXCR4 5 0.69 3.8 0.95
10 INT193811 Localization of CXCR4 6 0.75 7.68 0.58
11 INT193814 Positive_regulation of Positive_regulation of CXCR4 2 0.38 3.08 0.39
12 INT287286 Positive_regulation of Binding of CXCR4 2 0.53 0.78 0.39
13 INT245085 Positive_regulation of Negative_regulation of CXCR4 1 0.47 1.7 0.23
14 INT183764 Negative_regulation of Transcription of CXCR4 1 0.41 0.91 0.03
15 INT245080 Regulation of Negative_regulation of CXCR4 1 0.45 0.78 0.03
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