G:841

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Official Symbol CASP8
Aliases CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, FLJ17672, MGC78473
EntrezGene 841
UniProt Coming Soon
Unique Molecular Interactions 30
Total Molecular Interactions 33
Total Single Events 203
Unique Interaction Partners 23

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to CASP8. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to CASP8. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to CASP8. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
2 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
3 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
4 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
5 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
6 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
7 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
8 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
9 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
10 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
11 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
12 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
13 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
14 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
15 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
16 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
17 INT268520 MIR19B1 Regulation of CASP8 1 0.14 1 0
18 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0
19 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0
20 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
21 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
22 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
23 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
24 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
25 INT237923 CFLAR Positive_regulation of Localization of CASP8 1 0.02 1.54 0
26 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
27 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
28 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0
29 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
30 INT122482 Negative_regulation of CASP3 Negative_regulation of Positive_regulation of CASP8 1 0.14 1.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 841. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 841. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
2 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
3 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
4 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
5 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
6 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
7 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
8 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
9 INT176260 Binding of CASP8 5 0.36 2.73 0.27
10 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
11 INT185901 Localization of CASP8 7 0.55 5.38 0.09
12 INT336053 Regulation of Positive_regulation of CASP8 2 0.04 1.44 0.04
13 INT237978 Negative_regulation of Negative_regulation of CASP8 1 0.07 1.65 0.03
14 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0
15 INT265477 Positive_regulation of Gene_expression of CASP8 2 0.17 1.57 0
16 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0
17 INT203927 Positive_regulation of Localization of CASP8 2 0.08 1.98 0
18 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0
19 INT322579 Positive_regulation of Binding of CASP8 1 0.09 0.25 0
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