GO:0000012

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Name single strand break repair
Categary Process
Go Slim No
Go Link GO:0000012
Unique Molecular Interactions 86
Total Molecular Interactions 112
Total Single Events 880
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for single strand break repair. They are ordered first by their pain relevance and then by number of times they were reported for single strand break repair. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
3 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
4 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76
5 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
6 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
7 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
8 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
9 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1
10 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
11 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09
12 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
13 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
14 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
15 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
16 INT94654 Trpc2 Positive_regulation of Positive_regulation of Tyr 1 0.40 0 0.08
17 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
18 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
19 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07
20 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
21 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
22 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
23 INT313886 RPS6KB1 Positive_regulation of Gene_expression of XRCC1 1 0.01 0.8 0.05
24 INT313890 Akt1 Positive_regulation of Gene_expression of XRCC1 1 0.00 0.79 0.05
25 INT268677 IFNA2 Positive_regulation of XRCC1 1 0.05 0.75 0.05
26 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
27 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05
28 INT268674 IL2 Positive_regulation of XRCC1 1 0.08 0.75 0.05
29 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
30 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
31 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
32 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
33 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
34 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
35 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
36 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
37 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
38 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
39 INT245041 Binding of Xrcc1 and APTX 1 0.41 0.38 0
40 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
41 INT350981 VHL Regulation of XRCC1 1 0.01 1.42 0
42 INT121316 Tgfb1 Negative_regulation of Xrcc1 1 0.06 0.08 0
43 INT182403 Binding of OGG1 and XRCC1 1 0.35 0.14 0
44 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
45 INT303822 Tdp1 Regulation of TREH 1 0.02 0.92 0
46 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
47 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
48 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
49 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
50 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
51 INT278068 Binding of XRCC1 and Vhl 1 0.02 2.3 0
52 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
53 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
54 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
55 INT251983 XRCC1 Regulation of Binding of MET 1 0.05 0.4 0
56 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
57 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
58 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
59 INT304944 Positive_regulation of Binding of Tnp1 and Ca2 1 0.04 0.33 0
60 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
61 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
62 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
63 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
64 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
65 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
66 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
67 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
68 INT323185 Binding of LIG4 and OGG1 1 0.02 0.32 0
69 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
70 INT245039 Binding of Xrcc1 and Tdp1 1 0.39 0.77 0
71 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
72 INT121317 Tgfb1 Positive_regulation of Xrcc1 1 0.07 0.08 0
73 INT304945 Binding of Tnp1 and Ca2 1 0.03 0.97 0
74 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
75 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
76 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
77 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for single strand break repair. They are ordered first by their pain relevance and then by number of times they were reported in single strand break repair. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
2 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
3 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76
4 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55
5 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26
6 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
7 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
8 INT50743 Positive_regulation of Trpc2 12 0.44 1.99 1.87
9 INT120519 Localization of XRCC1 15 0.78 17.03 1.51
10 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
11 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
12 INT74018 Binding of XRCC1 19 0.31 24.78 1.24
13 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06
14 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
15 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
16 INT74021 Regulation of XRCC1 15 0.44 16.91 0.88
17 INT50744 Negative_regulation of Positive_regulation of Trpc2 1 0.21 0.51 0.85
18 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
19 INT206929 Negative_regulation of Gene_expression of XRCC1 4 0.25 6.14 0.74
20 INT303799 Phosphorylation of Tdp1 1 0.82 22.84 0.71
21 INT62421 Gene_expression of Trpc2 8 0.68 5.48 0.67
22 INT303804 Localization of Tdp1 1 0.80 11.71 0.59
23 INT333877 Protein_catabolism of LIG4 2 0.03 2.03 0.57
24 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
25 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
26 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
27 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
28 INT303808 Positive_regulation of Gene_expression of Tdp1 1 0.69 9.07 0.35
29 INT105934 Gene_expression of APTX 1 0.00 0 0.35
30 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
31 INT303811 Binding of Tdp1 1 0.37 8.69 0.33
32 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
33 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
34 INT127654 Positive_regulation of Gene_expression of XRCC1 11 0.38 13.7 0.26
35 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
36 INT303812 Regulation of Tdp1 1 0.45 3.32 0.19
37 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
38 INT85628 Positive_regulation of Positive_regulation of Trpc2 1 0.32 0.47 0.14
39 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
40 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
41 INT68177 Negative_regulation of APTX 1 0.20 0.33 0.13
42 INT129774 Binding of Trpc2 2 0.18 0.73 0.12
43 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
44 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
45 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
46 INT121495 Transcription of XRCC1 7 0.49 6.11 0.09
47 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
48 INT303805 Positive_regulation of Phosphorylation of Tdp1 1 0.50 3.27 0.09
49 INT303795 Negative_regulation of Tdp1 1 0.43 1.71 0.08
50 INT62423 Regulation of Gene_expression of Trpc2 1 0.45 0.33 0.08
51 INT303806 Negative_regulation of Gene_expression of Tdp1 1 0.58 3.26 0.08
52 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
53 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
54 INT105935 Positive_regulation of APTX 1 0.00 0 0.07
55 INT105936 Regulation of APTX 1 0.00 0 0.07
56 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
57 INT303801 Positive_regulation of Tdp1 1 0.60 9.8 0.06
58 INT278064 Positive_regulation of Localization of XRCC1 1 0.05 1.17 0.05
59 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
60 INT278063 Regulation of Positive_regulation of XRCC1 1 0.03 1.2 0.05
61 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
62 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
63 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
64 INT251953 Positive_regulation of Transcription of XRCC1 1 0.29 1.07 0.04
65 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
66 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
67 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
68 INT303810 Positive_regulation of Localization of Tdp1 1 0.46 0.67 0.03
69 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
70 INT204349 Regulation of SIRT1 8 0.61 1.99 0
71 INT256134 Localization of Sirt1 5 0.50 2.99 0
72 INT121304 Gene_expression of Xrcc1 4 0.77 2.95 0
73 INT204353 Transcription of SIRT1 3 0.68 0.67 0
74 INT121308 Positive_regulation of Gene_expression of Xrcc1 3 0.50 0.6 0
75 INT225981 Binding of Xrcc1 3 0.36 0.81 0
76 INT210708 Regulation of Gene_expression of XRCC1 3 0.34 3.11 0
77 INT121301 Positive_regulation of Xrcc1 2 0.50 0.16 0
78 INT245028 Negative_regulation of Gene_expression of Xrcc1 1 0.43 0.62 0
79 INT245027 Phosphorylation of Xrcc1 1 0.81 0.31 0
80 INT304943 Negative_regulation of Tnp1 1 0.04 0.42 0
81 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
82 INT289569 Transcription of Sirt1 1 0.71 0.25 0
83 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
84 INT304942 Negative_regulation of Positive_regulation of Tnp1 1 0.04 0.42 0
85 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0
86 INT132339 Regulation of Trpc2 1 0.22 0 0
87 INT300287 Localization of Sirt1 1 0.66 1.46 0
88 INT121303 Localization of Xrcc1 1 0.68 0 0
89 INT245025 Regulation of Gene_expression of Xrcc1 1 0.45 1.44 0
90 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
91 INT121305 Positive_regulation of Localization of Xrcc1 1 0.45 0 0
92 INT245029 Regulation of Xrcc1 1 0.45 0.51 0
93 INT303803 Transcription of Tdp1 1 0.53 0.56 0
94 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
95 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
96 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
97 INT245023 Negative_regulation of Xrcc1 1 0.58 0.9 0
98 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
99 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
100 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
101 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
102 INT304941 Positive_regulation of Tnp1 1 0.07 0.73 0
103 INT323201 Binding of LIG4 1 0.03 0.32 0
104 INT146369 Negative_regulation of Negative_regulation of XRCC1 1 0.35 0 0
105 INT275044 Binding of APTX 1 0.04 0.26 0
106 INT204331 Binding of SIRT1 1 0.47 0.39 0
107 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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