GO:0000050

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Name urea cycle
Categary Process
Go Slim No
Go Link GO:0000050
Unique Molecular Interactions 116
Total Molecular Interactions 154
Total Single Events 1217
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for urea cycle. They are ordered first by their pain relevance and then by number of times they were reported for urea cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86518 Ass1 Positive_regulation of Hmox2 1 0.03 0.08 1.27
2 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 0.03 0.25 0.93
3 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
4 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
5 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
6 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
7 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 0.01 0.19 0.5
8 INT17622 Ass1 Positive_regulation of Lhb 1 0.02 1.22 0.49
9 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.2 0.49
10 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
11 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
12 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
13 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
14 INT103935 Cps1 Negative_regulation of Cd69 1 0.03 0.07 0.46
15 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43
16 INT331927 Ptger2 Positive_regulation of Arg1 1 0.06 1.8 0.42
17 INT187837 Ass1 Regulation of Mcpt1 1 0.00 1.29 0.37
18 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21
19 INT326737 IL8 Positive_regulation of Gene_expression of ARG1 1 0.38 2.41 0.19
20 INT326739 IL8 Regulation of Gene_expression of ARG2 1 0.35 0.46 0.17
21 INT331768 Binding of Arg1 and NOSTRIN 1 0.01 0.6 0.17
22 INT331766 Binding of Arg1 and Nos2 1 0.17 0.6 0.17
23 INT304463 Ass1 Positive_regulation of P2rx4 1 0.01 0 0.14
24 INT326733 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG2 1 0.24 0.33 0.14
25 INT326735 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG1 1 0.32 0.33 0.14
26 INT237442 Ass1 Positive_regulation of S100b 1 0.00 0.18 0.13
27 INT317162 Binding of Bdnf and Htt 1 0.51 0.2 0.12
28 INT319315 Binding of Ap2a2 and Htt 1 0.28 0.64 0.11
29 INT304460 Ass1 Positive_regulation of Xist 1 0.00 0 0.09
30 INT75038 Ass1 Positive_regulation of Transcription of Ephx1 1 0.00 0.08 0.07
31 INT198079 Ass1 Positive_regulation of Gene_expression of Slc1a3 1 0.01 0 0.07
32 INT75037 Ass1 Positive_regulation of Ephx1 1 0.00 0.08 0.07
33 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
34 INT331924 Binding of Arg1 and Actvty1 1 0.03 1.11 0.05
35 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
36 INT304457 Ass1 Positive_regulation of Transcription of P2rx4 1 0.01 0 0.05
37 INT306527 Binding of Htt and Aifm1 1 0.20 0.82 0.04
38 INT239338 Arg2 Positive_regulation of RCT 1 0.01 1.15 0.03
39 INT317161 Htt Regulation of Transcription of Bdnf 1 0.48 0.41 0.03
40 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
41 INT326736 AR Regulation of Gene_expression of ARG2 1 0.34 0.43 0.03
42 INT326742 AR Regulation of Gene_expression of ARG1 1 0.24 0.43 0.03
43 INT326749 IL8 Positive_regulation of Gene_expression of ARG2 1 0.39 1.96 0.03
44 INT200311 Htt Positive_regulation of Rest 1 0.05 0.75 0.03
45 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03
46 INT326745 IL8 Positive_regulation of ARG2 1 0.26 0.26 0
47 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
48 INT326744 ARG1 Regulation of ARG2 1 0.50 1.04 0
49 INT121179 Binding of Htt and Rest 1 0.07 0.45 0
50 INT176554 Ass1 Positive_regulation of Gene_expression of Spp1 1 0.01 1.26 0
51 INT202403 Ass1 Positive_regulation of Mapk14 1 0.01 0 0
52 INT326740 Gene_expression of AR Negative_regulation of Gene_expression of ARG2 1 0.24 0.8 0
53 INT176535 Ass1 Positive_regulation of Lepr 1 0.00 0 0
54 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0
55 INT121177 Binding of Bdnf and Htt 1 0.23 0.44 0
56 INT249960 Arg1 Negative_regulation of NOS1 1 0.01 0.1 0
57 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0
58 INT121180 Htt Negative_regulation of Bdnf 1 0.43 0.47 0
59 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0
60 INT176555 Ass1 Positive_regulation of Spp1 1 0.01 0 0
61 INT146469 Otc Regulation of Cp 1 0.10 0.23 0
62 INT202394 Ass1 Positive_regulation of Map3k3 1 0.01 0 0
63 INT261893 Binding of Htt and Hap1 1 0.13 0.49 0
64 INT197675 Regulation of Binding of ESR1 and Arg1 1 0.05 0 0
65 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
66 INT326743 Gene_expression of AR Negative_regulation of Gene_expression of ARG1 1 0.32 0.8 0
67 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
68 INT317163 Htt Regulation of Bdnf 1 0.29 0.19 0
69 INT326738 Gene_expression of IL8 Positive_regulation of Gene_expression of ARG1 1 0.26 0.41 0
70 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0
71 INT121176 Htt Regulation of Bdnf 1 0.17 0.77 0
72 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0
73 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0
74 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
75 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0
76 INT326748 IL8 Positive_regulation of ARG1 1 0.26 0.26 0
77 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0
78 INT215341 Binding of Htt and Sp1 1 0.03 0.25 0
79 INT217140 MIR223 Regulation of CEBPA 1 0.17 0.59 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for urea cycle. They are ordered first by their pain relevance and then by number of times they were reported in urea cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94051 Positive_regulation of Arg1 41 0.60 36.22 13.72
2 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43
3 INT94055 Gene_expression of Arg1 22 0.68 20.81 6.13
4 INT36237 Gene_expression of Ass1 11 0.24 2.31 4.38
5 INT28030 Binding of Otc 5 0.37 2.72 4.3
6 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67
7 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36
8 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
9 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68
10 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6
11 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47
12 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
13 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14
14 INT94050 Negative_regulation of Arg1 6 0.39 6.07 2.06
15 INT94056 Positive_regulation of Gene_expression of Arg1 8 0.60 6.57 1.95
16 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
17 INT94054 Regulation of Arg1 5 0.47 5.37 1.57
18 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
19 INT22353 Positive_regulation of Cps1 6 0.17 0.98 1.14
20 INT331764 Regulation of Gene_expression of Arg1 7 0.36 4.65 1.1
21 INT120514 Negative_regulation of Gene_expression of Otc 4 0.41 1.19 1.08
22 INT108997 Localization of Htt 28 0.77 3.76 1.07
23 INT69442 Regulation of Otc 3 0.24 0.98 1.04
24 INT94053 Transcription of Arg1 5 0.46 3.11 1.02
25 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97
26 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96
27 INT77856 Binding of Cps1 6 0.30 2.32 0.95
28 INT245137 Transcription of Ass1 2 0.03 0.82 0.89
29 INT92337 Localization of Ass1 3 0.41 1.42 0.86
30 INT154886 Gene_expression of Htt 18 0.76 15.51 0.82
31 INT142016 Negative_regulation of Gene_expression of CEBPA 1 0.41 0.67 0.8
32 INT142018 Gene_expression of CEBPA 1 0.75 0.66 0.8
33 INT152474 Phosphorylation of Cps1 1 0.06 0 0.78
34 INT157186 Regulation of Cps1 4 0.22 0.54 0.67
35 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6
36 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57
37 INT215340 Localization of Htt 10 0.61 5.12 0.55
38 INT326769 Regulation of Gene_expression of ARG2 1 0.61 9.7 0.54
39 INT287204 Protein_catabolism of Htt 6 0.99 2.8 0.53
40 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5
41 INT281922 Positive_regulation of Gene_expression of ARG2 2 0.69 10.45 0.5
42 INT94047 Negative_regulation of Gene_expression of Arg1 1 0.37 1.37 0.5
43 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48
44 INT243418 Binding of Htt 14 0.30 5.94 0.44
45 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44
46 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44
47 INT326766 Positive_regulation of Gene_expression of ARG1 12 0.67 8.32 0.42
48 INT296112 Positive_regulation of Positive_regulation of Arg1 1 0.05 0.55 0.4
49 INT132864 Binding of Htt 15 0.46 2.34 0.38
50 INT136851 Regulation of Arg1 7 0.38 3.05 0.37
51 INT48336 Negative_regulation of ARG2 4 0.58 3.82 0.36
52 INT287207 Regulation of Protein_catabolism of Htt 3 0.45 1.73 0.35
53 INT94048 Positive_regulation of Positive_regulation of Arg1 2 0.44 1.91 0.32
54 INT27399 Protein_catabolism of Arg1 1 0.64 0 0.31
55 INT330614 Positive_regulation of Transcription of Arg1 1 0.15 0.92 0.29
56 INT239293 Gene_expression of Arg2 1 0.10 3.26 0.29
57 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28
58 INT326773 Positive_regulation of ARG2 1 0.69 1.89 0.27
59 INT37570 Localization of Otc 2 0.61 0.97 0.25
60 INT94052 Negative_regulation of Protein_catabolism of Arg1 1 0.37 0.69 0.25
61 INT94049 Protein_catabolism of Arg1 1 0.77 0.6 0.25
62 INT314003 Negative_regulation of Positive_regulation of Arg1 1 0.13 0.63 0.23
63 INT287205 Regulation of Htt 5 0.45 3.56 0.22
64 INT28031 Negative_regulation of Binding of Otc 1 0.43 0.36 0.22
65 INT211657 Localization of Arg1 4 0.53 3.48 0.2
66 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19
67 INT38044 Regulation of Gene_expression of Cps1 1 0.38 0 0.19
68 INT68735 Binding of Arg2 2 0.05 0.22 0.17
69 INT326763 Negative_regulation of ARG1 1 0.57 1.49 0.16
70 INT280717 Positive_regulation of Regulation of Arg1 1 0.12 0 0.16
71 INT313999 Regulation of Positive_regulation of Arg1 1 0.08 0.22 0.13
72 INT245135 Regulation of Transcription of Ass1 1 0.02 0.25 0.13
73 INT326764 Negative_regulation of Gene_expression of ARG1 1 0.57 3.52 0.13
74 INT185424 Binding of Ass1 2 0.36 1.66 0.12
75 INT280705 Localization of Arg1 2 0.22 0.26 0.08
76 INT326762 Negative_regulation of Positive_regulation of ARG2 1 0.58 0.25 0.08
77 INT280709 Positive_regulation of Positive_regulation of Otc 1 0.37 0 0.08
78 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07
79 INT331917 Negative_regulation of Positive_regulation of Arg1 1 0.48 1.22 0.07
80 INT152243 Binding of ARG2 2 0.37 0.67 0.06
81 INT261890 Positive_regulation of Gene_expression of Htt 1 0.43 0.85 0.06
82 INT152244 Negative_regulation of Binding of ARG2 1 0.00 0.11 0.06
83 INT123164 Positive_regulation of Arg2 2 0.04 0.34 0.05
84 INT123165 Positive_regulation of Positive_regulation of Arg2 1 0.01 0.34 0.05
85 INT317175 Positive_regulation of Localization of Htt 1 0.48 0 0.05
86 INT306521 Transcription of Htt 1 0.69 4.13 0.05
87 INT244700 Regulation of Gene_expression of ARG1 2 0.60 3.09 0.04
88 INT296111 Negative_regulation of Binding of Arg1 1 0.04 0.12 0.04
89 INT331204 Negative_regulation of Binding of Htt 1 0.04 0.64 0.04
90 INT296110 Binding of Arg1 1 0.03 0.07 0.04
91 INT261891 Negative_regulation of Gene_expression of Htt 1 0.37 1.12 0.04
92 INT326761 Localization of ARG2 1 0.74 0 0.03
93 INT326776 Localization of ARG1 1 0.73 0 0.03
94 INT331922 Binding of Arg1 1 0.30 0.74 0.03
95 INT239276 Positive_regulation of Gene_expression of Arg2 1 0.09 1.1 0.03
96 INT326778 Negative_regulation of Gene_expression of ARG2 1 0.58 7.05 0.03
97 INT154887 Transcription of Htt 3 0.66 0 0
98 INT261886 Regulation of Htt 2 0.43 2.06 0
99 INT313014 Positive_regulation of Binding of Htt 2 0.13 0.91 0
100 INT230374 Regulation of ARG1 2 0.60 1.94 0
101 INT341938 Positive_regulation of Negative_regulation of Htt 1 0.07 0.65 0
102 INT254883 Negative_regulation of Positive_regulation of Htt 1 0.05 1.14 0
103 INT326779 Binding of ARG1 1 0.36 0.56 0
104 INT144505 Negative_regulation of Arg2 1 0.35 0 0
105 INT68274 Positive_regulation of Arg2 1 0.01 0 0
106 INT326765 Positive_regulation of Transcription of ARG1 1 0.67 0.6 0
107 INT329344 Positive_regulation of Positive_regulation of ARG1 1 0.01 0.73 0
108 INT234425 Transcription of CEBPA 1 0.38 0.76 0
109 INT326774 Regulation of Transcription of ARG1 1 0.44 0.11 0
110 INT317177 Negative_regulation of Transcription of Htt 1 0.41 0 0
111 INT234408 Positive_regulation of CEBPA 1 0.27 0.75 0
112 INT317763 Regulation of Ass1 1 0.01 0.09 0
113 INT326760 Regulation of ARG2 1 0.61 0.95 0
114 INT323259 Gene_expression of Arg2 1 0.03 0.59 0
115 INT197673 Regulation of Gene_expression of Arg1 1 0.29 0 0
116 INT326780 Transcription of ARG1 1 0.69 0.71 0
117 INT331724 Protein_catabolism of Ass1 1 0.96 0.26 0
118 INT309469 Negative_regulation of Localization of Htt 1 0.34 0.13 0
119 INT326771 Positive_regulation of Transcription of ARG2 1 0.69 1.29 0
120 INT326782 Regulation of Regulation of ARG1 1 0.26 0.81 0
121 INT169661 Localization of Cps1 1 0.62 0.09 0
122 INT326781 Transcription of ARG2 1 0.71 3.93 0
123 INT211649 Regulation of Negative_regulation of Arg1 1 0.26 0.41 0
124 INT217187 Regulation of CEBPA 1 0.44 0.54 0
125 INT317170 Regulation of Binding of Htt 1 0.43 0 0
126 INT234426 Positive_regulation of Transcription of CEBPA 1 0.27 0.76 0
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