GO:0000075

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Name cell cycle checkpoint
Categary Process
Go Slim No
Go Link GO:0000075
Unique Molecular Interactions 413
Total Molecular Interactions 559
Total Single Events 3921
Pain Genes Associated 39

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell cycle checkpoint. They are ordered first by their pain relevance and then by number of times they were reported for cell cycle checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
4 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
5 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
6 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
7 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
8 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
9 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
10 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
11 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
12 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
13 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
14 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
15 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
16 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
17 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
18 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
19 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
20 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
21 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
22 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
23 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
24 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
25 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
26 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
27 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
28 INT58578 Binding of RPA1 and TACR1 1 0.01 0 0.48
29 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
30 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
31 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
32 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
33 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
34 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
35 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
36 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 0.03 0.62 0.36
37 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
38 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
39 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
40 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
41 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
42 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
43 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
44 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
45 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
46 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
47 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
48 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
49 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
50 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
51 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
52 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
53 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
54 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
55 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
56 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
57 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
58 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
59 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
60 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
61 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
62 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25
63 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
64 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
65 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
66 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
67 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
68 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
69 INT322017 RPA1 Positive_regulation of IL1B 1 0.00 0 0.21
70 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
71 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
72 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
73 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
74 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
75 INT91862 RPA1 Negative_regulation of Transcription of ATG9B 1 0.03 0.46 0.19
76 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
77 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
78 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
79 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
80 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
81 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
82 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
83 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
84 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
85 INT119264 Binding of RB1 and PPM1E 1 0.00 0.46 0.17
86 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
87 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
88 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
89 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
90 INT180503 Binding of SARS and PSMD6 1 0.22 2.44 0.16
91 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
92 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
93 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
94 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
95 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
96 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
97 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
98 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
99 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
100 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
101 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
102 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
103 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
104 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
105 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
106 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
107 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
108 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
109 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
110 INT168829 Binding of DDB1 and TRPC4AP 1 0.02 0.34 0.1
111 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
112 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
113 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
114 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
115 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
116 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
117 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08
118 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
119 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
120 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
121 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
122 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
123 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
124 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
125 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 0.04 0.42 0.08
126 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
127 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
128 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
129 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
130 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
131 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
132 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
133 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
134 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
135 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
136 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
137 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
138 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
139 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
140 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
141 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
142 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
143 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
144 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
145 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
146 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
147 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
148 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
149 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
150 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
151 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
152 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
153 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
154 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
155 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
156 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
157 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
158 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
159 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
160 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
161 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
162 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04
163 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04
164 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
165 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
166 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
167 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
168 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
169 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
170 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
171 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
172 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
173 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
174 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
175 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
176 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
177 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
178 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03
179 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
180 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
181 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
182 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
183 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
184 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
185 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
186 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
187 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
188 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
189 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
190 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0
191 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
192 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
193 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
194 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
195 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
196 INT182404 NFYA Regulation of CCNE2 1 0.00 0.09 0
197 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
198 INT304020 AR Regulation of TP53 1 0.24 1.11 0
199 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
200 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell cycle checkpoint. They are ordered first by their pain relevance and then by number of times they were reported in cell cycle checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
3 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
4 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
5 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
6 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
7 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
8 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
9 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
10 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
11 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
12 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44
13 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46
14 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
15 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
16 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
17 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
18 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
19 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
20 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
21 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
22 INT60585 Regulation of TP53 59 0.59 54.55 5.21
23 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
24 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
25 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
26 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
27 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
28 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
29 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
30 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
31 INT88197 Binding of ZAK 9 0.46 6.23 3.54
32 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
33 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
34 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
35 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
36 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
37 INT8103 Binding of TP53 46 0.44 40.2 2.96
38 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
39 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
40 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
41 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
42 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
43 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
44 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
45 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
46 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
47 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39
48 INT55952 Transcription of TP53 16 0.61 12.14 2.36
49 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
50 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
51 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
52 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
53 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
54 INT201458 Negative_regulation of Gene_expression of CCNE2 3 0.07 1.71 1.96
55 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
56 INT65855 Localization of TP53 18 0.76 17.08 1.89
57 INT306836 Negative_regulation of Gene_expression of CDC6 1 0.19 1.28 1.88
58 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
59 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
60 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
61 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
62 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
63 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
64 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
65 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
66 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
67 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55
68 INT306844 Localization of CCNE2 6 0.21 3.81 1.52
69 INT306875 Localization of CDC6 1 0.34 1.51 1.52
70 INT58581 Binding of RPA1 8 0.44 1.68 1.44
71 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
72 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
73 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
74 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
75 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
76 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
77 INT201463 Negative_regulation of CCNE2 7 0.39 3.31 1.36
78 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
79 INT219492 Negative_regulation of CDC6 2 0.20 1.74 1.31
80 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
81 INT63905 Regulation of RB1 13 0.62 12.67 1.28
82 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
83 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
84 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
85 INT201466 Positive_regulation of Gene_expression of CCNE2 13 0.20 8.62 1.26
86 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
87 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
88 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12
89 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
90 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
91 INT67638 Positive_regulation of PSMA5 1 0.21 1.15 1.05
92 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
93 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
94 INT13882 Binding of PSMB9 3 0.15 2.84 1
95 INT306847 Positive_regulation of Gene_expression of CDC6 1 0.23 0.16 0.99
96 INT184992 Positive_regulation of CDC6 2 0.28 0.7 0.96
97 INT78322 Positive_regulation of PSME1 2 0.44 1.8 0.95
98 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
99 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
100 INT201465 Positive_regulation of CCNE2 6 0.13 3.13 0.92
101 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
102 INT306851 Transcription of CCNE2 1 0.06 0.57 0.92
103 INT306882 Transcription of CDC6 1 0.24 0.57 0.92
104 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
105 INT113841 Gene_expression of CCNB1 11 0.75 3.46 0.86
106 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
107 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
108 INT78323 Negative_regulation of PSME1 1 0.37 0.5 0.78
109 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
110 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
111 INT108590 Negative_regulation of Negative_regulation of PSMA5 1 0.57 0.92 0.75
112 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
113 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
114 INT24128 Negative_regulation of ZAK 3 0.39 0 0.7
115 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
116 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
117 INT108586 Positive_regulation of Negative_regulation of PSMA5 1 0.49 0.82 0.67
118 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
119 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
120 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
121 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
122 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
123 INT48212 Binding of ATM 5 0.47 3.89 0.57
124 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
125 INT160778 Transcription of ATM 1 0.40 1.03 0.57
126 INT53195 Localization of ZAK 3 0.80 1.85 0.56
127 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
128 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
129 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
130 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
131 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
132 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51
133 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
134 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
135 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
136 INT72750 Regulation of Positive_regulation of ZAK 1 0.10 0 0.49
137 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
138 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
139 INT177869 Gene_expression of BUB1B 2 0.65 2.11 0.45
140 INT177866 Negative_regulation of BUB1B 1 0.32 1.23 0.45
141 INT177845 Negative_regulation of Gene_expression of BUB1B 1 0.23 0.75 0.45
142 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
143 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
144 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
145 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
146 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
147 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41
148 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
149 INT78324 Regulation of PSME1 1 0.61 0.49 0.41
150 INT194993 Binding of RB1 15 0.37 10.96 0.4
151 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
152 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
153 INT244151 Localization of DDB1 1 0.02 0.05 0.4
154 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
155 INT58580 Positive_regulation of Binding of RPA1 2 0.43 0 0.38
156 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
157 INT280560 Positive_regulation of Gene_expression of PSMB9 7 0.64 6.44 0.36
158 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
159 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
160 INT343970 Regulation of ZAK 1 0.07 0.14 0.34
161 INT57019 Gene_expression of PSMB1 1 0.38 0 0.34
162 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
163 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
164 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
165 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
166 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
167 INT91692 Positive_regulation of Binding of ZAK 1 0.44 0.76 0.31
168 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
169 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
170 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
171 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
172 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
173 INT167438 Localization of ATM 3 0.55 1.61 0.27
174 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
175 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
176 INT184987 Regulation of CDC6 2 0.12 0.27 0.25
177 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
178 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
179 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
180 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
181 INT131823 Negative_regulation of PSMB6 2 0.01 0.09 0.24
182 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
183 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
184 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
185 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
186 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
187 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21
188 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
189 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
190 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
191 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
192 INT165973 Phosphorylation of PSMA5 1 0.79 0.07 0.2
193 INT165972 Positive_regulation of Phosphorylation of PSMA5 1 0.49 0.07 0.2
194 INT280553 Regulation of PSMB9 2 0.57 1.46 0.19
195 INT209077 Positive_regulation of Negative_regulation of PSME3 1 0.37 0.13 0.19
196 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
197 INT293677 Transcription of RB1 1 0.62 0.8 0.18
198 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
199 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
200 INT201464 Regulation of CCNE2 3 0.08 2.79 0.16
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