GO:0000077

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Name DNA damage checkpoint
Categary Process
Go Slim No
Go Link GO:0000077
Unique Molecular Interactions 395
Total Molecular Interactions 489
Total Single Events 4270
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
2 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
3 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
4 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
5 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
6 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
7 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
8 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
9 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
10 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
11 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
12 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
13 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
14 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
15 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
16 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
17 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
18 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
19 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
20 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
21 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
22 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
23 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
24 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
25 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
26 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
27 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
28 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
29 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
30 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
31 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
32 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
33 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
34 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
35 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
36 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
37 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
38 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
39 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
40 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
41 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
42 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
43 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
44 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75
45 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
46 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 0.19 0.81 0.68
47 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
48 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
49 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
50 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
51 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
52 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65
53 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65
54 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64
55 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
56 INT223155 Binding of Mapk14 and Stat4 1 0.36 0.84 0.63
57 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
58 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
59 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
60 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
61 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
62 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
63 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
64 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
65 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57
66 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
67 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
68 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
69 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
70 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
71 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
72 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
73 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
74 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
75 INT164262 TGM7 Negative_regulation of E2F1 1 0.16 1.08 0.53
76 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5
77 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5
78 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
79 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5
80 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
81 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
82 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
83 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
84 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
85 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.14 0.2 0.47
86 INT131507 Ngf Positive_regulation of Mapk14 1 0.13 0.2 0.47
87 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
88 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
89 INT163040 E2f1 Positive_regulation of Transcription of Oprm1 1 0.00 0 0.46
90 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46
91 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
92 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
93 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44
94 INT249011 Gabrg1 Regulation of Clock 1 0.19 0 0.43
95 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
96 INT124088 Rab38 Negative_regulation of Mapk14 1 0.00 0.89 0.42
97 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42
98 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
99 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41
100 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41
101 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
102 INT152241 Mapk14 Positive_regulation of Localization of Nfkb1 1 0.25 0.13 0.39
103 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
104 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
105 INT249004 Helt Regulation of Clock 1 0.01 0.09 0.37
106 INT249015 Regulation of Helt Regulation of Clock 1 0.01 0.09 0.37
107 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
108 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 0.03 0.62 0.36
109 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
110 INT223874 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Ltp 1 0.13 0 0.34
111 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33
112 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31
113 INT288203 Binding of Cd14 and Mapk14 1 0.08 0.63 0.31
114 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
115 INT167982 Mapk14 Negative_regulation of gr 1 0.02 0.45 0.29
116 INT196584 Binding of Mapk14 and NeuN 1 0.02 0.39 0.27
117 INT270216 Mapk14 Positive_regulation of Mknk1 1 0.10 0.5 0.26
118 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
119 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.87 0.25
120 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24
121 INT327313 Positive_regulation of Mapk14 Positive_regulation of Phosphorylation of Khsrp 1 0.09 0.24 0.22
122 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
123 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
124 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
125 INT208942 Positive_regulation of Mapk14 Positive_regulation of Positive_regulation of Jun 1 0.10 0.42 0.2
126 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
127 INT284446 Dep1 Positive_regulation of Mapk14 1 0.01 0.58 0.18
128 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17
129 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
130 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
131 INT329985 Positive_regulation of Prkaca Positive_regulation of Positive_regulation of Mapk14 1 0.15 0.87 0.15
132 INT327324 Mapk6 Positive_regulation of Mapk14 1 0.01 0.29 0.15
133 INT327329 S100a8 Positive_regulation of Mapk14 1 0.00 0.36 0.14
134 INT327309 Il1 Positive_regulation of Mapk14 1 0.01 0.36 0.14
135 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
136 INT327319 Binding of Mapk14 and Ttpa 1 0.01 0.34 0.14
137 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14
138 INT224677 L1cam Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.39 0.13
139 INT327318 Mapk14 Regulation of Localization of Elavl1 1 0.09 0.42 0.13
140 INT327330 Mapk14 Regulation of Il1 1 0.01 0.33 0.12
141 INT325056 Binding of E2f1 and Ang 1 0.06 1.3 0.12
142 INT226907 Binding of E2f1 and Nfkb1 1 0.14 0.6 0.12
143 INT308004 Rsph1 Positive_regulation of Mapk14 1 0.02 0.61 0.12
144 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
145 INT331797 Ugcg Regulation of Negative_regulation of Mapk14 1 0.01 1.03 0.11
146 INT331794 Binding of Ugcg and Regulation of Negative_regulation of Mapk14 1 0.01 1.05 0.11
147 INT281022 Clock Negative_regulation of Per1 1 0.26 0.09 0.11
148 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
149 INT281023 Clock Negative_regulation of Per2 1 0.31 0.09 0.11
150 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11
151 INT314590 Binding of Ifnar1 and Positive_regulation of Mapk14 1 0.16 0 0.1
152 INT260944 Mapk14 Positive_regulation of Transcription of Aqp3 1 0.29 0.21 0.09
153 INT202402 Binding of Akt1 and Mapk14 1 0.11 0.13 0.09
154 INT87037 Binding of FBXO6 and Col5a3 1 0.00 0.48 0.09
155 INT260947 Mapk14 Positive_regulation of Aqp3 1 0.29 0.21 0.09
156 INT202406 Binding of Osm and Mapk14 1 0.21 0.13 0.09
157 INT260945 Mapk14 Positive_regulation of Gene_expression of Aqp3 1 0.29 0.21 0.09
158 INT202399 Binding of Mapk14 and Racgap1 1 0.07 0.13 0.09
159 INT202393 Binding of Mapk14 and Nexn 1 0.03 0.13 0.09
160 INT202401 Binding of Map3k3 and Mapk14 1 0.41 0.13 0.09
161 INT218662 Olr811 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.54 0.08
162 INT268925 Igfbp2 Negative_regulation of Phosphorylation of Mapk14 1 0.01 0.35 0.08
163 INT300304 Positive_regulation of Mapk14 Positive_regulation of Agt 1 0.14 1.5 0.08
164 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
165 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
166 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
167 INT231512 Positive_regulation of Tlr4 Positive_regulation of Mapk14 1 0.06 0.15 0.07
168 INT325275 IL1RAP Positive_regulation of Mapk14 1 0.13 0 0.07
169 INT231513 Tlr4 Positive_regulation of Positive_regulation of Mapk14 1 0.06 0.15 0.07
170 INT288204 Akt1 Regulation of Mapk14 1 0.01 0.09 0.07
171 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
172 INT325258 Il1rap Positive_regulation of Mapk14 1 0.08 0 0.07
173 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07
174 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
175 INT332897 Ppara Regulation of Transcription of Clock 1 0.24 0.31 0.06
176 INT308967 Gpr18 Positive_regulation of Mapk14 1 0.06 0.08 0.06
177 INT243670 Mp Regulation of Positive_regulation of Mapk14 1 0.00 0.06 0.06
178 INT218704 Mapk14 Regulation of EPHB2 1 0.01 0.33 0.05
179 INT218666 Olr811 Regulation of Mapk14 1 0.00 0.33 0.05
180 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
181 INT218676 Mapk8 Regulation of Mapk14 1 0.00 0.33 0.05
182 INT200889 Acsl1 Positive_regulation of Mapk14 1 0.01 0.09 0.05
183 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
184 INT332900 Ppara Regulation of Clock 1 0.21 0 0.05
185 INT344345 Mapk14 Regulation of Gene_expression of VEGFA 1 0.01 0.37 0.05
186 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
187 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
188 INT295294 Tlr4 Positive_regulation of Mapk14 1 0.00 0.39 0.05
189 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
190 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
191 INT213608 Binding of PER2 and CLOCK 1 0.22 0.65 0.04
192 INT178443 Negative_regulation of Mapk8 Positive_regulation of Negative_regulation of Mapk14 1 0.13 0.76 0.04
193 INT213607 Binding of CSNK1D and CLOCK 1 0.27 0.65 0.04
194 INT178436 Mapk14 Positive_regulation of Gene_expression of Hist1h1a 1 0.17 0.2 0.04
195 INT332889 Clock Regulation of Ppara 1 0.12 0 0.04
196 INT332886 Binding of Clock and Ppara 1 0.32 0 0.04
197 INT340552 Binding of Mapk1 and Mapk14 1 0.07 0.27 0.03
198 INT352460 Gse1 Negative_regulation of Gene_expression of Mapk14 1 0.02 0.05 0.03
199 INT213036 Hdl1 Positive_regulation of Phosphorylation of Mapk14 1 0.22 0.78 0.03
200 INT213004 Hdl1 Positive_regulation of Mapk14 1 0.22 0.97 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
2 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
3 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
4 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
5 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
6 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
7 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
8 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
9 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
10 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
11 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
12 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
13 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
14 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
15 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
16 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
17 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
18 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
19 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
20 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
21 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
22 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
23 INT159518 Gene_expression of Clock 4 0.35 2.34 6.91
24 INT170385 Regulation of Clock 29 0.49 4.95 6.39
25 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
26 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
27 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
28 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
29 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
30 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02
31 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86
32 INT88197 Binding of ZAK 9 0.46 6.23 3.54
33 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85
34 INT96901 Regulation of Negative_regulation of Mapk14 3 0.45 4.07 2.79
35 INT351263 Binding of CLOCK 1 0.18 0.46 2.71
36 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39
37 INT163283 Gene_expression of E2F1 21 0.71 3.77 2.26
38 INT170387 Transcription of Clock 11 0.63 1.78 1.83
39 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77
40 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74
41 INT168686 Transcription of Mapk14 6 0.52 2.96 1.67
42 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55
43 INT149815 Positive_regulation of Gene_expression of Clock 7 0.46 0.87 1.45
44 INT248976 Positive_regulation of Clock 8 0.48 0.15 1.38
45 INT306868 Positive_regulation of Gene_expression of E2F1 6 0.46 1.01 1.28
46 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26
47 INT118368 Positive_regulation of E2F1 10 0.69 0.8 1.13
48 INT126993 Binding of E2F1 5 0.44 1.39 1.12
49 INT126525 Regulation of Negative_regulation of Mapk14 2 0.41 0.81 1.11
50 INT178391 Localization of Mapk14 9 0.68 5.27 0.97
51 INT145028 Positive_regulation of Localization of Mapk14 2 0.20 0.85 0.96
52 INT231494 Regulation of Phosphorylation of Mapk14 2 0.24 2.59 0.93
53 INT351266 Regulation of Binding of CLOCK 1 0.21 0 0.92
54 INT175747 Regulation of CLOCK 4 0.21 0.06 0.84
55 INT219268 Negative_regulation of Negative_regulation of Mapk14 2 0.38 0.99 0.8
56 INT126990 Positive_regulation of Binding of E2F1 4 0.58 0 0.79
57 INT248971 Binding of Clock 8 0.34 1.12 0.73
58 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
59 INT24128 Negative_regulation of ZAK 3 0.39 0 0.7
60 INT314190 Negative_regulation of Localization of Mapk14 1 0.36 0.91 0.69
61 INT28118 Binding of Atm 13 0.38 12.24 0.68
62 INT56251 Binding of NBN 4 0.38 3.16 0.62
63 INT306839 Negative_regulation of Gene_expression of E2F1 2 0.39 0.24 0.61
64 INT248978 Localization of Clock 1 0.70 0.3 0.61
65 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
66 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57
67 INT53195 Localization of ZAK 3 0.80 1.85 0.56
68 INT118369 Regulation of E2F1 5 0.56 3.51 0.52
69 INT163038 Binding of E2f1 2 0.44 0.08 0.5
70 INT72750 Regulation of Positive_regulation of ZAK 1 0.10 0 0.49
71 INT163035 Gene_expression of E2f1 8 0.71 2.68 0.47
72 INT204005 Negative_regulation of Gene_expression of Clock 3 0.39 0.58 0.45
73 INT163037 Positive_regulation of Gene_expression of E2f1 1 0.11 0 0.44
74 INT163036 Positive_regulation of E2f1 1 0.11 0 0.44
75 INT169952 Gene_expression of E2f1 12 0.64 4.35 0.43
76 INT231499 Positive_regulation of Negative_regulation of Mapk14 3 0.24 1.58 0.43
77 INT304572 Regulation of Binding of Clock 1 0.30 0.29 0.43
78 INT172626 Localization of E2F1 3 0.78 1.97 0.4
79 INT196973 Regulation of Gene_expression of Clock 12 0.38 3.58 0.38
80 INT147152 Negative_regulation of E2F1 6 0.56 0.89 0.38
81 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
82 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
83 INT343970 Regulation of ZAK 1 0.07 0.14 0.34
84 INT207377 Positive_regulation of Regulation of Mapk14 1 0.20 0.67 0.32
85 INT91692 Positive_regulation of Binding of ZAK 1 0.44 0.76 0.31
86 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
87 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
88 INT301057 Regulation of Transcription of Mapk14 1 0.25 0.5 0.29
89 INT126991 Regulation of Binding of E2F1 1 0.23 0 0.28
90 INT126992 Positive_regulation of Regulation of E2F1 1 0.58 0 0.28
91 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
92 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
93 INT345923 Positive_regulation of Transcription of Mapk14 1 0.07 0.41 0.25
94 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
95 INT196920 Transcription of E2f1 4 0.68 2.65 0.21
96 INT196929 Positive_regulation of E2f1 10 0.66 4.29 0.19
97 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
98 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
99 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16
100 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16
101 INT325053 Regulation of E2f1 1 0.19 2.02 0.15
102 INT250776 Protein_catabolism of Mapk14 3 0.52 1.04 0.14
103 INT87034 Positive_regulation of FBXO6 2 0.38 0.89 0.14
104 INT245341 Regulation of Gene_expression of ATR 1 0.18 0.94 0.14
105 INT290777 Phosphorylation of Clock 1 0.42 0.41 0.14
106 INT169928 Positive_regulation of Gene_expression of E2f1 3 0.48 1.29 0.13
107 INT263138 Phosphorylation of ZAK 5 0.17 0.13 0.12
108 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
109 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
110 INT245339 Regulation of ATR 1 0.18 0.92 0.11
111 INT295368 Localization of Ptpn11 1 0.25 0 0.11
112 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
113 INT213470 Positive_regulation of Ptpn11 1 0.05 0.07 0.1
114 INT290793 Negative_regulation of Clock 6 0.39 1.48 0.09
115 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
116 INT213468 Regulation of Ptpn11 1 0.05 0.08 0.09
117 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08
118 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08
119 INT178395 Transcription of Mapk14 6 0.61 0.47 0.07
120 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07
121 INT163282 Negative_regulation of Phosphorylation of E2F1 1 0.35 0.33 0.07
122 INT163288 Phosphorylation of E2F1 1 0.66 0.33 0.07
123 INT175751 Localization of CLOCK 1 0.40 0 0.07
124 INT296212 Negative_regulation of CLOCK 1 0.04 0.24 0.07
125 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
126 INT139362 Negative_regulation of CHEK2 2 0.35 1.66 0.06
127 INT139365 Negative_regulation of Negative_regulation of CHEK1 1 0.23 1.67 0.06
128 INT139364 Negative_regulation of Negative_regulation of CHEK2 1 0.26 1.67 0.06
129 INT273525 Regulation of NBN 1 0.49 1.28 0.05
130 INT169929 Negative_regulation of E2f1 12 0.41 3.03 0.04
131 INT178408 Positive_regulation of Localization of Mapk14 2 0.42 0.87 0.04
132 INT269654 Positive_regulation of Phosphorylation of ZAK 1 0.10 0 0.04
133 INT290801 Regulation of Protein_catabolism of Clock 1 0.12 0.1 0.04
134 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
135 INT290785 Protein_catabolism of Clock 1 0.29 0.1 0.04
136 INT269412 Regulation of Gene_expression of ZAK 1 0.07 0 0.04
137 INT269621 Negative_regulation of Positive_regulation of ZAK 1 0.09 0 0.04
138 INT196912 Binding of E2f1 6 0.46 2.3 0.03
139 INT207803 Regulation of Atm 3 0.41 1.15 0.03
140 INT288182 Regulation of Transcription of Mapk14 1 0.40 0.33 0.03
141 INT288195 Negative_regulation of Transcription of Mapk14 1 0.08 0.06 0.03
142 INT288187 Positive_regulation of Transcription of Mapk14 1 0.09 0.06 0.03
143 INT207807 Localization of Atm 4 0.74 0.21 0
144 INT25419 Regulation of FBXO6 2 0.04 1.16 0
145 INT208213 Localization of ATR 2 0.50 0.19 0
146 INT212461 Gene_expression of Chek1 2 0.65 0.11 0
147 INT157237 Gene_expression of CLOCK 2 0.58 0.2 0
148 INT252642 Transcription of Atm 1 0.53 0.18 0
149 INT296150 Negative_regulation of Gene_expression of Chek1 1 0.35 0.11 0
150 INT178976 Binding of Clock 1 0.22 0.06 0
151 INT252942 Phosphorylation of Chek1 1 0.14 0.63 0
152 INT225246 Phosphorylation of Ptpn11 1 0.28 0.9 0
153 INT175755 Positive_regulation of CLOCK 1 0.37 0.12 0
154 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0
155 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0
156 INT269643 Negative_regulation of Phosphorylation of ZAK 1 0.09 0 0
157 INT217169 Positive_regulation of Transcription of E2F1 1 0.46 0.79 0
158 INT295391 Positive_regulation of Ptpn11 1 0.23 0 0
159 INT336529 Negative_regulation of Binding of Clock 1 0.32 0 0
160 INT260848 Transcription of NBN 1 0.57 0.54 0
161 INT295371 Positive_regulation of Positive_regulation of Ptpn11 1 0.15 0 0
162 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0
163 INT204008 Regulation of Transcription of Clock 1 0.12 0.1 0
164 INT295379 Gene_expression of Ptpn11 1 0.20 0 0
165 INT258060 Positive_regulation of Protein_catabolism of E2F1 1 0.08 0.52 0
166 INT169927 Protein_catabolism of E2f1 1 0.44 0.12 0
167 INT260850 Regulation of Gene_expression of NBN 1 0.38 0.57 0
168 INT175749 Positive_regulation of Regulation of CLOCK 1 0.25 0.06 0
169 INT87036 Gene_expression of FBXO6 1 0.00 0.17 0
170 INT196911 Phosphorylation of E2f1 1 0.77 0.39 0
171 INT196926 Localization of E2f1 1 0.76 1.17 0
172 INT178971 Regulation of Clock 1 0.14 0.1 0
173 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
174 INT196922 Positive_regulation of Positive_regulation of E2f1 1 0.44 0.75 0
175 INT329779 Positive_regulation of CHEK1 1 0.22 0.76 0
176 INT169276 Localization of NBN 1 0.08 0.08 0
177 INT235140 Binding of Atr 1 0.00 1.28 0
178 INT295369 Regulation of Binding of Ptpn11 1 0.15 0 0
179 INT196933 Positive_regulation of Binding of E2f1 1 0.44 0.31 0
180 INT234190 Gene_expression of BRIP1 1 0.55 0.6 0
181 INT196924 Negative_regulation of Gene_expression of E2f1 1 0.41 0.43 0
182 INT290423 Gene_expression of Ptpn11 1 0.39 0.15 0
183 INT258047 Negative_regulation of Protein_catabolism of E2F1 1 0.07 0.52 0
184 INT221708 Binding of CHEK2 1 0.01 0 0
185 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
186 INT273522 Negative_regulation of Gene_expression of NBN 1 0.34 0.91 0
187 INT290402 Regulation of Gene_expression of Ptpn11 1 0.26 0.15 0
188 INT296140 Negative_regulation of Chek1 1 0.35 0.45 0
189 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
190 INT225245 Negative_regulation of Phosphorylation of Ptpn11 1 0.19 0.26 0
191 INT352864 Regulation of BRIP1 1 0.51 0.13 0
192 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
193 INT252554 Positive_regulation of ATR 1 0.13 0 0
194 INT217233 Transcription of E2F1 1 0.48 0.78 0
195 INT329783 Phosphorylation of CHEK1 1 0.26 0.82 0
196 INT196930 Regulation of E2f1 1 0.43 0.23 0
197 INT157246 Negative_regulation of Transcription of CLOCK 1 0.41 0.09 0
198 INT295393 Binding of Ptpn11 1 0.12 0 0
199 INT147150 Negative_regulation of Negative_regulation of E2F1 1 0.41 0 0
200 INT157240 Transcription of CLOCK 1 0.67 0.09 0
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