GO:0000079

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Name regulation of cyclin-dependent protein kinase activity
Categary Process
Go Slim No
Go Link GO:0000079
Unique Molecular Interactions 300
Total Molecular Interactions 383
Total Single Events 2391
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
2 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
3 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
4 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
5 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
6 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
7 INT21424 Binding of Penk and Gtpbp4 1 0.02 0.16 1.2
8 INT64259 Binding of Gtpbp4 and Ptprg 1 0.06 0 1.1
9 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
10 INT61637 Binding of P2ry2 and Gtpbp4 1 0.02 0.1 0.99
11 INT153685 Binding of Bcl2l11 and Gtpbp4 1 0.08 0.76 0.93
12 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
13 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
14 INT142454 Npff Positive_regulation of Gtpbp4 1 0.56 0 0.78
15 INT142455 Binding of Npff and Gtpbp4 1 0.40 0 0.78
16 INT113931 Mors1 Positive_regulation of Gtpbp4 1 0.02 0 0.67
17 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
18 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
19 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
20 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
21 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
22 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
23 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
24 INT161387 Binding of PNOC and GTPBP4 1 0.03 1.05 0.59
25 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
26 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
27 INT81004 Htr1a Positive_regulation of Gtpbp4 1 0.20 0 0.5
28 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
29 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
30 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
31 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
32 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
33 INT56876 Regulation of Binding of Cd36 and Gtpbp4 1 0.00 0 0.4
34 INT56875 Binding of Cd36 and Gtpbp4 1 0.00 0 0.4
35 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37
36 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
37 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
38 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34
39 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
40 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
41 INT109282 Gdi2 Negative_regulation of Gtpbp4 1 0.01 0.13 0.32
42 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
43 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
44 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
45 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
46 INT304280 CCNE1 Positive_regulation of IL6 1 0.00 1.93 0.31
47 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
48 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
49 INT64892 ANTXR1 Regulation of Gtpbp4 1 0.00 0.47 0.28
50 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
51 INT237380 Binding of Cdkn2d and Il12b 1 0.01 0.45 0.26
52 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
53 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
54 INT47600 Ccno Regulation of MBD2 1 0.00 0.22 0.24
55 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
56 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
57 INT146826 Binding of Galr1 and Gtpbp4 1 0.03 0.17 0.22
58 INT297965 MAPK14 Negative_regulation of GADD45A 1 0.05 1 0.21
59 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
60 INT95896 Npy Positive_regulation of Positive_regulation of Gtpbp4 1 0.12 0 0.2
61 INT221955 Binding of ELAVL1 and CDK5R1 1 0.01 0.93 0.19
62 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
63 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
64 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
65 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
66 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16
67 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
68 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
69 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
70 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
71 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
72 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
73 INT314867 Binding of Cdc7 and Cdkn2b 1 0.25 1.16 0.14
74 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
75 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
76 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
77 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
78 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
79 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
80 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
81 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13
82 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
83 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12
84 INT184522 Positive_regulation of Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.95 0.11
85 INT184521 Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.94 0.11
86 INT184520 Ptger2 Regulation of Ccnd1 1 0.00 0.94 0.11
87 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
88 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
89 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
90 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
91 INT292555 Binding of MAPK8 and GTPBP4 1 0.00 0.36 0.09
92 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
93 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
94 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
95 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
96 INT209706 Binding of GTPBP4 and MRGPRX1 1 0.01 0 0.08
97 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
98 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
99 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
100 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
101 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08
102 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08
103 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07
104 INT194723 GADD45A Regulation of Regulation of MAPK1 1 0.06 0 0.07
105 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
106 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
107 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
108 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
109 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
110 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
111 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
112 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
113 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
114 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
115 INT333851 Binding of Ccna1 and Mir17 1 0.04 0.52 0.05
116 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
117 INT194672 GADD45A Positive_regulation of Positive_regulation of MAPK1 1 0.14 0.06 0.05
118 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
119 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
120 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
121 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
122 INT194688 PAK1 Positive_regulation of GADD45A 1 0.11 0 0.05
123 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
124 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
125 INT333839 Binding of Ccna1 and Tpt1 1 0.07 0.48 0.04
126 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
127 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
128 INT316489 Stat3 Positive_regulation of Transcription of Ccnb1 1 0.02 1.27 0.04
129 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04
130 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
131 INT194726 Binding of GADD45A and MAP3K4 1 0.06 0 0.04
132 INT333844 Binding of Ccna1 and E2f2 1 0.00 0.48 0.04
133 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04
134 INT194741 IL18 Positive_regulation of Gene_expression of GADD45A 1 0.05 0 0.04
135 INT194679 IL12A Positive_regulation of GADD45A 1 0.04 0 0.04
136 INT194704 IL18 Positive_regulation of GADD45A 1 0.08 0 0.04
137 INT194736 Positive_regulation of MAPK1 Positive_regulation of Gene_expression of GADD45A 1 0.13 0 0.04
138 INT333848 Binding of Ccna1 and Rb1 1 0.04 0.48 0.04
139 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
140 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
141 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03
142 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
143 INT237206 LGALS4 Regulation of Gene_expression of Ccnb1 1 0.05 0 0.03
144 INT221962 UTS2R Regulation of Gene_expression of CDK5R1 1 0.09 0.43 0.03
145 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
146 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
147 INT221963 ELAVL1 Regulation of Gene_expression of CDK5R1 1 0.01 0.58 0.03
148 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
149 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
150 INT262150 Binding of Rare1 and Sfn 1 0.01 0.33 0.03
151 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
152 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
153 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
154 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0
155 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
156 INT258203 S1PR1 Positive_regulation of GTPBP4 1 0.00 0.29 0
157 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
158 INT319686 Positive_regulation of Sfn Positive_regulation of Nfe2l2 1 0.18 0 0
159 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
160 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
161 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
162 INT170858 Binding of IFI27 and Ccne2 1 0.01 0.17 0
163 INT182404 NFYA Regulation of CCNE2 1 0.00 0.09 0
164 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
165 INT182397 NFYA Regulation of CCNB1 1 0.00 0.09 0
166 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
167 INT269932 Pcna Negative_regulation of Cdkn2b 1 0.09 0.07 0
168 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
169 INT272514 Cdk4 Positive_regulation of Phosphorylation of Ccnd3 1 0.01 0 0
170 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
171 INT215686 Cdkn2b Negative_regulation of Cdkn1c 1 0.01 0 0
172 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
173 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
174 INT219416 CCNA2 Regulation of HNF4A 1 0.00 0.11 0
175 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
176 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
177 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0
178 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0
179 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
180 INT194743 GADD45A Positive_regulation of Negative_regulation of MAPK1 1 0.13 0.06 0
181 INT318222 GADD45A Regulation of FOXO3 1 0.16 0.52 0
182 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
183 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
184 INT269920 Positive_regulation of Binding of Ccnd1 and Qsox1 1 0.10 0 0
185 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
186 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
187 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
188 INT333843 Ccne1 Regulation of Regulation of Mir103-2 1 0.06 0 0
189 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
190 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
191 INT196434 Binding of Ccne2 and Cdc25a 1 0.01 0.48 0
192 INT269926 Cdkn2b Negative_regulation of Pcna 1 0.08 0.07 0
193 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
194 INT269925 Binding of Ccnd1 and Qsox1 1 0.07 0 0
195 INT258204 LPA Positive_regulation of GTPBP4 1 0.00 0.29 0
196 INT240685 Binding of DIRAS3 and KCNQ4 1 0.18 0.95 0
197 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
198 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
199 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
200 INT233274 Tpt1 Regulation of Cdkn1a 1 0.05 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9298 Positive_regulation of Gtpbp4 64 0.69 12.29 41.97
2 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
3 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
4 INT21421 Regulation of Gtpbp4 15 0.30 2.7 13.49
5 INT67915 Negative_regulation of Gtpbp4 18 0.33 6.31 10.17
6 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
7 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
8 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
9 INT68434 Gene_expression of Gtpbp4 15 0.54 5.5 7.91
10 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44
11 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
12 INT6341 Binding of Gtpbp4 11 0.44 1.54 7.3
13 INT77756 Positive_regulation of GTPBP4 16 0.11 2.6 7.29
14 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46
15 INT103723 Regulation of Positive_regulation of Gtpbp4 5 0.22 1.56 6.35
16 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
17 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
18 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
19 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
20 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
21 INT74203 Positive_regulation of Positive_regulation of Gtpbp4 6 0.50 0.33 4.13
22 INT167446 Regulation of CCNA2 2 0.39 2.01 3.49
23 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
24 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
25 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
26 INT192676 Binding of PTEN 14 0.46 10.58 3.06
27 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
28 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
29 INT237655 Binding of Sfn 1 0.42 3.62 2.55
30 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
31 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
32 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26
33 INT219458 Negative_regulation of CCNA2 9 0.38 1.23 2.21
34 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
35 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
36 INT177841 Gene_expression of CCNA2 2 0.50 0.64 1.97
37 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
38 INT201458 Negative_regulation of Gene_expression of CCNE2 3 0.07 1.71 1.96
39 INT68435 Regulation of Gene_expression of Gtpbp4 4 0.34 0.96 1.89
40 INT9297 Localization of Gtpbp4 4 0.17 0.88 1.89
41 INT306836 Negative_regulation of Gene_expression of CDC6 1 0.19 1.28 1.88
42 INT57618 Binding of GTPBP4 9 0.43 1.61 1.87
43 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77
44 INT96823 Positive_regulation of Positive_regulation of GTPBP4 3 0.05 0.41 1.67
45 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
46 INT241672 Positive_regulation of CCNA2 4 0.44 1.56 1.57
47 INT306844 Localization of CCNE2 6 0.21 3.81 1.52
48 INT306875 Localization of CDC6 1 0.34 1.51 1.52
49 INT241668 Negative_regulation of Transcription of CCNA2 1 0.27 0.44 1.5
50 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
51 INT201463 Negative_regulation of CCNE2 7 0.39 3.31 1.36
52 INT114969 Gene_expression of CDK5R1 3 0.75 11.24 1.33
53 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31
54 INT79099 Negative_regulation of Positive_regulation of Gtpbp4 4 0.20 0.06 1.31
55 INT219492 Negative_regulation of CDC6 2 0.20 1.74 1.31
56 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
57 INT201466 Positive_regulation of Gene_expression of CCNE2 13 0.20 8.62 1.26
58 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26
59 INT57619 Gene_expression of GTPBP4 3 0.04 0.22 1.2
60 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
61 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15
62 INT81440 Regulation of GTPBP4 3 0.02 0.09 1.1
63 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
64 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07
65 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
66 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
67 INT86798 Positive_regulation of Binding of Gtpbp4 1 0.29 0 1.01
68 INT306847 Positive_regulation of Gene_expression of CDC6 1 0.23 0.16 0.99
69 INT241665 Transcription of CCNA2 1 0.44 0.38 0.98
70 INT21109 Phosphorylation of Gtpbp4 2 0.22 0.28 0.97
71 INT184992 Positive_regulation of CDC6 2 0.28 0.7 0.96
72 INT201465 Positive_regulation of CCNE2 6 0.13 3.13 0.92
73 INT306851 Transcription of CCNE2 1 0.06 0.57 0.92
74 INT306882 Transcription of CDC6 1 0.24 0.57 0.92
75 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9
76 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86
77 INT113841 Gene_expression of CCNB1 11 0.75 3.46 0.86
78 INT146013 Negative_regulation of Gene_expression of Ccne1 4 0.21 1.19 0.85
79 INT146014 Gene_expression of Ccne1 5 0.54 1.31 0.84
80 INT146012 Negative_regulation of Ccne2 1 0.20 0.13 0.84
81 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
82 INT77663 Positive_regulation of CDK5R1 3 0.67 0.43 0.79
83 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
84 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
85 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
86 INT98784 Gene_expression of Ccnb1 11 0.59 4.53 0.75
87 INT224579 Gene_expression of Cdkn2d 6 0.41 4.23 0.68
88 INT103237 Regulation of Localization of Gtpbp4 2 0.03 0.19 0.64
89 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
90 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
91 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63
92 INT77662 Regulation of CDK5R1 2 0.60 1.93 0.63
93 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
94 INT221978 Regulation of Gene_expression of CDK5R1 1 0.59 5.08 0.61
95 INT58987 Positive_regulation of Ccne1 1 0.49 0 0.59
96 INT58988 Positive_regulation of Gene_expression of Ccne1 1 0.67 0 0.59
97 INT91896 Negative_regulation of Gene_expression of Gtpbp4 2 0.13 1.33 0.58
98 INT58989 Gene_expression of Ccne1 2 0.75 0.79 0.58
99 INT161322 Localization of PTEN 9 0.73 5.65 0.57
100 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
101 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
102 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
103 INT100191 Gene_expression of Cdkn2b 1 0.65 0.06 0.51
104 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
105 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
106 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
107 INT237651 Negative_regulation of Sfn 3 0.51 1.7 0.49
108 INT264100 Gene_expression of CCNT1 2 0.34 2.45 0.49
109 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47
110 INT241675 Negative_regulation of Gene_expression of CCNA2 1 0.27 0.22 0.43
111 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
112 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
113 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
114 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
115 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
116 INT160456 Positive_regulation of Localization of Gtpbp4 1 0.03 0.19 0.4
117 INT177858 Positive_regulation of Gene_expression of CCNA2 2 0.44 0.42 0.37
118 INT225223 Localization of Cdkn2b 2 0.62 1.29 0.37
119 INT241667 Positive_regulation of Regulation of CCNA2 1 0.32 0 0.35
120 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
121 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
122 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
123 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
124 INT237161 Regulation of Ccnb1 5 0.17 2.71 0.32
125 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
126 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
127 INT304298 Positive_regulation of CCNE1 2 0.46 2.95 0.31
128 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
129 INT196426 Gene_expression of Cdkn2b 6 0.67 4.29 0.29
130 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
131 INT188074 Gene_expression of GADD45A 12 0.65 5.11 0.28
132 INT237652 Positive_regulation of Sfn 3 0.49 1.17 0.27
133 INT203616 Positive_regulation of CDKN1C 2 0.60 12.62 0.27
134 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
135 INT123541 Regulation of Gene_expression of Cdkn2b 1 0.26 0.06 0.26
136 INT91549 Regulation of Binding of GTPBP4 1 0.05 0.09 0.26
137 INT184987 Regulation of CDC6 2 0.12 0.27 0.25
138 INT165096 Positive_regulation of Binding of GTPBP4 1 0.11 0 0.25
139 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
140 INT248401 Gene_expression of CDKN1C 21 0.67 14.52 0.23
141 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
142 INT264095 Negative_regulation of Gene_expression of Ccne2 1 0.02 0.34 0.22
143 INT170847 Gene_expression of Ccne2 6 0.58 2.98 0.21
144 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
145 INT98783 Negative_regulation of Gene_expression of Ccnb1 1 0.26 0.69 0.21
146 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
147 INT42569 Binding of Ccne1 1 0.21 0.38 0.19
148 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
149 INT248400 Regulation of CDKN1C 1 0.45 2.92 0.17
150 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
151 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
152 INT201464 Regulation of CCNE2 3 0.08 2.79 0.16
153 INT23890 Binding of CDK5R1 2 0.36 0.23 0.16
154 INT292259 Regulation of Gene_expression of CCNT1 1 0.27 1.27 0.15
155 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
156 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
157 INT248403 Positive_regulation of Gene_expression of CDKN1C 1 0.40 7.77 0.14
158 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
159 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
160 INT185019 Binding of CDC6 2 0.21 0.31 0.13
161 INT145248 Negative_regulation of Negative_regulation of Ccnd1 1 0.23 0.47 0.13
162 INT221969 Negative_regulation of CDK5R1 1 0.41 0.44 0.13
163 INT184998 Negative_regulation of Binding of CDC6 1 0.11 0.19 0.13
164 INT196428 Negative_regulation of Binding of Ccnd1 1 0.14 1.17 0.13
165 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
166 INT196427 Negative_regulation of Transcription of Ccnd1 1 0.14 1.17 0.12
167 INT169908 Localization of Ccnd1 7 0.57 2.68 0.11
168 INT311866 Gene_expression of CDK5R2 1 0.06 1.06 0.11
169 INT292237 Negative_regulation of Gene_expression of CCNT1 1 0.19 0.58 0.11
170 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
171 INT225189 Binding of CCNE2 5 0.10 2.27 0.1
172 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1
173 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
174 INT302244 Negative_regulation of CCNE1 1 0.01 1.03 0.1
175 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
176 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
177 INT306284 Binding of CCNB1 1 0.28 0.13 0.09
178 INT286183 Regulation of Blm 1 0.36 1.3 0.09
179 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
180 INT221976 Phosphorylation of CDK5R1 1 0.61 0.4 0.09
181 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
182 INT286184 Gene_expression of Blm 1 0.39 2.16 0.09
183 INT194803 Positive_regulation of Gene_expression of GADD45A 4 0.36 1.8 0.08
184 INT226414 Negative_regulation of Ccnb1 2 0.02 2.16 0.08
185 INT221965 Positive_regulation of Gene_expression of CDK5R1 1 0.67 0.29 0.08
186 INT127998 Negative_regulation of GTPBP4 1 0.03 0.17 0.08
187 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
188 INT221977 Transcription of CDK5R1 1 0.51 0.59 0.08
189 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07
190 INT194776 Positive_regulation of GADD45A 4 0.46 2.28 0.07
191 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07
192 INT185030 Binding of CDKN2B 3 0.35 2.6 0.07
193 INT201461 Regulation of Gene_expression of CCNE2 2 0.05 1.09 0.07
194 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
195 INT167441 Localization of CCNA2 1 0.54 0.39 0.07
196 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
197 INT131375 Negative_regulation of GADD45A 2 0.40 0.82 0.06
198 INT173183 Regulation of CCNE1 1 0.05 0.4 0.06
199 INT113842 Negative_regulation of CCNB1 1 0.40 0.53 0.06
200 INT333827 Localization of Ccna1 1 0.41 0.51 0.05
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