GO:0000083

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Name regulation of transcription involved in G1/S phase of mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:0000083
Unique Molecular Interactions 66
Total Molecular Interactions 85
Total Single Events 952
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of transcription involved in G1/S phase of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for regulation of transcription involved in G1/S phase of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT306823 Binding of E2F4 and GOPC 1 0.06 0.23 0.91
4 INT306831 Positive_regulation of Binding of E2F4 and NOLC1 1 0.10 0.46 0.85
5 INT306826 Binding of E2F4 and NOLC1 1 0.08 0.41 0.84
6 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
7 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
8 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
9 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
10 INT304280 CCNE1 Positive_regulation of IL6 1 0.00 1.93 0.31
11 INT119264 Binding of RB1 and PPM1E 1 0.00 0.46 0.17
12 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
13 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
14 INT221668 Sema3a Positive_regulation of NPAT 1 0.36 0.47 0.09
15 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08
16 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
17 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
18 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07
19 INT169962 Binding of Rb1 and E2f4 1 0.25 0.56 0.04
20 INT169960 Binding of Rbl2 and E2f4 1 0.27 1.06 0.04
21 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
22 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03
23 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
24 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
25 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
26 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
27 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0
28 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
29 INT303406 Binding of NPAT and Myo1f 1 0.06 0 0
30 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
31 INT334322 Binding of RB1 and TP53 1 0.34 2 0
32 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
33 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
34 INT273774 Binding of GPER and RB1 1 0.01 0.45 0
35 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
36 INT303405 Binding of NPAT and Jag1 1 0.39 0 0
37 INT322607 Binding of RRM2 and TF 1 0.02 0.09 0
38 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
39 INT303342 Binding of NPAT and TCAP 1 0.40 0 0
40 INT306825 Positive_regulation of Binding of E2F2 and RB1 1 0.04 0.05 0
41 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
42 INT333448 RB1 Positive_regulation of TFDP1 1 0.05 0 0
43 INT330696 Phosphorylation of RB1 Positive_regulation of Gene_expression of E2F2 1 0.01 1 0
44 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
45 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
46 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
47 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
48 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
49 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
50 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0
51 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
52 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
53 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
54 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
55 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0
56 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
57 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0
58 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
59 INT147144 E2F1 Positive_regulation of Transcription of TYMS 1 0.26 0 0
60 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of transcription involved in G1/S phase of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in regulation of transcription involved in G1/S phase of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
2 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46
3 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
4 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
5 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88
6 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
7 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
8 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
9 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
10 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
11 INT306869 Gene_expression of E2F4 1 0.58 1.1 2.11
12 INT306836 Negative_regulation of Gene_expression of CDC6 1 0.19 1.28 1.88
13 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
14 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
15 INT68952 Localization of PCNA 17 0.62 5.64 1.78
16 INT306853 Binding of E2F4 1 0.28 1.37 1.63
17 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
18 INT306875 Localization of CDC6 1 0.34 1.51 1.52
19 INT219492 Negative_regulation of CDC6 2 0.20 1.74 1.31
20 INT63905 Regulation of RB1 13 0.62 12.67 1.28
21 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
22 INT281849 Binding of RRM2 5 0.17 0.43 1.07
23 INT306847 Positive_regulation of Gene_expression of CDC6 1 0.23 0.16 0.99
24 INT184992 Positive_regulation of CDC6 2 0.28 0.7 0.96
25 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
26 INT306882 Transcription of CDC6 1 0.24 0.57 0.92
27 INT306888 Positive_regulation of Binding of E2F4 1 0.37 0.58 0.87
28 INT306840 Positive_regulation of Gene_expression of E2F4 1 0.37 0.58 0.82
29 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
30 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
31 INT306884 Negative_regulation of E2F4 1 0.44 0.61 0.62
32 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
33 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51
34 INT176264 Binding of PCNA 21 0.21 9.08 0.51
35 INT13717 Positive_regulation of TYMS 3 0.40 1.64 0.49
36 INT77338 Negative_regulation of RRM2 2 0.38 0 0.49
37 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
38 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
39 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
40 INT306864 Negative_regulation of Gene_expression of E2F4 1 0.32 0.28 0.41
41 INT194993 Binding of RB1 15 0.37 10.96 0.4
42 INT306859 Localization of E2F4 1 0.56 0.65 0.4
43 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
44 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
45 INT304298 Positive_regulation of CCNE1 2 0.46 2.95 0.31
46 INT129470 Regulation of RRM2 4 0.22 0.36 0.27
47 INT184987 Regulation of CDC6 2 0.12 0.27 0.25
48 INT237464 Positive_regulation of Negative_regulation of TYMS 2 0.20 0.53 0.23
49 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
50 INT221610 Gene_expression of NPAT 1 0.65 0.18 0.19
51 INT293677 Transcription of RB1 1 0.62 0.8 0.18
52 INT94168 Positive_regulation of Phosphorylation of RB1 12 0.60 6.6 0.15
53 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
54 INT274773 Gene_expression of RRM2 1 0.08 0.21 0.15
55 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
56 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
57 INT197627 Localization of RB1 3 0.69 4.16 0.13
58 INT185019 Binding of CDC6 2 0.21 0.31 0.13
59 INT314724 Regulation of Localization of RB1 1 0.15 1.25 0.13
60 INT184998 Negative_regulation of Binding of CDC6 1 0.11 0.19 0.13
61 INT279806 Regulation of TYMS 2 0.05 1 0.12
62 INT167436 Localization of CDK1 2 0.14 0.41 0.1
63 INT302244 Negative_regulation of CCNE1 1 0.01 1.03 0.1
64 INT186055 Binding of CDK1 3 0.35 1.43 0.09
65 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09
66 INT147148 Transcription of TYMS 2 0.30 0.5 0.06
67 INT237463 Regulation of Gene_expression of TYMS 1 0.12 0.51 0.06
68 INT173183 Regulation of CCNE1 1 0.05 0.4 0.06
69 INT237466 Regulation of Transcription of TYMS 1 0.26 0.5 0.06
70 INT288233 Localization of TYMS 2 0.22 2.17 0.04
71 INT288232 Binding of TYMS 2 0.11 2.77 0.04
72 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
73 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
74 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
75 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
76 INT302266 Negative_regulation of Phosphorylation of CCNE1 1 0.02 0.29 0.03
77 INT174197 Negative_regulation of Gene_expression of RB1 4 0.47 4.25 0
78 INT314725 Gene_expression of CCNE1 3 0.52 2.45 0
79 INT348463 Protein_catabolism of RB1 2 0.11 2.22 0
80 INT225170 Regulation of Phosphorylation of RB1 2 0.36 1.12 0
81 INT225167 Negative_regulation of Binding of RB1 2 0.34 1.25 0
82 INT247431 Positive_regulation of Negative_regulation of RB1 2 0.45 2.58 0
83 INT169956 Positive_regulation of Transcription of PCNA 2 0.10 0.09 0
84 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0
85 INT310442 Gene_expression of POLA1 1 0.30 0.97 0
86 INT326142 Positive_regulation of Gene_expression of TYMS 1 0.16 2.47 0
87 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
88 INT147145 Negative_regulation of Transcription of TYMS 1 0.15 0 0
89 INT293681 Positive_regulation of Positive_regulation of RB1 1 0.39 0.27 0
90 INT186225 Regulation of NPAT 1 0.05 0 0
91 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
92 INT169925 Localization of E2f4 1 0.55 0.08 0
93 INT293672 Positive_regulation of Transcription of RB1 1 0.45 0.4 0
94 INT169922 Binding of E2f4 1 0.25 0.08 0
95 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
96 INT273783 Regulation of Gene_expression of RB1 1 0.29 0.67 0
97 INT310440 Positive_regulation of POLA1 1 0.18 0.09 0
98 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
99 INT169938 Gene_expression of E2f4 1 0.46 0.07 0
100 INT310439 Regulation of POLA1 1 0.24 2.21 0
101 INT310443 Negative_regulation of POLA1 1 0.16 0.31 0
102 INT314716 Positive_regulation of Gene_expression of CCNE1 1 0.16 1.48 0
103 INT202676 Negative_regulation of NPAT 1 0.41 0 0
104 INT169915 Regulation of Gene_expression of E2f4 1 0.19 0 0
105 INT252988 Negative_regulation of Binding of PCNA 1 0.06 1.25 0
106 INT288825 Positive_regulation of Binding of PCNA 1 0.06 1.29 0
107 INT302253 Phosphorylation of CCNE1 1 0.03 0.29 0
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