GO:0000084

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Name S phase of mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:0000084
Unique Molecular Interactions 201
Total Molecular Interactions 284
Total Single Events 2547
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for S phase of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for S phase of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
4 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
5 INT116107 CDK4 Positive_regulation of Phosphorylation of EID1 1 0.01 0.32 0.86
6 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
7 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
8 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
9 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
10 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
11 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
12 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
13 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
14 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
15 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
16 INT58578 Binding of RPA1 and TACR1 1 0.01 0 0.48
17 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
18 INT7636 RFC1 Negative_regulation of Localization of Oxt 1 0.14 0 0.39
19 INT7634 RFC1 Negative_regulation of Localization of AVP 1 0.46 0 0.39
20 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
21 INT255555 Binding of Ptgds and Tfdp1 1 0.14 1.14 0.36
22 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
23 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
24 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
25 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
26 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
27 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
28 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
29 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
30 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25
31 INT322017 RPA1 Positive_regulation of IL1B 1 0.00 0 0.21
32 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
33 INT91862 RPA1 Negative_regulation of Transcription of ATG9B 1 0.03 0.46 0.19
34 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
35 INT119264 Binding of RB1 and PPM1E 1 0.00 0.46 0.17
36 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
37 INT180503 Binding of SARS and PSMD6 1 0.22 2.44 0.16
38 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
39 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
40 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
41 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
42 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
43 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
44 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
45 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
46 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
47 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
48 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
49 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08
50 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
51 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
52 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
53 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
54 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 0.04 0.42 0.08
55 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
56 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
57 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
58 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
59 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
60 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
61 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
62 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
63 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
64 INT308831 Binding of RFC1 and IGKV2D-29 1 0.02 0 0.06
65 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
66 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
67 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
68 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
69 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
70 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
71 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
72 INT207702 CCND1 Regulation of MSMB 1 0.22 0.69 0.04
73 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04
74 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04
75 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
76 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
77 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
78 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
79 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
80 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
81 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
82 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03
83 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
84 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
85 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
86 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
87 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03
88 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
89 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
90 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
91 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
92 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0
93 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
94 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
95 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
96 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
97 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
98 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
99 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
100 INT209454 Binding of PSMD1 and PSMD2 1 0.15 0 0
101 INT165318 Binding of PSMD1 and CHPT1 1 0.23 0.57 0
102 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
103 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
104 INT334322 Binding of RB1 and TP53 1 0.34 2 0
105 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
106 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
107 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
108 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
109 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
110 INT273774 Binding of GPER and RB1 1 0.01 0.45 0
111 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
112 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
113 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
114 INT276607 Binding of DBT and PSMD1 1 0.00 0.08 0
115 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
116 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
117 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
118 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
119 INT306825 Positive_regulation of Binding of E2F2 and RB1 1 0.04 0.05 0
120 INT209452 Binding of PSMD2 and PSMD3 1 0.07 0.2 0
121 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 0.07 0 0
122 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
123 INT333448 RB1 Positive_regulation of TFDP1 1 0.05 0 0
124 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
125 INT330696 Phosphorylation of RB1 Positive_regulation of Gene_expression of E2F2 1 0.01 1 0
126 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
127 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
128 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
129 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
130 INT219411 CCNF Regulation of SKP2 1 0.22 0.11 0
131 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
132 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
133 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
134 INT299698 Binding of CFB and PSMC2 1 0.00 0.14 0
135 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0
136 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
137 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
138 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
139 INT182935 KCNIP3 Regulation of CDKN1A 1 0.45 0.96 0
140 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
141 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
142 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
143 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
144 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
145 INT209453 Binding of PSMD1 and PSMD3 1 0.08 0.2 0
146 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
147 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
148 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
149 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0
150 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
151 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
152 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
153 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
154 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
155 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0
156 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
157 INT186051 IFI27 Regulation of Gene_expression of CCND1 1 0.30 0.66 0
158 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
159 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
160 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0
161 INT182917 Binding of VDR and Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.31 0
162 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
163 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
164 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
165 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
166 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0
167 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
168 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
169 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
170 INT224290 ESR1 Positive_regulation of CCND1 1 0.17 0.07 0
171 INT182931 VDR Positive_regulation of Gene_expression of CDKN1A 1 0.48 0.86 0
172 INT182911 KCNIP3 Positive_regulation of CDKN1A 1 0.51 0.35 0
173 INT299708 Binding of C3 and PSMC2 1 0.00 0.14 0
174 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0
175 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
176 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0
177 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0
178 INT145334 Binding of BCL9 and Positive_regulation of Transcription of CCND1 1 0.41 0 0
179 INT182915 Binding of CDKN1A and KCNIP3 1 0.35 0 0
180 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
181 INT219415 CCNE2 Regulation of SKP2 1 0.11 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for S phase of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in S phase of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
2 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
3 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
4 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
5 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
6 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
7 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46
8 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
9 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
10 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
11 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
12 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
13 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
14 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
15 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
16 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
17 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
18 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
19 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
20 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
21 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
22 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
23 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
24 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
25 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
26 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
27 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
28 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66
29 INT163359 Gene_expression of RFC1 9 0.65 3.34 2.64
30 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
31 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
32 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
33 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
34 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
35 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
36 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08
37 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
38 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
39 INT306836 Negative_regulation of Gene_expression of CDC6 1 0.19 1.28 1.88
40 INT68952 Localization of PCNA 17 0.62 5.64 1.78
41 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
42 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
43 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
44 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
45 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
46 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
47 INT116116 Phosphorylation of CDK4 3 0.56 2.18 1.56
48 INT306875 Localization of CDC6 1 0.34 1.51 1.52
49 INT58581 Binding of RPA1 8 0.44 1.68 1.44
50 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
51 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
52 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
53 INT219492 Negative_regulation of CDC6 2 0.20 1.74 1.31
54 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
55 INT63905 Regulation of RB1 13 0.62 12.67 1.28
56 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
57 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
58 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12
59 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
60 INT67638 Positive_regulation of PSMA5 1 0.21 1.15 1.05
61 INT147602 Negative_regulation of CDK4 8 0.35 4.6 1.04
62 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
63 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
64 INT155466 Negative_regulation of Tfdp1 1 0.38 1.35 1.01
65 INT13882 Binding of PSMB9 3 0.15 2.84 1
66 INT306847 Positive_regulation of Gene_expression of CDC6 1 0.23 0.16 0.99
67 INT184992 Positive_regulation of CDC6 2 0.28 0.7 0.96
68 INT78322 Positive_regulation of PSME1 2 0.44 1.8 0.95
69 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
70 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
71 INT306882 Transcription of CDC6 1 0.24 0.57 0.92
72 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
73 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87
74 INT252442 Binding of RFC1 3 0.05 0.3 0.84
75 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81
76 INT182077 Positive_regulation of RFC1 3 0.07 1.65 0.81
77 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
78 INT78323 Negative_regulation of PSME1 1 0.37 0.5 0.78
79 INT108590 Negative_regulation of Negative_regulation of PSMA5 1 0.57 0.92 0.75
80 INT251735 Binding of FEN1 1 0.17 1.13 0.74
81 INT40476 Negative_regulation of RFC1 5 0.18 2.85 0.72
82 INT306883 Negative_regulation of Phosphorylation of CDK4 1 0.17 1.06 0.71
83 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
84 INT108586 Positive_regulation of Negative_regulation of PSMA5 1 0.49 0.82 0.67
85 INT106608 Regulation of Gene_expression of SKP2 1 0.50 0.26 0.63
86 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62
87 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
88 INT252443 Regulation of RFC1 1 0.03 0.35 0.59
89 INT128498 Regulation of CCND1 17 0.39 12.51 0.58
90 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
91 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
92 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
93 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
94 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51
95 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51
96 INT176264 Binding of PCNA 21 0.21 9.08 0.51
97 INT144483 Localization of Tfdp1 3 0.68 2.48 0.49
98 INT146522 Negative_regulation of Positive_regulation of CCND1 3 0.30 2.04 0.48
99 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
100 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
101 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45
102 INT306885 Positive_regulation of SKP2 1 0.21 0.6 0.45
103 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
104 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
105 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
106 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41
107 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
108 INT78324 Regulation of PSME1 1 0.61 0.49 0.41
109 INT194993 Binding of RB1 15 0.37 10.96 0.4
110 INT203568 Regulation of SKP2 3 0.26 1.61 0.38
111 INT58580 Positive_regulation of Binding of RPA1 2 0.43 0 0.38
112 INT280560 Positive_regulation of Gene_expression of PSMB9 7 0.64 6.44 0.36
113 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
114 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
115 INT57019 Gene_expression of PSMB1 1 0.38 0 0.34
116 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
117 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
118 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
119 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
120 INT147981 Gene_expression of Tfdp1 2 0.58 0.28 0.32
121 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
122 INT282276 Binding of Tfdp1 1 0.16 1.16 0.31
123 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3
124 INT229244 Positive_regulation of Gene_expression of RFC1 1 0.09 0.07 0.3
125 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
126 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
127 INT186057 Binding of CCND1 8 0.31 5.92 0.26
128 INT184987 Regulation of CDC6 2 0.12 0.27 0.25
129 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
130 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24
131 INT131823 Negative_regulation of PSMB6 2 0.01 0.09 0.24
132 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
133 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
134 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
135 INT40477 Negative_regulation of Negative_regulation of RFC1 1 0.18 0.4 0.22
136 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
137 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21
138 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
139 INT165973 Phosphorylation of PSMA5 1 0.79 0.07 0.2
140 INT165972 Positive_regulation of Phosphorylation of PSMA5 1 0.49 0.07 0.2
141 INT280553 Regulation of PSMB9 2 0.57 1.46 0.19
142 INT209077 Positive_regulation of Negative_regulation of PSME3 1 0.37 0.13 0.19
143 INT293677 Transcription of RB1 1 0.62 0.8 0.18
144 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
145 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
146 INT57020 Transcription of PSMB1 1 0.26 0 0.16
147 INT91870 Negative_regulation of Gene_expression of RPA1 1 0.58 0.4 0.16
148 INT94168 Positive_regulation of Phosphorylation of RB1 12 0.60 6.6 0.15
149 INT90493 Negative_regulation of PSMB9 3 0.54 0.88 0.15
150 INT91871 Transcription of RPA1 1 0.69 0.38 0.15
151 INT91866 Positive_regulation of Gene_expression of RPA1 1 0.69 0.38 0.15
152 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
153 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
154 INT144486 Positive_regulation of Tfdp1 4 0.38 3.15 0.13
155 INT233867 Negative_regulation of SKP2 3 0.24 2.25 0.13
156 INT197627 Localization of RB1 3 0.69 4.16 0.13
157 INT185019 Binding of CDC6 2 0.21 0.31 0.13
158 INT314724 Regulation of Localization of RB1 1 0.15 1.25 0.13
159 INT184998 Negative_regulation of Binding of CDC6 1 0.11 0.19 0.13
160 INT201462 Binding of CDK2 12 0.39 5.2 0.12
161 INT15564 Regulation of PSMD2 1 0.00 0 0.12
162 INT165320 Protein_catabolism of PSMD1 1 0.61 1.37 0.11
163 INT165319 Regulation of Protein_catabolism of PSMD1 1 0.31 1.37 0.11
164 INT334958 Positive_regulation of Localization of PSMD1 1 0.10 0.87 0.1
165 INT226076 Regulation of RPA1 1 0.25 0.43 0.1
166 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
167 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
168 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09
169 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
170 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
171 INT194320 Localization of RPA1 2 0.06 0.17 0.09
172 INT302272 Localization of CDK2 2 0.30 1.09 0.09
173 INT280554 Negative_regulation of Positive_regulation of PSMB9 1 0.40 0.9 0.09
174 INT233872 Negative_regulation of Negative_regulation of SKP2 2 0.24 0.94 0.08
175 INT189116 Gene_expression of PSMB10 1 0.18 0.3 0.08
176 INT182074 Negative_regulation of Gene_expression of RFC1 1 0.03 0.76 0.08
177 INT285256 Positive_regulation of Negative_regulation of PSMD2 1 0.04 0 0.08
178 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
179 INT145375 Transcription of CCND1 7 0.52 3.86 0.07
180 INT185284 Binding of CDK4 7 0.25 4.79 0.07
181 INT337665 Positive_regulation of PSME3 1 0.45 2.51 0.07
182 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
183 INT173191 Regulation of CDK4 1 0.26 0.39 0.06
184 INT166204 Gene_expression of PSME1 3 0.32 1.94 0.05
185 INT176590 Positive_regulation of Transcription of CCND1 1 0.17 0.27 0.05
186 INT202765 Positive_regulation of PSMD3 1 0.12 0.51 0.05
187 INT339094 Gene_expression of Ezh2 1 0.78 67.79 0.05
188 INT263801 Localization of PSME1 2 0.07 1.72 0.04
189 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
190 INT337650 Positive_regulation of Positive_regulation of PSME3 1 0.32 1.33 0.04
191 INT337661 Positive_regulation of Positive_regulation of PSME1 1 0.05 1.31 0.04
192 INT337662 Localization of PSME3 1 0.52 1.26 0.04
193 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03
194 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
195 INT186663 Protein_catabolism of PSMB9 2 0.60 0.39 0.03
196 INT266166 Negative_regulation of RPA1 2 0.08 1.65 0.03
197 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
198 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
199 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
200 INT214219 Regulation of PSMD6 1 0.01 0.05 0.03
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