GO:0000096

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Name sulfur amino acid metabolic process
Categary Process
Go Slim No
Go Link GO:0000096
Unique Molecular Interactions 104
Total Molecular Interactions 137
Total Single Events 1333
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sulfur amino acid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for sulfur amino acid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
8 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
9 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
10 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
11 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
12 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
13 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
14 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
15 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
16 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 0.58 0.81 1.23
17 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
18 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
19 INT110236 Hk1 Regulation of CSAD 1 0.01 1.57 0.84
20 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
21 INT151252 CSAD Positive_regulation of Positive_regulation of Ltp 1 0.06 0.81 0.67
22 INT151251 CSAD Regulation of Positive_regulation of Ltp 1 0.04 0.82 0.65
23 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
24 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
25 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54
26 INT261498 CBS Positive_regulation of DSE 1 0.00 0 0.5
27 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
28 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
29 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
30 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
31 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41
32 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
33 INT50514 CSAD Regulation of Cebpz 1 0.02 0.48 0.38
34 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
35 INT261499 CBS Positive_regulation of CNR1 1 0.01 0.48 0.35
36 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
37 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
38 INT156898 Binding of cerebral blood flow and CSAD 1 0.00 0.45 0.33
39 INT156897 Binding of CSAD and Cebpz 1 0.13 0.45 0.33
40 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
41 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
42 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
43 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26
44 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
45 INT35014 IFNA1 Positive_regulation of ADI1 1 0.03 0.17 0.23
46 INT35013 IFNG Positive_regulation of ADI1 1 0.22 0.16 0.21
47 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
48 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
49 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
50 INT69949 Car2 Positive_regulation of MTAP 1 0.02 0.41 0.18
51 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
52 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
53 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
54 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
55 INT3751 Binding of GOT1 and PIK3C2A 1 0.08 0.68 0.12
56 INT101809 Gene_expression of NFE2L2 Positive_regulation of Gene_expression of GCLC 1 0.75 0 0.12
57 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12
58 INT101811 NFE2L2 Regulation of Gene_expression of GCLC 1 0.67 0.06 0.12
59 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
60 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
61 INT101807 Gene_expression of KEAP1 Negative_regulation of Positive_regulation of GCLC 1 0.46 0 0.08
62 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
63 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
64 INT11237 PAEP Positive_regulation of MRI1 1 0.07 0.46 0.07
65 INT193564 Binding of STMN1 and MRI1 1 0.07 0.06 0.07
66 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
67 INT245966 TCN1 Regulation of MTR 1 0.02 0.18 0.05
68 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
69 INT279907 Binding of GCLM and IRF8 1 0.22 0.82 0.05
70 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
71 INT245967 Negative_regulation of TCN1 Regulation of MTR 1 0.02 0.18 0.05
72 INT279902 Binding of GCLM and CARD8 1 0.28 0.82 0.05
73 INT279896 Binding of GCLM and STX6 1 0.24 0.82 0.05
74 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
75 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
76 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
77 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
78 INT164188 SLPI Negative_regulation of Localization of CNDP2 1 0.03 0 0
79 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
80 INT164181 NLRP2 Negative_regulation of Localization of CNDP2 1 0.05 0 0
81 INT259081 Binding of Hbb-ar and ENOPH1 1 0.00 1.36 0
82 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
83 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0
84 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
85 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
86 INT164184 NLRP2 Negative_regulation of CNDP2 1 0.05 0 0
87 INT328906 Binding of LMNA and CSAD 1 0.11 0 0
88 INT252805 ENOPH1 Positive_regulation of Gene_expression of ESR1 1 0.00 2.46 0
89 INT299373 Binding of DBT and ENOPH1 1 0.00 0.24 0
90 INT284094 VWF Negative_regulation of CNDP2 1 0.14 1.16 0
91 INT351614 APRT Positive_regulation of MTAP 1 0.00 0.22 0
92 INT164187 SLPI Negative_regulation of CNDP2 1 0.03 0 0
93 INT351615 MTAP Positive_regulation of Gene_expression of OR4G6P 1 0.00 0.22 0
94 INT252792 ENOPH1 Positive_regulation of Gene_expression of DDIT3 1 0.03 2.42 0
95 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sulfur amino acid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in sulfur amino acid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
4 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
5 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
6 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
7 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
8 INT180497 Binding of MRI1 45 0.42 28.35 14.77
9 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
10 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
11 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
12 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
13 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
14 INT156827 Localization of MRI1 25 0.65 16.06 8.33
15 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07
16 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47
17 INT261511 Localization of CBS 1 0.02 5.06 7.27
18 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
19 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
20 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
21 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
22 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8
23 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
24 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
25 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
26 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
27 INT35009 Binding of CSAD 12 0.41 10.74 3.21
28 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
29 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
30 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
31 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91
32 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84
33 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
34 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53
35 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35
36 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
37 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
38 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
39 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
40 INT66082 Regulation of CSAD 5 0.27 4.72 1.99
41 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
42 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
43 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
44 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
45 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
46 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
47 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
48 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26
49 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
50 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
51 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
52 INT16669 Gene_expression of CNDP2 8 0.26 1.7 1.12
53 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08
54 INT157361 Localization of MTR 2 0.31 1.4 1.05
55 INT3529 Regulation of GOT1 6 0.52 2.4 1.01
56 INT93244 Localization of CSAD 2 0.60 1.59 1
57 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97
58 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
59 INT10373 Gene_expression of ADI1 8 0.25 5.97 0.92
60 INT261514 Positive_regulation of Localization of CBS 1 0.01 0.67 0.91
61 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
62 INT202190 Gene_expression of CBS 7 0.32 4.19 0.88
63 INT11028 Binding of CNDP2 6 0.24 3.47 0.87
64 INT265569 Negative_regulation of Binding of MRI1 1 0.16 0.79 0.87
65 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
66 INT162818 Transcription of CSAD 1 0.60 1.15 0.78
67 INT12099 Localization of GOT1 2 0.35 2.54 0.72
68 INT24584 Positive_regulation of MTR 4 0.44 0.07 0.7
69 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
70 INT4344 Positive_regulation of MTAP 2 0.19 1.83 0.67
71 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
72 INT261508 Negative_regulation of CBS 1 0.01 0.39 0.61
73 INT96618 Positive_regulation of Positive_regulation of CSAD 1 0.39 1.15 0.59
74 INT215180 Positive_regulation of CNDP2 1 0.15 0.69 0.58
75 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
76 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
77 INT41989 Regulation of NFS1 1 0.01 0.75 0.53
78 INT78090 Gene_expression of MAT1A 2 0.65 0.93 0.52
79 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5
80 INT327120 Positive_regulation of Positive_regulation of MRI1 1 0.05 0 0.5
81 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48
82 INT186542 Regulation of MTAP 3 0.06 1.66 0.46
83 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45
84 INT354256 Negative_regulation of Gene_expression of CSAD 1 0.08 0.75 0.45
85 INT245316 Negative_regulation of ADI1 1 0.01 0.77 0.45
86 INT245315 Negative_regulation of Gene_expression of ADI1 1 0.01 0.77 0.45
87 INT50548 Binding of ENOPH1 8 0.35 2.64 0.43
88 INT47387 Negative_regulation of Positive_regulation of GOT1 2 0.26 1.04 0.43
89 INT24583 Protein_catabolism of MTR 1 0.57 0 0.42
90 INT261515 Positive_regulation of CBS 2 0.47 2.63 0.41
91 INT41988 Positive_regulation of NFS1 2 0.02 1.28 0.4
92 INT342465 Protein_catabolism of MRI1 1 0.04 0.79 0.38
93 INT338169 Binding of MTAP 1 0.36 0.76 0.37
94 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
95 INT259859 Regulation of CBS 1 0.01 1.26 0.34
96 INT26194 Regulation of MTR 1 0.19 1.1 0.33
97 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
98 INT59998 Regulation of CNDP2 2 0.21 0.05 0.31
99 INT225138 Positive_regulation of ENOPH1 4 0.15 2 0.28
100 INT225139 Positive_regulation of Binding of ENOPH1 1 0.12 0.7 0.28
101 INT259857 Regulation of Gene_expression of CBS 1 0.01 1.07 0.27
102 INT264998 Regulation of Binding of MRI1 1 0.31 1.34 0.27
103 INT101822 Negative_regulation of Positive_regulation of GCLC 1 0.57 0.07 0.23
104 INT266791 Positive_regulation of Gene_expression of ENOPH1 1 0.04 0.85 0.22
105 INT35015 Positive_regulation of ADI1 2 0.15 2.75 0.21
106 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21
107 INT55871 Binding of GOT1 1 0.04 2.22 0.19
108 INT59996 Localization of CNDP2 3 0.63 0.17 0.16
109 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16
110 INT322764 Regulation of GCLM 2 0.27 0.85 0.15
111 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15
112 INT50551 Negative_regulation of Binding of ENOPH1 1 0.42 1.05 0.15
113 INT48515 Regulation of Gene_expression of CNDP2 1 0.16 0.09 0.15
114 INT55773 Binding of MTR 2 0.30 0.74 0.14
115 INT259858 Protein_catabolism of CBS 1 0.03 1.46 0.14
116 INT197565 Gene_expression of GCLM 3 0.25 1.47 0.13
117 INT10372 Binding of ADI1 3 0.10 1.67 0.12
118 INT259060 Negative_regulation of ENOPH1 2 0.04 2.64 0.12
119 INT342900 Negative_regulation of Regulation of GOT1 1 0.04 0.42 0.12
120 INT50552 Transcription of ENOPH1 2 0.67 0.45 0.1
121 INT351822 Transcription of GCLM 1 0.27 0.66 0.1
122 INT50549 Localization of ENOPH1 2 0.64 0.45 0.09
123 INT299895 Binding of MAT1A 1 0.18 0.36 0.09
124 INT186543 Gene_expression of MTAP 1 0.11 0.48 0.08
125 INT351827 Negative_regulation of Gene_expression of GCLM 1 0.16 0.69 0.08
126 INT315554 Localization of NFS1 1 0.43 0.28 0.07
127 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
128 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
129 INT55772 Negative_regulation of Negative_regulation of MTR 1 0.41 0 0.07
130 INT200068 Phosphorylation of ENOPH1 1 0.17 0.11 0.06
131 INT137310 Positive_regulation of GCLM 1 0.49 0.4 0.05
132 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
133 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
134 INT197485 Regulation of Positive_regulation of GOT1 1 0.01 0.44 0.04
135 INT197486 Positive_regulation of Regulation of GOT1 1 0.01 0.44 0.04
136 INT175217 Regulation of ENOPH1 5 0.06 0.44 0
137 INT186262 Transcription of GCLC 3 0.23 1.19 0
138 INT234117 Positive_regulation of Binding of MRI1 2 0.44 0.19 0
139 INT234406 Localization of ADI1 2 0.06 4.52 0
140 INT315583 Positive_regulation of Binding of NFS1 1 0.25 0 0
141 INT299896 Positive_regulation of MAT1A 1 0.23 0.4 0
142 INT234401 Positive_regulation of Positive_regulation of ADI1 1 0.03 1.46 0
143 INT313321 Negative_regulation of Transcription of GCLC 1 0.15 0 0
144 INT315571 Binding of NFS1 1 0.19 0 0
145 INT47058 Positive_regulation of Negative_regulation of MTR 1 0.41 0 0
146 INT68931 Negative_regulation of Localization of ENOPH1 1 0.04 0 0
147 INT47059 Positive_regulation of Positive_regulation of MTR 1 0.44 0 0
148 INT246068 Regulation of GCLC 1 0.24 0.11 0
149 INT312375 Transcription of CNDP2 1 0.18 0.81 0
150 INT328909 Regulation of Gene_expression of CSAD 1 0.16 0 0
151 INT241848 Protein_catabolism of CNDP2 1 0.02 0.81 0
152 INT234429 Positive_regulation of Localization of ADI1 1 0.03 1.92 0
153 INT315573 Negative_regulation of Gene_expression of NFS1 1 0.24 0.74 0
154 INT315619 Regulation of Gene_expression of NFS1 1 0.26 0.74 0
155 INT315612 Gene_expression of NFS1 1 0.39 1.68 0
156 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
157 INT241849 Positive_regulation of Protein_catabolism of CNDP2 1 0.01 0.82 0
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