GO:0000151

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Name ubiquitin ligase complex
Categary Component
Go Slim No
Go Link GO:0000151
Unique Molecular Interactions 103
Total Molecular Interactions 151
Total Single Events 738
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ubiquitin ligase complex. They are ordered first by their pain relevance and then by number of times they were reported for ubiquitin ligase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
2 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
3 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
4 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
5 INT159125 Binding of OPRM1 and SUGT1 1 0.03 0.31 0.57
6 INT251730 Binding of CD70 and SUGT1 1 0.01 0.85 0.49
7 INT231713 Binding of SUGT1 and GPR174 1 0.00 0.82 0.47
8 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
9 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
10 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
11 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
12 INT341794 Binding of SUGT1 and CEP68 1 0.00 1.1 0.33
13 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
14 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
15 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
16 INT261976 Binding of PDCD1 and SUGT1 1 0.00 1.3 0.25
17 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
18 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
19 INT250553 Binding of RS1 and SUGT1 3 0.00 3.36 0.22
20 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22
21 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
22 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
23 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
24 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
25 INT178336 Binding of SUGT1 and Chdh 1 0.00 0.98 0.17
26 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
27 INT341813 Binding of SUGT1 and Aia1 1 0.00 0.48 0.16
28 INT118257 Binding of ENPP1 and SUGT1 1 0.00 0.87 0.16
29 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
30 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
31 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
32 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
33 INT298829 Binding of LCT and SUGT1 1 0.00 0.39 0.11
34 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
35 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
36 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
37 INT2993 Binding of HLA-B and SUGT1 1 0.00 0.6 0.1
38 INT168827 Binding of TRPC4AP and UBR1 1 0.00 0.34 0.1
39 INT350011 Binding of BMI1 and IL6 1 0.01 0.58 0.1
40 INT267156 Binding of VDR and SUGT1 1 0.04 3.4 0.09
41 INT316127 IL10 Regulation of UBR1 1 0.00 1.06 0.08
42 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
43 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
44 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
45 INT260565 T2dm2 Regulation of SUGT1 1 0.00 1.43 0.05
46 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
47 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
48 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05
49 INT267155 Binding of INS and SUGT1 1 0.02 0.81 0.04
50 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
51 INT184134 Binding of Cish and Rbx1 1 0.10 0 0.03
52 INT239340 Cand1 Positive_regulation of RCT 1 0.11 1.26 0.03
53 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
54 INT289626 Binding of SNRNP70 and SUGT1 3 0.03 2.49 0
55 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
56 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
57 INT247846 Positive_regulation of Narfl Positive_regulation of Positive_regulation of Ube4a 1 0.00 0.82 0
58 INT265848 Binding of HSD11B1 and Cand1 1 0.40 0.85 0
59 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
60 INT275123 Binding of HLA-E and SUGT1 1 0.00 0.93 0
61 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
62 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0
63 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
64 INT290028 Binding of SUGT1 and CHDH 1 0.00 0.88 0
65 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0
66 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0
67 INT245727 Binding of SUGT1 and DISC1 1 0.00 1.57 0
68 INT232595 Binding of BRCA1 and HEPACAM 1 0.02 0.89 0
69 INT333033 Binding of Itch and Laptm5 1 0.01 0 0
70 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0
71 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 0.09 0 0
72 INT339044 Binding of PITX2 and SUGT1 1 0.00 2.25 0
73 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
74 INT356377 Dmd Positive_regulation of Negative_regulation of Mib2 1 0.03 0.51 0
75 INT247850 Positive_regulation of Narfl Regulation of Ube4a 1 0.00 1.86 0
76 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
77 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
78 INT189684 RNF2 Regulation of TERT 1 0.02 0.46 0
79 INT314689 Binding of KITLG and UBR1 1 0.00 0.71 0
80 INT243628 Binding of Nfatc2 and Stub1 1 0.06 0 0
81 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0
82 INT339046 Binding of RENBP and SUGT1 1 0.00 0.38 0
83 INT200488 Binding of ACE and SUGT1 1 0.01 0.28 0
84 INT333031 Binding of Itch and Mul1 1 0.02 0 0
85 INT332907 Binding of LPL and SUGT1 1 0.00 1.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ubiquitin ligase complex. They are ordered first by their pain relevance and then by number of times they were reported in ubiquitin ligase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3002 Binding of SUGT1 62 0.24 55.9 14.91
2 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23
3 INT165228 Binding of BMI1 13 0.47 25.36 7.97
4 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43
5 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54
6 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
7 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11
8 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
9 INT171251 Regulation of BMI1 8 0.20 10.46 2.01
10 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
11 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4
12 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
13 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3
14 INT207183 Binding of Bmi1 1 0.01 16.24 1.14
15 INT128412 Positive_regulation of Cand1 5 0.67 3.58 1.1
16 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
17 INT16024 Regulation of Cand1 5 0.60 2.74 1.04
18 INT217683 Localization of BMI1 7 0.68 6.28 0.87
19 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82
20 INT159126 Localization of SUGT1 3 0.06 1.76 0.81
21 INT161471 Gene_expression of Bmi1 9 0.76 11.47 0.72
22 INT99673 Localization of Cand1 1 0.73 0.15 0.62
23 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
24 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
25 INT89258 Localization of STUB1 3 0.14 0.67 0.49
26 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
27 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41
28 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
29 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
30 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
31 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
32 INT287838 Phosphorylation of Cand1 1 0.80 0.64 0.29
33 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
34 INT161464 Regulation of Gene_expression of Bmi1 1 0.44 3.01 0.26
35 INT203471 Localization of Stub1 1 0.23 0.5 0.21
36 INT168693 Negative_regulation of Binding of Nedd4 1 0.31 0.29 0.21
37 INT168696 Positive_regulation of Binding of Nedd4 1 0.34 0.29 0.21
38 INT161469 Regulation of Bmi1 1 0.61 2.41 0.19
39 INT34862 Gene_expression of UBE4B 7 0.50 4.65 0.18
40 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
41 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
42 INT323897 Positive_regulation of Gene_expression of BMI1 2 0.22 3.8 0.17
43 INT187405 Gene_expression of Cand1 8 0.65 7.25 0.16
44 INT154710 Gene_expression of UBR1 3 0.47 1.64 0.15
45 INT168841 Protein_catabolism of UBR1 2 0.03 0.42 0.14
46 INT161470 Regulation of Negative_regulation of Bmi1 1 0.27 1.49 0.13
47 INT161473 Negative_regulation of Bmi1 1 0.42 1.49 0.13
48 INT172815 Gene_expression of Cand1 4 0.65 1.86 0.12
49 INT267163 Positive_regulation of Gene_expression of SUGT1 1 0.06 1.48 0.09
50 INT308642 Localization of UBE4B 1 0.06 0.32 0.09
51 INT184167 Binding of STUB1 5 0.07 0.72 0.08
52 INT243617 Binding of Stub1 3 0.09 0.16 0.08
53 INT239272 Positive_regulation of Gene_expression of Cand1 3 0.49 4.22 0.08
54 INT151835 Positive_regulation of UBE4B 1 0.48 0.68 0.08
55 INT287849 Positive_regulation of Phosphorylation of Cand1 1 0.49 0.07 0.08
56 INT247882 Positive_regulation of Ube4a 4 0.01 2.17 0.07
57 INT267169 Positive_regulation of Binding of SUGT1 1 0.06 2.22 0.07
58 INT11531 Binding of UBR1 1 0.01 0.07 0.07
59 INT235489 Positive_regulation of Cand1 2 0.49 2.19 0.06
60 INT161472 Positive_regulation of Gene_expression of Bmi1 1 0.68 1.43 0.06
61 INT304935 Transcription of Bmi1 1 0.08 0.65 0.05
62 INT239299 Positive_regulation of Negative_regulation of Cand1 1 0.67 1.06 0.04
63 INT210910 Positive_regulation of Localization of SUGT1 1 0.03 1.58 0.04
64 INT239305 Negative_regulation of Cand1 1 0.57 4.98 0.04
65 INT172814 Localization of Cand1 2 0.73 0.96 0.03
66 INT287857 Binding of Cand1 2 0.47 0.13 0.03
67 INT344009 Negative_regulation of Localization of BRCA1 1 0.30 0.18 0.03
68 INT356374 Gene_expression of Mib2 1 0.07 2.53 0.03
69 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
70 INT247881 Regulation of Ube4a 1 0.00 3.69 0.03
71 INT178332 Regulation of SUGT1 4 0.05 3.88 0
72 INT286085 Binding of Cand1 3 0.36 1.25 0
73 INT259116 Transcription of BRCA1 3 0.44 3.77 0
74 INT186224 Binding of UBE4B 3 0.22 0.32 0
75 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
76 INT196230 Regulation of STUB1 2 0.05 0.8 0
77 INT267272 Transcription of BMI1 2 0.48 1.35 0
78 INT187404 Negative_regulation of Gene_expression of Cand1 1 0.41 0.14 0
79 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
80 INT325783 Positive_regulation of UBR1 1 0.01 0.05 0
81 INT303351 Binding of Rbx1 1 0.18 0 0
82 INT187660 Regulation of Gene_expression of Cand1 1 0.44 0.45 0
83 INT119064 Regulation of Gene_expression of BRCA1 1 0.53 0.05 0
84 INT247858 Protein_catabolism of Ube4a 1 0.01 0.52 0
85 INT325798 Regulation of UBR1 1 0.00 0 0
86 INT356367 Negative_regulation of Mib2 1 0.04 0.5 0
87 INT298220 Negative_regulation of Negative_regulation of SUGT1 1 0.01 0.94 0
88 INT342089 Regulation of Gene_expression of Stub1 1 0.02 0.16 0
89 INT333019 Binding of Itch 1 0.13 0 0
90 INT333021 Negative_regulation of Positive_regulation of Itch 1 0.14 0 0
91 INT187406 Negative_regulation of Regulation of Cand1 1 0.42 0.14 0
92 INT221271 Negative_regulation of Binding of BRCA1 1 0.28 0.93 0
93 INT250156 Negative_regulation of Gene_expression of UBE4B 1 0.29 0.43 0
94 INT356369 Negative_regulation of Gene_expression of Mib2 1 0.05 0.81 0
95 INT313091 Negative_regulation of Stub1 1 0.07 0.25 0
96 INT247875 Gene_expression of Ube4a 1 0.01 0.94 0
97 INT334189 Regulation of Binding of BRCA1 1 0.13 0.8 0
98 INT333024 Positive_regulation of Itch 1 0.17 0 0
99 INT217687 Negative_regulation of Positive_regulation of BMI1 1 0.01 0.69 0
100 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0
101 INT247861 Negative_regulation of Ube4a 1 0.00 2.02 0
102 INT267271 Regulation of Gene_expression of BMI1 1 0.25 0.7 0
103 INT288898 Negative_regulation of Cand1 1 0.42 0.39 0
104 INT217690 Negative_regulation of Negative_regulation of BMI1 1 0.01 0.76 0
105 INT187409 Regulation of Cand1 1 0.26 0.13 0
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