GO:0000155

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Name two-component sensor activity
Categary Function
Go Slim No
Go Link GO:0000155
Unique Molecular Interactions 21
Total Molecular Interactions 24
Total Single Events 310
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for two-component sensor activity. They are ordered first by their pain relevance and then by number of times they were reported for two-component sensor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
2 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24
3 INT210551 Binding of KCNH2 and KCNE2 1 0.08 0 0.19
4 INT326605 Binding of HTR1A and KCNH2 1 0.00 0.45 0.14
5 INT280617 Fig4 Regulation of Pdk4 1 0.09 0 0.13
6 INT352943 Pik3cb Positive_regulation of Pdk1 1 0.09 0.21 0.06
7 INT321297 Positive_regulation of Binding of Akt1 and Pdk1 1 0.15 0.13 0.03
8 INT321291 Binding of Akt1 and Pdk1 1 0.11 0.13 0.03
9 INT291103 FFAR1 Regulation of Gene_expression of PDK4 1 0.03 0 0
10 INT291106 INS Regulation of Gene_expression of PDK4 1 0.14 0 0
11 INT291098 PYGM Positive_regulation of PDK4 1 0.02 0 0
12 INT291112 PYGM Positive_regulation of Gene_expression of PDK4 1 0.02 0 0
13 INT353872 Binding of KCNH1 and KCNH2 1 0.25 0.98 0
14 INT291104 PYGM Regulation of Gene_expression of PDK4 1 0.01 0 0
15 INT291108 AGL Regulation of Gene_expression of PDK4 1 0.01 0 0
16 INT291110 PYGM Positive_regulation of Transcription of PDK4 1 0.02 0 0
17 INT297856 Pdk4 Positive_regulation of Positive_regulation of Gopc 1 0.07 0.1 0
18 INT353871 Negative_regulation of Binding of KCNH1 and KCNH2 1 0.30 0.98 0
19 INT297849 Pdk4 Positive_regulation of Positive_regulation of Snord116 1 0.50 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for two-component sensor activity. They are ordered first by their pain relevance and then by number of times they were reported in two-component sensor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85
2 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14
3 INT144264 Gene_expression of KCNH1 6 0.65 17.69 2.83
4 INT100743 Regulation of KCNH2 6 0.54 2.37 2.61
5 INT86602 Binding of KCNH2 14 0.36 4.65 2.58
6 INT276172 Negative_regulation of Gene_expression of Pdk1 1 0.30 0.62 2.04
7 INT276200 Gene_expression of Pdk1 1 0.48 0.62 1.99
8 INT100742 Regulation of Gene_expression of KCNH2 1 0.62 0.57 1.83
9 INT276182 Phosphorylation of Pdk1 1 0.59 1.04 1.5
10 INT189574 Positive_regulation of PDK4 9 0.66 3.11 0.55
11 INT321314 Positive_regulation of Pdk1 3 0.22 0.74 0.55
12 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52
13 INT309564 Positive_regulation of KCNH1 1 0.14 0.13 0.41
14 INT280680 Gene_expression of Pdk4 1 0.68 1.53 0.4
15 INT280660 Positive_regulation of Pdk4 1 0.61 0 0.31
16 INT353887 Positive_regulation of Gene_expression of KCNH1 1 0.41 1.93 0.3
17 INT353888 Negative_regulation of Gene_expression of KCNH1 1 0.48 1.36 0.29
18 INT280686 Binding of Pdk4 1 0.33 0.29 0.29
19 INT280630 Regulation of Pdk4 1 0.54 0.35 0.25
20 INT210568 Positive_regulation of Localization of KCNH2 1 0.38 0 0.21
21 INT210570 Localization of KCNH2 2 0.63 0.8 0.2
22 INT291123 Regulation of PDK4 4 0.43 0.3 0.18
23 INT353879 Binding of KCNH1 1 0.30 1.56 0.16
24 INT147341 Negative_regulation of Binding of KCNH2 1 0.39 0.59 0.15
25 INT150109 Gene_expression of Pdk4 2 0.53 3.79 0.12
26 INT150105 Positive_regulation of Gene_expression of Pdk4 2 0.41 2.96 0.12
27 INT189569 Transcription of PDK4 2 0.68 0.52 0.12
28 INT189565 Positive_regulation of Transcription of PDK4 2 0.48 0.52 0.12
29 INT171668 Positive_regulation of Positive_regulation of KCNH2 1 0.08 0.46 0.11
30 INT93128 Regulation of Negative_regulation of KCNH2 1 0.31 0 0.07
31 INT152819 Negative_regulation of Pdk1 1 0.02 0.25 0.06
32 INT276206 Negative_regulation of Phosphorylation of Pdk1 1 0.31 0.31 0.06
33 INT198670 Negative_regulation of Pdk4 1 0.00 1.49 0.04
34 INT352937 Regulation of Pdk1 1 0.10 0.07 0.04
35 INT291150 Gene_expression of PDK4 25 0.74 0.34 0.03
36 INT210569 Negative_regulation of Gene_expression of KCNH2 2 0.41 0 0.03
37 INT280639 Negative_regulation of Gene_expression of Pdk4 1 0.37 0.3 0.03
38 INT353882 Regulation of KCNH1 1 0.37 1.04 0.03
39 INT335078 Phosphorylation of Pdk4 1 0.27 0.22 0.03
40 INT297780 Positive_regulation of Pdk4 5 0.61 2.39 0
41 INT291137 Regulation of Negative_regulation of PDK4 1 0.43 0 0
42 INT291116 Negative_regulation of PDK4 1 0.56 0.07 0
43 INT291133 Regulation of Gene_expression of PDK4 1 0.59 0 0
44 INT291153 Positive_regulation of Gene_expression of PDK4 1 0.48 0.06 0
45 INT291115 Positive_regulation of Regulation of PDK4 1 0.48 0 0
46 INT353886 Localization of KCNH1 1 0.61 0.8 0
47 INT353884 Negative_regulation of Localization of KCNH1 1 0.35 0.8 0
48 INT353880 Negative_regulation of Localization of KCNH2 1 0.36 0.8 0
49 INT142323 Negative_regulation of Negative_regulation of KCNH2 1 0.51 0 0
50 INT297817 Negative_regulation of Pdk4 1 0.38 0.99 0
51 INT335116 Regulation of Positive_regulation of PDK4 1 0.02 0.23 0
52 INT280652 Localization of Pdk4 1 0.65 0 0
53 INT297835 Regulation of Pdk4 1 0.40 0.57 0
54 INT339760 Positive_regulation of Positive_regulation of PDK4 1 0.31 0.39 0
55 INT291121 Negative_regulation of Gene_expression of PDK4 1 0.56 0.05 0
56 INT353881 Negative_regulation of KCNH1 1 0.35 0.89 0
57 INT353885 Positive_regulation of Gene_expression of KCNH2 1 0.42 1.28 0
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