GO:0000159

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Name protein phosphatase type 2A complex
Categary Component
Go Slim No
Go Link GO:0000159
Unique Molecular Interactions 85
Total Molecular Interactions 118
Total Single Events 483
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein phosphatase type 2A complex. They are ordered first by their pain relevance and then by number of times they were reported for protein phosphatase type 2A complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
2 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
3 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
4 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
5 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4
6 INT196828 Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.4
7 INT266553 Ppp2r1a Positive_regulation of Fig4 1 0.00 0 0.38
8 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
9 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
10 INT235872 Phosphorylation of Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.31
11 INT235886 Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.3
12 INT196825 Prkaca Positive_regulation of Phosphorylation of Ppp2ca 1 0.20 0 0.29
13 INT196831 Positive_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.29
14 INT196814 Negative_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.17 0 0.29
15 INT313446 Syp Regulation of Ppp2ca 1 0.58 0.62 0.26
16 INT90280 Binding of Ppp1cc and Ppp2ca 1 0.34 0.22 0.22
17 INT313449 Siglec1 Regulation of Ppp2ca 1 0.03 0.61 0.17
18 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
19 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
20 INT130922 HMHA1 Positive_regulation of Protein_catabolism of CYCS 1 0.06 1.39 0.14
21 INT130917 HMHA1 Positive_regulation of CYCS 1 0.06 1.39 0.14
22 INT196827 Phosphorylation of Prkaca Positive_regulation of Ppp2ca 1 0.18 0 0.11
23 INT196819 Prkaca Positive_regulation of Binding of Ppp2ca 1 0.20 0 0.11
24 INT313430 Syp Positive_regulation of Ppp2ca 1 0.66 0.08 0.09
25 INT313447 Ppp2ca Regulation of Phosphorylation of Syp 1 0.43 0 0.08
26 INT313469 Ppp2ca Regulation of Phosphorylation of Siglec1 1 0.06 0 0.08
27 INT196810 Binding of Prkaca and Ppp2ca 1 0.14 0 0.07
28 INT113218 TNFRSF25 Positive_regulation of Localization of CYCS 1 0.18 0.74 0.07
29 INT118260 Binding of TNF and CYCS 1 0.40 2.01 0.07
30 INT313463 Ppp2ca Regulation of Syp 1 0.43 0.6 0.06
31 INT300449 VEGFA Positive_regulation of Protein_catabolism of Ppp2r2b 1 0.00 1.51 0.05
32 INT252801 PPP2R4 Regulation of Positive_regulation of CREB1 1 0.01 2.71 0.04
33 INT252780 Positive_regulation of CREB1 Positive_regulation of PPP2R4 1 0.01 2.71 0.04
34 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
35 INT313462 Syp Positive_regulation of Binding of Ppp2ca 1 0.47 0 0.04
36 INT341237 ROS1 Negative_regulation of Ppp2r1a 1 0.01 0.31 0.04
37 INT313464 Negative_regulation of Ppp2ca Positive_regulation of Phosphorylation of Mapk1 1 0.09 0 0.03
38 INT313445 53T Regulation of Ppp2ca 1 0.00 0 0.03
39 INT239466 Ppp2r1a Regulation of Phosphorylation of Akt1 1 0.01 0 0.03
40 INT351167 CAV1 Negative_regulation of Ppp2r1a 1 0.08 1.5 0
41 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0
42 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0
43 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0
44 INT313465 Syp Regulation of Regulation of Ppp2ca 1 0.26 0.56 0
45 INT313426 Positive_regulation of Ppp2ca Positive_regulation of Bax 1 0.46 0.36 0
46 INT313431 Positive_regulation of Binding of Ppp2ca and Gopc 1 0.11 0.34 0
47 INT313456 Binding of Ppp2ca and Gopc 1 0.08 0.68 0
48 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein phosphatase type 2A complex. They are ordered first by their pain relevance and then by number of times they were reported in protein phosphatase type 2A complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT196782 Positive_regulation of Ppp2ca 32 0.61 1.89 4.33
2 INT90277 Negative_regulation of Ppp2ca 15 0.41 4.04 4.02
3 INT95119 Localization of CYCS 23 0.78 14.86 3.49
4 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25
5 INT91837 Negative_regulation of Ppp2r1a 4 0.48 0.95 2.41
6 INT90272 Gene_expression of Ppp2ca 18 0.68 4.69 2.08
7 INT105086 Positive_regulation of CYCS 9 0.49 5.82 1.45
8 INT144805 Regulation of Negative_regulation of Ppp2ca 1 0.28 0.24 1.38
9 INT114822 Negative_regulation of PPP2R4 2 0.57 1.89 1.28
10 INT111340 Positive_regulation of Localization of CYCS 7 0.67 4.83 1.19
11 INT196785 Regulation of Ppp2ca 5 0.54 2.1 1.17
12 INT53028 Negative_regulation of CYCS 6 0.57 2.65 1.11
13 INT142777 Phosphorylation of PPP2R4 2 0.61 1.03 1.07
14 INT142776 Positive_regulation of Phosphorylation of PPP2R4 1 0.45 1.04 1.07
15 INT90278 Localization of Ppp2ca 4 0.66 1.12 0.94
16 INT196754 Binding of Ppp2ca 5 0.37 0.42 0.89
17 INT1523 Binding of CYCS 4 0.47 0.53 0.8
18 INT133484 Negative_regulation of Localization of CYCS 4 0.42 2.77 0.7
19 INT196753 Negative_regulation of Phosphorylation of Ppp2ca 3 0.37 0.52 0.7
20 INT169216 Negative_regulation of Positive_regulation of CYCS 1 0.42 0.82 0.7
21 INT196742 Positive_regulation of Positive_regulation of Ppp2ca 4 0.44 0.05 0.68
22 INT53022 Gene_expression of CYCS 5 0.65 4.01 0.66
23 INT296253 Negative_regulation of Gene_expression of Ppp2ca 3 0.41 1.71 0.62
24 INT196765 Positive_regulation of Gene_expression of Ppp2ca 4 0.44 1.05 0.6
25 INT26187 Regulation of CYCS 2 0.60 0.87 0.44
26 INT167616 Protein_catabolism of Ppp2cb 1 0.02 0.87 0.42
27 INT243978 Binding of Ppp2r1a 2 0.08 0 0.36
28 INT270927 Regulation of Binding of Ppp2r1a 1 0.04 0 0.29
29 INT270929 Regulation of Ppp2r1a 1 0.02 0 0.28
30 INT196761 Regulation of Positive_regulation of Ppp2ca 2 0.40 0.05 0.22
31 INT196763 Positive_regulation of Regulation of Ppp2ca 1 0.30 0 0.21
32 INT196759 Negative_regulation of Negative_regulation of Ppp2ca 2 0.30 0.17 0.2
33 INT192857 Gene_expression of Ppp2r1a 6 0.47 1.74 0.19
34 INT55496 Phosphorylation of Ppp2r2b 1 0.23 0 0.16
35 INT55497 Negative_regulation of Phosphorylation of Ppp2r2b 1 0.16 0 0.16
36 INT196770 Negative_regulation of Positive_regulation of Ppp2ca 1 0.27 0 0.16
37 INT55499 Localization of Ppp2r2b 1 0.26 0 0.15
38 INT55498 Negative_regulation of Ppp2r2b 1 0.16 0 0.15
39 INT78375 Localization of PPP2R4 1 0.73 0.43 0.14
40 INT130925 Protein_catabolism of CYCS 1 0.86 1.37 0.14
41 INT200943 Negative_regulation of PPP2CA 1 0.10 0.13 0.14
42 INT1524 Positive_regulation of Binding of CYCS 1 0.67 0 0.14
43 INT245803 Protein_catabolism of Ppp2r2b 2 0.02 3.02 0.13
44 INT192856 Regulation of Gene_expression of Ppp2r1a 2 0.16 0.62 0.12
45 INT313409 Positive_regulation of Phosphorylation of Ppp2ca 1 0.39 0.16 0.11
46 INT313423 Positive_regulation of Localization of Ppp2ca 1 0.44 0.12 0.1
47 INT243986 Positive_regulation of Binding of Ppp2r1a 1 0.09 0 0.08
48 INT243946 Negative_regulation of Binding of Ppp2r1a 1 0.07 0 0.08
49 INT239456 Phosphorylation of Ppp2r1a 2 0.16 1.01 0.07
50 INT53027 Positive_regulation of Negative_regulation of CYCS 1 0.45 0.07 0.07
51 INT300432 Negative_regulation of Protein_catabolism of Ppp2r2b 1 0.01 1.52 0.05
52 INT313406 Positive_regulation of Binding of Ppp2ca 1 0.44 0 0.04
53 INT239453 Positive_regulation of Gene_expression of Ppp2r1a 1 0.03 0 0.03
54 INT313421 Regulation of Phosphorylation of Ppp2ca 1 0.40 0 0.03
55 INT239455 Positive_regulation of Ppp2r1a 1 0.03 0 0.03
56 INT167236 Regulation of Localization of CYCS 1 0.44 0 0
57 INT313407 Regulation of Regulation of Ppp2ca 1 0.24 0.56 0
58 INT342452 Gene_expression of PPP2CA 1 0.20 0.49 0
59 INT287854 Negative_regulation of Ppp2cb 1 0.04 0 0
60 INT293342 Regulation of PPP2R4 1 0.03 0 0
61 INT300435 Gene_expression of Ppp2r2b 1 0.02 0.56 0
62 INT342450 Positive_regulation of PPP2CA 1 0.15 1.07 0
63 INT300434 Positive_regulation of Ppp2r2b 1 0.01 0.67 0
64 INT348481 Positive_regulation of Positive_regulation of CYCS 1 0.18 0.32 0
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